phenobarbital has been researched along with Liver Diseases in 146 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 8.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| "To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation." | 7.76 | Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. ( Claeys, S; Daminet, S; de Rooster, H; Gommeren, K; Hamaide, A, 2010) |
| "This investigation was designed to determine if liver diseases can modify the pharmacodynamics of the central nervous system depressants phenobarbital and ethanol." | 7.67 | Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats. ( Danhof, M; Hisaoka, M; Levy, G, 1985) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 7.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 5.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| "Phenobarbital pretreatment potentiated the hepatic necrosis produced by both thioacetamide and thioacetamide sulfine." | 5.26 | Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. ( Holscher, MA; Hunter, AL; Neal, RA, 1977) |
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 4.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| "To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation." | 3.76 | Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. ( Claeys, S; Daminet, S; de Rooster, H; Gommeren, K; Hamaide, A, 2010) |
| "The mechanism of prolongation of sleeping (anesthesia) time after phenobarbital (PB) treatment was assessed in mice with ethionine (ET)-induced liver disorders (ET-treated group)." | 3.69 | Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice. ( Kawai, Y; Noguchi, M, 1996) |
| " Hepatotoxic compounds such as CCl4, galactosamine and thioacetamide that cause hepatic necrosis and compounds such as hydrazine and ethionine that cause fatty liver all result in elevated urinary taurine levels in rats." | 3.69 | Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro. ( Timbrell, JA; Waterfield, CJ, 1996) |
| "To determine whether brief periods of hypoxia could produce hepatic injury, we pretreated Sprague-Dawley rats with phenobarbital, deprived them of food for 24 hr, and then exposed them to various hypoxic mixtures of nitrogen and oxygen for various lengths of time." | 3.67 | Brief periods of hypoxia can produce hepatic injury in rats. ( Cahalan, MK; Eger, EI; Eger, RR; Fassoulaki, A; Ferrell, LD; Harper, MH; Johnson, BH; Smuckler, EA, 1984) |
| "This investigation was designed to determine if liver diseases can modify the pharmacodynamics of the central nervous system depressants phenobarbital and ethanol." | 3.67 | Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats. ( Danhof, M; Hisaoka, M; Levy, G, 1985) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 3.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| "Serum squalene levels did not change in patients with acute hepatitis, chronic active hepatitis and liver cirrhosis, but were significantly reduced in patients with intra- and extrahepatic cholestasis." | 3.66 | Serum squalene levels in hepatobiliary diseases. ( Hirayama, C; Ikawa, S; Yamanishi, Y, 1978) |
| "Salicylamide glucuronide (SAMG) in 0-6 and 6-12 hours-urine specimens was determined after oral administration of salicylamide in 7 normal volunteers (NV), in 51 cases of various liver diseases and hyperbilirubinemias, and in 19 cases after drug administration, to predict the in vivo drug metabolism in man and its change by drugs." | 3.65 | Salycylamide glucuronide formation in liver disease and its change by drugs. ( Adachi, Y; Wakisaka, G; Yamamoto, T, 1975) |
| " Sequential addition of cholestyramine and phenobarbital to his medical regimen, following an initial response to bile drainage, resulted in the disappearance of xanthomas and pruritus, and the restoration of normal serum concentrations of lipids and bile acids." | 3.65 | Immunodeficiency, xanthomas and obstructive liver disease. ( Hanson, RF; Isenberg, JN; Page, AR; Sharp, HL; Williams, GC; Zavoral, J, 1976) |
| "Experimental hepatic necrosis was induced in phenobarbital pretreated rats by means of the intraperitoneal administration of an acetaminophen-dimethyl sulfixide (DMSO) mixture." | 3.65 | Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen. ( Hart, FE; Willson, RA, 1977) |
| "Treatment of rats with phenobarbital, which stimulates the activity of the drug-metabolizing enzymes in the liver, potentiates hepatic necrosis elicited by bromobenzene and a number of other chemically inert halogenated aromatic hydrocarbons." | 3.65 | Possible mechanism of liver necrosis caused by aromatic organic compounds. ( Brodie, BB; Cho, AK; Gillette, JR; Krishna, G; Reid, WD; Sipes, G, 1971) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| " For studies of toxic processes, 1H NMR spectroscopy of biofluids allows monitoring of endogenous metabolite profiles that alter characteristically in response to changes in physiological status." | 1.37 | A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity. ( Ando, Y; Fukuhara, K; Ohno, A; Okuda, H; Yamoto, T, 2011) |
| "Caffeine was a competitive inhibitor of APAP bioactivation in microsomes from beta NF- and acetone-treated mice." | 1.29 | Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents. ( Jaw, S; Jeffery, EH, 1993) |
| " Protein binding of PB was unchanged in ET-treated animals, but the extent of bioavailability of PB tended to increase." | 1.29 | Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury. ( Fukushima, T; Kawai, Y; Kuwamura, Y; Noguchi, M; Tanaka, K, 1993) |
| " AMD activity at 48 hr after dosing of PB in the ET-treated rats was increased in the same degree as that in the control (normal)." | 1.29 | Effects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury. ( Fujitsuka, T; Honda, K; Kawai, Y; Noguchi, M, 1994) |
| "Phenobarbital pretreatment of the rats did not affect any of these kinetic parameters." | 1.28 | Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol. ( Dunbar, D; Fraser, JM; Kaminsky, LS; Seaman, M, 1992) |
| " In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion." | 1.28 | Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| " These data cannot support the concept that induction of cytochrome P-450 leads to greater formation of the hypothetical toxic metabolite of acetaminophen, or that induction enhances its hepatotoxicity, in the rat." | 1.27 | Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat. ( Lerche, A; Pedersen, NT; Poulsen, HE, 1985) |
| " The activities of NADPH-cytochrome P-450 reductase, AHH, and ECOD following treatment with HCB were similar to those found after dosing with PB." | 1.27 | A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. ( Buhler, DR; Carpenter, HM; Williams, DE, 1985) |
| "Antipyrine was chosen as a model drug." | 1.27 | Impairment of drug elimination in patients with liver disease. ( Datta, DV; Mathur, VS; Narang, AP, 1985) |
| "Acetylhydrazine did not produce detectable lesions in organs other than the liver, despite the occurrence of covalent binding to protein in those organs." | 1.27 | Acetylhydrazine hepatotoxicity: the role of covalent binding. ( Timbrell, JA; Woodward, KN, 1984) |
| "The effects of acute and chronic administration of D-Galactosamine (GalN), Ethanol and Phenobarbital were investigated on the activities of lysosomal enzymes, i." | 1.26 | [Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)]. ( Sato, R, 1978) |
| "Phenobarbital pretreatment potentiated the hepatic necrosis produced by both thioacetamide and thioacetamide sulfine." | 1.26 | Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. ( Holscher, MA; Hunter, AL; Neal, RA, 1977) |
| " Prior dosing with phenobarbitone augments CCl4 toxicity only in the adult and the newborn but the foetus continues to be resistant." | 1.25 | Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine. ( Chopra, P; Das, PK; Dhar, A; Nayak, NC, 1975) |
| "Antipyrine has been used as a model drug to investigate the effects of liver disease on drug metabolism in man." | 1.25 | Determinants of serum antipyrine half-lives in patients with liver disease. ( Branch, RA; Herbert, CM; Read, AE, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 111 (76.03) | 18.7374 |
| 1990's | 24 (16.44) | 18.2507 |
| 2000's | 8 (5.48) | 29.6817 |
| 2010's | 3 (2.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vorne, M | 1 |
| Arvela, P | 1 |
| Alavaikko, M | 1 |
| Das, BK | 1 |
| Bepary, S | 1 |
| Datta, BK | 1 |
| Chowdhury, AA | 1 |
| Ali, MS | 1 |
| Rouf, AS | 1 |
| Girish, C | 1 |
| Koner, BC | 1 |
| Jayanthi, S | 1 |
| Rao, KR | 1 |
| Rajesh, B | 1 |
| Pradhan, SC | 1 |
| Shaik, IH | 1 |
| Mehvar, R | 1 |
| Gommeren, K | 1 |
| Claeys, S | 1 |
| de Rooster, H | 1 |
| Hamaide, A | 1 |
| Daminet, S | 1 |
| Fukuhara, K | 1 |
| Ohno, A | 1 |
| Ando, Y | 1 |
| Yamoto, T | 1 |
| Okuda, H | 1 |
| SYAM, NK | 1 |
| KUTT, H | 2 |
| WINTERS, W | 1 |
| SCHERMAN, R | 1 |
| MCDOWELL, F | 1 |
| MARCHAND, L | 1 |
| TEULIE, G | 1 |
| BALIER, C | 1 |
| DUBOIS, EL | 1 |
| Gaskill, CL | 1 |
| Miller, LM | 1 |
| Mattoon, JS | 1 |
| Hoffmann, WE | 1 |
| Burton, SA | 1 |
| Gelens, HC | 1 |
| Ihle, SL | 1 |
| Miller, JB | 1 |
| Shaw, DH | 1 |
| Cribb, AE | 1 |
| Amacher, DE | 1 |
| Adler, R | 1 |
| Herath, A | 1 |
| Townsend, RR | 1 |
| Ferencz, V | 1 |
| Horváth, C | 1 |
| Kári, B | 1 |
| Gaál, J | 1 |
| Mészáros, S | 1 |
| Wolf, Z | 1 |
| Hegedus, D | 1 |
| Horváth, A | 1 |
| Folhoffer, A | 1 |
| Szalay, F | 1 |
| Sevilla, A | 1 |
| Howman-Giles, R | 1 |
| Saleh, H | 1 |
| Trpezanovski, J | 1 |
| Concannon, R | 1 |
| Williams, K | 1 |
| Chung, D | 1 |
| Uren, R | 1 |
| Yoshimura, N | 1 |
| Sameshima, T | 1 |
| Miyao, J | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| Sharma, S | 1 |
| Bhatia, A | 1 |
| Das, PK | 2 |
| Rull, S | 1 |
| Rodríguez-San Román, JL | 1 |
| Velilla, JP | 1 |
| Bruni, J | 1 |
| Albright, PS | 1 |
| Fassoulaki, A | 2 |
| Eger, EI | 2 |
| Johnson, BH | 2 |
| Ferrell, LD | 2 |
| Smuckler, EA | 2 |
| Harper, MH | 2 |
| Eger, RR | 2 |
| Cahalan, MK | 2 |
| Buchet, JP | 1 |
| Geubel, A | 1 |
| Pauwels, S | 1 |
| Mahieu, P | 1 |
| Lauwerys, R | 1 |
| Leo, MA | 1 |
| Lowe, N | 1 |
| Lieber, CS | 1 |
| Woodward, KN | 1 |
| Timbrell, JA | 2 |
| Asconapé, JJ | 1 |
| Penry, JK | 1 |
| Evans, MA | 1 |
| Uetrecht, J | 1 |
| Wood, AJ | 1 |
| Phythyon, JM | 1 |
| Wood, M | 1 |
| Itoh, S | 1 |
| Satoh, T | 1 |
| Tsukada, Y | 1 |
| Igarashi, M | 1 |
| Ichinoe, A | 1 |
| Sakata, T | 1 |
| Nováková, O | 1 |
| Musil, J | 1 |
| Buckiová, D | 1 |
| Stiehl, A | 2 |
| Kawasaki, H | 1 |
| Murawaki, Y | 1 |
| Noguchi, M | 4 |
| Fujitsuka, T | 1 |
| Honda, K | 1 |
| Kawai, Y | 4 |
| Tanaka, K | 1 |
| Kuwamura, Y | 1 |
| Fukushima, T | 1 |
| Jaw, S | 1 |
| Jeffery, EH | 1 |
| Gunawardhana, L | 1 |
| Mobley, SA | 1 |
| Sipes, IG | 1 |
| Bunch, SE | 2 |
| Wada, S | 2 |
| Kato, T | 1 |
| Mutai, M | 1 |
| Ozaki, K | 1 |
| Yamaguchi, S | 2 |
| Kim, DJ | 1 |
| Baba-Toriyama, H | 1 |
| Asamoto, M | 1 |
| Ito, N | 3 |
| Tsuda, H | 1 |
| Gadberry, MG | 1 |
| DeNicola, DB | 1 |
| Carlson, GP | 1 |
| Nitoh, S | 1 |
| Mabuchi, M | 1 |
| Huang, R | 1 |
| Okuno, H | 1 |
| Takasu, M | 1 |
| Shiozaki, Y | 1 |
| Inoue, K | 1 |
| Waterfield, CJ | 1 |
| Videla, LA | 1 |
| Arisi, AC | 1 |
| Fuzaro, AP | 1 |
| Koch, OR | 2 |
| Junqueira, VB | 1 |
| Aoki, K | 1 |
| Takimoto, M | 1 |
| Ota, H | 1 |
| Yoshida, T | 1 |
| Adachi, Y | 2 |
| Wakisaka, G | 1 |
| Yamamoto, T | 2 |
| Ford, EJ | 2 |
| Rivera, R | 1 |
| Kok, PJ | 1 |
| Seidel, B | 1 |
| Holtkamp, HC | 1 |
| Huisman, J | 1 |
| Sato, R | 1 |
| Watanabe, A | 1 |
| Hobara, N | 1 |
| Nagashima, H | 1 |
| Tatematsu, M | 1 |
| Murasaki, G | 1 |
| Nakanishi, K | 1 |
| Miyata, Y | 1 |
| Shinohara, Y | 1 |
| Gopinath, C | 1 |
| Nayak, NC | 1 |
| Chopra, P | 1 |
| Dhar, A | 1 |
| Frimmer, M | 1 |
| Homann, J | 1 |
| Rufeger, U | 1 |
| Schenker, S | 1 |
| Hoyumpa, AM | 1 |
| Wilkinson, GR | 1 |
| Willson, RA | 2 |
| Hart, FE | 2 |
| Oleĭnik, AN | 1 |
| Lee, JS | 1 |
| Hrdlicka, J | 1 |
| Seawright, AA | 2 |
| Singh, D | 1 |
| Vijayvargiya, R | 1 |
| Kakrani, AL | 1 |
| Butler, WH | 4 |
| Yamanishi, Y | 1 |
| Ikawa, S | 1 |
| Hirayama, C | 2 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Datta, DV | 3 |
| Nair, R | 2 |
| Nair, CR | 2 |
| Hunter, AL | 1 |
| Holscher, MA | 1 |
| Neal, RA | 1 |
| Cammann, R | 1 |
| Wiechert, P | 1 |
| Loginov, AS | 1 |
| Remmer, H | 1 |
| Isenberg, JN | 1 |
| Hanson, RF | 1 |
| Williams, GC | 1 |
| Zavoral, J | 1 |
| Page, AR | 1 |
| Sharp, HL | 1 |
| Singh, S | 1 |
| Chhuttani, PN | 1 |
| Mitchell, JR | 2 |
| Snodgrass, WR | 1 |
| Gillette, JR | 4 |
| Böhm, N | 1 |
| Moser, B | 1 |
| Williams, CN | 1 |
| Kodavanti, PR | 1 |
| Kodavanti, UP | 1 |
| Faroon, OM | 1 |
| Mehendale, HM | 1 |
| Kaminsky, LS | 1 |
| Fraser, JM | 1 |
| Seaman, M | 1 |
| Dunbar, D | 1 |
| Manjeshwar, S | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Van Dyke, RA | 1 |
| Mostafapour, S | 1 |
| Marsh, HM | 1 |
| Li, Y | 1 |
| Chopp, M | 1 |
| Ogawa, K | 1 |
| Hasegawa, R | 1 |
| Dayrell-Hart, B | 1 |
| Steinberg, SA | 1 |
| VanWinkle, TJ | 1 |
| Farnbach, GC | 1 |
| Cunninghame, ME | 1 |
| Evans, JG | 1 |
| Foster, GR | 1 |
| Goldin, RD | 1 |
| Freeth, CJ | 1 |
| Nieman, E | 1 |
| Oliveira, DB | 1 |
| Locke, SJ | 1 |
| Brauer, M | 1 |
| Saeter, G | 1 |
| Seglen, PO | 1 |
| Masuda, Y | 1 |
| Nakamura, Y | 1 |
| Mockli, G | 1 |
| Crowley, M | 1 |
| Stern, R | 1 |
| Warnock, ML | 1 |
| Marzella, L | 1 |
| Muhvich, K | 1 |
| Myers, RA | 1 |
| Ahmed, AE | 1 |
| Grissom, M | 1 |
| el-Azhary, R | 1 |
| Haque, A | 1 |
| Boor, PJ | 1 |
| Costanzi, J | 1 |
| Nhachi, CF | 1 |
| Chikuni, O | 1 |
| Xian, M | 1 |
| Inoue, S | 1 |
| Matsunuma, N | 1 |
| Goto, N | 1 |
| Fujiwara, K | 1 |
| Becker, GL | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 1 |
| Conway, MB | 1 |
| Center, SA | 1 |
| Castleman, WL | 1 |
| Baldwin, BH | 1 |
| Hornbuckle, WE | 1 |
| Tennant, BC | 1 |
| Várkonyi, S | 1 |
| Jungbauer, G | 1 |
| Szepesi, E | 1 |
| Stillman, AE | 1 |
| Earnest, DL | 1 |
| Woolfenden, JM | 1 |
| Poulsen, HE | 1 |
| Lerche, A | 1 |
| Pedersen, NT | 1 |
| Carpenter, HM | 1 |
| Williams, DE | 1 |
| Buhler, DR | 1 |
| Narang, AP | 1 |
| Mathur, VS | 1 |
| Plummer, JL | 1 |
| Hall, PM | 1 |
| Jenner, MA | 1 |
| Cousins, MJ | 1 |
| Danhof, M | 1 |
| Hisaoka, M | 1 |
| Levy, G | 1 |
| Smith, JS | 1 |
| Harrison, GG | 1 |
| Coltorti, M | 1 |
| Di Simone, A | 1 |
| Di Cesare, D | 1 |
| Rinaldi, M | 1 |
| Dhar, GJ | 1 |
| Pierach, CA | 1 |
| Ahamed, PN | 1 |
| Howard, RB | 1 |
| Lannek, B | 1 |
| Onoe, T | 1 |
| Khaliq, SU | 1 |
| Hempsall, V | 1 |
| Magos, L | 2 |
| Porta, EA | 1 |
| Hartroft, WS | 1 |
| Brodie, BB | 3 |
| Reid, WD | 3 |
| Cho, AK | 1 |
| Sipes, G | 1 |
| Krishna, G | 3 |
| Whitfield, JB | 1 |
| Pounder, RE | 1 |
| Neale, G | 1 |
| Moss, DW | 1 |
| Cohen, AB | 1 |
| Rosenthal, WS | 1 |
| Stenger, RJ | 5 |
| Strohmeyer, G | 1 |
| Bianchi, L | 1 |
| Ohnacker, H | 1 |
| Braun, W | 1 |
| Wöckel, W | 1 |
| Giertler, U | 1 |
| Vollmar, F | 1 |
| Wrights, N | 1 |
| Prescott, LF | 1 |
| Mattocks, AR | 1 |
| Branch, RA | 1 |
| Herbert, CM | 1 |
| Read, AE | 2 |
| Jollow, DJ | 1 |
| Potter, WZ | 1 |
| Davis, DC | 1 |
| Gillette, R | 1 |
| Kröner, H | 1 |
| Schlag, P | 1 |
| Staib, W | 1 |
| van Leenhoff, JA | 1 |
| Hickman, R | 1 |
| Saunders, SJ | 1 |
| Terblanche, J | 1 |
| Chandra, SV | 1 |
| Nakamura, M | 1 |
| Okuda, K | 1 |
| Abe, H | 1 |
| Kühn, HA | 1 |
| Richter, E | 1 |
| Clodi, PH | 1 |
| Bloomer, JR | 1 |
| Berk, PD | 1 |
| Howe, RB | 1 |
| Berlin, NI | 1 |
| Reyes, H | 1 |
| Cooksley, WG | 1 |
| Powell, LW | 1 |
| Schaude, G | 1 |
| Siess, M | 1 |
| Vogell, W | 1 |
| Niessing, J | 1 |
| Johnson, EA | 2 |
| Del Rio, A | 1 |
| Noya, M | 1 |
| De Oya, JC | 1 |
| Gartner, LM | 1 |
| Arias, IM | 1 |
| Scholler, KL | 1 |
| Müller, E | 1 |
| von Plehwe, U | 1 |
| Miller, RA | 1 |
| Williamson, JN | 1 |
| Clauberg, G | 1 |
| Conning, DM | 1 |
| Litchfield, MH | 1 |
| Robinson, SH | 1 |
| Köhler, P | 1 |
| Mey, U | 1 |
| Burger, PC | 1 |
| Herdson, PB | 1 |
23 reviews available for phenobarbital and Liver Diseases
| Article | Year |
|---|---|
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
[Current aspects of primary biliary cirrhosis (2)].
Topics: Azathioprine; Biliary Tract Diseases; Cholestyramine Resin; Cyclosporins; Diagnosis, Differential; H | 1983 |
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas | 1982 |
[Various problems in therapy and prognosis of drug-induced liver diseases].
Topics: Chemical and Drug Induced Liver Injury; Diet, Fat-Restricted; Drug-Related Side Effects and Adverse | 1995 |
Hepatotoxicity associated with pharmacologic agents in dogs and cats.
Topics: Animals; Anthelmintics; Benzimidazoles; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; | 1993 |
The effect of parenchymal liver disease on the disposition and elimination of sedatives and analgesics.
Topics: Analgesics; Anti-Anxiety Agents; Barbiturates; Diazepam; Half-Life; Hepatitis; Humans; Hypnotics and | 1975 |
[Effect of phenobarbital on the intrahepatic metabolism of bilirubin].
Topics: Animals; Bile; Bilirubin; Biological Transport, Active; Cytoplasm; Drug Evaluation; Drug Interaction | 1978 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Massive hepatic necrosis in a child after administration of phenobarbital.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Hypersensitivity; Humans; Liver Disea | 1989 |
Biochemical and genetic factors regulating dilantin metabolism in man.
Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzy | 1971 |
[Ultramicroscopic pathology of the liver].
Topics: Adenosine Triphosphatases; Aminopyrine; Animals; Bile; Cytoplasm; Glucose; Humans; Hypoxia; Lipoprot | 1968 |
Recent advances in molecular pathology: a review of the effects of alcohol on the liver.
Topics: Acute Disease; Alcoholic Intoxication; Alcoholism; Animals; Butyrates; Chemical and Drug Induced Liv | 1970 |
[Advances in the field of liver diseases].
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Chronic Disease; Drug Synergism; Enzyme Induc | 1972 |
[6 Beta-hydroxycortisol].
Topics: 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Animals; Chemical Phenomena; Che | 1967 |
Organelle pathology of the liver. The endoplasmic reticulum.
Topics: Animals; Chlordan; DDT; Endoplasmic Reticulum; Ethanol; Glycogen; Lipid Metabolism; Liver; Liver Dis | 1970 |
[Recent progress in the study of liver diseases].
Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Bilirubin; Biological Transport; Chemical and Drug | 1971 |
[Pathophysiology and clinical aspects of intrahepatic cholestasis].
Topics: Alkaline Phosphatase; Animals; Arsphenamine; Bile Acids and Salts; Bilirubin; Chlorpromazine; Cholan | 1970 |
[Detoxification function of the liver].
Topics: Animals; Bilirubin; Biological Transport; DDT; Dogs; Ethanol; Female; Glycolysis; Humans; Liver; Liv | 1970 |
[Influence of Y and Z protein binding in the hepatic uptake of bilirubin and other organic anions].
Topics: Acetates; Amides; Animals; Bilirubin; Birds; Carcinogens; Fishes; Guinea Pigs; Humans; Insecticides; | 1971 |
[Enzyme induction therapy of liver diseases].
Topics: Adrenal Cortex Hormones; Anabolic Agents; Cholestasis; Endoplasmic Reticulum; Enzyme Induction; Gluc | 1971 |
Drug metabolism and interaction with particular reference to the liver.
Topics: Animals; Biotransformation; Cytochromes; Drug Interactions; Enzyme Induction; Humans; Hydroxylation; | 1971 |
1 trial available for phenobarbital and Liver Diseases
| Article | Year |
|---|---|
Interpretation of plasma bilirubin levels based on studies with radioactive bilirubin.
Topics: Bilirubin; Carbon Isotopes; Clinical Trials as Topic; Depression, Chemical; Glutethimide; Humans; Hy | 1971 |
122 other studies available for phenobarbital and Liver Diseases
| Article | Year |
|---|---|
Effect of phenobarbital on hepatic injury induced by chronic carbon tetrachloride treatment.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Drug Synergism; Excitatory Am | 1981 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Mice; | 2009 |
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Catalase; Cytochrome P-450 | 2010 |
Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Liver Diseases; Male; Phenobarbital; Portal Sy | 2010 |
A 1H NMR-based metabolomics approach for mechanistic insight into acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Benzoquinones; Chemical and Drug Induced Liver Inj | 2011 |
A CASE OF HYDATID CYST OF THE LIVER SUCCESSFULLY REMEDIED.
Topics: Child; Chlorpromazine; Dogs; Echinococcosis; Formaldehyde; Humans; India; Liver Diseases; Liver Dise | 1964 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis | 1964 |
[Leukemia in an epileptic treated with gardenal and dihydan; recovery; fatal mysoline poisoning with fatty degeneration of the liver and acute epithelial nephritis].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Hydantoins; Leukemia; Leukocytosis; Liver Diseases; | 1955 |
Toxic hepatic necrosis associated with taking dilantin, tridione and phenobarbital; report of a case.
Topics: Aged; Barbital; Hepatitis; Humans; Hydantoins; Liver; Liver Diseases; Phenobarbital; Phenytoin; Trim | 1950 |
Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Chemical and Drug Induced Live | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Bone disorders in experimentally induced liver disease in growing rats.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Carbon Tet | 2005 |
Hepatobiliary scintigraphy with SPECT in infancy.
Topics: Biliary Atresia; Female; Humans; Infant; Infant, Newborn; Liver Diseases; Male; Phenobarbital; Retro | 2007 |
[Protective effect of alpha-tocopherol on fluoroxene toxicity in mice (author's transl)].
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethers; Liver Diseases; Male; Mice; Phenobarbital; | 1980 |
Role of microsomal drug detoxifying enzyme systems in paracetamol induced liver injury in rats.
Topics: Acetaminophen; Acid Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Glucose-6-Phosphat | 1983 |
Brief periods of hypoxia can produce hepatic injury in rats.
Topics: Animals; Enzyme Induction; Hypoxia; Liver Diseases; Oxygen; Phenobarbital; Rats; Rats, Inbred Strain | 1984 |
The influence of liver disease on the methylation of arsenite in humans.
Topics: Adult; Aminopyrine; Arsenic; Arsenicals; Arsenites; Female; Humans; Liver Diseases; Liver Function T | 1984 |
Decreased hepatic vitamin A after drug administration in men and in rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Humans; Kidney; Liver; Liver Diseases; Methylcholan | 1984 |
Acetylhydrazine hepatotoxicity: the role of covalent binding.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Hydrazines; Liv | 1984 |
Role of protein binding in cocaine-induced hepatic necrosis.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cocaine; Cricetinae; Esterase | 1983 |
Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fasting; Fluorides; Halothane; Hypoxia; Liver Disea | 1983 |
Drug-induced liver injury and microsomal arylamidase activity in needle biopsy of human liver.
Topics: Adult; Aged; Aminopeptidases; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Clinical Enzym | 1980 |
The effect of dibutyl sulphide on hepatocytes studied by means of the isolated rat liver perfusion after preceding exposure to tetrachloromethane and phenobarbital in vivo.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Perfus | 1981 |
[Treatment of cholestatic liver diseases with phenobarbital and ursodeoxycholic acid].
Topics: Cholestasis, Intrahepatic; Cystic Fibrosis; Female; Humans; Liver Diseases; Liver Function Tests; Ma | 1993 |
Effects of phenobarbital on drug metabolizing enzyme activities and other biochemical parameters in rats with DL-ethionine-induced liver injury.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Liver Injury; Enz | 1994 |
Toxicokinetics of phenobarbital in rats with DL-ethionine-induced liver injury.
Topics: Animals; Biological Availability; Blood Proteins; Chemical and Drug Induced Liver Injury; Ethionine; | 1993 |
Interaction of caffeine with acetaminophen. 1. Correlation of the effect of caffeine on acetaminophen hepatotoxicity and acetaminophen bioactivation following treatment of mice with various cytochrome P450 inducing agents.
Topics: Acetaminophen; Acetone; Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflav | 1993 |
Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorobenzenes; Free Radical | 1993 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Pneumotoxicity and hepatotoxicity of styrene and styrene oxide.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Bronchoalveolar Lavage Fluid; Buthionine Sulfoximine; C | 1996 |
Effects of phenobarbital on aniline metabolism in primary liver cell culture of rats with ethionine-induced liver disorder.
Topics: Acetaminophen; Aminophenols; Aniline Compounds; Animals; Cells, Cultured; Chemical and Drug Induced | 1996 |
Sleeping time after phenobarbital treatment and the brain levels of gamma-aminobutyric acid and phenobarbital at the regaining of righting response point in ethionine-induced liver-disordered mice.
Topics: Anesthesia; Anesthesia Recovery Period; Animals; Brain Chemistry; Carcinogens; Chemical and Drug Ind | 1996 |
Protective effect of rifampicin against acute liver injury induced by carbon tetrachloride in mice.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Lip | 1995 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbute | 1996 |
Prolonged phenobarbital pretreatment abolishes the early oxidative stress component induced in the liver by acute lindane intoxication.
Topics: Acute Disease; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Excitatory Amino | 2000 |
Participation of CYP2A in cocaine-induced hepatotoxicity in female mice.
Topics: Alanine Transaminase; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cocaine; Cyt | 2000 |
Salycylamide glucuronide formation in liver disease and its change by drugs.
Topics: Adolescent; Adult; Aged; Barbiturates; Bilirubin; Child; Female; Gilbert Disease; Glucuronates; Hepa | 1975 |
The modification of the dehydromyodesmone-induced hepatic lesion in cattle by microsomal drug metabolizing enzymes.
Topics: Aminopyrine N-Demethylase; Animals; Bilirubin; Cattle; Chemical and Drug Induced Liver Injury; Enzym | 1978 |
A new procedure for the visualization of multiple forms of gamma-glutamyl transferase (GGT). Results in normals, patients receiving enzyme-inducing drugs and patients having liver parenchymal lesions.
Topics: Adolescent; Adult; Anilides; Anticonvulsants; Electrophoresis, Cellulose Acetate; Enzyme Induction; | 1978 |
[Clinical and experimental histochemical studies on the activities of liver lysosomal enzymes and gamma-glutamyl transpeptidase (gamma-GTP) (author's transl)].
Topics: Acetylglucosaminidase; Acid Phosphatase; Adenosine Triphosphatases; Alcoholism; Animals; Anticonvuls | 1978 |
[Biochemical and morphological study on hepato-toxicity of azathioprine in rat (author's transl)].
Topics: Alkaline Phosphatase; Animals; Azathioprine; Chemical and Drug Induced Liver Injury; gamma-Glutamylt | 1979 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
The effect of induced hepatic microsomal amidopyrine demethylase activity on the susceptibility of the liver of the calf and horse to carbon disulphide.
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Aminopyrine N-Demethylase; Animals; Aspartate Amino | 1976 |
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Topics: Age Factors; Animals; Animals, Newborn; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury | 1975 |
[Inhibition by diethyldithiocarbamate (DEDTC) of acute hepatotoxic effects induced by polyhalogenated hydrocarbons (PHHC)].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Ditioca | 1976 |
Experimental hepatic injury: the sequential changes in drug metabolizing enzyme activities after administration of acetaminophen.
Topics: Acetaminophen; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Chemical and Drug Induced Li | 1977 |
The effect of size and timing of a pretreatment dose of phenobarbitone on the liver lesion caused by ngaione in the mouse.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Dose-Response Relat | 1979 |
Activity and inducibility of hepatic microsomal enzymes in liver diseases.
Topics: Adolescent; Adult; Aged; Enzyme Induction; Half-Life; Humans; Liver Diseases; Microsomes, Liver; Mid | 1977 |
Long-term effects of phenobarbitone-Na on male Fischer rats.
Topics: Animals; Hyperplasia; Liver; Liver Diseases; Liver Neoplasms; Male; Neoplasms, Experimental; Phenoba | 1978 |
Serum squalene levels in hepatobiliary diseases.
Topics: Acute Disease; Adult; Azathioprine; Biliary Tract Diseases; Cholestasis; Cholesterol; Cholestyramine | 1978 |
[Therapeutic induction of hepatic enzymes].
Topics: Animals; Enzyme Induction; Humans; Liver; Liver Diseases; Phenobarbital; Rats | 1978 |
Estimation of hepatic bilirubin UDP-glucuronyl transferase in patients with noncirrhotic portal fibrosis and liver disease: Significance and limitations.
Topics: Adult; Bilirubin; Enzyme Induction; Glucuronosyltransferase; Hexosyltransferases; Humans; In Vitro T | 1975 |
Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system.
Topics: Acetamides; Aminopyrine; Aniline Compounds; Animals; Chemical and Drug Induced Liver Injury; Drug In | 1977 |
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy | 1977 |
[Treatment of chronic diseases of the liver].
Topics: Adrenal Cortex Hormones; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Phenob | 1977 |
[Biotransformation and its modification by barbiturates].
Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Live | 1977 |
In vitro spectral alteration of hepatic cytochrome P-450 by experimental drug injury.
Topics: Acetaminophen; Animals; Buffers; Chemical and Drug Induced Liver Injury; Cysteamine; Cysteine; Cytoc | 1977 |
Immunodeficiency, xanthomas and obstructive liver disease.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Child; Cholestyramine Resin; Cholic Acids; Humans; Hype | 1976 |
Hepatic bromsulphthalein-glutathione conjugating enzyme activity in patients with liver disease with particular reference to effects of enzyme inducer.
Topics: Enzyme Induction; Female; Glutathione; Humans; Liver; Liver Diseases; Phenobarbital; Pregnancy; Sulf | 1976 |
The role of biotransformation in chemical-induced liver injury.
Topics: Acetaminophen; Animals; Biotransformation; Bromobenzenes; Chemical and Drug Induced Liver Injury; Cr | 1976 |
[Reversible hyperplasia and hypertrophy of the mouse liver during functional phenobarbital load].
Topics: Animals; Hyperplasia; Hypertrophy; Liver Diseases; Mice; Phenobarbital | 1975 |
Bile-acid metabolism and the liver.
Topics: Barbiturates; Bile Acids and Salts; Cholestasis; Humans; Liver; Liver Cirrhosis; Liver Diseases; Phe | 1976 |
Pivotal role of hepatocellular regeneration in the ultimate hepatotoxicity of CCl4 in chlordecone-, mirex-, or phenobarbital-pretreated rats.
Topics: Animals; Autoradiography; Carbon Tetrachloride; Cell Size; Chemical and Drug Induced Liver Injury; C | 1992 |
Rat liver metabolism and toxicity of 2,2,2-trifluoroethanol.
Topics: Acetaldehyde; Animals; Antibodies, Monoclonal; Biotransformation; Chemical and Drug Induced Liver In | 1992 |
Inhibition of DNA synthesis by phenobarbital in primary cultures of hepatocytes from normal rat liver and from hepatic nodules.
Topics: Animals; Carcinogens; Cells, Cultured; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Liv | 1992 |
Immunocytochemical detection of the 72-kDa heat shock protein in halothane--induced hepatotoxicity in rats.
Topics: Animals; Antibodies, Monoclonal; Chemical and Drug Induced Liver Injury; Halothane; Heat-Shock Prote | 1992 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Hepatotoxicity of phenobarbital in dogs: 18 cases (1985-1989).
Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Female; Liver; Liver Diseases; | 1991 |
An ultrastructural study of spontaneous and phenobarbitone-induced nodules in the mouse liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Liver Neoplasms, Experimenta | 1991 |
Liver damage in long-term anticonvulsant therapy: a serological and histological study.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Combinatio | 1991 |
The response of the rat liver in situ to bromobenzene--in vivo proton magnetic resonance imaging and 31P magnetic resonance spectroscopy studies.
Topics: Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 Enzyme Sy | 1991 |
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li | 1990 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile; Chemical and Drug Induced Liver In | 1987 |
A comparative study of the hepatotoxicity of 1-fluoropentane and 1-fluorohexane.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Synergism; Hydrocarbons, Fluorinated; Liver; L | 1988 |
Enhancing effect of phenobarbital sodium on Tyzzer's disease in mice.
Topics: Animals; Bacillus; Bacterial Infections; Female; Liver; Liver Diseases; Mice; Mice, Inbred ICR; Necr | 1988 |
Halogenated anesthetics increase oxygen consumption in isolated hepatocytes from phenobarbital-treated rats.
Topics: Anesthetics; Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 En | 1987 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |
A comparison of zixoryn and phenobarbital induced infusion cholangiography in hepatic patients.
Topics: Adult; Aged; Benzhydryl Compounds; Cholangiography; Enzyme Induction; Female; Humans; Liver Diseases | 1985 |
Hepatobiliary scintigraphy for cholestasis in congenital hepatic fibrosis. Diagnosis and treatment.
Topics: Bile Ducts, Intrahepatic; Child; Cholangitis; Cholestasis; Dehydrocholic Acid; Gentamicins; Humans; | 1985 |
Phenobarbital induction does not potentiate hepatotoxicity but accelerates liver cell necrosis from acetaminophen overdose in the rat.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 1985 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Ch | 1985 |
Impairment of drug elimination in patients with liver disease.
Topics: Adult; Antipyrine; Female; Half-Life; Humans; Kinetics; Liver Diseases; Liver Function Tests; Male; | 1985 |
Nitrous oxide does not hinder the repair of halothane-induced hepatic injury in the rat.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Bretylium Compounds; Chemical an | 1985 |
Sex differences in halothane metabolism and hepatotoxicity in a rat model.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Biotransformation; Breath Tests; Chemical and | 1985 |
Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats.
Topics: Animals; Blood Proteins; Brain; Carbon Tetrachloride Poisoning; Cholestasis, Extrahepatic; Ethanol; | 1985 |
The effects of multiple anaesthetics on the livers of rats subjected to microsomal enzyme induction. A preliminary report.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Enzyme | 1973 |
Effect of phenobarbital administration on liver and plasma gamma-glutamyl-transpeptidase: clinical and experimental investigations.
Topics: Animals; Body Weight; Chronic Disease; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; ga | 1973 |
Diphenylhydantoin--induced hepatic necrosis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female | 1974 |
Toxicity of halogenated oxyquinolines in dogs. A clinical study. II. History, symptoms, laboratory findings, therapy, and follow-up.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dehydration; Dog Diseases; Dogs; Electrocardiograph | 1974 |
Protective effect of phenobarbitone against fulvine-induced hepatic damage and hypertensive pulmonary vascular disease in the rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Chemical and Drug Induced Liver Injury; Female; Heart Ventric | 1973 |
Histochemical studies of hydropic degeneration of the rat liver induced by carbon disulphide.
Topics: Acid Phosphatase; Adenosine Triphosphatases; Animals; Carbon Disulfide; Cell Membrane; Chemical and | 1974 |
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Topics: Animals; Autoradiography; Benzene Derivatives; Carbon Isotopes; Chemical and Drug Induced Liver Inju | 1971 |
Serum -glytamyl transpeptidase activity in liver disease.
Topics: Acyltransferases; Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit | 1972 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E | 1974 |
Autoimmune response in experimental halothan-induced liver injury.
Topics: Animals; Antibody Formation; Autoantibodies; Chemical and Drug Induced Liver Injury; Dose-Response R | 1973 |
[Drugs and the liver].
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Enzyme Induction; Halothane; Humans; Liver; Liver Di | 1972 |
[Phenobarbital treatment of benign recurrent intrahepatic cholestasis].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biopsy; Cholestasis; Female; Humans; I | 1972 |
[Treatment of cholestasis with phenobarbital].
Topics: Bile Ducts, Intrahepatic; Cholestasis; Humans; Liver Cirrhosis; Liver Diseases; Phenobarbital | 1972 |
Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Chemical and Drug Induced Liver Injury; Enzyme Induction; Glu | 1973 |
Potentiation by previous drug therapy of hepatotoxicity following paracetamol overdosage.
Topics: Acetaminophen; Adolescent; Adult; Amobarbital; Aspartate Aminotransferases; Bilirubin; Chemical and | 1973 |
Effect of pretreatment with phenobarbitone and CS2 on lesions caused in the mouse by 3-hydroxymethyl furan (N,N-diethyl)-carbamate.
Topics: Acute Kidney Injury; Animals; Carbamates; Carbon Disulfide; Chemical and Drug Induced Liver Injury; | 1973 |
Determinants of serum antipyrine half-lives in patients with liver disease.
Topics: Adult; Alkaline Phosphatase; Antipyrine; Aspartate Aminotransferases; Bilirubin; Half-Life; Hepatiti | 1973 |
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
Topics: Acetaminophen; Animals; Carbon Radioisotopes; Cell Nucleus; Chemical and Drug Induced Liver Injury; | 1973 |
Biochemical mechanism of hepatic necrosis induced by aromatic hydrocarbons.
Topics: Animals; Benzene Derivatives; Bromine; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; | 1973 |
[Studies concerning the relationship between the release of enzymes and electrolyte shift in the liver (author's transl)].
Topics: Alanine Transaminase; Animals; Calcium; Carbon Tetrachloride Poisoning; Chloramphenicol; Dinitrophen | 1974 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |
An ultrastructural study of carbon disulphide induced liver injury in the rat.
Topics: Animals; Carbon Disulfide; Cell Nucleus; Chemical and Drug Induced Liver Injury; Cytoplasm; Endoplas | 1974 |
[Histological, histochemical and electron microscopical findings in foreign substance induced liver hypertrophy in white mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum; Halothane; Hyper | 1967 |
Modifying effect of 3-amino-1,2,4-triazole on phenobarbital-induced changes in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrom | 1972 |
[Phenobarbital treatment of indirect hyperbilirubinemia states in various hepatic diseases].
Topics: Administration, Oral; Hepatitis; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Liver C | 1972 |
II. Hereditary diseases of pharmacogenetic interest. Pharmacologic and genetic determinants of disordered bilirubin transport and metabolism in the liver.
Topics: Animals; Bilirubin; Glucuronates; Guinea Pigs; Humans; Hyperbilirubinemia, Hereditary; Liver; Liver | 1968 |
[Stimulation and depression of toxicity of chloroform for the liver by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1970 |
Effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Injections, Intraperi | 1970 |
[Studies on the influence of inhalation anesthesia and surgery on liver function with special reference to halothane].
Topics: Anesthesia, Inhalation; Anesthetics; Animals; Chloroform; Enzyme Activation; Enzyme Induction; Halot | 1970 |
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul | 1971 |
Increase of serum alkaline phosphatase activity due to enzyme "induction" in the liver of beagle dogs.
Topics: Alkaline Phosphatase; Animals; Dogs; Enzyme Induction; Liver; Liver Diseases; Phenobarbital | 1971 |
Increased bilirubin formation from nonhemoglobin sources in rats with disorders of the liver.
Topics: Animals; Bilirubin; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Erythrop | 1969 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |
[Hemolysis due to disturbed drug detoxication in hepatopathies].
Topics: Anemia, Hemolytic; Bilirubin; Chronic Disease; Erythrocytes; Hemolysis; Heparin; Humans; Iron; Jaund | 1966 |
Phenobarbital-induced fine structural changes in rat liver.
Topics: Animals; Hepatomegaly; Liver Diseases; Phenobarbital; Proadifen; Rats | 1966 |