phenobarbital has been researched along with Leukemia L 1210 in 7 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Procarbazine treatment with doses of 200-400 mg/kg/day given IP for 3 consecutive days increased mean lifespan by 39%-46%." | 1.27 | The in vivo cytotoxic activity of procarbazine and procarbazine metabolites against L1210 ascites leukemia cells in CDF1 mice and the effects of pretreatment with procarbazine, phenobarbital, diphenylhydantoin, and methylprednisolone upon in vivo procarba ( Shiba, DA; Weinkam, RJ, 1983) |
| "Four alkyl ethers of p-N,N-bis(2-chloroethyl)aminophenol were selected to study the effects of microsomal enzyme induction by phenobarbital on the toxicity changes as reflected by LD50 and alteration of survival times in L-1210 leukemic mice." | 1.26 | Effects of microsomal enzyme induction on toxicity of p-N, N-bis (2-chloroethyl)aminophenyl alkyl ethers in mice and survival times in L-1210 leukemic mice. ( Bauguess, CT; Chang, SP; Wynn, JE, 1982) |
| "Phenobarbital-pretreated mice, inoculated i." | 1.26 | Alterations in adriamycin efficacy by phenobarbital. ( Bachur, NR; Reich, SD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shiba, DA | 1 |
| Weinkam, RJ | 1 |
| Lesca, P | 1 |
| Monsarrat, B | 1 |
| Cros, S | 1 |
| Paoletti, C | 1 |
| Bauguess, CT | 1 |
| Chang, SP | 1 |
| Wynn, JE | 1 |
| Reich, SD | 1 |
| Bachur, NR | 1 |
| Field, RB | 1 |
| Gang, M | 1 |
| Kline, I | 1 |
| Venditti, JM | 1 |
| Waravdekar, VS | 1 |
| Hill, DL | 1 |
| Laster, WR | 1 |
| Struck, RF | 1 |
| Hart, LG | 1 |
| Adamson, RH | 1 |
7 other studies available for phenobarbital and Leukemia L 1210
| Article | Year |
|---|---|
The in vivo cytotoxic activity of procarbazine and procarbazine metabolites against L1210 ascites leukemia cells in CDF1 mice and the effects of pretreatment with procarbazine, phenobarbital, diphenylhydantoin, and methylprednisolone upon in vivo procarba
Topics: Animals; Drug Interactions; Leukemia L1210; Male; Methylprednisolone; Mice; Mice, Inbred Strains; Ph | 1983 |
Influence of inducers of monooxygenases on cytotoxic efficiency of ellipticine on leukemia L1210 cells.
Topics: Alkaloids; Animals; Aroclors; Biotransformation; Cell Survival; Cells, Cultured; Ellipticines; Enzym | 1981 |
Effects of microsomal enzyme induction on toxicity of p-N, N-bis (2-chloroethyl)aminophenyl alkyl ethers in mice and survival times in L-1210 leukemic mice.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Leukemia L1210; Mice; Mice, Inbred DBA; Mice, Inbr | 1982 |
Alterations in adriamycin efficacy by phenobarbital.
Topics: Alcohol Oxidoreductases; Animals; Daunorubicin; Doxorubicin; Leukemia L1210; Liver; Mice; Mice, Inbr | 1976 |
The effect of phenobarbital or 2-diethylaminoethyl-2,2-diphenylvalerate on the activation of cyclophosphamide in vivo.
Topics: Animals; Biological Assay; Cyclophosphamide; Drug Interactions; Drug Synergism; Kinetics; Leukemia L | 1972 |
Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.
Topics: Amides; Animals; Carbon Isotopes; Carcinoma, Squamous Cell; Chromatography, Paper; Clone Cells; Cycl | 1972 |
Effect of microsomal enzyme modifiers on toxicity and therapeutic activity of cyclophosphamide in mice.
Topics: Animals; Cyclophosphamide; Environment; Female; Hardness; Leukemia L1210; Mice; Phenobarbital; Proad | 1969 |