phenobarbital has been researched along with Magnesium Deficiency in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital failed to abolish or depress recurrent seizures in 70% of hippocampi." | 3.74 | Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. ( Brumback, AC; Dzhala, VI; Staley, KJ, 2008) |
| "Loreclezole was also shown to inhibit 'low Ca2+' and 'low Mg2+' epileptogenesis at similar concentrations to those active on inhibition." | 1.28 | In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus. ( Ashton, D; Willems, R, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, AJ | 1 |
| Jones, NA | 1 |
| Williams, CM | 1 |
| Stephens, GJ | 1 |
| Whalley, BJ | 1 |
| Dzhala, VI | 1 |
| Brumback, AC | 1 |
| Staley, KJ | 1 |
| Belknap, JK | 1 |
| Berg, JH | 1 |
| Ondrusek, G | 1 |
| Waddingham, S | 1 |
| Jooste, PL | 1 |
| Wolfswinkel, JM | 1 |
| Schoeman, JJ | 1 |
| Strydom, NB | 1 |
| Buck, DR | 1 |
| Mahoney, AW | 1 |
| Hendricks, DG | 1 |
| Katz, SH | 1 |
| Gerstman, I | 1 |
| Lautenbacher, HW | 1 |
| Hediger, ML | 1 |
| Ashton, D | 1 |
| Willems, R | 1 |
| Campbell, TC | 1 |
| Hayes, JR | 1 |
| Josephson, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Bumetanide for Newborn Seizures: A Phase I Study of Pharmacokinetics and Safety of Bumetanide for Neonatal Seizures[NCT00830531] | Phase 1 | 43 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenobarbital and Magnesium Deficiency
| Article | Year |
|---|---|
Role of nutrition in the drug-metabolizing enzyme system.
Topics: Ascorbic Acid Deficiency; Calcium; Carbohydrates; Carcinogens; Catalysis; Chemical and Drug Induced | 1974 |
8 other studies available for phenobarbital and Magnesium Deficiency
| Article | Year |
|---|---|
Development of multi-electrode array screening for anticonvulsants in acute rat brain slices.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Evaluation | 2010 |
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.
Topics: Animals; Anticonvulsants; Bumetanide; Chloride Channels; Chlorides; Drug Synergism; Drug Therapy, Co | 2008 |
Barbiturate withdrawal and magnesium deficiency in mice.
Topics: Animals; Barbiturates; Body Weight; Brain; Humans; Magnesium; Magnesium Deficiency; Male; Mice; Mice | 1978 |
Epileptic-type convulsions and magnesium deficiency.
Topics: Acclimatization; Adult; Chlorides; Epilepsy; Hot Temperature; Humans; Magnesium; Magnesium Deficienc | 1979 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar | 1978 |
Letter: Failure to confirm anticonvulsant hypomagnesaemia.
Topics: Epilepsy; Humans; Magnesium Deficiency; Phenobarbital; Phenytoin | 1976 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Aci | 1992 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |