phenobarbital has been researched along with Lipidoses in 11 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Lipidoses: Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phospholipidosis (PLD) is a lysosomal storage disorder induced by compounds, notably cationic amphiphilic drugs, which although reversible interferes with cellular phospholipids." | 1.38 | In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets. ( Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T, 2012) |
| "Phospholipidosis is an adverse effect caused by numerous cationic amphiphilic drugs and can affect many cell types." | 1.36 | Predicting phospholipidosis using machine learning. ( Glen, RC; Lowe, R; Mitchell, JB, 2010) |
| "In addition to the phospholipidosis in utero, drug exposure results in toxicity to the offspring; newborn rats die within 48 h of birth." | 1.27 | Newborn response to cationic amphiphilic drugs. ( Kacew, S; Reasor, MJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (81.82) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lowe, R | 1 |
| Glen, RC | 1 |
| Mitchell, JB | 1 |
| Fischer, H | 1 |
| Atzpodien, EA | 1 |
| Csato, M | 1 |
| Doessegger, L | 1 |
| Lenz, B | 1 |
| Schmitt, G | 1 |
| Singer, T | 1 |
| Kacew, S | 3 |
| Narbaitz, R | 2 |
| Ruddick, JA | 1 |
| Villeneuve, DC | 1 |
| Reasor, MJ | 1 |
| Duckett, S | 1 |
| Cracco, J | 1 |
| Lublin, F | 1 |
| Scott, T | 1 |
| Nixon, DW | 1 |
| Mayger, WE | 1 |
| Applegarth, DA | 1 |
| Dunn, HG | 1 |
| Viukari, NM | 2 |
| Matti, N | 1 |
| Viukari, A | 1 |
| Tammisto, P | 2 |
11 other studies available for phenobarbital and Lipidoses
| Article | Year |
|---|---|
Predicting phospholipidosis using machine learning.
Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Bio | 2010 |
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse | 2012 |
The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats.
Topics: Animals; Animals, Newborn; Chlorphentermine; Drug Interactions; Kidney Diseases; Lipidoses; Male; Ph | 1981 |
Role of drug metabolism in protection against chlorphentermine-induced pulmonary phospholipidosis in adult rat.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Chlorphentermine; Cytochrome P | 1981 |
Newborn response to cationic amphiphilic drugs.
Topics: Animals; Animals, Newborn; Chlorphentermine; Dexamethasone; Drug Interactions; Female; Fetus; Gentam | 1985 |
Electron microscopical diagnosis of lipidosis with the use of rectal biopsy.
Topics: Adolescent; Aggression; Biopsy; Chlorpromazine; Epilepsy; Gait; Humans; Inclusion Bodies; Intellectu | 1974 |
Progressive myoclonus with epilepsy.
Topics: Adult; Child; Chlordiazepoxide; Epilepsy; Female; Humans; Inclusion Bodies; Lipidoses; Myoclonic Cer | 1972 |
Failure of enzymatic induction.
Topics: Enzyme Induction; Hexosaminidases; Humans; Infant; Lipidoses; Lysosomes; Male; Phenobarbital | 1972 |
Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.
Topics: Ataxia; Brain; Humans; L-Lactate Dehydrogenase; Lipidoses; Phenobarbital; Phenytoin; Primidone; Seiz | 1969 |
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |