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phenobarbital and Kidney Neoplasms

phenobarbital has been researched along with Kidney Neoplasms in 15 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Kidney Neoplasms: Tumors or cancers of the KIDNEY.

Research Excerpts

ExcerptRelevanceReference
"05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36."3.67Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989)
" In contrast, only DEHP and BBS induced toxic renal lesions."1.27The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988)
"Pretreatment with phenobarbital led to a marked increase in binding of DES to kidney microsomes but not to liver microsomes from female hamsters and male and female rats."1.27Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity. ( Haaf, H; Metzler, M, 1985)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199013 (86.67)18.7374
1990's2 (13.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Uchida, E1
Hirono, I1
Arai, M1
Hibino, T1
Takino, H1
Ouchi, N1
Hirasawa, Y1
Shirachi, DY1
Johansen, MG1
McGowan, JP1
Tu, SH1
Hirose, M1
Shirai, T2
Tsuda, H1
Fukushima, S2
Ogiso, T2
Ito, N3
Schmähl, D1
Danisman, A1
Habs, M1
Diehl, B1
Klaunig, JE1
Siglin, JC1
Schafer, LD1
Hartnett, JA1
Weghorst, CM1
Olson, MJ1
Hampton, JA1
Konishi, N1
Donovan, PJ1
Ward, JM3
Thamavit, W1
Kurata, Y1
Asamoto, M1
Diwan, BA3
Ohshima, M1
Rice, JM2
Nims, RW1
Hu, H1
Lubet, RA1
Masuda, A1
Imaida, K1
Hagiwara, A1
Anderson, LM1
Lindsey, K1
Porta, EA1
Dytioco, S1
Aquino, T1
Dorado, RD1
Ooka, S1
Markell, N1
Haaf, H1
Metzler, M1
McLean, AE1
Magee, PN1

Other Studies

15 other studies available for phenobarbital and Kidney Neoplasms

ArticleYear
Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats.
    Journal of cancer research and clinical oncology, 1981, Volume: 100, Issue:3

    Topics: Animals; Azo Compounds; Cycasin; Female; gamma-Glutamyltransferase; Kidney Neoplasms; Liver Neoplasm

1981
Comparative enhancing effects of polychlorinated biphenyls and phenobarbital on dimethylnitrosamine-induced hepatic and renal tumorigenesis in rats.
    Developments in toxicology and environmental science, 1983, Volume: 11

    Topics: Animals; Dimethylnitrosamine; Drug Synergism; Kidney; Kidney Neoplasms; Liver; Liver Neoplasms; Male

1983
Tumorigenic effect of sodium arsenite in rat kidney.
    Proceedings of the Western Pharmacology Society, 1983, Volume: 26

    Topics: Animals; Arsenic; Arsenites; Body Weight; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neopl

1983
Effect of phenobarbital, polychlorinated biphenyl and sodium saccharin on hepatic and renal carcinogenesis in unilaterally nephrectomized rats given N-ethyl-N-hydroxyethylnitrosamine orally.
    Carcinogenesis, 1981, Volume: 2, Issue:12

    Topics: Animals; Carcinogens; Diethylnitrosamine; Kidney Neoplasms; Liver Neoplasms; Male; Neoplasms, Experi

1981
Experimental investigations on the influence upon the chemical carcinogenesis. IIIrd communication: studies with 1,2-dimethylhydrazine.
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1976, May-03, Volume: 86, Issue:1

    Topics: Animals; BCG Vaccine; Diet; Dimethylhydrazines; Ear Neoplasms; Female; Hydrazines; Immunosuppressive

1976
Correlation between species and tissue sensitivity to chemical carcinogenesis in rodents and the induction of DNA synthesis.
    Progress in clinical and biological research, 1991, Volume: 369

    Topics: Animals; Barbiturates; Carcinogens; Cell Division; DNA Replication; Female; Gasoline; Kidney; Kidney

1991
Differential effects of renal carcinogens and tumor promoters on growth promotion and inhibition of gap junctional communication in two rat renal epithelial cell lines.
    Carcinogenesis, 1990, Volume: 11, Issue:6

    Topics: Acetates; Animals; Barbital; Barbiturates; Carcinogens; Cell Communication; Cell Division; Cell Line

1990
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
    Cancer letters, 1989, Volume: 45, Issue:2

    Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N

1989
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell

1989
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
    Carcinogenesis, 1989, Volume: 10, Issue:1

    Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz

1989
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
    Japanese journal of cancer research : Gann, 1988, Volume: 79, Issue:4

    Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop

1988
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
    Toxicology and applied pharmacology, 1988, Volume: 96, Issue:3

    Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno

1988
Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
    Research communications in chemical pathology and pharmacology, 1986, Volume: 52, Issue:3

    Topics: Animals; Diethylnitrosamine; Female; Glucans; Glucose; Hepatectomy; Kidney Neoplasms; Liver Neoplasm

1986
Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity.
    Carcinogenesis, 1985, Volume: 6, Issue:4

    Topics: Animals; Cricetinae; Diethylstilbestrol; Female; In Vitro Techniques; Kidney; Kidney Neoplasms; Live

1985
Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.
    British journal of experimental pathology, 1970, Volume: 51, Issue:6

    Topics: Animals; DDT; Enzyme Induction; Kidney Neoplasms; Male; Microsomes, Liver; Neoplasms, Experimental;

1970