phenobarbital has been researched along with Learning Disabilities in 17 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rats in experiment 1 received 1% creatine or cyclocreatine chow from age (P) 21-65 days, underwent kainate induced status epilepticus on P35 and were compared, as adults, to kainate alone rats and to normal controls." | 3.72 | Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats. ( Abu Rialy, S; Farhat, F; Francis, E; Geha, G; Kurdit, RM; Lteif, L; Maraashli, W; Mikati, MA; Rahmeh, AA, 2004) |
| " To test the effect of antiepileptic drugs on kindled seizures and kindling-induced learning deficits we injected ethosuximide, dipropylacetate, and phenobarbital prior to each kindling stimulation or after kindling completion, and tested these animals in a shuttle-box paradigm." | 3.69 | Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments. ( Becker, A; Brosz, M; Grecksch, G, 1995) |
| "Gravid Sprague-Dawley-derived rats were injected SC twice daily with either 20 or 40 mg/kg pentobarbital sodium (PT), sodium phenobarbital (PH), or the same volume of the saline vehicle on days 9-21 of pregnancy." | 3.67 | Maternal barbiturate administration and offspring response to shock. ( Chao, S; Grace, R; Mackler, B; Martin, DC; Martin, JC; Shores, P, 1985) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication." | 1.32 | A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003) |
| "In 1993, 27% of patients were being treated for epilepsy and in 1995/6, 30." | 1.30 | The management of epilepsy in a hospital for people with a learning disability. ( Carvill, S; Cassidy, G; Clarke, D, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (35.29) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akman, O | 1 |
| Moshé, SL | 1 |
| Galanopoulou, AS | 1 |
| Burton, KJ | 1 |
| Allen, S | 1 |
| Gordon, N | 1 |
| Newton, RW | 1 |
| Mikati, MA | 1 |
| Kurdit, RM | 1 |
| Rahmeh, AA | 1 |
| Farhat, F | 1 |
| Abu Rialy, S | 1 |
| Lteif, L | 1 |
| Francis, E | 1 |
| Geha, G | 1 |
| Maraashli, W | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| Sarishvili, AG | 1 |
| Mitagvariia, NP | 1 |
| Azikuri, GSh | 1 |
| Tsintsadze, TG | 1 |
| Lazrishvili, IL | 1 |
| Wallace, SJ | 1 |
| Matarazzo, EB | 1 |
| Becker, A | 1 |
| Grecksch, G | 1 |
| Brosz, M | 1 |
| Gervais-Fagnou, DD | 1 |
| Tuchek, JM | 1 |
| Carvill, S | 1 |
| Clarke, D | 1 |
| Cassidy, G | 1 |
| Dessens, AB | 1 |
| Cohen-Kettenis, PT | 1 |
| Mellenbergh, GJ | 1 |
| Koppe, JG | 1 |
| van De Poll, NE | 1 |
| Boer, K | 1 |
| Stores, G | 1 |
| Calandre, EP | 1 |
| Dominguez-Granados, R | 1 |
| Gomez-Rubio, M | 1 |
| Molina-Font, JA | 1 |
| Yanai, J | 2 |
| Laxer, U | 1 |
| Pick, CG | 1 |
| Trombka, D | 1 |
| Martin, JC | 1 |
| Martin, DC | 1 |
| Mackler, B | 1 |
| Grace, R | 1 |
| Shores, P | 1 |
| Chao, S | 1 |
| Kleinberger, N | 1 |
2 reviews available for phenobarbital and Learning Disabilities
| Article | Year |
|---|---|
Glucose transporter type1 (GLUT-1) deficiency.
Topics: Anticonvulsants; Antioxidants; Ascorbic Acid; Blood-Brain Barrier; Caffeine; Central Nervous System | 2003 |
Behavioural effects of anti-epileptic drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Confusion; Disorders of Excess | 1975 |
15 other studies available for phenobarbital and Learning Disabilities
| Article | Year |
|---|---|
Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Disease | 2015 |
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem | 2003 |
Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.
Topics: Acute Disease; Aggression; Animals; Anticonvulsants; Creatine; Creatinine; Dietary Supplements; Emot | 2004 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
[Changes in emotional state and learning process disorders in rats with experimental hepatic encephalopathy].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Emotions; Hepatic Encephalopathy; Hypnotics and Se | 2006 |
Febrile convulsions: their significance for later intellectual development and behaviour.
Topics: Child; Child Behavior Disorders; Child Development; Child, Preschool; Female; Follow-Up Studies; Hum | 1984 |
[Antiepileptic therapy and its eventual risks].
Topics: Child; Female; Humans; Intellectual Disability; Learning Disabilities; Phenobarbital; Risk | 1981 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuxim | 1995 |
Learning impairment in 1-2-day-old epileptic chicks.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Chickens; Discrimination Learning; | 1996 |
The management of epilepsy in a hospital for people with a learning disability.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Uti | 1999 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children.
Topics: Child; Epilepsy; Female; Follow-Up Studies; Humans; Intelligence; Learning Disabilities; Male; Pheno | 1990 |
Dopaminergic denervation reverses behavioral deficits induced by prenatal exposure to phenobarbital.
Topics: Animals; Cholinergic Fibers; Dopamine; Female; Hippocampus; Hydroxydopamines; Learning Disabilities; | 1989 |
Maternal barbiturate administration and offspring response to shock.
Topics: Animals; Avoidance Learning; Body Weight; Brain; Conditioning, Operant; Electroshock; Female; Humans | 1985 |
Early phenobarbital-induced alterations in hippocampal acetylcholinesterase activity and behavior.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Brain Diseases; Butyrylcholinesterase; Cerebellum; | 1985 |