phenobarbital has been researched along with Malaria in 11 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Eight hours after 2 of 3 prophylactic antimalarial treatments with mefloquine generalized tonic-clonic seizures occurred." | 3.68 | [Suspected convulsive side-effect of mefloquine (Lariam)]. ( Besser, R; Krämer, G, 1991) |
| "The prevalence of epilepsy is high in many areas of Africa." | 2.43 | Epilepsy and mortality in Africa: a review of the literature. ( Diop, AG; Hauser, WA; Hesdorffer, DC; Logroscino, G, 2005) |
| "Malaria is a major problem in children in many parts of Papua New Guinea; it has a high mortality and, if observations from other countries are applicable, significant long-term morbidity." | 2.38 | Malaria in children in Papua New Guinea. ( Vince, JD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diop, AG | 1 |
| Hesdorffer, DC | 1 |
| Logroscino, G | 1 |
| Hauser, WA | 1 |
| Sadarangani, M | 1 |
| Seaton, C | 1 |
| Scott, JA | 1 |
| Ogutu, B | 1 |
| Edwards, T | 1 |
| Prins, A | 1 |
| Gatakaa, H | 1 |
| Idro, R | 1 |
| Berkley, JA | 1 |
| Peshu, N | 1 |
| Neville, BG | 1 |
| Newton, CR | 1 |
| Pass, MA | 1 |
| Geoffrion, Y | 1 |
| Deslauriers, R | 1 |
| Butler, KW | 1 |
| Smith, IC | 1 |
| Srivastava, P | 1 |
| Sharma, SN | 1 |
| Shukla, OP | 1 |
| Pandey, VC | 1 |
| Vince, JD | 1 |
| Besser, R | 1 |
| Krämer, G | 1 |
| White, NJ | 1 |
| Looareesuwan, S | 1 |
| Phillips, RE | 1 |
| Chanthavanich, P | 1 |
| Warrell, DA | 1 |
| Heischkeil, R | 1 |
| Quevauviller, A | 1 |
| Sarrazin, G | 1 |
| Einheber, A | 1 |
| Wren, RE | 1 |
| Klobukowski, CJ | 1 |
| McCarthy, JS | 1 |
| Furner, RL | 1 |
| Van Dyke, K | 1 |
| Stitzel, RE | 1 |
2 reviews available for phenobarbital and Malaria
| Article | Year |
|---|---|
Epilepsy and mortality in Africa: a review of the literature.
Topics: Africa; Anticonvulsants; Cause of Death; Child; Developing Countries; Epilepsy; Humans; Malaria; Mal | 2005 |
Malaria in children in Papua New Guinea.
Topics: Antimalarials; Cause of Death; Child; Child Welfare; Child, Preschool; Clinical Protocols; Communica | 1992 |
1 trial available for phenobarbital and Malaria
| Article | Year |
|---|---|
Single dose phenobarbitone prevents convulsions in cerebral malaria.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Clinical Trials as Topic; Double-Blind Method; Femal | 1988 |
8 other studies available for phenobarbital and Malaria
| Article | Year |
|---|---|
Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Data Int | 2008 |
Use of 13C nuclear magnetic resonance spectroscopy for the evaluation of hepatic drug-metabolizing enzyme activity in perfused mouse livers.
Topics: Aminopyrine; Animals; Enzyme Activation; Inactivation, Metabolic; Liver; Magnetic Resonance Spectros | 1984 |
Studies of the hepatic mitochondrial and microsomal mixed-function oxidase system during Plasmodium yoelii infection and inducer treatment in Swiss albino mice.
Topics: Animals; Cytochrome P-450 Enzyme System; GABA Modulators; Malaria; Mice; Microsomes, Liver; Mitochon | 1997 |
[Suspected convulsive side-effect of mefloquine (Lariam)].
Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clo | 1991 |
[Antimetabolites of folic acid metabolism with chemotherapeutic activity against rodent malaria (Plasmodium vinckei)].
Topics: Aminopterin; Animals; Cycloheximide; Female; Folic Acid; Folic Acid Antagonists; Hydantoins; Malaria | 1973 |
[Modifications of the hypnotic activity of barbiturates in mice under impaludation with Plasmodium berghei].
Topics: Animals; Malaria; Mice; Pentobarbital; Phenobarbital; Thiopental; Time Factors | 1969 |
Interference of hepatic drug metabolism in Plasmodium berghei-infected mice and its therapeutic modification: A study of hexobarbital sleeping time and phenobarbital-induced liver stimulation.
Topics: Animals; Female; Hematocrit; Hexobarbital; Liver; Malaria; Mice; Organ Size; Phenobarbital; Plasmodi | 1970 |
Effects of malarial infection on host microsomal drug-metabolizing enzymes.
Topics: Aniline Compounds; Animals; Anisoles; Blood Cell Count; Cytochromes; Endoplasmic Reticulum; Enzyme I | 1970 |