phenobarbital has been researched along with Microcephaly in 5 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Microcephaly: A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "While cocaine is now used much more frequently than heroin by women of childbearing age, we have found that a significant number of mothers have abused both drugs during their pregnancy." | 3.67 | Perinatal outcome of infants exposed to cocaine and/or heroin in utero. ( Durand, DJ; Fulroth, R; Phillips, B, 1989) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "With the diagnosis of neonatal Graves' disease established, both twins were treated with propranolol (2 mg/kg." | 1.30 | [Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism]. ( Grüters, A; Hüfner, M; Lakomek, M; Roth, C; Siggelkow, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Awa, HD | 1 |
| Chelo, D | 1 |
| Kinkela, MN | 1 |
| Ndombo, PO | 1 |
| Roth, C | 1 |
| Siggelkow, H | 1 |
| Grüters, A | 1 |
| Hüfner, M | 1 |
| Lakomek, M | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 1 |
| Thakker, JC | 1 |
| Kothari, SS | 1 |
| Deshmukh, CT | 1 |
| Deshpande, PG | 1 |
| Dalwai, WM | 1 |
| Joshi, MK | 1 |
| Kandoth, PW | 1 |
| Fulroth, R | 1 |
| Phillips, B | 1 |
| Durand, DJ | 1 |
5 other studies available for phenobarbital and Microcephaly
| Article | Year |
|---|---|
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
[Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism].
Topics: Adrenergic beta-Antagonists; Adult; Antithyroid Agents; Autoantibodies; Developmental Disabilities; | 1997 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
Hypoplasia of nails and phalanges: a teratogenic manifestation of phenobarbitone.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Female; Fingers; Humans; Microcephaly; | 1991 |
Perinatal outcome of infants exposed to cocaine and/or heroin in utero.
Topics: Cocaine; Drug Synergism; Female; Fetal Growth Retardation; Heroin; Humans; Infant, Newborn; Microcep | 1989 |