phenobarbital has been researched along with Lung Neoplasms in 42 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36." | 3.67 | Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989) |
| "To investigate the role of monomethyltriazenes as the active metabolites of antitumor dimethyltriazenes, the in vivo simultaneous treatment with an inducer (phenobarbital, PB) or an inhibitor (carbon tetrachloride, CCl4) of hepatic drug metabolism was examined in mice bearing Lewis lung carcinoma." | 3.67 | Effects of an inducer and an inhibitor of hepatic metabolism on the antitumor action of dimethyltriazenes. ( Giraldi, T; Lassiani, L; Perissin, L; Sava, G; Zorzet, S, 1988) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications." | 1.35 | Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases. ( Banelli, E; Bulzonetti, N; Caiazzo, R; Dionisi, F; Lichtner, M; Musio, D; Parisi, E; Parisi, G; Raffetto, N; Vullo, V, 2009) |
| " PB produced a twofold increase in liver MF over controls after 27 weeks of treatment, but a similar increase was not observed with longer dosing times; at later time points, the MF in the PB groups was lower than that of the control group, suggesting that PB is not producing direct DNA damage in the liver." | 1.33 | Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice. ( de Boer, J; Fairchild, D; Glickman, B; Johnson, A; Kanazawa, N; Mirsalis, JC; Nguyen, T; Shimon, JA; Winegar, RA, 2005) |
| " The public health implication of this lack of linearity in the low-dose area of the dose-response curve raises the question of whether low doses of carcinogens will reduce cancer risk." | 1.30 | Can the concept of hormesis Be generalized to carcinogenesis? ( Baldwin, LA; Calabrese, EJ, 1998) |
| "The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20." | 1.28 | Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989) |
| "The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment." | 1.27 | Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988) |
| "Choline was not effective in inhibiting the development of lung metastases in either case." | 1.27 | Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (76.19) | 18.7374 |
| 1990's | 6 (14.29) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Musio, D | 1 |
| Parisi, E | 1 |
| Dionisi, F | 1 |
| Parisi, G | 1 |
| Caiazzo, R | 1 |
| Bulzonetti, N | 1 |
| Lichtner, M | 1 |
| Raffetto, N | 1 |
| Vullo, V | 1 |
| Banelli, E | 1 |
| HALLER, CG | 1 |
| Mirsalis, JC | 1 |
| Shimon, JA | 1 |
| Johnson, A | 1 |
| Fairchild, D | 1 |
| Kanazawa, N | 1 |
| Nguyen, T | 1 |
| de Boer, J | 1 |
| Glickman, B | 1 |
| Winegar, RA | 1 |
| Kaledin, VI | 1 |
| Il'nitskaia, SI | 1 |
| Baginskaia, NV | 1 |
| Kholodar', AV | 1 |
| Obut, TA | 1 |
| Maeura, Y | 1 |
| Williams, GM | 1 |
| Jones, DH | 1 |
| Bleehen, NM | 1 |
| Workman, P | 1 |
| Walton, MI | 1 |
| Alley, MC | 1 |
| Powis, G | 1 |
| Appel, PL | 1 |
| Kooistra, KL | 1 |
| Lieber, MM | 1 |
| Tsuchiya, E | 1 |
| Concetti, HF | 1 |
| Sugano, H | 1 |
| Kitagawa, T | 1 |
| Diwan, BA | 2 |
| Rice, JM | 2 |
| Ward, JM | 2 |
| Ohshima, M | 1 |
| Lynch, PH | 1 |
| Nomura, T | 1 |
| Okamoto, E | 1 |
| Gotoh, H | 1 |
| Namba, T | 1 |
| Tanaka, H | 1 |
| Sakamoto, Y | 1 |
| Friedman, GD | 1 |
| Naito, M | 1 |
| Naito, Y | 1 |
| Ito, A | 1 |
| Pollard, M | 1 |
| Luckert, PH | 1 |
| Scheu, J | 1 |
| Salvolini, U | 1 |
| Bonetti, MG | 1 |
| Ciritella, P | 1 |
| Giri, RK | 1 |
| Baral, RN | 1 |
| Das, BR | 1 |
| Takegawa, K | 1 |
| Mitsumori, K | 1 |
| Onodera, H | 1 |
| Shimo, T | 1 |
| Takahashi, M | 2 |
| Yasuhara, K | 1 |
| Calabrese, EJ | 1 |
| Baldwin, LA | 1 |
| Hukkanen, J | 1 |
| Lassila, A | 1 |
| Päivärinta, K | 1 |
| Valanne, S | 1 |
| Sarpo, S | 1 |
| Hakkola, J | 1 |
| Pelkonen, O | 1 |
| Raunio, H | 1 |
| Lindenschmidt, TO | 1 |
| Zimmermann, HG | 1 |
| Clemmesen, J | 1 |
| Uchida, E | 1 |
| Hirono, I | 1 |
| Balanski, RM | 1 |
| Dzhioev, FK | 1 |
| Lee, YS | 1 |
| Seo, JS | 1 |
| Chung, HT | 1 |
| Cho, KJ | 1 |
| Jan, JJ | 1 |
| Thamavit, W | 1 |
| Fukushima, S | 1 |
| Kurata, Y | 1 |
| Asamoto, M | 1 |
| Ito, N | 2 |
| Suchy, BK | 1 |
| Sarafoff, M | 1 |
| Kerler, R | 1 |
| Rabes, HM | 1 |
| Olsen, JH | 1 |
| Boice, JD | 1 |
| Jensen, JP | 1 |
| Fraumeni, JF | 1 |
| Shirai, T | 1 |
| Masuda, A | 1 |
| Imaida, K | 1 |
| Ogiso, T | 1 |
| Klaunig, JE | 1 |
| Pereira, MA | 2 |
| Ruch, RJ | 1 |
| Weghorst, CM | 1 |
| Sava, G | 1 |
| Zorzet, S | 1 |
| Perissin, L | 1 |
| Giraldi, T | 1 |
| Lassiani, L | 1 |
| Shivapurkar, N | 1 |
| Hoover, KL | 1 |
| Poirier, LA | 1 |
| Cavaliere, A | 1 |
| Bufalari, A | 1 |
| Vitali, R | 1 |
| Leo, MA | 1 |
| Lowe, N | 1 |
| Lieber, CS | 1 |
| Knutsen, GL | 1 |
| Herren-Freund, SL | 1 |
| Macmahon, B | 1 |
| Adenis, L | 1 |
| Vlaeminck, MN | 1 |
| Driessens, J | 1 |
| Niitani, H | 1 |
| Sadoff, L | 1 |
| Riley, S | 1 |
| Quan, L | 1 |
| Rowe, J | 1 |
| Hendricks, GL | 1 |
| Barnes, WT | 1 |
| Hood, HL | 1 |
| van den Brenk, HA | 1 |
| Sharpington, C | 1 |
| de Azevedo e Silva, E | 1 |
| Yamamoto, RS | 1 |
| Weisburger, JH | 1 |
| Weisburger, EK | 1 |
42 other studies available for phenobarbital and Lung Neoplasms
| Article | Year |
|---|---|
Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases.
Topics: Anticonvulsants; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Mid | 2009 |
[Palliative treatment of lung tumors].
Topics: Atropine; Humans; Lung Neoplasms; Palliative Care; Phenobarbital; Procaine | 1957 |
Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.
Topics: Animals; Carcinogens; Clone Cells; Diethylnitrosamine; Female; Gene Frequency; Liver; Liver Neoplasm | 2005 |
[Effect of phenobarbital and thyroxine on hepatocarcinogenesis initiated in mice by nitrosoethylurea and diethylnitrosamine].
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Ethylnitrosourea; F | 2005 |
Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Diet; Dose-Response Relationship, Drug; Dr | 1984 |
The role of dexamethasone in the modification of misonidazole pharmacokinetics.
Topics: Adult; Aged; Dexamethasone; Drug Interactions; Female; Humans; Kinetics; Lung Neoplasms; Male; Metab | 1983 |
Activation and inactivation of cancer chemotherapeutic agents by rat hepatocytes cocultured with human tumor cell lines.
Topics: Animals; Antineoplastic Agents; Carbon Tetrachloride; Cell Survival; Colony-Forming Units Assay; Cyc | 1984 |
Lack of promotion effect of phenobarbital on pulmonary tumorigenesis in ddy mice initiated by transplacental exposure to 1-ethyl-1-nitrosourea.
Topics: Animals; Ethylnitrosourea; Female; Lung; Lung Neoplasms; Male; Mice; Nitrosourea Compounds; Phenobar | 1984 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp | 1984 |
Diminution of chemically induced lung neoplasia in mice by phenobarbital pre-treatment.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Lung Neoplasms; Mice; Mice, Inb | 1982 |
Barbiturates and lung cancer in humans.
Topics: California; Computers; Epidemiologic Methods; Female; Humans; Lung Neoplasms; Male; Pentobarbital; P | 1981 |
Effect of phenobarbital on the development of tumors in mice treated neonatally with N-ethyl-N-nitrosourea.
Topics: Animals; Ethylnitrosourea; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neop | 1982 |
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Ne | 1995 |
Accidental intrathecal injection of ionic water-soluble contrast medium: report of a case, including treatment.
Topics: Aged; Analgesia, Epidural; Bone Neoplasms; Consciousness Disorders; Contrast Media; Critical Care; D | 1996 |
Induction of lung carcinogenesis in AKR-mice by N-nitrosodiethylamine/phenobarbitone, associated with high expression of c-myc and c-jun oncoproteins.
Topics: Animals; Carcinogens; Diethylnitrosamine; Lung Neoplasms; Male; Mice; Mice, Inbred AKR; Neoplasm Pro | 1997 |
[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].
Topics: Animals; Antithyroid Agents; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nitrosamines; Phen | 1996 |
Can the concept of hormesis Be generalized to carcinogenesis?
Topics: Animals; Caffeic Acids; Carcinogenicity Tests; Carcinogens; Cell Division; Dioxins; DNA Ligases; Dos | 1998 |
Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line.
Topics: Adenocarcinoma; Anti-Inflammatory Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cy | 2000 |
[Surgical laparoscopy].
Topics: Biopsy; Breast Neoplasms; Humans; Laparoscopy; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; | 1975 |
Statistical studies in the aetiology of malignant neoplasms. V. Trends and risks. Denmark 1943--72.
Topics: Adolescent; Adult; Aged; Air Pollution; Animals; Carcinogens; Child; Child, Preschool; Denmark; Fema | 1977 |
Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.
Topics: Adenoma; Animals; Animals, Newborn; Dimethylnitrosamine; Drug Synergism; Liver Neoplasms; Lung Neopl | 1979 |
[The relationship between the activity of microsomal enzymes and pulmonary carcinogenesis in mice].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenoma; Animals; Antineoplastic Agents; Barbital; Chlorpromazine; | 1976 |
Lung adenoma development and NK activity in mice treated with multiple carcinogens.
Topics: Adenoma; Animals; Diethylnitrosamine; Female; Killer Cells, Natural; Lung Neoplasms; Methylnitrosour | 1992 |
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N | 1989 |
Promotion of malignant 'embryonal' liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Crosses, Genetic; Diethylnitrosamine; Female; Hemang | 1989 |
Amplification, rearrangements, and enhanced expression of c-myc in chemically induced rat liver tumors in vivo and in vitro.
Topics: Animals; Blotting, Northern; Blotting, Southern; Gene Amplification; Gene Expression Regulation, Neo | 1989 |
Cancer among epileptic patients exposed to anticonvulsant drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark; | 1989 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship | 1988 |
Effects of an inducer and an inhibitor of hepatic metabolism on the antitumor action of dimethyltriazenes.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carbon Tetrachloride; Carcinoma; Liver; Lung Neop | 1988 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N | 1986 |
Carcinogenicity and cocarcinogenicity test of phenobarbital sodium in adult BALB/c mice.
Topics: Animals; Cocarcinogenesis; Female; Hydrazines; Liver Neoplasms, Experimental; Lung Neoplasms; Male; | 1986 |
Interaction of drugs and retinol.
Topics: Animals; Drug Interactions; Ethanol; Hydroxylation; In Vitro Techniques; Kinetics; Lung Neoplasms; M | 1986 |
Effect of subsequent treatment of chloroform or phenobarbital on the incidence of liver and lung tumors initiated by ethylnitrosourea in 15 day old mice.
Topics: Animals; Chloroform; Cocarcinogenesis; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; L | 1985 |
Phenobarbital: epidemiological evidence.
Topics: Brain Neoplasms; Child; Female; Fetus; Follow-Up Studies; Humans; Lung Neoplasms; Male; Neoplasms; P | 1985 |
[Pulmonary adenoma in Swiss mice receiving urethane. 8. Action of phenobarbital].
Topics: Adenoma; Animals; Drug Antagonism; Female; Lung Neoplasms; Male; Mice; Neoplasms, Experimental; Phen | 1970 |
[Current usage of antineoplastic agents].
Topics: Antineoplastic Agents; Bronchial Neoplasms; Chloroquine; Chymotrypsin; Cyclophosphamide; Female; Fib | 1971 |
New endocrine observations in a male patient with choriocarcinoma.
Topics: Adult; Brain Neoplasms; Cerebrospinal Fluid Proteins; Choriocarcinoma; Cyclophosphamide; Dactinomyci | 1974 |
Seven-year "cure" of lung cancer with metastasis to the brain.
Topics: Adenocarcinoma; Brain Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Phe | 1972 |
Effect of phenobarbital on growth of a metastasising, allogeneic sarcoma in the rat.
Topics: Animals; Body Weight; Cobalt Isotopes; Female; Immunosuppression Therapy; Lung Neoplasms; Lymphatic | 1972 |
[Inhibitory action of the pre-treatment with phenobarbital on the pulmonary carcinogenic activity of ethyl urethane in mice].
Topics: Animals; Female; Lung Neoplasms; Male; Phenobarbital; Rats; Urethane | 1967 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; | 1971 |