phenobarbital has been researched along with Liver Neoplasms in 322 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this investigation is to study the ultrastructure of liver and liver neoplasms after long-term administration of phenobarbital." | 7.66 | Ultrastructural study of rat liver and liver neoplasms after long-term treatment with phenobarbital. ( Becker, J; Feldman, D; Swarm, RL, 1981) |
| "Some excess risk of liver cancer was also found in cohort studies of patients hospitalized for epilepsy in Sweden and Taiwan, in the absence, however, of association with any specific drugs." | 6.50 | A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer. ( La Vecchia, C; Negri, E, 2014) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 5.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| " While CAR activation by its activators, such as phenobarbital (PB), induces hepatocyte proliferation and liver carcinogenesis in rodents, it remains unclear whether PXR activation drives liver cancer." | 4.02 | The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice. ( Hosaka, T; Ishimura, M; Kakizaki, S; Nobusawa, S; Sasaki, T; Shizu, R; Yoshinari, K, 2021) |
| "We established a cell line (MHB-2) from a hepatoblastoma (HB) induced by diethylnitrosamine (DEN) and sodium phenobarbital (PB) in male B6C3F1 mice and examined the biological characteristics of MHB-2." | 3.70 | Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma. ( Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T, 2000) |
| "Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[alpha]anthracene and 12-O-tetradecanoylphorbol 13-acetate, and mouse hepatic tumors induced by N-nitrosodiethylamine and phenobarbital, were inhibited by lantadenes." | 3.69 | Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors. ( Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H, 1997) |
| "Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine; subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg body weight for up to 49 weeks." | 3.68 | DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. ( Barthel, G; Bursch, W; Schulte-Hermann, R; Timmermann-Trosiener, I, 1990) |
| " Liver carcinogenesis was initiated by intraperitoneal injection of diethylnitrosamine (DEN) in male B6C3F1 mice at 100 or 200 mumol/kg body weight once a week for 10 weeks (total exposure 1000 or 2000 mumol/kg body weight)." | 3.68 | Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. ( Iatropoulos, MJ; Tokumo, K; Williams, GM, 1991) |
| "Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens." | 3.68 | Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. ( Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S, 1991) |
| "Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice." | 3.68 | Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice. ( Bazare, JJ; Harmon, JR; Law, MG; Leakey, JE; Webb, PJ; Wolff, GL, 1991) |
| " In contrast, the liver neoplasm promoter phenobarbital increased the multiplicity, although not the incidence, of liver neoplasms when given after FAA." | 3.67 | Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide. ( Furuya, K; Levine, WG; Mori, H; Numoto, S; Williams, GM, 1985) |
| "05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36." | 3.67 | Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989) |
| "0 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) for 140 days after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if 345-HBB had tumor-promoting ability in a two-stage hepatocarcinogenesis assay." | 3.66 | Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability. ( Aust, SD; Goodman, JI; Jensen, RK; Sleight, SD; Trosko, JE, 1983) |
| "The purpose of this investigation is to study the ultrastructure of liver and liver neoplasms after long-term administration of phenobarbital." | 3.66 | Ultrastructural study of rat liver and liver neoplasms after long-term treatment with phenobarbital. ( Becker, J; Feldman, D; Swarm, RL, 1981) |
| "Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to male Fischer rats led to hepatocellular carcinoma in 100 percent with metastasis to the lung in 40 percent, of the animals living for the full experimental period of 20 weeks." | 3.65 | Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. ( Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH, 1975) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Some excess risk of liver cancer was also found in cohort studies of patients hospitalized for epilepsy in Sweden and Taiwan, in the absence, however, of association with any specific drugs." | 2.50 | A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer. ( La Vecchia, C; Negri, E, 2014) |
| "Phenobarbital (PB) is a non-genotoxic indirect CAR activator, which induces cytochrome P450 (CYP) and other xenobiotic metabolizing enzymes and is known to produce liver foci/tumors in mice and rats." | 2.50 | Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. ( Bailey, J; Bars, R; Bell, D; Cattley, RC; Elcombe, CR; Ferguson, SS; Geter, D; Goetz, A; Goodman, JI; Hester, S; Jacobs, A; Lake, BG; Omiecinski, CJ; Peffer, RC; Schoeny, R; Wolf, DC; Xie, W, 2014) |
| "Within the cells of the liver and tumors, gallium is found in lysosomes, and rough endoplasmic reticulum." | 2.36 | Mechanisms of localization of gallium-67 in tumors. ( Larson, SM, 1978) |
| "Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC)." | 1.48 | Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis. ( Dozmorov, M; Fisher, PB; Ghosh, S; Jariwala, N; Lai, Z; Mendoza, RG; Mukhopadhyay, ND; Robertson, CL; Sarkar, D; Subler, MA; Windle, JJ, 2018) |
| "Phenobarbital (PB) is a cytochrome P450 (CYP) 2B inducer, and piperonyl butoxide (PBO) is a CYP1A/2B inducer." | 1.39 | Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. ( Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A, 2013) |
| "Group-II animals were kept untreated as hepatocellular carcinoma control." | 1.39 | Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats. ( Jhala, M; Joseph, JP; Kumar, P; Raval, SK; Sadariya, KA, 2013) |
| "Phenobarbital treatment caused a significant decrease in triiodothyronine and free thyroxine concentrations (17% and 40%, respectively) in the sensitive C3H/He mice by the end of 60-day treatment, while in the resistant mice, these changes were not observed." | 1.36 | The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility. ( Kaledin, V; Merkulova, T; Obut, T; Pakharukova, M; Smetanina, M, 2010) |
| "Female breast cancer is one of the major causes of death among women while male breast cancer is relatively uncommon and accounts for about 1% of all breast cancers in both sexes." | 1.34 | Male breast cancer with mandibular metastasis. A case report. ( Amaddeo, P; Barbaglio, A; Faldi, F; Fontana, S; Ghilardi, R; Pericotti, S, 2007) |
| "Within the scope of the Rat Liver Foci Bioassay the model carcinogens N-nitrosomorpholine (NNM), 2-acetylaminoflouren (2-AAF), phenobarbital (PB), and clofibrate (CF) were analyzed concerning their potency and dose-response relationship to induce foci of altered hepatocytes (FAHs), which are known to be precursor lesions of liver adenoma and carcinoma." | 1.34 | Comparison of mode of action of four hepatocarcinogens: a model-based approach. ( Bannasch, P; Groos, J; Kopp-Schneider, A; Schwarz, M, 2007) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "Phenobarbital (PB) is a nongenotoxic rodent carcinogen which induces global hypomethylation and regions of hypermethylation in mouse liver." | 1.33 | Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice. ( Bachman, AN; Goodman, JI; Phillips, JM, 2006) |
| " The authors discuss the possible development of adenomas of the liver as a result of long-term use of phenobarbital." | 1.32 | [Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital]. ( Bedrna, J; Ferko, A; Nozicka, J, 2003) |
| "In PB- and BS-treated livers, hepatomegaly was attributable to hepatocyte proliferation and enzyme induction." | 1.31 | Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates. ( Fujieda, Y; Furukawa, S; Goryo, M; Hayashi, K; Ikeyama, S; Miyamoto, Y; Okada, K; Tamura, T; Usuda, K, 2000) |
| "The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 1.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| "Phenobarbital sodium (PB) was administered at dietary levels of 0 (control), 8, 30, 125 and 500 ppm to groups of 20 male F344/DuCrj rats for 104 weeks." | 1.30 | Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. ( Fukushima, S; Funae, Y; Hagiwara, A; Ito, N; Masuda, C; Miyata, E; Sano, M; Shirai, T; Tamano, S, 1999) |
| "Rats treated with tamoxifen for 3 months but not promoted with phenobarbital also developed liver tumors over a longer period of time." | 1.29 | Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: promotion by phenobarbital. ( Carthew, P; De Matteis, F; Dorman, BM; Edwards, RE; Heydon, RT; Martin, EA; Smith, LL; White, IN, 1995) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| " On investigating the dose response curve for tumour promotion one finds that hepatocellular carcinomas only appear at a high dosage of phenobarbital and it seems likely that the human exposure to inducers in food, and in therapy with anticonvulsants, is in the dosage range well below that which causes promotion of liver cancer." | 1.28 | Nutrition and enzyme inducers in liver tumor promotion in human and rat. ( Driver, H; McDanell, R; McLean, EM, 1990) |
| " In the second experiment, the effect of chronic administration of PB and NAF given after I without S or after S without I was analyzed." | 1.27 | Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1986) |
| " This suggests that the chronic administration of a xenobiotic is not the only way to promote cancer development." | 1.27 | Promoting effect of portocaval anastomosis in rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Pector, JC; Préat, V; Roberfroid, M; Taper, H, 1984) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| ") at 4 weeks of age with N-nitrosodiethylamine (DEN) at a dosage of 80 mg/kg." | 1.27 | Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. ( Lynch, P; Ohshima, M; Riggs, C; Ward, JM, 1984) |
| " Similar dose-response data were obtained at various doses of two promoting agents effective in hepatocarcinogenesis, PB and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in livers of F-344 female rats following initiation with DEN (10 mg/kg) 24 h post-70% hepatectomy." | 1.27 | A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci. ( Campbell, HA; Glauert, HP; Goldsworthy, TL; Kennan, W; Maronpot, RR; Moran, S; Pitot, HC, 1987) |
| "It is concluded, that HepG2 hepatoma cells behave similar to the normal hepatocytes in terms of ALDH regulation and can be used for studies on the activity of ALDH as modified by added xenobiotics." | 1.27 | Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes. ( Marselos, M; Michalopoulos, G; Strom, SC, 1987) |
| "Acetoxime was highly volatile and was not mutagenic in the Ames test under a variety of conditions." | 1.27 | Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone. ( Lawson, TA; Markin, RS; Mirvish, SS; Nickols, JG, 1988) |
| "Choline was not effective in inhibiting the development of lung metastases in either case." | 1.27 | Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986) |
| "Diethylnitrosamine was used as the initiator and phenobarbital and partial hepatectomy as promoters." | 1.26 | Short-term in vivo initiation/promotion bioassay for hepatocarcinogens. ( Ford, JO; Pereira, MA, 1980) |
| "National Cancer Institute and two Federal Agencies, seven drugs were listed." | 1.26 | Epidemiological studies of medically used drugs. ( Clemmesen, J; Hjalgrim-Jensen, S, 1980) |
| "In the spectrum of hepatomas studied, 16alpha-hydroxylase activity was significantly decreased in parallel with the increase in hepatoma growth rate." | 1.26 | Metabolism of estrogens in hepatomas of different growth rates. ( Abul-Hajj, YJ; Morris, HP, 1977) |
| "Amount of cytochrome P-450 in hepatoma tissues also showed similar values as that in hyperplastic nodules." | 1.26 | Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. ( Fukumoto, Y; Noda, K; Okita, K; Takemoto, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 178 (55.28) | 18.7374 |
| 1990's | 72 (22.36) | 18.2507 |
| 2000's | 33 (10.25) | 29.6817 |
| 2010's | 32 (9.94) | 24.3611 |
| 2020's | 7 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Kiuchi, Y | 1 |
| Suzuki, H | 2 |
| Hirohashi, T | 1 |
| Tyson, CA | 1 |
| Sugiyama, Y | 1 |
| Li, S | 2 |
| Li, Y | 1 |
| Sun, H | 1 |
| Jiang, Y | 1 |
| Pan, K | 1 |
| Su, Y | 1 |
| Bu, N | 1 |
| Yoshinari, K | 2 |
| Shizu, R | 2 |
| van Kesteren, P | 1 |
| Pronk, M | 1 |
| Heusinkveld, H | 1 |
| Luijten, M | 1 |
| Hakkert, B | 1 |
| Kende, A | 1 |
| Lai, F | 1 |
| Lim, PP | 1 |
| Swindale, L | 1 |
| Hofstra, A | 1 |
| Zhang, F | 1 |
| McInnes, E | 1 |
| Currie, R | 1 |
| Cowie, D | 1 |
| Ishimura, M | 1 |
| Nobusawa, S | 1 |
| Hosaka, T | 1 |
| Sasaki, T | 1 |
| Kakizaki, S | 1 |
| Yamada, T | 3 |
| Cohen, SM | 2 |
| Lake, BG | 7 |
| Kakehashi, A | 1 |
| Ishii, N | 1 |
| Okuno, T | 1 |
| Fujioka, M | 1 |
| Gi, M | 1 |
| Fukushima, S | 9 |
| Wanibuchi, H | 2 |
| Okuda, Y | 1 |
| Kushida, M | 1 |
| Kikumoto, H | 1 |
| Nakamura, Y | 1 |
| Higuchi, H | 1 |
| Kawamura, S | 2 |
| Robertson, CL | 1 |
| Mendoza, RG | 1 |
| Jariwala, N | 1 |
| Dozmorov, M | 1 |
| Mukhopadhyay, ND | 1 |
| Subler, MA | 1 |
| Windle, JJ | 1 |
| Lai, Z | 1 |
| Fisher, PB | 1 |
| Ghosh, S | 1 |
| Sarkar, D | 1 |
| Pathak, S | 1 |
| Catanzaro, R | 1 |
| Vasan, D | 1 |
| Marotta, F | 1 |
| Chabria, Y | 1 |
| Jothimani, G | 1 |
| Verma, RS | 1 |
| Ramachandran, M | 1 |
| Khuda-Bukhsh, AR | 1 |
| Banerjee, A | 2 |
| Ji, Z | 1 |
| Settivari, RS | 1 |
| LeBaron, MJ | 1 |
| La Vecchia, C | 1 |
| Negri, E | 1 |
| Morita, R | 3 |
| Yafune, A | 2 |
| Shiraki, A | 2 |
| Itahashi, M | 2 |
| Akane, H | 2 |
| Nakane, F | 2 |
| Suzuki, K | 3 |
| Shibutani, M | 3 |
| Mitsumori, K | 6 |
| Elcombe, CR | 1 |
| Peffer, RC | 1 |
| Wolf, DC | 1 |
| Bailey, J | 1 |
| Bars, R | 1 |
| Bell, D | 1 |
| Cattley, RC | 1 |
| Ferguson, SS | 1 |
| Geter, D | 1 |
| Goetz, A | 1 |
| Goodman, JI | 9 |
| Hester, S | 1 |
| Jacobs, A | 1 |
| Omiecinski, CJ | 3 |
| Schoeny, R | 1 |
| Xie, W | 1 |
| Joseph, JP | 1 |
| Raval, SK | 1 |
| Sadariya, KA | 1 |
| Jhala, M | 1 |
| Kumar, P | 1 |
| Segawa, R | 1 |
| Hayashi, H | 3 |
| Ogawa, T | 1 |
| Takimoto, N | 1 |
| Hara, S | 1 |
| Luisier, R | 1 |
| Unterberger, EB | 1 |
| Schwarz, M | 16 |
| Moggs, J | 1 |
| Terranova, R | 1 |
| van Nimwegen, E | 1 |
| Braeuning, A | 6 |
| Omura, K | 2 |
| Uehara, T | 2 |
| Morikawa, Y | 2 |
| Minami, K | 2 |
| Kanki, M | 2 |
| Yamada, H | 2 |
| Ono, A | 2 |
| Urushidani, T | 2 |
| Klaunig, JE | 8 |
| Gehen, SC | 1 |
| Wang, Z | 1 |
| Klein, PJ | 1 |
| Billington, R | 1 |
| Lu, M | 1 |
| Wu, J | 1 |
| He, F | 1 |
| Wang, XL | 1 |
| Li, C | 1 |
| Chen, ZN | 1 |
| Bian, H | 1 |
| Wood, CE | 1 |
| Hester, SD | 1 |
| Chorley, BN | 1 |
| Carswell, G | 1 |
| George, MH | 1 |
| Ward, W | 1 |
| Vallanat, B | 1 |
| Ren, H | 1 |
| Fisher, A | 1 |
| Lake, AD | 1 |
| Okerberg, CV | 1 |
| Gaillard, ET | 1 |
| Moore, TM | 1 |
| Deangelo, AB | 2 |
| Kobayashi, K | 2 |
| Hashimoto, M | 1 |
| Honkakoski, P | 1 |
| Negishi, M | 1 |
| Groll, N | 2 |
| Kollotzek, F | 1 |
| Goepfert, J | 1 |
| Joos, TO | 2 |
| Riegler, T | 1 |
| Nejabat, M | 1 |
| Eichner, J | 1 |
| Stiebellehner, M | 1 |
| Subosits, S | 1 |
| Bilban, M | 1 |
| Zell, A | 1 |
| Huber, WW | 1 |
| Schulte-Hermann, R | 7 |
| Grasl-Kraupp, B | 3 |
| Hamaoka, A | 1 |
| Matsuda, T | 1 |
| Konishi, E | 1 |
| Taguchi, T | 1 |
| Petrikat, T | 1 |
| Vetter, S | 1 |
| Wenz, C | 1 |
| Dengjel, J | 1 |
| Gretzmeier, C | 1 |
| Weiss, F | 1 |
| Poetz, O | 1 |
| Lambert, CB | 1 |
| Spire, C | 1 |
| Claude, N | 1 |
| Guillouzo, A | 1 |
| Marx-Stoelting, P | 1 |
| Borowiak, M | 1 |
| Knorpp, T | 1 |
| Birchmeier, C | 1 |
| Buchmann, A | 7 |
| Phillips, JM | 3 |
| Burgoon, LD | 2 |
| Hirose, Y | 1 |
| Nagahori, H | 1 |
| Deguchi, Y | 1 |
| Tomigahara, Y | 1 |
| Nishioka, K | 1 |
| Uwagawa, S | 1 |
| Isobe, N | 1 |
| Okuno, Y | 1 |
| Nakagawa, K | 1 |
| Hosoe, K | 1 |
| Hidaka, T | 1 |
| Nabae, K | 2 |
| Kawabe, M | 2 |
| Kitano, M | 1 |
| Pakharukova, M | 1 |
| Smetanina, M | 1 |
| Kaledin, V | 1 |
| Obut, T | 1 |
| Merkulova, T | 1 |
| Singh, Y | 1 |
| Rignall, B | 2 |
| Hammad, S | 1 |
| Othman, A | 1 |
| von Recklinghausen, I | 1 |
| Godoy, P | 1 |
| Hoehme, S | 1 |
| Drasdo, D | 1 |
| Hengstler, JG | 1 |
| Bishayee, A | 1 |
| Mbimba, T | 1 |
| Thoppil, RJ | 1 |
| Háznagy-Radnai, E | 1 |
| Sipos, P | 1 |
| Darvesh, AS | 1 |
| Folkesson, HG | 1 |
| Hohmann, J | 1 |
| Calvisi, DF | 1 |
| Cerminara, C | 1 |
| Bagnolo, V | 1 |
| De Leonardis, F | 1 |
| Coniglio, A | 1 |
| Roberto, D | 1 |
| Compagnone, E | 1 |
| Curatolo, P | 1 |
| Urbanik, T | 1 |
| Boger, RJ | 1 |
| Longerich, T | 1 |
| Becker, K | 1 |
| Ehrenberg, KR | 1 |
| Hövelmeyer, N | 1 |
| Hahn, M | 1 |
| Schuchmann, M | 1 |
| Jäger, D | 1 |
| Waisman, A | 1 |
| Wörns, MA | 1 |
| Schulze-Bergkamen, H | 1 |
| Wang, M | 1 |
| Halasi, M | 1 |
| Kabirov, K | 1 |
| Landolfi, J | 1 |
| Lyubimov, AV | 1 |
| Gartel, AL | 1 |
| Gerloff, T | 1 |
| Geier, A | 1 |
| Roots, I | 1 |
| Meier, PJ | 1 |
| Gartung, C | 1 |
| Oliver, JD | 1 |
| Roberts, RA | 1 |
| Rossmanith, W | 1 |
| Chabicovsky, M | 1 |
| Peter, B | 1 |
| Schausberger, E | 1 |
| Ferko, A | 1 |
| Bedrna, J | 1 |
| Nozicka, J | 1 |
| Hagiwara, A | 4 |
| Imai, N | 1 |
| Doi, Y | 1 |
| Hirota, T | 1 |
| Yoshino, H | 1 |
| Tsushima, Y | 1 |
| Aoki, H | 1 |
| Yasuhara, K | 1 |
| Koda, T | 1 |
| Nakamura, M | 1 |
| Shirai, T | 7 |
| THERET, C | 1 |
| CONNEY, AH | 1 |
| BURNS, JJ | 1 |
| FOUTS, JR | 3 |
| POTTER, VR | 1 |
| HART, LG | 1 |
| ADAMSON, RH | 1 |
| MORRIS, HP | 5 |
| Singh, JP | 1 |
| Selvendiran, K | 1 |
| Banu, SM | 1 |
| Padmavathi, R | 1 |
| Sakthisekaran, D | 2 |
| Cardani, R | 1 |
| Zavanella, T | 1 |
| Numazawa, S | 1 |
| Shindo, S | 1 |
| Maruyama, K | 1 |
| Chibana, F | 1 |
| Kawahara, Y | 1 |
| Ashino, T | 1 |
| Tanaka, S | 1 |
| Yoshida, T | 2 |
| Bachman, AN | 1 |
| Juberg, DR | 1 |
| Mudra, DR | 1 |
| Hazelton, GA | 1 |
| Parkinson, A | 2 |
| Leonard, N | 1 |
| Draper, A | 1 |
| Ogilvie, BW | 1 |
| Zhang, Q | 1 |
| Bae, Y | 1 |
| Kemper, JK | 1 |
| Kemper, B | 1 |
| Itoh, T | 1 |
| Moto, M | 1 |
| Kuroiwa, Y | 1 |
| Sakai, H | 1 |
| Sakakima, Y | 1 |
| Hayakawa, A | 1 |
| Nagasaka, T | 1 |
| Nakao, A | 1 |
| Fontana, S | 1 |
| Ghilardi, R | 1 |
| Barbaglio, A | 1 |
| Amaddeo, P | 1 |
| Faldi, F | 1 |
| Pericotti, S | 1 |
| Groos, J | 1 |
| Bannasch, P | 2 |
| Kopp-Schneider, A | 1 |
| Chakraborty, T | 1 |
| Chatterjee, A | 1 |
| Rana, A | 1 |
| Srivastawa, S | 1 |
| Damodaran, S | 1 |
| Chatterjee, M | 3 |
| Page, JL | 1 |
| Strom, SC | 2 |
| Thirunavukkarasu, C | 1 |
| Premkumar, K | 1 |
| Sheriff, AK | 1 |
| Wiebel, FJ | 1 |
| Kiefer, F | 1 |
| Murdia, US | 1 |
| Kitagawa, T | 7 |
| Imai, F | 1 |
| Sato, K | 3 |
| Watanabe, R | 2 |
| Sugano, H | 2 |
| Pitot, HC | 13 |
| Goldsworthy, T | 3 |
| Campbell, HA | 3 |
| Poland, A | 1 |
| Ford, JO | 1 |
| Pereira, MA | 6 |
| Uchida, E | 2 |
| Hirono, I | 2 |
| Williams, GM | 8 |
| Katayama, S | 1 |
| Ohmori, T | 1 |
| Herren, SL | 2 |
| Britt, AL | 1 |
| Khoury, MK | 1 |
| Stout, DL | 2 |
| Becker, FF | 4 |
| Jensen, RK | 2 |
| Sleight, SD | 2 |
| Aust, SD | 2 |
| Trosko, JE | 2 |
| de Gerlache, J | 8 |
| Lans, M | 8 |
| Taper, H | 4 |
| Préat, V | 5 |
| Roberfroid, M | 5 |
| Garrett, CT | 1 |
| Queral, AE | 1 |
| Timmermann-Trosiener, I | 4 |
| Schuppler, J | 3 |
| Ohde, G | 1 |
| Ward, JM | 9 |
| Mori, H | 4 |
| Furuya, K | 4 |
| Fan, MC | 1 |
| Li, SS | 1 |
| Liu, Y | 1 |
| Wang, MS | 1 |
| Hasegawa, R | 2 |
| Tatematsu, M | 4 |
| Tsuda, H | 4 |
| Ito, N | 13 |
| Vesell, ES | 1 |
| Duthu, GS | 1 |
| Nestor, MS | 1 |
| Berliner, JA | 1 |
| Philpot, RM | 1 |
| Hankinson, O | 1 |
| Altanerová, V | 1 |
| Arai, M | 1 |
| Hibino, T | 1 |
| Takino, H | 1 |
| Ouchi, N | 1 |
| Hirasawa, Y | 1 |
| Pector, JC | 1 |
| Ohshima, M | 3 |
| Lynch, P | 2 |
| Riggs, C | 2 |
| Furukawa, F | 1 |
| Toyoda, K | 1 |
| Kokubo, T | 1 |
| Takahashi, M | 3 |
| Hayashi, Y | 1 |
| Malvaldi, G | 1 |
| Chieli, E | 1 |
| Saviozzi, M | 1 |
| Roome, N | 1 |
| Moore, MA | 1 |
| Natria, T | 1 |
| Hirose, M | 2 |
| Ogiso, T | 2 |
| Moran, S | 2 |
| Sirica, AE | 1 |
| Weeks, J | 1 |
| Koliada, AIu | 1 |
| Gel'shteĭn, VI | 1 |
| Kobliakov, VA | 1 |
| Taper, HS | 2 |
| Roberfroid, MB | 1 |
| Fort, L | 1 |
| Imaida, K | 3 |
| Kurata, Y | 2 |
| Stevens, FJ | 2 |
| Peraino, C | 14 |
| Rice, JM | 6 |
| Creasia, D | 1 |
| Nakanishi, K | 4 |
| Clemmesen, J | 5 |
| Hjalgrim-Jensen, S | 3 |
| Kunz, W | 3 |
| Schaude, G | 2 |
| Tennekes, H | 1 |
| Abanobi, SE | 1 |
| Lombardi, B | 1 |
| Shinozuka, H | 2 |
| Hino, O | 1 |
| Allen, B | 1 |
| Lindahl, R | 1 |
| McLean, AE | 4 |
| Smith, M | 1 |
| Driver, HE | 3 |
| Naito, M | 1 |
| Naito, Y | 1 |
| Ito, A | 1 |
| Gurkalo, VK | 2 |
| Feldman, D | 1 |
| Swarm, RL | 1 |
| Becker, J | 1 |
| Lee, MS | 2 |
| Wang, CY | 1 |
| King, CM | 1 |
| Shibata, M | 1 |
| Mochizuki, Y | 1 |
| Furukawa, K | 2 |
| Sawada, N | 2 |
| Gotoh, M | 1 |
| Cameron, R | 1 |
| Hazra, AK | 1 |
| Batra, JK | 1 |
| Raj, HG | 1 |
| Venkitasurbamanian, TA | 1 |
| Olsen, JH | 1 |
| Schulgen, G | 1 |
| Boice, JD | 1 |
| Whysner, J | 1 |
| Travis, LB | 1 |
| Johnson, FB | 1 |
| McGee, JO | 1 |
| Carthew, P | 2 |
| Martin, EA | 2 |
| White, IN | 2 |
| De Matteis, F | 1 |
| Edwards, RE | 1 |
| Dorman, BM | 1 |
| Heydon, RT | 1 |
| Smith, LL | 2 |
| Kim, SH | 1 |
| Lee, YS | 2 |
| Kim, TH | 1 |
| Jang, JJ | 1 |
| Ray, JS | 1 |
| Harbison, ML | 1 |
| McClain, RM | 4 |
| Hammerl, R | 1 |
| Kirchner, T | 1 |
| Neumann, HG | 1 |
| Paolini, M | 1 |
| Biagi, GL | 1 |
| Cantelli-Forti, G | 1 |
| Bauer, C | 1 |
| Otoshi, T | 1 |
| Iwata, H | 1 |
| Takada, N | 2 |
| Nishisawa, Y | 1 |
| Morii, H | 1 |
| Mizoguchi, Y | 1 |
| Futakuchi, M | 1 |
| Kim, DJ | 2 |
| Cui, L | 1 |
| Weghorst, CM | 5 |
| Devor, DE | 2 |
| Henneman, JR | 3 |
| Werle-Schneider, G | 1 |
| Glatt, H | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Dragan, YP | 1 |
| Laufer, C | 1 |
| Koleske, AJ | 1 |
| Drinkwater, N | 1 |
| Stevenson, DE | 3 |
| Walborg, EF | 3 |
| Kolaja, KL | 2 |
| Van Asten, JG | 1 |
| Te Koppele, JM | 1 |
| Horbach, GJ | 1 |
| Dubois, M | 1 |
| Plaisance, H | 1 |
| Thomé, JP | 1 |
| Kremers, P | 1 |
| Chaumontet, C | 1 |
| Suschetet, M | 1 |
| Honikman-Leban, E | 1 |
| Krutovskikh, VA | 1 |
| Berges, R | 1 |
| Le Bon, AM | 1 |
| Heberden, C | 1 |
| Shahin, MM | 1 |
| Yamasaki, H | 1 |
| Martel, P | 1 |
| Hiruma, S | 1 |
| Kimura, M | 1 |
| Lehmann, K | 1 |
| Gopalan-Kriczky, P | 1 |
| Qin, GZ | 1 |
| Lotlikar, PD | 1 |
| Lii, CK | 1 |
| Ko, JJ | 1 |
| Chen, HW | 1 |
| Kim, HC | 1 |
| Nishikawa, A | 1 |
| Allen, PT | 1 |
| Poirier, LA | 2 |
| Thorgeirsson, SS | 1 |
| Santoni-Rugiu, E | 1 |
| Inada, A | 1 |
| Nakanishi, T | 1 |
| Tokuda, H | 1 |
| Nishino, H | 1 |
| Sharma, OP | 1 |
| Phillips, JC | 1 |
| Price, RJ | 1 |
| Cunninghame, ME | 1 |
| Osimitz, TG | 1 |
| Cockburn, A | 1 |
| Gabriel, KL | 1 |
| Preiss, FJ | 1 |
| Butler, WH | 5 |
| Lee, GH | 1 |
| Ooasa, T | 1 |
| Osanai, M | 1 |
| Lee, KK | 1 |
| Hong, JT | 1 |
| Sumida, A | 1 |
| Yamamoto, I | 1 |
| Zhou, Q | 1 |
| Morisaki, T | 1 |
| Azuma, J | 1 |
| Spinardi, AL | 1 |
| Kaneno, R | 1 |
| Rodrigues, MA | 1 |
| Salvadori, DM | 1 |
| Rocha, NS | 1 |
| Barbisan, LF | 1 |
| Ribeiro, LR | 1 |
| de Camargo, JL | 1 |
| Thièry, JP | 1 |
| Blazsek, I | 1 |
| Legras, S | 1 |
| Marion, S | 1 |
| Reynes, M | 1 |
| Anjo, A | 1 |
| Adam, R | 1 |
| Misset, JL | 1 |
| Yoshida, M | 1 |
| Miyajima, K | 1 |
| Shiraki, K | 1 |
| Ando, J | 1 |
| Kudoh, K | 1 |
| Nakae, D | 3 |
| Maekawa, A | 1 |
| Miyata, E | 1 |
| Tamano, S | 1 |
| Sano, M | 1 |
| Masuda, C | 1 |
| Funae, Y | 1 |
| Kolluri, S | 1 |
| Elbirt, KK | 1 |
| Bonkovsky, HL | 1 |
| Löw-Baselli, A | 1 |
| Hufnagl, K | 1 |
| Parzefall, W | 1 |
| Furukawa, S | 1 |
| Usuda, K | 1 |
| Fujieda, Y | 1 |
| Tamura, T | 1 |
| Miyamoto, Y | 1 |
| Hayashi, K | 1 |
| Ikeyama, S | 1 |
| Goryo, M | 1 |
| Okada, K | 1 |
| Sakairi, T | 1 |
| Goto, K | 1 |
| Tsuchiya, T | 1 |
| Sugimoto, J | 1 |
| Mutai, M | 1 |
| Vijayaraghavan, M | 1 |
| Yano, Y | 1 |
| Otani, S | 1 |
| Yamamoto, S | 1 |
| Basak, R | 2 |
| Bhattacharya, R | 1 |
| Davies, R | 1 |
| Styles, J | 1 |
| Brown, K | 1 |
| Brown, JE | 1 |
| Watanabe, T | 1 |
| Sugie, S | 2 |
| Okamoto, K | 1 |
| Rahman, KM | 1 |
| Ushida, J | 1 |
| Barsness, L | 1 |
| Hirakawa, T | 1 |
| Ishikawa, T | 2 |
| Nemoto, N | 1 |
| Takayama, S | 1 |
| Lindenschmidt, TO | 1 |
| Zimmermann, HG | 1 |
| Schmähl, D | 1 |
| Danisman, A | 1 |
| Habs, M | 1 |
| Diehl, B | 1 |
| Owens, IS | 2 |
| Nebert, DW | 2 |
| Weisburger, JH | 1 |
| Madison, RM | 1 |
| Viguera, C | 1 |
| Weisburger, EK | 1 |
| Williams, MT | 1 |
| Gaylor, JL | 2 |
| Swenson, DH | 1 |
| Lin, JK | 1 |
| Miller, EC | 3 |
| Miller, JA | 3 |
| Gessner, T | 1 |
| Nishizumi, M | 1 |
| Abul-Hajj, YJ | 1 |
| Okita, K | 1 |
| Noda, K | 1 |
| Fukumoto, Y | 1 |
| Takemoto, T | 1 |
| Wislocki, PG | 1 |
| McCoy, EC | 1 |
| Rosenkranz, HS | 1 |
| Larson, SM | 1 |
| Vlasov, NN | 1 |
| Reynolds, ES | 1 |
| Moslen, MT | 1 |
| Szabo, S | 1 |
| Jaeger, RJ | 1 |
| Murphy, SD | 1 |
| Appel, KE | 1 |
| Rickart, R | 1 |
| Kunz, HW | 1 |
| Murasaki, G | 1 |
| Rapoport, EA | 1 |
| Konikova, AS | 1 |
| Kadlubar, FF | 1 |
| Drinkwater, NR | 1 |
| Farwell, DC | 1 |
| Nolan, CE | 1 |
| Herbst, EJ | 1 |
| Jones, G | 1 |
| Hempsall, V | 1 |
| Jansen, JD | 1 |
| Smith, GJ | 1 |
| Ohl, VS | 1 |
| Litwack, G | 1 |
| Rossi, L | 1 |
| Ravera, M | 1 |
| Repetti, G | 1 |
| Santi, L | 1 |
| Fry, RJ | 8 |
| Staffeldt, E | 7 |
| Christopher, JP | 2 |
| Gans, JH | 1 |
| Bartsch, H | 1 |
| Malaveille, C | 1 |
| Montesano, R | 1 |
| Bauer-Hofmann, R | 3 |
| Mahr, J | 2 |
| Kress, S | 1 |
| Sutherland, IA | 1 |
| Chen, ZY | 1 |
| Farin, F | 1 |
| Eaton, DL | 1 |
| Maruyama, H | 2 |
| Amanuma, T | 1 |
| Takashima, Y | 1 |
| Yoshiji, H | 1 |
| Tsutsumi, M | 3 |
| Tsujiuchi, T | 1 |
| Denda, A | 2 |
| Konishi, Y | 4 |
| Hendrich, S | 2 |
| Leveston, AO | 1 |
| Lindroos, P | 1 |
| Tsai, WH | 1 |
| Zarnegar, R | 1 |
| Michalopoulos, GK | 1 |
| Armato, U | 1 |
| Testolin, L | 1 |
| Menegazzi, M | 1 |
| Menapace, L | 1 |
| Ribecco, M | 1 |
| Carcereri dePrati, A | 1 |
| Miwa, M | 1 |
| Nishiwaki-Matsushima, R | 1 |
| Ohta, T | 1 |
| Nishiwaki, S | 1 |
| Suganuma, M | 1 |
| Kohyama, K | 1 |
| Carmichael, WW | 1 |
| Fujiki, H | 1 |
| Lijinsky, W | 1 |
| Kovatch, RM | 1 |
| Thomas, BJ | 1 |
| Belisario, MA | 1 |
| Arena, AR | 1 |
| Pecce, R | 1 |
| Borgia, R | 1 |
| Staiano, N | 1 |
| De Lorenzo, F | 1 |
| Vorce, RL | 1 |
| Khoury, MM | 1 |
| Glauert, HP | 2 |
| Davis, RA | 1 |
| Wolff, GL | 1 |
| Leakey, JE | 1 |
| Bazare, JJ | 1 |
| Harmon, JR | 1 |
| Webb, PJ | 1 |
| Law, MG | 1 |
| Lechner, MC | 1 |
| Barroso, M | 1 |
| Decloitre, F | 1 |
| Lafarge-Frayssinet, C | 2 |
| Ouldelhkim, M | 1 |
| Frayssinet, C | 2 |
| Siglin, JC | 2 |
| Sell, S | 1 |
| Hunt, JM | 1 |
| Dunsford, HA | 1 |
| Chisari, FV | 1 |
| Visser, O | 1 |
| van den Berg, JW | 1 |
| Koole-Lesuis, H | 1 |
| Voortman, G | 1 |
| Wilson, JH | 1 |
| Tokumo, K | 1 |
| Iatropoulos, MJ | 1 |
| Schafer, LD | 1 |
| Hartnett, JA | 1 |
| Olson, MJ | 1 |
| Hampton, JA | 1 |
| Jirtle, RL | 1 |
| Meyer, SA | 1 |
| Brockenbrough, JS | 1 |
| Saeter, G | 2 |
| Seglen, PO | 2 |
| Xu, YH | 2 |
| Sattler, GL | 1 |
| Maronpot, R | 1 |
| Neveu, MJ | 1 |
| Hully, JR | 1 |
| Paul, DL | 1 |
| Tanaka, T | 1 |
| Jack, EM | 1 |
| Stäubli, W | 1 |
| Waechter, F | 1 |
| Bentley, P | 1 |
| Suter, J | 1 |
| Bieri, F | 1 |
| Muakkassah-Kelly, SF | 1 |
| Cruz-Orive, LM | 1 |
| Ding, LA | 1 |
| Wright, AS | 1 |
| Fandrey, J | 1 |
| Seydel, FP | 1 |
| Siegers, CP | 1 |
| Jelkmann, W | 1 |
| Schwarze, PE | 1 |
| Fox, TR | 1 |
| Schumann, AM | 1 |
| Watanabe, PG | 1 |
| Yano, BL | 1 |
| Maher, VM | 1 |
| McCormick, JJ | 1 |
| Wang, JH | 1 |
| Hinrichsen, LI | 1 |
| Whitacre, CM | 1 |
| Cechner, RL | 1 |
| Sudilovsky, O | 1 |
| Blaich, G | 1 |
| Raabe, H | 1 |
| Metzler, M | 1 |
| Barthel, G | 1 |
| Bursch, W | 1 |
| McLean, EM | 1 |
| Driver, H | 1 |
| McDanell, R | 2 |
| Kirsch-Volders, M | 2 |
| Deleener, A | 2 |
| Büsser, MT | 1 |
| Lutz, WK | 1 |
| Thamavit, W | 1 |
| Asamoto, M | 1 |
| Diwan, BA | 4 |
| Lubet, RA | 3 |
| Nims, RW | 3 |
| Herren-Freund, SL | 1 |
| Numoto, S | 2 |
| Furukawa, NT | 1 |
| Yanagi, S | 3 |
| Sakamoto, M | 3 |
| Nakano, T | 2 |
| Hayes, MA | 2 |
| Roberts, E | 1 |
| Safe, SH | 1 |
| Farber, E | 2 |
| Cameron, RG | 1 |
| Beer, DG | 1 |
| Russell, JJ | 1 |
| Staffeldt, EF | 1 |
| Wright, BJ | 1 |
| Prapuolenis, A | 1 |
| Carnes, BA | 1 |
| Goldsworthy, TL | 1 |
| Kennan, W | 2 |
| Maronpot, RR | 1 |
| Kaufmann, WK | 3 |
| MacKenzie, SA | 2 |
| Kaufman, DG | 2 |
| Hu, H | 1 |
| Rolin-Limbosch, S | 1 |
| Moens, W | 1 |
| Szpirer, C | 1 |
| Marselos, M | 1 |
| Michalopoulos, G | 1 |
| Takahashi, S | 3 |
| Uchida, K | 1 |
| Shiraiwa, K | 1 |
| Shibata, K | 1 |
| Kamiya, T | 1 |
| Masuda, A | 1 |
| Rizvi, TA | 1 |
| Sarma, DS | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Estadella, MD | 1 |
| Pujol, MJ | 1 |
| Domingo, J | 1 |
| Mirvish, SS | 2 |
| Markin, RS | 1 |
| Lawson, TA | 1 |
| Nickols, JG | 1 |
| Tacchi-Bedford, AM | 1 |
| Schmitt, R | 1 |
| Wolf, CR | 1 |
| Oesch, F | 1 |
| Lee, G | 1 |
| Pickett, CB | 1 |
| Telakowski-Hopkins, CA | 1 |
| Ding, GJ | 1 |
| Ding, VD | 1 |
| King, RG | 1 |
| Shivapurkar, N | 1 |
| Hoover, KL | 1 |
| Evans, JG | 1 |
| Collins, MA | 1 |
| Savage, SA | 1 |
| Tsao, MS | 1 |
| Novicki, DL | 1 |
| Porta, EA | 1 |
| Dytioco, S | 1 |
| Aquino, T | 1 |
| Dorado, RD | 1 |
| Ooka, S | 1 |
| Markell, N | 1 |
| Maislos, M | 1 |
| Sobel, R | 1 |
| Shany, S | 1 |
| Hasuike, A | 1 |
| Kumazawa, K | 1 |
| Vesselinovitch, SD | 1 |
| Levine, WG | 1 |
| Timchalk, C | 1 |
| Charles, AK | 1 |
| Abraham, R | 1 |
| Thorpe, E | 1 |
| Walker, AI | 1 |
| Schneiderman, MA | 1 |
| Haschen, RJ | 1 |
| Miyake, Y | 1 |
| Takamiya, K | 1 |
| Chen, SH | 1 |
| Kitagawa, H | 1 |
| Rogers, LA | 1 |
| Thomas, C | 1 |
| Robinson, SH | 1 |
| Rugstad, HE | 1 |
| Yannoni, C | 1 |
| Tashjian, AH | 1 |
| Emmelot, P | 1 |
| Bos, CJ | 1 |
| Feinstein, RN | 1 |
| Cameron, EC | 1 |
| Phillips, JL | 1 |
| Benedict, WF | 2 |
| Gielen, JE | 2 |
| Niwa, A | 1 |
| Bebert, DW | 1 |
| Galotti, T | 1 |
| D'Amico, E | 1 |
| Marchese, E | 1 |
| Bompiani, R | 1 |
| Terranova, T | 1 |
| Russo, M | 1 |
| Jackson, SH | 1 |
| Epstein, RA | 1 |
| Kisieleski, WE | 1 |
| Okuda, K | 1 |
| Abe, H | 1 |
| Buu-Hoï, NP | 1 |
| Hien, DP | 1 |
| Saint-Ruf, G | 1 |
| Servoin-Sidoine, J | 1 |
| Marshall, A | 1 |
| Sidransky, H | 1 |
24 reviews available for phenobarbital and Liver Neoplasms
| Article | Year |
|---|---|
Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development.
Topics: Constitutive Androstane Receptor; Humans; Liver; Liver Neoplasms; Phenobarbital; Pregnane X Receptor | 2022 |
Letter to the editor regarding the review article by Yamada et al. (2021) titled "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)".
Topics: Animals; Constitutive Androstane Receptor; Hepatocytes; Humans; Liver; Liver Neoplasms; Phenobarbita | 2022 |
Mode of action hypothesis testing in chemical safety assessments using metabolomics as supporting evidence: Phenobarbital and cyclobutrifluram metabolomics profile comparison.
Topics: Animals; Chemical Safety; Hepatocytes; Liver; Liver Neoplasms; Male; Metabolomics; Mice; Phenobarbit | 2023 |
A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer.
Topics: Anticonvulsants; Epidemiologic Studies; Epilepsy; Humans; Liver Neoplasms; Molecular Epidemiology; P | 2014 |
Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Constitutive Androstane Receptor; Cytoch | 2014 |
Regulation of gene expression by CAR: an update.
Topics: Active Transport, Cell Nucleus; Animals; Biotransformation; Carcinoma, Hepatocellular; Cholesterol; | 2015 |
Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cricetinae; Cytochrome P-450 CYP4A; DNA Replication; Enzyme | 2009 |
Receptor-mediated hepatocarcinogenesis: role of hepatocyte proliferation and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Cell Division; Dieldrin; Dioxins; Hepatocytes; Liver; Liver Neoplas | 2002 |
Report of ICPEMC Task Group 5 on the differentiation between genotoxic and non-genotoxic carcinogens.
Topics: Animals; Butylated Hydroxytoluene; Carcinogens; Cell Line; DDT; Dieldrin; Dioxins; Drug Evaluation, | 1984 |
Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepate | 1982 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Humans; Liver Neoplasms; Liver | 1995 |
The species specificity of dieldrin- or phenobarbital- induced hepatocarcinogenesis: case studies with implications for human health risk assessment.
Topics: Animals; Dieldrin; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Occupational Diseases; Oc | 1995 |
A mechanistic relationship between thyroid follicular cell tumours and hepatocellular neoplasms in rodents.
Topics: Adenocarcinoma, Follicular; Animals; Carcinogens; Carcinoma, Hepatocellular; Environmental Pollutant | 1999 |
Mechanisms of localization of gallium-67 in tumors.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Gallium; Gallium Radioisotopes; G | 1978 |
Liver tumour promotion by phenobarbital: comparison of rat and human studies.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Epilepsy; Humans; Liver Neoplasms; Liver Neoplasms, | 1992 |
Liver tumor promoter phenobarbital: a biphasic modulator of hepatocyte proliferation.
Topics: Animals; Carcinogens; Cell Division; DNA Replication; Liver; Liver Neoplasms; Phenobarbital; Rats; T | 1991 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Mouse liver tumors and microsomal enzyme-inducing drugs: experimental and clinical perspectives with phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Cell Communication; Cocarcinogenesis; DNA Damage; Humans; Liver | 1990 |
Liver tumour promotion by chemicals: models and mechanisms.
Topics: Cell Division; Choline Deficiency; Cocarcinogenesis; Humans; Liver Neoplasms; Orotic Acid; Phenobarb | 1986 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
[Progress in diagnostic enzymology].
Topics: Alcoholism; Aminopeptidases; Amylases; Aspartate Aminotransferases; Cholinesterases; Creatine Kinase | 1973 |
[Recent progress in the study of liver diseases].
Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Bilirubin; Biological Transport; Chemical and Drug | 1971 |
298 other studies available for phenobarbital and Liver Neoplasms
| Article | Year |
|---|---|
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Blotting, Northern; Caco-2 Cells; Carcinoma, | 1998 |
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Fruit; Gene Ex | 2021 |
The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice.
Topics: Animals; Carcinogenesis; Cell Proliferation; Constitutive Androstane Receptor; Hepatocytes; Liver; L | 2021 |
Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR).
Topics: Animals; Constitutive Androstane Receptor; Hepatocytes; Humans; Liver; Liver Neoplasms; Mice; Phenob | 2021 |
Progression of Hepatic Adenoma to Carcinoma in
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Apoptosis; Cell Proliferation; Deoxyguanosine; Diseas | 2017 |
Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.
Topics: Androstanes; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; C | 2017 |
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Move | 2018 |
Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in
Topics: Animals; Biomarkers; Blood Glucose; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Catalase | 2020 |
Pilot studies evaluating the nongenotoxic rodent carcinogens phenobarbital and clofibrate in the rat Pig-a assay.
Topics: Animals; Biological Assay; Carcinogens; Clofibrate; Glycosylphosphatidylinositols; Liver; Liver Neop | 2019 |
Enhanced liver tumor promotion activity in rats subjected to combined administration of phenobarbital and orphenadrine.
Topics: Animals; Cytochrome P-450 CYP2B1; Diethylnitrosamine; Drug Combinations; Drug Synergism; Enzyme Indu | 2013 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemica | 2013 |
Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; L | 2013 |
Modifying effects of liver tumor promotion in rats subjected to co-administration of indole-3-carbinol and phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Syst | 2014 |
Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion.
Topics: Animals; beta Catenin; Binding Sites; Carcinogenesis; Cell Proliferation; Computational Biology; Com | 2014 |
Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?
Topics: Animals; Carcinogens; Cell Proliferation; Cocarcinogenesis; Constitutive Androstane Receptor; Humans | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
Topics: Adenoma, Liver Cell; Allyl Compounds; Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transform | 2015 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Latent carcinogenicity of early-life exposure to dichloroacetic acid in mice.
Topics: Animals; Dichloroacetic Acid; DNA Methylation; Dose-Response Relationship, Drug; Eating; Environment | 2015 |
Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells.
Topics: Animals; Calpain; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Rel | 2016 |
Proinflammatory mesenchymal effects of the non-genotoxic hepatocarcinogen phenobarbital: a novel mechanism of antiapoptosis and tumor promotion.
Topics: Animals; Apoptosis; Carcinogens; Cells, Cultured; Hepatocytes; Inflammation; Liver Neoplasms; Male; | 2015 |
Is the question of phenobarbital as potential liver cancer risk factor for humans really resolved?
Topics: Humans; Liver; Liver Neoplasms; Phenobarbital; Risk Factors | 2016 |
[A Case of Luminal-HER2 Advanced Breast Cancer with Liver Metastasis Showed Pathological Complete Response to the Therapy with Pertuzumab plus Trastuzumab plus Docetaxel].
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; | 2016 |
Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro.
Topics: Animals; Anticonvulsants; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Constitutive An | 2016 |
Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Line, Tumor; Cluster Analysis; Cytochrome P- | 2009 |
Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met.
Topics: Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Glutamate-Ammonia Ligase; Liver; Liver Neoplasms | 2009 |
Phenobarbital elicits unique, early changes in the expression of hepatic genes that affect critical pathways in tumor-prone B6C3F1 mice.
Topics: Animals; Carcinogenicity Tests; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Li | 2009 |
Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes.
Topics: Adult; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Cyclopropanes; Cytochrome P-450 CYP2 | 2009 |
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; D | 2009 |
Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay.
Topics: Animals; Antineoplastic Agents, Phytogenic; Diethylnitrosamine; Flavonoids; Functional Food; Glutath | 2010 |
The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility.
Topics: Animals; Constitutive Androstane Receptor; DNA; Gene Expression Regulation; Genetic Predisposition t | 2010 |
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.
Topics: Animals; beta Catenin; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cell Separation; | 2010 |
Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; DNA Mutational Analysis; Immunohistochemistr | 2011 |
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Prolifer | 2011 |
Of mice and men: the nonrandom genomic instability in hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Genes, myc; | 2011 |
Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report.
Topics: Adenoma, Liver Cell; Adolescent; Anticonvulsants; Epilepsy; Female; Humans; Intracranial Arterioveno | 2012 |
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.
Topics: Animals; Biliary Tract Diseases; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Dimethylnitr | 2012 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
Functional analysis of the rat bile salt export pump gene promoter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2002 |
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell | 2002 |
[Pigmented hepatocellular adenoma of the liver caused by long-term use of phenobarbital].
Topics: Adenoma, Liver Cell; Adult; Anticonvulsants; Female; Humans; Liver Neoplasms; Phenobarbital; Pigment | 2003 |
Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Carotenoids; Disease Models, Animal; Food | 2003 |
[Effects of gardenal and chlorpromazine 4560 R. P. on histology of hepatomas induced by 2-acetamino fluorene].
Topics: Animals; Carcinoma, Hepatocellular; Chlorpromazine; Fluorenes; Histological Techniques; Liver Neopla | 1957 |
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS.
Topics: Aminopyrine; Androgens; Benzopyrenes; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Ethionine; | 1963 |
FACTORS AFFECTING HEPATIC MICROSOMAL ENZYME SYSTEMS INVOLVED IN DRUG METABOLISM.
Topics: Alloxan; Aminopyrine; Carcinoma, Hepatocellular; Chlordan; Chlorpromazine; Codeine; Hexobarbital; Ja | 1963 |
BIOCHEMISTRY OF REGULATION OF ENZYME ACTIVITY AND SYNTHESIS. SESSION CHAIRMAN'S COMMENTS.
Topics: Adenosine Triphosphate; Biochemistry; Carcinoma, Hepatocellular; Feedback; Liver; Liver Neoplasms; M | 1963 |
THE STIMULATION OF DRUG METABOLISM IN VARIOUS RAT HEPATOMAS.
Topics: Aminopyrine; Aniline Compounds; Benzoates; Blood; Carcinoma, Hepatocellular; Chlordan; Hexobarbital; | 1965 |
Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Diethylnitrosamine; Flavonoids; | 2004 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital.
Topics: Active Transport, Cell Nucleus; Animals; Cell Nucleus; Constitutive Androstane Receptor; Cytochrome | 2005 |
Phenobarbital induces progressive patterns of GC-rich and gene-specific altered DNA methylation in the liver of tumor-prone B6C3F1 mice.
Topics: Animals; Carcinogens; DNA Methylation; GC Rich Sequence; Gene Expression Regulation; Genes, ras; Gen | 2006 |
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Cell Enlargement; Cell Proli | 2006 |
On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.
Topics: Animals; Benzodiazepines; Blotting, Western; Body Weight; Carcinogens; Cytochrome P-450 CYP1A1; Cyto | 2006 |
Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.
Topics: Animals; Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line | 2006 |
The initiation activity of norfloxacin does not result in the induction of hepatocellular tumors in rats.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Carcinogenicity Tests; Carcinogens; Carcinoma, | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Male breast cancer with mandibular metastasis. A case report.
Topics: Aged; Androstadienes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplast | 2007 |
Comparison of mode of action of four hepatocarcinogens: a model-based approach.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Diethylnitrosamine; Female; Liver Neoplasms | 2007 |
Cell proliferation and hepatocarcinogenesis in rat initiated by diethylnitrosamine and promoted by phenobarbital: potential roles of early DNA damage and liver metallothionein expression.
Topics: Animals; Antimetabolites; Bromodeoxyuridine; Carcinogens; Cell Proliferation; Copper; Diethylnitrosa | 2007 |
Regulation of the human cathepsin E gene by the constitutive androstane receptor.
Topics: Amino Acid Motifs; Carcinoma; Cathepsin E; Cells, Cultured; Constitutive Androstane Receptor; Gene E | 2007 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosami | 2008 |
Phenobarbital induces cytochrome P-450- and cytochrome P-448-dependent monooxygenases in rat hepatoma cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 Enzym | 1984 |
Re-elevation of gamma-glutamyl transpeptidase activity in periportal hepatocytes of rats with age.
Topics: Aging; Animals; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Male; Phenobarbital; Precancerous | 1980 |
Induction of gamma-glutamyl transpeptidase activity by dietary phenobarbital in "spontaneous" hepatic tumors of C3H mice.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Liver Neoplasms; Male; Mic | 1980 |
Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Dioxins; Drug Synergism; Female; gamma-Gluta | 1980 |
Short-term in vivo initiation/promotion bioassay for hepatocarcinogens.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Interactions; gamma | 1980 |
Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats.
Topics: Animals; Azo Compounds; Cycasin; Female; gamma-Glutamyltransferase; Kidney Neoplasms; Liver Neoplasm | 1981 |
Enhancement of hepatocarcinogenesis by sequential administration of chemicals: summation versus promotion effects.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Iron; Li | 1981 |
Initiation/promotion assay for chemical carcinogens in rat liver.
Topics: Animals; Carcinogens; gamma-Glutamyltransferase; Hepatectomy; Liver Neoplasms; Male; Neoplasms, Expe | 1982 |
Occurrence of progressive DNA damage coincident with the appearance of foci of altered hepatocytes.
Topics: Animals; Diethylnitrosamine; DNA; Female; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver Neopl | 1982 |
Polybrominated biphenyls as promoters in experimental hepatocarcinogenesis in rats.
Topics: Acyltransferases; Animals; Biphenyl Compounds; Carcinogens; Diethylnitrosamine; Female; Liver; Liver | 1982 |
Promotion of chemically initiated hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Humans; Liver; Liver Neoplasms; Male; Mod | 1982 |
Tumor promotion in rat liver.
Topics: Animals; Carcinogens; Cocarcinogenesis; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, | 1983 |
Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di(2-ethylhexyl)phthalate.
Topics: Animals; Choline Deficiency; Diet; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver Neoplasm | 1984 |
Aberrant expression of adaptation to phenobarbital may cause selective growth of foci of altered cells in rat liver.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; DNA Replication; Enzyme Induction; Female; gam | 1984 |
Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.
Topics: Animals; Autoradiography; Cell Division; Cocarcinogenesis; DNA; Female; gamma-Glutamyltransferase; H | 1981 |
Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms.
Topics: Adenoma; Aging; Animals; Carcinoma, Hepatocellular; Disease Susceptibility; Eosine Yellowish-(YS); g | 1983 |
Enhanced survival and absence of progressive growth of transplanted rat liver altered eosinophilic foci and neoplastic nodules in phenobarbital-treated rats.
Topics: Animals; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Eosine Yellowis | 1983 |
A constitutive deficiency in the monooxygenase system of spontaneous mouse liver tumors.
Topics: alpha-Fetoproteins; Animals; Cytochrome P-450 Enzyme System; Glucuronosyltransferase; Liver; Liver N | 1984 |
[Studies on the mechanism of carcinogenesis. V. Differential changes in activities of enzymes involved in ornithine metabolism in early phase of hepatocarcinogenesis induced by diethylnitrosamine].
Topics: Animals; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; Ornithine; Ornit | 1982 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Complex, dynamically interacting host factors that affect the disposition of drugs and carcinogens.
Topics: Animals; Antipyrine; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Enzyme | 1982 |
Characterization of NADPH-cytochrome P-450 reductase in a mouse hepatoma cell line.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Carcinoma, Hepatocellular; Cell Line; En | 1983 |
Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability.
Topics: Animals; Body Weight; Female; Liver Neoplasms; Organ Size; Phenobarbital; Polybrominated Biphenyls; | 1983 |
Infectivity of avian myelocytomatosis virus MC29 in rats.
Topics: 2-Acetylaminofluorene; Animals; Avian Leukosis Virus; Chickens; Hepatectomy; Liver; Liver Neoplasms; | 1983 |
Comparative enhancing effects of polychlorinated biphenyls and phenobarbital on dimethylnitrosamine-induced hepatic and renal tumorigenesis in rats.
Topics: Animals; Dimethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Male | 1983 |
Promoting effect of portocaval anastomosis in rat hepatocarcinogenesis.
Topics: Animals; Liver; Liver Circulation; Liver Neoplasms; Male; Phenobarbital; Portacaval Shunt, Surgical; | 1984 |
Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
Topics: Animals; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; | 1984 |
[Establishment of test methods for examining promoters of hepatocarcinogenesis--promoting effects of phenobarbital, butylated hydroxytoluene and barbital].
Topics: Animals; Barbital; Barbiturates; Butylated Hydroxytoluene; Cocarcinogenesis; Diethylnitrosamine; Liv | 1984 |
Promotive effects of thiobenzamide on liver carcinogenesis.
Topics: Amides; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobar | 1983 |
Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Histocytochemistry; | 1984 |
Distinction between liver neoplasm promoting and syncarcinogenic effects demonstrated by exposure to phenobarbital or diethylnitrosamine either before or after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Drug Synergism; Liver; Liver Neopla | 1984 |
Modification of the development of N-nitrosomorpholine-induced hepatic lesions by 2-acetylaminofluorene, phenobarbital and 4,4'-diaminodiphenylmethane: a sequential histological and histochemical analysis.
Topics: 2-Acetylaminofluorene; Aniline Compounds; Animals; Carcinogens; Drug Interactions; Liver; Liver Neop | 1984 |
Mechanisms of inhibition by simultaneously administered phenobarbital of 3'-methyl-4-(dimethylamino)azobenzene-induced hepatocarcinogenesis in the rat.
Topics: Animals; Carcinogens; Enzyme Induction; Liver; Liver Neoplasms; Male; Methyldimethylaminoazobenzene; | 1980 |
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experi | 1981 |
[Localization of cytochrome P-450PB in the rat liver and primary liver tumors of different histological structure after administration of inductor aroclor 1254].
Topics: Adenocarcinoma; Animals; Aroclors; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 Enzyme System; Di | 1982 |
Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimenta | 1983 |
Morphological alterations and DNase deficiency in phenobarbital promotion of N-nitrosomorpholine initiated rat hepatocarcinogenesis.
Topics: Animals; Carcinogens; Deoxyribonucleases; Drug Synergism; Liver; Liver Neoplasms; Male; Neoplasms, E | 1983 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Liver as a model system for analyzing mechanisms of tumor initiation and promotion.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Drug Evaluation, Preclinical; Liver Neoplasms; Mice; Ne | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Epidemiological studies of medically used drugs.
Topics: 2-Naphthylamine; Brain Neoplasms; Epidemiologic Methods; Female; Humans; Isoniazid; Liver Neoplasms; | 1980 |
Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.
Topics: Animals; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neopl | 1982 |
Development of a model to simulate the characteristics of rat liver tumor promotion by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Liver Neoplasms; Mathematics; Models, | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Effect of diazepam on hepatocarcinogenesis in the rat.
Topics: Animals; Diazepam; Diet; Drug Interactions; Liver; Liver Neoplasms; Male; Methyldimethylaminoazobenz | 1982 |
Sequential 2-acetylaminofluorene--phenobarbital exposure induces a cytosolic aldehyde dehydrogenase during rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Cocarcinogenesis; Drug Administration Sche | 1982 |
Morphological classification of mouse liver tumors based on biological characteristics.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Chlordan; Liver Neoplasms; Mice; Mice, Inbred Strains; | 1982 |
Liver tumours after single dose dimethylnitrosamine, low and high protein diet, and phenobarbitone.
Topics: Animals; Dietary Proteins; Dimethylnitrosamine; Liver Neoplasms; Male; Neoplasms, Experimental; Phen | 1982 |
Effect of phenobarbital on the development of tumors in mice treated neonatally with N-ethyl-N-nitrosourea.
Topics: Animals; Ethylnitrosourea; Female; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred A; Neop | 1982 |
The influence of hepatocarcinogens on the central effects of phenobarbital an D-amphetamine.
Topics: 2-Acetylaminofluorene; Animals; Behavior, Animal; Brain; Dextroamphetamine; Diethylnitrosamine; Live | 1980 |
Ultrastructural study of rat liver and liver neoplasms after long-term treatment with phenobarbital.
Topics: Age Factors; Animals; Cytoplasm; Diet; Endoplasmic Reticulum; Female; Liver; Liver Neoplasms; Micros | 1981 |
Effects of partial hepatectomy and dietary phenobarbital on liver and mammary tumorigenesis by two N-hydroxy-N-acylaminobiphenyls in female CD rats.
Topics: Aminobiphenyl Compounds; Animals; Body Weight; Female; Hepatectomy; Hydroxamic Acids; Liver Neoplasm | 1981 |
Does phenobarbital cause intracranial tumors? A follow-up through 35 years.
Topics: Adult; Brain Neoplasms; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neoplasm | 1981 |
Induction of hyperplastic liver nodules by phenobarbital in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Drug Synergism; Hyperplasia; Liver; Liver Neoplasms; Male; Ne | 1980 |
Dose-dependent enhancing effect of phenobarbital on hepatocarcinogenesis initiated by diethylnitrosamine in the rat.
Topics: Animals; Diet; Diethylnitrosamine; Dose-Response Relationship, Drug; Drug Synergism; Liver Neoplasms | 1981 |
Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Hyperplasia; Liver Neoplasms; Male; | 1981 |
Initiation and promotion of liver tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Kinetics; Liver Neoplasms; Neoplasms, Expe | 1981 |
Changes in hepatic polyamine levels during acute and chronic administration of aflatoxin B1 to rats.
Topics: Aflatoxins; Animals; Carcinogens; Drug Interactions; Liver; Liver Neoplasms; Male; Neoplasms, Experi | 1980 |
Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma.
Topics: Aged; Aged, 80 and over; Biliary Tract Neoplasms; Case-Control Studies; Epilepsy; Female; Humans; Li | 1995 |
Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: promotion by phenobarbital.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Diet; DNA Damage; Drug Synergism; Female; Liver; Liver Neop | 1995 |
Development of altered hepatocyte foci by separate and combined treatments with radiation and diethylnitrosamine in neonatal rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Female; Gamma Rays; Glutathione Transferase; Liver; Liver | 1994 |
Alterations in the methylation status and expression of the raf oncogene in phenobarbital-induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Cell Division; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Liver Neoplasms; | 1994 |
Synergistic effects of trans-4-acetylaminostilbene and 2-acetylaminofluorene at the level of tumor initiation.
Topics: 2-Acetylaminofluorene; Aging; Animals; Biomarkers, Tumor; Carcinogens; Drug Synergism; Female; gamma | 1994 |
Further mechanisms of non-genotoxic carcinogenesis.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver Neoplasms; Phenobarbit | 1994 |
22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver medium-term bioassay.
Topics: Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Liver | 1994 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1994 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Fe | 1994 |
Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats.
Topics: Adenosine Triphosphatases; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Female; Live | 1993 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.
Topics: Albumins; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Female; Glutathione Tra | 1993 |
The effect of dieldrin and phenobarbital on preneoplastic hepatic lesion growth in male F344 rat and B6C3F1 mouse.
Topics: Animals; Carcinogens; Dieldrin; Liver Neoplasms; Male; Mice; Mice, Inbred Strains; Phenobarbital; Pr | 1995 |
The influence of aging on dimethylnitrosamine-demethylase enzyme kinetics in rat liver microsomes.
Topics: Aging; Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Glutathione Transferase; Is | 1995 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos | 1996 |
Hierarchical cluster analysis of environmental pollutants through P450 induction in cultured hepatic cells.
Topics: 7-Alkoxycoumarin O-Dealkylase; Analysis of Variance; Animals; Antibody Specificity; Benz(a)Anthracen | 1996 |
Lack of tumor-promoting effects of flavonoids: studies on rat liver preneoplastic foci and on in vivo and in vitro gap junctional intercellular communication.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Animals; Carcinogens; Cell Line; Cricetinae; Flavanones; Flavon | 1996 |
Potentiation of aflatoxin B1-induced hepatocarcinogenesis in the rat by pretreatment with buthionine sulfoximine.
Topics: Aflatoxin B1; Animals; Buthionine Sulfoximine; Carcinogens; Drug Synergism; Enzyme Inhibitors; Gluta | 1997 |
No inhibition of gamma-glutamyl transpeptidase-positive foci by vitamin E with or without phenobarbital.
Topics: Animals; Dinoprost; Fatty Acids; Female; Fish Oils; gamma-Glutamyltransferase; Glutathione Transfera | 1997 |
Enhancing effects of phenobarbital and 3-methylcholanthrene on GST-P-positive liver cell foci development in a new medium-term rat liver bioassay using D-galactosamine.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Body Weight; Carcinogens; Diet; Diethylnitrosami | 1997 |
Suppression by phenobarbital of ethionine-induced hepatocellular carcinoma formation and hepatic S-adenosylethionine levels.
Topics: Adenosine; Animals; Body Weight; Ethionine; Liver; Liver Neoplasms; Male; Methylation; Organ Size; P | 1997 |
Interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Gene Expression; Gene Expression Regulation, Neoplast | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; | 1997 |
Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats.
Topics: Administration, Oral; Animals; Antimetabolites; Body Weight; Bromodeoxyuridine; Cell Division; Cytoc | 1997 |
Mechanism of the paradoxical, inhibitory effect of phenobarbital on hepatocarcinogenesis initiated in infant B6C3F1 mice with diethylnitrosamine.
Topics: Adenoma; Animals; Animals, Newborn; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Cell Divi | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Evaluation of induction of CYP3A mRNA using the HepG2 cell line and reverse transcription-PCR.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone | 1999 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Chick Embryo; Colonic Neopla | 1999 |
Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenoma; Animals; Anti-Infective Agents; Carcinogenicity Tests; Cell Di | 1999 |
Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diet; Dose-Respo | 1999 |
Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC).
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Chick Embryo; Chickens; Enzyme Ind | 1999 |
Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis.
Topics: Animals; Cell Division; Cells, Cultured; Cyproterone Acetate; DNA; Glutathione Transferase; Liver; L | 2000 |
Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates.
Topics: Animals; Apoptosis; Barbital; Barbiturates; Body Weight; Bromodeoxyuridine; Cell Division; Hepatomeg | 2000 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver N | 2000 |
Inhibitory effects of S-methylcysteine and cysteine on the promoting potential of sodium phenobarbital on rat liver carcinogenesis.
Topics: Animals; Carcinogens; Cysteine; Disease Models, Animal; Glutathione Transferase; Immunohistochemistr | 2000 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
1 alpha,25-Dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis.
Topics: Animals; Calcitriol; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship, | 2001 |
Short-term dosing of alpha-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han rats.
Topics: Animals; Animals, Genetically Modified; Carcinogens; Chromatography, High Pressure Liquid; Disease P | 2001 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; gamma-Glu | 1978 |
Induction of enzyme-altered islands in rat liver by a single treatment with benzo[a]pyrene after partial hepatectomy.
Topics: Adenosine Triphosphatases; Animals; Benzopyrenes; gamma-Glutamyltransferase; Hepatectomy; Liver; Liv | 1979 |
Letter: Phenobarbitone, liver tumours, and thorotrast.
Topics: Adenoma, Bile Duct; Aged; Carcinoma, Hepatocellular; Denmark; Epilepsy; Female; Humans; Liver Neopla | 1975 |
[Surgical laparoscopy].
Topics: Biopsy; Breast Neoplasms; Humans; Laparoscopy; Liver Neoplasms; Lung Neoplasms; Neoplasm Metastasis; | 1975 |
Experimental investigations on the influence upon the chemical carcinogenesis. IIIrd communication: studies with 1,2-dimethylhydrazine.
Topics: Animals; BCG Vaccine; Diet; Dimethylhydrazines; Ear Neoplasms; Female; Hydrazines; Immunosuppressive | 1976 |
Enhancement of azo-dye hepatocarcinogenesis with dietary phenobarbital in rats.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Carcinogens; Drug Synergism; Fluorenes; L | 1977 |
Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.
Topics: Animals; Benzopyrenes; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; E | 1975 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosup | 1975 |
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Topics: Animals; Buffers; Carcinoma, Hepatocellular; Cholesterol; Cholestyramine Resin; Cyanides; Cytochrome | 1976 |
Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.
Topics: Aflatoxins; Animals; Carcinogens; Carcinoma, Hepatocellular; DNA; Intestine, Small; Kidney; Liver; L | 1977 |
A comparison of steroid glucuronlytransferases of rat liver and hepatoma, and effects of phenobarbitone and 3-methylcholanthrene induction.
Topics: Animals; Carcinoma, Hepatocellular; Enzyme Induction; Estradiol; Estrone; Glucuronosyltransferase; K | 1976 |
Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Male; Neopl | 1976 |
Metabolism of estrogens in hepatomas of different growth rates.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Enzyme Activation; Estrogens; Kinetics; Liver; Li | 1977 |
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplas | 1976 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne | 1977 |
The stability of events in the natural history of neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Mammary Neoplasms, Experimental; | 1977 |
[Effect of different classes of modifying factors on experimental hepatic carcinogenesis].
Topics: 2-Acetylaminofluorene; Alkanesulfonates; Animals; Antimetabolites, Antineoplastic; Cytochrome P-450 | 1979 |
Hepatotoxicity of vinyl chloride and 1,1-dichloroethylene. Role of mixed function oxidase system.
Topics: Animals; Aroclors; Carcinogens; Cell Membrane; Cytochrome P-450 Enzyme System; Dichloroethylenes; En | 1975 |
Statistical studies in the aetiology of malignant neoplasms. V. Trends and risks. Denmark 1943--72.
Topics: Adolescent; Adult; Aged; Air Pollution; Animals; Carcinogens; Child; Child, Preschool; Denmark; Fema | 1977 |
Influence of drugs on activation and inactivation of hepatocarcinogenic nitrosamines.
Topics: Alkylation; Animals; Biotransformation; Carcinogens; DNA; Liver Neoplasms; Male; Methylcholanthrene; | 1979 |
Enhancing effect of chemicals on production of hyperplastic liver nodules induced by n-2-fluorenylacetamide in hepatectomized rats.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Flavonoids; Fluorenes; Hepatectomy; Liver; Liver Neo | 1978 |
Radiotracer studies on protein metabolism in different focuses of growth in vivo.
Topics: Amino Acids; Animals; Carcinoma 256, Walker; Carcinoma, Ehrlich Tumor; Hepatectomy; Liver; Liver Neo | 1979 |
The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse.
Topics: Age Factors; Animals; Azo Compounds; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Hep | 1979 |
Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.
Topics: Adenoma; Animals; Animals, Newborn; Dimethylnitrosamine; Drug Synergism; Liver Neoplasms; Lung Neopl | 1979 |
Long-term effects of phenobarbitone-Na on male Fischer rats.
Topics: Animals; Hyperplasia; Liver; Liver Diseases; Liver Neoplasms; Male; Neoplasms, Experimental; Phenoba | 1978 |
Liver ornithine decarboxylase during phenobarbital promotion of nitrosamine carcinogenesis.
Topics: Animals; Carboxy-Lyases; Diethylnitrosamine; Liver; Liver Neoplasms; Male; Neoplasms, Experimental; | 1978 |
Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.
Topics: Anticonvulsants; Denmark; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neopla | 1978 |
Pathological and toxicological data on chlorinated pesticides and phenobarbital.
Topics: Animals; Body Weight; Carcinogens; DDT; Drug Interactions; Female; Insecticides; Liver Neoplasms; Ma | 1978 |
Histochemical observations on nodules induced in the mouse liver by phenobarbitone.
Topics: Animals; Histocytochemistry; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Neoplasm Transpla | 1978 |
Medical and toxicological research on dieldrin and related compounds.
Topics: Adult; Animals; Carcinogens; DDT; Dieldrin; Dogs; Haplorhini; Humans; Liver Neoplasms; Male; Maximum | 1976 |
Ligandin, the glutathione S-transferases, and chemically induced hepatocarcinogenesis: a review.
Topics: Adrenalectomy; Animals; Azo Compounds; Binding Sites; Carcinogens; Castration; Glucuronates; Glutath | 1977 |
Long-term administration of DDT or phenobarbital-Na in Wistar rats.
Topics: Age Factors; Animals; Body Weight; DDT; Drug Administration Schedule; Female; Liver Neoplasms; Male; | 1977 |
Enhancing effects of phenobarbitone and butylated hydroxytoluene on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylated Hydroxytoluene; Cresols; Diet; DNA; Drug Synergism; Fluore | 1977 |
Effects of varying the onset and duration of exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Drug Synergism; Fluorenes; Liver Neoplasms; Male; Neoplasms, Experim | 1977 |
Diethylnitrosamine-induced changes in mouse liver morphology and function.
Topics: Animals; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Hexobarbital; Liver; Liver Neoplasms; M | 1976 |
In vitro metabolism and microsome-mediated mutagenicity of dialkylnitrosamines in rat, hamster, and mouse tissues.
Topics: Animals; Carbon Dioxide; Chromosomes, Bacterial; Cricetinae; Enzyme Induction; Liver; Liver Neoplasm | 1975 |
Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Topics: 2-Acetylaminofluorene; Amobarbital; Animals; DDT; DNA, Neoplasm; Drug Synergism; Liver; Liver Neopla | 1975 |
The tumour promoters dieldrin and phenobarbital increase the frequency of c-Ha-ras wild-type, but not of c-Ha-ras mutated focal liver lesions in male C3H/He mice.
Topics: Amino Acid Sequence; Animals; Codon; Dieldrin; Genes, ras; Glucose-6-Phosphatase; Liver; Liver Neopl | 1992 |
Association between growth stimulation by phenobarbital and expression of cytochromes P450 1A1, 1A2, 2B1/2 and 3A1 in hepatic hyperplastic nodules in male F344 rats.
Topics: Animals; Cell Division; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; gamma-Glutamyltrans | 1992 |
Possible enhancing effect of the immunosuppressive agent, 6-mercaptopurine(6-MP) on focal lesion development in cirrhotic liver induced by carbon tetrachloride but not furfural in F344 rats.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Drug Synergism; Fu | 1992 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1992 |
Plasma levels of HGF in rats treated with tumor promoters.
Topics: Animals; Carcinogens; Clofibric Acid; Fibric Acids; Growth Substances; Hepatocyte Growth Factor; Hex | 1992 |
The exposure of carcinogen-initiated primary neonatal rat hepatocytes to tumor promoters modulates both the transcripts and the enzymatic activity of nuclear poly(ADP-ribose) polymerase.
Topics: Animals; Animals, Newborn; Benzamides; Calcium; Cell Cycle; Cell Nucleus; Cells, Cultured; Dimethyln | 1992 |
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers, Tumor; Cyanobacteria; Diethy | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2.
Topics: Carcinoma, Hepatocellular; Enzyme Induction; Humans; Liver Neoplasms; Methylcholanthrene; Mutagens; | 1991 |
Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Carcinoma, Hepatocellular; Chloroform; DNA, Neoplasm; Gene Expression Regulation, Neoplasti | 1991 |
Screen of five alkyl carbamates for initiating and promoting activity in rat liver.
Topics: Animals; Carbamates; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransfera | 1991 |
Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Carcinogens; Cytoch | 1991 |
Modulation of P-450 IIC7 and IIIA1,2 mRNA in pre-neoplastic liver. Effect of promotion by phenobarbital.
Topics: alpha-Fetoproteins; Alpha-Globulins; Animals; Blotting, Northern; Carcinogens; Cytochrome P-450 Enzy | 1990 |
Role of hepatocyte proliferation in alpha-hexachlorocyclohexane and phenobarbital tumor promotion in B6C3F1 mice.
Topics: Animals; Carcinogens; Cell Division; Crosses, Genetic; Diethylnitrosamine; DNA Replication; Female; | 1991 |
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression | 1991 |
Porphyrin synthesis by human hepatocytes and HepG2 cells--effects of enzyme inducers and delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; Dim | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liv | 1991 |
Correlation between species and tissue sensitivity to chemical carcinogenesis in rodents and the induction of DNA synthesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; DNA Replication; Female; Gasoline; Kidney; Kidney | 1991 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1990 |
Reversible alteration in the expression of the gap junctional protein connexin 32 during tumor promotion in rat liver and its role during cell proliferation.
Topics: Animals; Biomarkers, Tumor; Carcinogens; Cell Division; Connexins; Diethylnitrosamine; Ethylnitrosou | 1990 |
Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Cell Transformation, N | 1990 |
Ultrastructural changes in chemically induced preneoplastic focal lesions in the rat liver: a stereological study.
Topics: Animals; Animals, Newborn; Biomarkers, Tumor; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1990 |
[Inhibition effect of epicatechin on phenobarbitol-induced proliferation precancerous liver cells].
Topics: Animals; Catechin; Diethylnitrosamine; Flavonoids; Liver Neoplasms; Male; Phenobarbital; Precancerou | 1990 |
Mutations in the Ha-ras proto-oncogene in spontaneous and chemically induced liver tumours of the CF1 mouse.
Topics: Aflatoxin B1; Aflatoxins; Animals; Base Sequence; Carcinogens; Dieldrin; DNA, Neoplasm; Genes, ras; | 1990 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoi | 1990 |
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; | 1990 |
Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
Topics: Animals; Base Sequence; Benzidines; Chloroform; Clofibric Acid; Codon; DNA Mutational Analysis; DNA, | 1990 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Modification of 7,8-benzoflavone metabolism in hamster liver and kidney microsomes by hepatic tumor inducing treatments.
Topics: Animals; Benzoflavones; Biotransformation; Carcinogens; Cricetinae; Diethylstilbestrol; Flavonoids; | 1990 |
DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.
Topics: Animals; Body Weight; Carcinogens; Cell Division; DNA Replication; Female; Liver; Liver Neoplasms; N | 1990 |
[Concept of tumor promoters in hepatocarcinogenesis].
Topics: Bile Acids and Salts; Carcinogens; Cell Transformation, Neoplastic; Humans; Hydrocarbons, Chlorinate | 1990 |
Nutrition and enzyme inducers in liver tumor promotion in human and rat.
Topics: Animals; Brassica; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Epilepsy; Humans; | 1990 |
Increased silver stainability of metaphase chromosomes from rat hepatocytes during in vivo hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Chromosomes; Diethylnitrosamine; Liver Neoplasms; Metaphas | 1985 |
Stimulation of DNA synthesis in rat and mouse liver by various tumor promoters.
Topics: Adipates; Aflatoxin B1; Aflatoxins; Aldrin; Animals; Benzidines; Biological Availability; Carbon Tet | 1987 |
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N | 1989 |
Promotion of malignant 'embryonal' liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Crosses, Genetic; Diethylnitrosamine; Female; Hemang | 1989 |
Tumor phenotype and susceptibility to progression as an expression of subpopulations of initiated murine cells.
Topics: alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Susceptibi | 1985 |
Mutations at codon 61 of the Ha-ras proto-oncogene in precancerous liver lesions of the B6C3F1 mouse.
Topics: Animals; Base Sequence; Codon; Diethylnitrosamine; Genes, ras; Liver; Liver Neoplasms; Male; Mice; M | 1989 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital.
Topics: Animals; Body Weight; Catalase; gamma-Glutamyltransferase; Glutathione Peroxidase; Glutathione Trans | 1985 |
Evidence for lack of promotion of the growth of the common naturally occurring basophilic focal hepatocellular proliferative lesions in aged F344/NCr rats by phenobarbital.
Topics: Adenoma; Aging; Animals; Basophils; Cell Division; DNA; Female; gamma-Glutamyltransferase; Liver; Li | 1985 |
Comparative study on pyruvate kinase activity-reducing action of various promoters of hepatocarcinogenesis.
Topics: Animals; Body Weight; Carcinogens; Dexamethasone; Diet; Ethinyl Estradiol; gamma-Glutamyltransferase | 1986 |
Influences of different polychlorinated biphenyls on cytocidal, mitoinhibitory, and nodule-selecting activities of N-2-fluorenylacetamide in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Cell Survival; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver | 1986 |
Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine.
Topics: Albumins; Animals; Female; gamma-Glutamyltransferase; Gene Expression Regulation; Liver; Liver Neopl | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Ne | 1986 |
Effects of rat strain, diet composition, and phenobarbital on hepatic gamma-glutamyl transpeptidase histochemistry and on the induction of altered hepatocyte foci and hepatic tumors by diethylnitrosamine.
Topics: Animals; Cell Transformation, Neoplastic; Diet; gamma-Glutamyltransferase; Liver; Liver Neoplasms; P | 1987 |
A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Dioxins; D | 1987 |
Factors influencing the initiation by gamma rays of hepatocarcinogenesis in the rat.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cells, Cultured; DNA Repair; Dose-Response Relations | 1987 |
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell | 1989 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz | 1989 |
Effects of tumour promoters on metabolic cooperation between human hepatoma cells.
Topics: Carcinogens; Carcinoma, Hepatocellular; Cell Communication; Cell Line; Humans; Hypoxanthine Phosphor | 1986 |
Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes.
Topics: Aldehyde Dehydrogenase; Aldehydes; Benzaldehydes; Carcinoma, Hepatocellular; Cells, Cultured; Liver; | 1987 |
Possible model of liver carcinogenesis using inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Male; NAD; Phenobarbita | 1986 |
Promotion of hepatocarcinogenesis by suxibuzone in rats initiated with 3'-methyl-4-dimethylaminoazobenzene.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Drug Interactions; Liver; Liver Neoplasms; | 1987 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.
Topics: Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; L | 1988 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl | 1988 |
Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone.
Topics: Animals; Carcinogens; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Oxazolidin | 1988 |
Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates.
Topics: 7-Alkoxycoumarin O-Dealkylase; Amobarbital; Animals; Barbital; Barbiturates; Cytochrome P-450 CYP2B1 | 1987 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Influences of diethylnitrosamine on longevity of surrounding hepatocytes and progression of transplanted persistent nodules during phenobarbital promotion of hepatocarcinogenesis.
Topics: Animals; Aroclors; Cell Survival; Chlorodiphenyl (54% Chlorine); Diethylnitrosamine; Female; Liver; | 1987 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
Expression of genes encoding glutathione S-transferases in normal and preneoplastic liver.
Topics: Animals; Gene Expression Regulation; Glutathione Transferase; Liver; Liver Neoplasms; Methylcholanth | 1987 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N | 1986 |
The histology and development of hepatic nodules in C3H/He mice following chronic administration of phenobarbitone.
Topics: Animals; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Necrosis; Phenobarbital; Time Factors | 1986 |
In vitro colonization ability appears soon after initiation of hepatocarcinogenesis in the rat.
Topics: Animals; Dimethylnitrosamine; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred F344 | 1986 |
Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
Topics: Animals; Diethylnitrosamine; Female; Glucans; Glucose; Hepatectomy; Kidney Neoplasms; Liver Neoplasm | 1986 |
Effect of in vivo exposure to the liver tumor promoters phenobarbital or DDT on the gap junctions of rat hepatocytes: a quantitative freeze-fracture analysis.
Topics: Animals; DDT; Freeze Fracturing; Intercellular Junctions; Liver; Liver Neoplasms; Male; Microscopy, | 1987 |
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liv | 1987 |
Leiomyoblastoma associated with intractable hypercalcemia and elevated 1,25-dihydroxycholecalciferol levels. Treatment by hepatic enzyme induction.
Topics: Adult; Calcitriol; Enzyme Induction; Female; Humans; Hypercalcemia; Leiomyoma; Liver; Liver Neoplasm | 1985 |
Enhancement of hepatocarcinogenesis by sorbitan fatty acid ester, a liver pyruvate kinase activity-reducing substance.
Topics: Animals; Bile Ducts; Body Weight; Hemangioma; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; | 1985 |
Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Carcinogens; Drug Synergism; Live | 1985 |
Quantitative relationship between hepatocytic neoplasms and islands of cellular alteration during hepatocarcinogenesis in the male F344 rat.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Liver Neoplasms; Male; Phenobarbital; Rats; Rats, Inbred | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In | 1985 |
The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, -BHC and -BHC.
Topics: Administration, Oral; Animals; DDT; Dieldrin; Female; Hepatomegaly; Hexachlorocyclohexane; Hyperplas | 1973 |
Letter: Phenobarbitone and liver tumours.
Topics: Humans; Liver Neoplasms; Neoplasms; Phenobarbital | 1974 |
Abnormal microsomal cytochromes and electron transport in Morris hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Fractionation; Cell Line; Cytochrome P-450 Enzyme System; C | 1974 |
Effect of phenobarbital and DL-ethionine on 4-(dimethylamino)azobenzene-metabolizing enzymes and carcinogenesis.
Topics: Animals; Cytochrome P-450 Enzyme System; Ethionine; Liver; Liver Neoplasms; Male; Microsomes, Liver; | 1973 |
The effect of phenobarbital on drug metabolic enzyme activity, ultrastructure and growth of a "minimal deviation" hepatoma (Morris 7800).
Topics: Animals; Carcinoma, Hepatocellular; Endoplasmic Reticulum; Hexobarbital; Liver; Liver Neoplasms; Mal | 1967 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7535.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Fluorenes; Glucosephosp | 1968 |
[The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis].
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Drug Synergism; Halothane; H | 1969 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7635.
Topics: Acetates; Amides; Animals; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Neoplasms, Experim | 1969 |
Labeled bilirubin production by a clonal strain of rat hepatoma cells.
Topics: Animals; Bilirubin; Carbon Isotopes; Carcinoma, Hepatocellular; Clone Cells; Fibroblasts; Glycine; I | 1971 |
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Topics: Acetates; Amides; Animals; Autoradiography; Carcinoma, Hepatocellular; Cell Division; Cell Transform | 1971 |
Studies on plasma membranes. XV. A sex difference in alkaline phosphatase activities of plasma membranes isolated from rat liver.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Calcium; Carcinogens; Carcinoma, Hepatocellular; Ca | 1971 |
Aldehyde dehydrogenase activity in a rat hepatoma.
Topics: Acetamides; Acrylamides; Aldehydes; Animals; Carcinoma, Hepatocellular; Electrophoresis; Fluorenes; | 1972 |
Carbohydrate composition of rat hepatocyte nuclear membrane as compared to normal, Morris hepatoma 7800, and phenobarbital-induced microsomal membranes.
Topics: Animals; Carbohydrates; Carcinoma, Hepatocellular; Cell Nucleus; Chromatography, Gas; Galactosamine; | 1973 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinoma, Hepatocellular; Cell Line; Cricetinae; Culture | 1973 |
Energy coupling and extramitochondrial electron transport in slices of Morris hepatoma 3924 A.
Topics: Aminopyrine; Animals; Antimycin A; Biological Transport; Carcinoma, Hepatocellular; Cyanides; Dinitr | 1974 |
The metabolic effects of nonvolatile anesthetics on mammalian hepatoma cells in vitro. I. Inhibition of cell replication.
Topics: Amobarbital; Anesthetics, Local; Animals; Barbiturates; Carcinoma, Hepatocellular; Cell Count; Cell | 1971 |
Brief communication: Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital.
Topics: Administration, Oral; Animals; Diet; Female; Liver Neoplasms; Mice; Mice, Inbred C3H; Neoplasms, Exp | 1973 |
Effects of varying the exposure to phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.
Topics: Animals; Diet; Drug Synergism; Fluorenes; Liver Neoplasms; Neoplasms, Experimental; Phenobarbital; R | 1973 |
[Canceromimetic properties of the tetrachloro-2,3,7,8 dibenzo-p-dioxin ("dioxin")].
Topics: Animals; Arginase; Carcinogens; Dioxins; Enzyme Induction; Glycolates; Liver; Liver Neoplasms; Male; | 1971 |
Polycyclic hydrocarbon-produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chromosome Ab | 1972 |
Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.
Topics: Aflatoxins; Animals; Biotransformation; Body Weight; Carcinogens; Enzyme Induction; Liver; Liver Neo | 1971 |
Labeling in vivo of rat liver proteins by tritium-labeled dimethylnitrosamine. Effect of prior treatment with 3-methylcholanthrene, phenobarbitone, dimethylformamide, diethyl-formamide, aminoacetonitrile, ethionine and carbon tetrachloride.
Topics: Amides; Animals; Carbon Tetrachloride; Carcinogens; Dimethylformamide; Endoplasmic Reticulum; Ethion | 1971 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7409.
Topics: Animals; Body Weight; Carcinogens; Fluorenes; Liver Neoplasms; Male; Neoplasms, Experimental; Organ | 1967 |