phenobarbital has been researched along with Liver Steatosis in 39 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the peroxisome proliferator, dehydroepiandrosterone sulfate (DHEAS), and the typical cytochrome P450 (CYP) inducers phenobarbital (PB) and 3-methylcholanthrene (3-MC) on fatty liver were examined in rats." | 7.81 | Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet. ( Goto, H; Ito, Y; Matsumoto, S; Sato, M; Senba, T; Takeuchi, K; Umehara, K; Yamada, H, 2015) |
| " The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital (PB)." | 7.70 | Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital. ( Goto, H; Makita, T; Yamashita, S, 1998) |
| "The possible influence of a potent enzyme inducer, phenobarbitone, on white phosphorus fatty liver, was studied." | 7.66 | Accentuation of white phosphorus induced fatty liver by phenobarbitone in male rats compared to female rats. ( Claude, JR; Jacqueson, A; Thevenin, M; Truhaut, R; Warnet, JM, 1979) |
| "The effects of the peroxisome proliferator, dehydroepiandrosterone sulfate (DHEAS), and the typical cytochrome P450 (CYP) inducers phenobarbital (PB) and 3-methylcholanthrene (3-MC) on fatty liver were examined in rats." | 3.81 | Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet. ( Goto, H; Ito, Y; Matsumoto, S; Sato, M; Senba, T; Takeuchi, K; Umehara, K; Yamada, H, 2015) |
| " The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital (PB)." | 3.70 | Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital. ( Goto, H; Makita, T; Yamashita, S, 1998) |
| "The possible influence of a potent enzyme inducer, phenobarbitone, on white phosphorus fatty liver, was studied." | 3.66 | Accentuation of white phosphorus induced fatty liver by phenobarbitone in male rats compared to female rats. ( Claude, JR; Jacqueson, A; Thevenin, M; Truhaut, R; Warnet, JM, 1979) |
| " Phenobarbital induced the microsomal drugmetabolizing enzyme system in the fatty liver of genetically obese mice in the same way 2-3-fold as in the non-fatty liver of the lean littermates." | 3.66 | [Studies on drug metabolism in obese men and mice (author's transl)]. ( Grimmel, K; Richter, E; Zilly, W, 1979) |
| "Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease." | 1.51 | New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. ( Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C, 2019) |
| "Phenobarbital treatment greatly increased nuclear CAR accumulation in the livers of KO males as compared to those of wild type (WT) males." | 1.40 | The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. ( Kanayama, T; Moore, R; Negishi, M; Ohno, M; Ray, M, 2014) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| "The influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (CCl4) was investigated in a group of rhesus monkeys." | 1.25 | Protein deficiency in carbon tetrachloride-induced hepatic lesions. ( Deo, MG; Ramalingaswami, V; Roy, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (76.92) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 2 (5.13) | 29.6817 |
| 2010's | 4 (10.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maeso-Díaz, R | 1 |
| Boyer-Diaz, Z | 1 |
| Lozano, JJ | 1 |
| Ortega-Ribera, M | 1 |
| Peralta, C | 1 |
| Bosch, J | 1 |
| Gracia-Sancho, J | 1 |
| Ohno, M | 1 |
| Kanayama, T | 1 |
| Moore, R | 1 |
| Ray, M | 1 |
| Negishi, M | 1 |
| Takeuchi, K | 1 |
| Goto, H | 2 |
| Ito, Y | 1 |
| Sato, M | 1 |
| Matsumoto, S | 1 |
| Senba, T | 1 |
| Yamada, H | 1 |
| Umehara, K | 1 |
| Marmugi, A | 1 |
| Lukowicz, C | 1 |
| Lasserre, F | 1 |
| Montagner, A | 1 |
| Polizzi, A | 1 |
| Ducheix, S | 1 |
| Goron, A | 1 |
| Gamet-Payrastre, L | 1 |
| Gerbal-Chaloin, S | 1 |
| Pascussi, JM | 1 |
| Moldes, M | 1 |
| Pineau, T | 1 |
| Guillou, H | 1 |
| Mselli-Lakhal, L | 1 |
| Sugatani, J | 1 |
| Wada, T | 1 |
| Osabe, M | 1 |
| Yamakawa, K | 1 |
| Yoshinari, K | 1 |
| Miwa, M | 1 |
| Peffer, RC | 1 |
| Moggs, JG | 1 |
| Pastoor, T | 1 |
| Currie, RA | 1 |
| Wright, J | 1 |
| Milburn, G | 1 |
| Waechter, F | 1 |
| Rusyn, I | 1 |
| Vincenzi, L | 1 |
| Meldolesi, J | 1 |
| Morini, MT | 1 |
| Bassan, P | 1 |
| Schneider, S | 1 |
| Charles, F | 1 |
| Chichmanian, RM | 1 |
| Montoya, ML | 1 |
| Rampal, P | 1 |
| Loranger, A | 1 |
| Duclos, S | 1 |
| Grenier, A | 1 |
| Price, J | 1 |
| Wilson-Heiner, M | 1 |
| Baribault, H | 1 |
| Marceau, N | 1 |
| Yamashita, S | 1 |
| Makita, T | 1 |
| Margaria, E | 1 |
| Palieri Furlan, L | 1 |
| Marioni, A | 1 |
| Magro, M | 1 |
| Lovera, C | 1 |
| Deo, MG | 1 |
| Roy, H | 1 |
| Ramalingaswami, V | 2 |
| Jacqueson, A | 1 |
| Thevenin, M | 1 |
| Warnet, JM | 1 |
| Claude, JR | 1 |
| Truhaut, R | 1 |
| Grimmel, K | 2 |
| Richter, E | 1 |
| Zilly, W | 1 |
| el-Dessoukey, EA | 1 |
| Tahani, HM | 1 |
| Awadallah, R | 1 |
| Zinat, HA | 1 |
| Kotb, NA | 1 |
| Takashima, K | 1 |
| Ohyama, K | 1 |
| Mori, T | 1 |
| Takeyama, S | 1 |
| Hahn, HK | 1 |
| Tuma, DJ | 2 |
| Barak, AJ | 3 |
| Sorrell, MF | 3 |
| Marsh, AR | 1 |
| Fraser, HS | 1 |
| Breckenridge, A | 1 |
| Lewis, B | 1 |
| Thompson, GR | 1 |
| Haller, JS | 1 |
| Salas, M | 1 |
| Tuchweber, B | 1 |
| Glauert, HP | 1 |
| Pitot, HC | 1 |
| Becker, E | 1 |
| Messner, B | 1 |
| Berndt, J | 1 |
| Ariyoshi, T | 3 |
| Remmer, H | 3 |
| Elies, W | 1 |
| Heni, N | 1 |
| Porta, EA | 1 |
| Koch, OR | 1 |
| Hartroft, WS | 1 |
| Chopra, P | 1 |
| Roy, S | 1 |
| Nayak, NC | 1 |
| Tuna, DJ | 1 |
| Hepner, GW | 1 |
| Vesell, ES | 1 |
| Noffsinger, JK | 1 |
| Blinder, LV | 1 |
| Gasparian, SA | 1 |
| Maliugin, EF | 1 |
| Kliuchnikova, ZhI | 1 |
| Archakov, AI | 1 |
| Freundt, KJ | 1 |
| Liebaldt, GP | 1 |
| Sieber, KH | 1 |
| Torrielli, MV | 1 |
| Ugazio, G | 2 |
| Gabriel, L | 1 |
| Burdino, E | 2 |
| Pani, P | 1 |
| Gravela, E | 1 |
| Mazzarino, C | 1 |
| Koff, RS | 1 |
| Carter, EA | 1 |
| Lui, S | 1 |
| Isselbacher, KJ | 1 |
| Takabatake, E | 2 |
| Chalvardjian, A | 1 |
| Beneke, G | 1 |
| Brauchle, I | 1 |
| Rakow, L | 1 |
1 review available for phenobarbital and Liver Steatosis
| Article | Year |
|---|---|
Recent advances in molecular pathology: a review of the effects of alcohol on the liver.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Butyrates; Chemical and Drug Induced Liv | 1970 |
38 other studies available for phenobarbital and Liver Steatosis
| Article | Year |
|---|---|
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Li | 2019 |
The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P450 Family 2; Epigenesis, Genetic; Fatty Liver; | 2014 |
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Topics: Animals; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone Su | 2015 |
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; Cells, Cultured; Co | 2016 |
Dietary inulin alleviates hepatic steatosis and xenobiotics-induced liver injury in rats fed a high-fat and high-sucrose diet: association with the suppression of hepatic cytochrome P450 and hepatocyte nuclear factor 4alpha expression.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Constitutive Androstane Receptor; Cytoch | 2006 |
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.
Topics: Administration, Oral; Animals; Antigens, Differentiation; Aryl Hydrocarbon Hydroxylases; Cell Prolif | 2007 |
Protective effect of phenobarbital and SKF 525a on the acute ethanol-induced fatty liver.
Topics: Animals; Antidotes; Ethanol; Fatty Liver; Liver; Male; Microsomes; Phenobarbital; Proadifen; Rats; T | 1967 |
[Acute hepatitis associated with microvesicular steatosis induced by Atrium].
Topics: Acute Disease; Adult; Barbiturates; Blood Chemical Analysis; Chemical and Drug Induced Liver Injury; | 1995 |
Simple epithelium keratins are required for maintenance of hepatocyte integrity.
Topics: Animals; Bile; Blotting, Western; Cell Survival; Epithelium; Fatty Liver; Female; Glycogen; Hepatect | 1997 |
Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital.
Topics: Analysis of Variance; Animals; Cells, Cultured; Dehydroepiandrosterone; Dietary Sucrose; Energy Inta | 1998 |
[Endogenous intoxications of pregnancy: jaundice of pregnancy].
Topics: Adult; Arginine; Bicarbonates; Cholestasis; Cholestyramine Resin; Dextrans; Fatty Liver; Female; Glu | 1979 |
Protein deficiency in carbon tetrachloride-induced hepatic lesions.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Glucos | 1975 |
Accentuation of white phosphorus induced fatty liver by phenobarbitone in male rats compared to female rats.
Topics: Animals; Drug Synergism; Fatty Liver; Female; Male; Nitrophenols; Phenobarbital; Phosphorus; Rats; S | 1979 |
[Studies on drug metabolism in obese men and mice (author's transl)].
Topics: Adolescent; Adult; Animals; Enzyme Induction; Fatty Liver; Female; Hexobarbital; Humans; Male; Mice; | 1979 |
Effect of phenobarbitone and propionyl-promazine on serum enzymes in carbon-tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1978 |
Hypolipidemic effect of alpha-mono-p-myristyloxy-alpha'-methylcinnamoyl glycerol (LK-903) in rats.
Topics: Animals; Cinnamates; Clofibrate; Diet; Fatty Liver; Glycerides; Hypolipidemic Agents; Intubation, Ga | 1978 |
Effect of phenobarbital on lipid peroxidation in the liver.
Topics: Animals; Body Weight; Fatty Liver; Lipid Metabolism; Liver; Male; NADPH-Ferrihemoprotein Reductase; | 1976 |
Accentuation of ethanol-induced fatty liver by phenobarbitone.
Topics: Animals; Cholesterol; Drug Synergism; Ethanol; Fatty Liver; Liver; Phenobarbital; Rats; Triglyceride | 1977 |
Reye syndrome: diagnostic and therapeutic considerations.
Topics: Adolescent; Amino Acids; Brain; Child; Exchange Transfusion, Whole Blood; Fatty Liver; Glucose; Huma | 1977 |
Prevention by steroids of cerium hepatotoxicity.
Topics: Animals; Cerium; Chemical and Drug Induced Liver Injury; Dexamethasone; Endoplasmic Reticulum; Estra | 1976 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Two mechanisms of CCl4-induced fatty liver: lipid peroxidation or covalent binding studied in cultured rat hepatocytes.
Topics: Animals; Binding, Competitive; Carbon Tetrachloride; Cells, Cultured; Fatty Liver; Female; Lipid Per | 1987 |
[Effect of phenobarbital and diphenylhydantoin on different lipid fractions of liver].
Topics: Animals; Choline Deficiency; Ethanol; Fatty Liver; Liver; Phenobarbital; Phenytoin; Phospholipids; R | 1968 |
[Effect of various drugs on lipid content and drug metabolizing enzymes in rat liver following experimentally induced fatty degeneration].
Topics: Animals; Choline Deficiency; Enzyme Induction; Fatty Liver; Lipid Metabolism; Liver; Male; Microsome | 1970 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 1972 |
Hepatic and serum lipid patterns during development of phenobarbital induced fatty livers in rats.
Topics: Animals; Biological Transport; Cholesterol; Esters; Fatty Acids; Fatty Liver; Lipid Metabolism; Lipi | 1974 |
Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis.
Topics: Administration, Oral; Adult; Aged; Alcoholism; Aminopyrine; Breath Tests; Carbon Dioxide; Carbon Rad | 1974 |
Phenobarbital-induced fatty livers in the rat.
Topics: Animals; Cholesterol; Choline; Choline Deficiency; Dietary Fats; Dietary Proteins; Fatty Liver; Inje | 1973 |
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1973 |
Effect of barbiturates on the liver of rats exposed to carbon disulphide vapour.
Topics: Animals; Barbiturates; Carbon Disulfide; Chemical and Drug Induced Liver Injury; Environmental Expos | 1974 |
Effect of drug pretreatment on CBrCl3-induced liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bromine; Chemical and Drug Induced Liver | 1974 |
On the mechanism of fatty liver in white phosphorus-poisoned rats.
Topics: Aniline Compounds; Animals; Benzoates; Fatty Liver; Female; Glutathione; Liver; Luminescent Measurem | 1972 |
[Behavior of lipoproteins in hepatic steatosis].
Topics: Animals; Carbon Tetrachloride Poisoning; Fasting; Fatty Liver; Lipoproteins; Phenobarbital; Rats; Tr | 1971 |
Prevention of the ethanol-induced fatty liver in the rat by phenobarbital.
Topics: Alcohol Oxidoreductases; Animals; Chemistry Techniques, Analytical; Ethanol; Fatty Liver; Female; La | 1970 |
Drug metabolism in ethanol-induced fatty liver.
Topics: Animals; Body Weight; Choline Deficiency; Cytochromes; Endoplasmic Reticulum; Ethanol; Fatty Liver; | 1970 |
Drug metabolism in ethionine-induced fatty liver.
Topics: Animals; Cytochromes; Enzyme Induction; Ethanol; Ethionine; Fatty Liver; Female; In Vitro Techniques | 1970 |
Effect of phenobarbital on the development of fatty livers in choline-deficient rats.
Topics: Animals; Choline; Deficiency Diseases; Fatty Liver; Humans; Liver; Male; Phenobarbital; Phospholipid | 1970 |
[Effect of phenobarbital on the fatty liver of genetically obese mice].
Topics: Animals; Fatty Liver; Lipids; Liver; Mice; Obesity; Organ Size; Phenobarbital; Proteins; RNA | 1971 |