phenobarbital has been researched along with Leukemia, Lymphoid in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Leukemia, Lymphoid: Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves with and without phenobarbital pretreatment showed a constant 90% (1-log) reduction in the toxicity of cyclophosphamide to leukemic colony-forming units, whereas enzyme induction had no effect on the toxicity of the drug to normal bone marrow colony-forming units." | 1.26 | The effect of phenobarbital on cyclophosphamide antitumor activity. ( Alberts, DS; van Daalen Wetters, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alberts, DS | 1 |
| van Daalen Wetters, T | 1 |
| Endtz, LJ | 1 |
| Leeksma, CH | 1 |
| Kerkhofs, H | 1 |
| Mulder, OG | 1 |
| Mosmans, FA | 1 |
| Meinardi, H | 1 |
| Goldenberg, GJ | 1 |
3 other studies available for phenobarbital and Leukemia, Lymphoid
| Article | Year |
|---|---|
The effect of phenobarbital on cyclophosphamide antitumor activity.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Dose-Response Relationship, Drug; Drug In | 1976 |
[Acute leukemia induced by diphenylhydantoin? Apropos of 4 cases].
Topics: Adult; Bone Marrow; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukemia, Lymphoid; Lung; L | 1973 |
Drug-induced stimulation of nitrogen mustard and choline transport and other systems in L5178Y lymphoblasts in vitro.
Topics: Amino Acids; Aminoisobutyric Acids; Aminolevulinic Acid; Animals; Atropine; Biological Transport; Ce | 1974 |