phenobarbital has been researched along with Kidney Neoplasms in 15 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Kidney Neoplasms: Tumors or cancers of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36." | 3.67 | Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989) |
| " In contrast, only DEHP and BBS induced toxic renal lesions." | 1.27 | The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988) |
| "Pretreatment with phenobarbital led to a marked increase in binding of DES to kidney microsomes but not to liver microsomes from female hamsters and male and female rats." | 1.27 | Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity. ( Haaf, H; Metzler, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (86.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uchida, E | 1 |
| Hirono, I | 1 |
| Arai, M | 1 |
| Hibino, T | 1 |
| Takino, H | 1 |
| Ouchi, N | 1 |
| Hirasawa, Y | 1 |
| Shirachi, DY | 1 |
| Johansen, MG | 1 |
| McGowan, JP | 1 |
| Tu, SH | 1 |
| Hirose, M | 1 |
| Shirai, T | 2 |
| Tsuda, H | 1 |
| Fukushima, S | 2 |
| Ogiso, T | 2 |
| Ito, N | 3 |
| Schmähl, D | 1 |
| Danisman, A | 1 |
| Habs, M | 1 |
| Diehl, B | 1 |
| Klaunig, JE | 1 |
| Siglin, JC | 1 |
| Schafer, LD | 1 |
| Hartnett, JA | 1 |
| Weghorst, CM | 1 |
| Olson, MJ | 1 |
| Hampton, JA | 1 |
| Konishi, N | 1 |
| Donovan, PJ | 1 |
| Ward, JM | 3 |
| Thamavit, W | 1 |
| Kurata, Y | 1 |
| Asamoto, M | 1 |
| Diwan, BA | 3 |
| Ohshima, M | 1 |
| Rice, JM | 2 |
| Nims, RW | 1 |
| Hu, H | 1 |
| Lubet, RA | 1 |
| Masuda, A | 1 |
| Imaida, K | 1 |
| Hagiwara, A | 1 |
| Anderson, LM | 1 |
| Lindsey, K | 1 |
| Porta, EA | 1 |
| Dytioco, S | 1 |
| Aquino, T | 1 |
| Dorado, RD | 1 |
| Ooka, S | 1 |
| Markell, N | 1 |
| Haaf, H | 1 |
| Metzler, M | 1 |
| McLean, AE | 1 |
| Magee, PN | 1 |
15 other studies available for phenobarbital and Kidney Neoplasms
| Article | Year |
|---|---|
Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats.
Topics: Animals; Azo Compounds; Cycasin; Female; gamma-Glutamyltransferase; Kidney Neoplasms; Liver Neoplasm | 1981 |
Comparative enhancing effects of polychlorinated biphenyls and phenobarbital on dimethylnitrosamine-induced hepatic and renal tumorigenesis in rats.
Topics: Animals; Dimethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Male | 1983 |
Tumorigenic effect of sodium arsenite in rat kidney.
Topics: Animals; Arsenic; Arsenites; Body Weight; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neopl | 1983 |
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experi | 1981 |
Experimental investigations on the influence upon the chemical carcinogenesis. IIIrd communication: studies with 1,2-dimethylhydrazine.
Topics: Animals; BCG Vaccine; Diet; Dimethylhydrazines; Ear Neoplasms; Female; Hydrazines; Immunosuppressive | 1976 |
Correlation between species and tissue sensitivity to chemical carcinogenesis in rodents and the induction of DNA synthesis.
Topics: Animals; Barbiturates; Carcinogens; Cell Division; DNA Replication; Female; Gasoline; Kidney; Kidney | 1991 |
Differential effects of renal carcinogens and tumor promoters on growth promotion and inhibition of gap junctional communication in two rat renal epithelial cell lines.
Topics: Acetates; Animals; Barbital; Barbiturates; Carcinogens; Cell Communication; Cell Division; Cell Line | 1990 |
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N | 1989 |
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell | 1989 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz | 1989 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno | 1988 |
Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
Topics: Animals; Diethylnitrosamine; Female; Glucans; Glucose; Hepatectomy; Kidney Neoplasms; Liver Neoplasm | 1986 |
Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity.
Topics: Animals; Cricetinae; Diethylstilbestrol; Female; In Vitro Techniques; Kidney; Kidney Neoplasms; Live | 1985 |
Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.
Topics: Animals; DDT; Enzyme Induction; Kidney Neoplasms; Male; Microsomes, Liver; Neoplasms, Experimental; | 1970 |