phenobarbital has been researched along with Muscle Contraction in 19 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with phenobarbital reduced, whereas previous application of tri-O-cresyl phosphate (TOCP) enhanced, effectiveness of soman administered i." | 1.27 | Phrenic nerve-diaphragm preparation in situ for studying the detoxification of soman in the rat liver. ( Bosković, B; Cetković, S, 1988) |
| "Using isolated rat aortic strips (AS) and portal veins (PV), it was found that all of the barbiturates studied (thiopental, secobarbital, pentobarbital, amobarbital, phenobarbital, and barbital): a) inhibit development of spontaneous mechanical activity (vasomotion) in AS and PV in concentrations used to induce surgical anesthesia or concentrations used for anticonvulsive therapy; b) dose-dependent attenuate contractions induced by epinephrine and potassium (K+); c) cause non-competitive displacement of the dose-response curves of these vasoactive compounds; d) attenuate calcium (Ca++)-induced contractions of K+-depolarized AS and PV; e) rapidly relax drug-induced, as well as Ca++-induced, contractions of AS and PV." | 1.25 | Barbiturates and aortic and venous smooth-muscle function. ( Altura, BM; Altura, BT, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (5.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mietens, A | 1 |
| Tasch, S | 1 |
| Stammler, A | 1 |
| Konrad, L | 1 |
| Feuerstacke, C | 1 |
| Middendorff, R | 1 |
| Rosenberg, FJ | 1 |
| Cooke, WJ | 1 |
| Marín, J | 1 |
| Rico, ML | 1 |
| Salaices, M | 1 |
| Turski, WA | 1 |
| Schwarz, M | 2 |
| Turski, L | 2 |
| Sontag, KH | 2 |
| Coceani, F | 1 |
| Kelsey, L | 1 |
| Ackerley, C | 1 |
| Rabinovitch, M | 1 |
| Gelboin, H | 1 |
| Delini-Stula, A | 1 |
| Radeke, E | 1 |
| Vassout, A | 1 |
| Lidgren, L | 1 |
| Nilsson, BE | 1 |
| Wallöe, A | 1 |
| Gandhi, IC | 1 |
| Jindal, MN | 1 |
| Patel, VK | 1 |
| Tilson, HA | 1 |
| Cabe, PA | 1 |
| Elliott, RC | 1 |
| Altura, BT | 1 |
| Altura, BM | 1 |
| Curry, C | 1 |
| Lenox, WC | 1 |
| Spannhake, EW | 1 |
| Hirshman, CA | 1 |
| Cetković, S | 1 |
| Bosković, B | 1 |
| Klockgether, T | 1 |
| Ranney, RE | 1 |
| Dean, RR | 1 |
| Karim, A | 1 |
| Radzialowski, FM | 1 |
| Méhes, J | 1 |
| Decsi, L | 1 |
| Várszegi, MK | 1 |
| Hideg, H | 1 |
| Hankovszky, OH | 1 |
| Hauschild, R | 1 |
| Seewald, HJ | 1 |
| Robichaud, RC | 1 |
| Gylys, JA | 1 |
| Sledge, KL | 1 |
| Hillyard, IW | 1 |
| Agarwal, SL | 1 |
| Bhargava, V | 1 |
19 other studies available for phenobarbital and Muscle Contraction
| Article | Year |
|---|---|
Time-lapse imaging as a tool to investigate contractility of the epididymal duct--effects of cGMP signaling.
Topics: Animals; Biological Transport; Cyclic GMP; Epididymis; Gene Expression Regulation, Enzymologic; Guan | 2014 |
A peripheral component of centrally acting muscle relaxants: chlormezanone and mephenesin.
Topics: Animals; Cats; Chlormezanone; Female; Male; Mephenesin; Muscle Contraction; Neural Conduction; Neuro | 1967 |
Interference of pentobarbitone with the contraction of vascular smooth muscle in goat middle cerebral artery.
Topics: Animals; Calcium; Cerebral Arteries; Female; Goats; In Vitro Techniques; Muscle Contraction; Muscle, | 1981 |
A specific benzodiazepine antagonist CGS 8216 reverses the muscle relaxant effect of diazepam but not that of phenobarbitone.
Topics: Animals; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electromyography; Female; Male; Mu | 1984 |
Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues.
Topics: Aging; Animals; Animals, Newborn; Aorta; Cells, Cultured; Cytochrome P-450 Enzyme System; Dexamethas | 1994 |
Some aspects of the psychopharmacological activity of maprotiline (Ludiomil): effects of single and repeated treatments.
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Anthracenes; Behavior, Animal; Body Temperature; Clomip | 1978 |
Bone mineral content in epileptics.
Topics: Aged; Bone and Bones; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Minerals; Muscle C | 1979 |
Mechaism of neuromuscular blockade with some antiepileptic drugs.
Topics: Abdominal Muscles; Anesthetics, Local; Animals; Anticonvulsants; Cats; Diaphragm; Ethosuximide; Fema | 1976 |
Assessment of chemically-induced changes in the neuromuscular function of rats using a new recording grip meter.
Topics: Animals; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Male; Muscle Contraction; Neuromuscula | 1978 |
Interactions of suxamethonium and barbiturate drugs at the avian neuromuscular junction.
Topics: Animals; Barbiturates; Chickens; Drug Interactions; Methohexital; Muscle Contraction; Neuromuscular | 1977 |
Barbiturates and aortic and venous smooth-muscle function.
Topics: Amobarbital; Animals; Aorta, Thoracic; Barbiturates; Calcium; Depression, Chemical; Dose-Response Re | 1975 |
Contractile responses of guinea pig trachea to oxybarbiturates and thiobarbiturates.
Topics: Animals; Barbiturates; Cyclooxygenase Inhibitors; Guinea Pigs; In Vitro Techniques; Male; Methohexit | 1991 |
Phrenic nerve-diaphragm preparation in situ for studying the detoxification of soman in the rat liver.
Topics: Animals; Diaphragm; Dose-Response Relationship, Drug; Electric Stimulation; Inactivation, Metabolic; | 1988 |
ZK 91296, an anticonvulsant beta-carboline which lacks muscle relaxant properties.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepinones; Carbolines; Convulsants; Diazepam; | 1985 |
Disopyramide phosphate: pharmacokinetic and pharmacologic relationships of a new antiarrhythmic agent.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Computers; Dicumarol; Dogs; Electrocardiograp | 1971 |
Inhibitory effect of 1-alkylbenzimidazoles on gastric secretion in the rat.
Topics: Acetylcholine; Animals; Behavior, Animal; Blood Pressure; Bradycardia; Carbachol; Cats; Central Nerv | 1966 |
[Spontaneous motility of the human fallopian tube and pharmacologic effect on it in a in-vitro study].
Topics: Adult; Diazepam; Ethanol; Fallopian Tubes; Female; Humans; In Vitro Techniques; Manometry; Middle Ag | 1974 |
The pharmacology of prazepam. A new benzodiazepine derivative.
Topics: Aggression; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Cats; Chlordiazepoxide; Dia | 1970 |
Study of the effects of tranquillizers on the acetylcholine, 5 hydroxytryptamine, adrenaline and nor-adrenaline responses of the cardiac, smooth and skeletal muscle.
Topics: Acetylcholine; Animals; Anura; Chlorpromazine; Epinephrine; Guinea Pigs; Heart; Intestines; Meprobam | 1964 |