phenobarbital has been researched along with Lactic Acidosis in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions." | 8.12 | Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. ( Karbwang, J; Na-Bangchang, K; Rajoli, RKR; Sae-Heng, T; Siccardi, M, 2022) |
| "Patients with cerebral malaria with polymorphic Cytochrome P450 2C19 (CYP2C19) genotypes who receive concurrent treatment with quinine are at risk of inadequate or toxic therapeutic drug concentrations due to metabolic drug interactions." | 4.12 | Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria. ( Karbwang, J; Na-Bangchang, K; Rajoli, RKR; Sae-Heng, T; Siccardi, M, 2022) |
| " High PG levels can cause lactic acidosis." | 3.91 | Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital. ( Pouwels, PJW; van de Lagemaat, M; van de Pol, LA; Witjes, BCM; Zonnenberg, IA, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sae-Heng, T | 1 |
| Rajoli, RKR | 1 |
| Siccardi, M | 1 |
| Karbwang, J | 1 |
| Na-Bangchang, K | 1 |
| Pouwels, PJW | 1 |
| van de Lagemaat, M | 1 |
| van de Pol, LA | 1 |
| Witjes, BCM | 1 |
| Zonnenberg, IA | 1 |
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
3 other studies available for phenobarbital and Lactic Acidosis
| Article | Year |
|---|---|
Physiologically based pharmacokinetic modeling for dose optimization of quinine-phenobarbital coadministration in patients with cerebral malaria.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adolescent; Adult; Anticonvulsants; Antimalarials; Area Under | 2022 |
Spectroscopic detection of brain propylene glycol in neonates: Effects of different pharmaceutical formulations of phenobarbital.
Topics: Acidosis, Lactic; Brain; Drug Compounding; Female; Humans; Infant, Newborn; Intensive Care, Neonatal | 2019 |
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |