phenobarbital has been researched along with Manganese Poisoning in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Manganese Poisoning: Manganese poisoning is associated with chronic inhalation of manganese particles by individuals who work with manganese ore. Clinical features include CONFUSION; HALLUCINATIONS; and an extrapyramidal syndrome (PARKINSON DISEASE, SECONDARY) that includes rigidity; DYSTONIA; retropulsion; and TREMOR. (Adams, Principles of Neurology, 6th ed, p1213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital pretreatment, which induced hepatic but not pulmonary CMT metabolism, protected against CMT-depended pneumotoxicity suggesting escape of an active CMT metabolite from the liver is not responsible for the pneumotoxic response." | 1.29 | Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl. ( Blanchard, KT; Clay, RJ; Morris, JB, 1996) |
| "Phenobarbital pretreatment prevented the convulsions and pulmonary damage produced by a 50 mg/kg i." | 1.27 | The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat. ( Hanzlik, RP; Hogberg, K; Penney, DA; Traiger, GJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanzlik, RP | 2 |
| Stitt, R | 1 |
| Traiger, GJ | 2 |
| Blanchard, KT | 1 |
| Clay, RJ | 1 |
| Morris, JB | 1 |
| Penney, DA | 1 |
| Hogberg, K | 1 |
3 other studies available for phenobarbital and Manganese Poisoning
| Article | Year |
|---|---|
Toxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in rats: role of metabolism.
Topics: Animals; Bile; Biotransformation; Kidney; Lethal Dose 50; Liver; Male; Manganese; Manganese Poisonin | 1980 |
Pulmonary activation and toxicity of cyclopentadienyl manganese tricarbonyl.
Topics: Animals; Biotransformation; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme System; Liver; L | 1996 |
The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat.
Topics: Animals; Body Weight; Drug Tolerance; Lethal Dose 50; Male; Manganese; Manganese Poisoning; Organ Si | 1985 |