phenobarbital has been researched along with Kidney Diseases in 30 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| "Phenobarbital pretreatment increased methoxyflurane nephrotoxicity in vivo (increased diuresis and blood urea nitrogen and decreased urine osmolality) and induced in vitro hepatic microsomal methoxyflurane metabolism to inorganic fluoride (2-fold), dichloroacetatic acid (1." | 1.33 | New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway. ( Kharasch, ED; Liggitt, HD; Park, SB; Schroeder, JL; Sheffels, P; Whittington, D, 2006) |
| " FDVE-mercapturic acid sulfoxides were more toxic than other FDVE conjugates to renal proximal tubular cells in culture." | 1.32 | Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats. ( Altuntas, TG; Kharasch, ED; Liggitt, HD; Schroeder, JL; Sheffels, P, 2004) |
| "Phenobarbital pretreatment potentiates NDPS and N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS, a nephrotoxic metabolite of NDPS) nephrotoxicity in male rats." | 1.31 | Gender differences in the potentiation of N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity by phenobarbital. ( Anestis, DK; Ball, JG; Brown, PI; Hong, SK; Rankin, GO; Valentovic, MA, 2001) |
| "Pretreatment of phenobarbital (PB) had no remarkable effect on the dichromate-induced nephrotoxicity." | 1.28 | Nephrotoxicity of sodium dichromate depending on the route of administration. ( Kim, E; Na, KJ, 1991) |
| "As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age." | 1.28 | Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats. ( Appenroth, D; Bräunlich, H; Friese, KH; Gambaryan, S, 1990) |
| "Phenobarbital pretreatment had only minor effects on ESX- or MSX-induced renal effects, with no significant morphological changes detected between treated and pair-fed control groups." | 1.28 | Acute effects of the antiepileptic succinimides on the urinary tract and potentiation of phensuximide-induced urotoxicity by phenobarbital. ( Brown, PI; Nicoll, DW; Rankin, GO; Teets, VJ, 1990) |
| "Phenobarbital pretreatment also potentiated in vitro 14CHCl3 metabolism to 14CO2 and covalently bound radioactivity in rabbit renal cortical slices and microsomes." | 1.27 | Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys. ( Bailie, MB; Hook, JB; Newton, JF; Smith, JH, 1984) |
| "Cimetidine did not enhance cyclosporine nephrotoxicity." | 1.27 | Effect of phenobarbital and cimetidine on experimental cyclosporine nephrotoxicity: preliminary observations. ( Benner, KE; Bennett, WM; Houghton, DC; Sasaki, AW; Schwass, DE, 1986) |
| " It was found that high concentrations of beta-cyclodextrin were toxic to the animals in the single exchange technique employed." | 1.26 | beta-Cyclodextrin as an aid to peritoneal dialysis. Renal toxicity of beta-cyclodextrin in the rat. ( Field, FP; Hansen, DA; Mufson, RA; Perrin, JH; Torosian, G, 1978) |
| "Phenobarbital sodium was given in drinking water (0." | 1.26 | Effects of drugs on mushroom poisoning induced in the rat by Cortinarius speciosissimus. ( Nieminen, L, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (76.67) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| JENNINGS, RC | 1 |
| SHAIKH, VA | 1 |
| ALLEN, WM | 1 |
| Sheffels, P | 2 |
| Schroeder, JL | 2 |
| Altuntas, TG | 1 |
| Liggitt, HD | 2 |
| Kharasch, ED | 2 |
| Park, SB | 1 |
| Whittington, D | 1 |
| Kacew, S | 1 |
| Narbaitz, R | 1 |
| Bruni, J | 1 |
| Albright, PS | 1 |
| Turk, JW | 1 |
| Ladenson, JH | 1 |
| Bailie, MB | 1 |
| Smith, JH | 1 |
| Newton, JF | 1 |
| Hook, JB | 1 |
| Asconapé, JJ | 1 |
| Penry, JK | 1 |
| Baden, JM | 1 |
| Rice, SA | 1 |
| Mazze, RI | 3 |
| Kampf, D | 1 |
| Roots, I | 1 |
| Hildebrandt, AG | 1 |
| Verrotti, A | 1 |
| Greco, R | 1 |
| Pascarella, R | 1 |
| Matera, V | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Hong, SK | 1 |
| Anestis, DK | 1 |
| Valentovic, MA | 1 |
| Ball, JG | 1 |
| Brown, PI | 2 |
| Rankin, GO | 2 |
| Hitt, BA | 2 |
| Perrin, JH | 1 |
| Field, FP | 1 |
| Hansen, DA | 1 |
| Mufson, RA | 1 |
| Torosian, G | 1 |
| Hvidberg, EF | 1 |
| Dam, M | 1 |
| Brodeur, J | 1 |
| Paquin, P | 1 |
| Authier, L | 1 |
| Geadah, D | 1 |
| Yamauchi, M | 1 |
| Côté, MG | 1 |
| Nieminen, L | 1 |
| Rosenkranz, RP | 1 |
| Henderson, GL | 1 |
| Kim, E | 1 |
| Na, KJ | 1 |
| Appenroth, D | 1 |
| Gambaryan, S | 1 |
| Friese, KH | 1 |
| Bräunlich, H | 1 |
| Teets, VJ | 1 |
| Nicoll, DW | 1 |
| Nakagawa, Y | 1 |
| Tayama, K | 1 |
| Burke, MD | 1 |
| Whiting, PH | 1 |
| Schwass, DE | 1 |
| Sasaki, AW | 1 |
| Houghton, DC | 1 |
| Benner, KE | 1 |
| Bennett, WM | 1 |
| Cousins, MJ | 1 |
| Kosek, JC | 1 |
| Love, FV | 1 |
| Reid, WD | 1 |
| Ilett, KF | 1 |
| Glick, JM | 1 |
| Krishna, G | 1 |
| Paulson, DF | 1 |
| Fraley, EE | 1 |
| Barrientos Guzmám, A | 1 |
| Rivas Manga, MC | 1 |
| Llamazares Ortega, C | 1 |
| Hernando Avendaño, L | 1 |
| Strolin-Benedetti, M | 1 |
| Benakis, A | 1 |
| Glasson, B | 1 |
| Roy, HG | 1 |
| Kelkar, MK | 1 |
3 reviews available for phenobarbital and Kidney Diseases
| Article | Year |
|---|---|
The clinical pharmacology of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Ethosuximide; Female; Hal | 1984 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas | 1982 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
27 other studies available for phenobarbital and Kidney Diseases
| Article | Year |
|---|---|
RENAL ISCHAEMIA DUE TO THROMBOSIS OF RENAL ARTERY RESULTING FROM METASTASES FROM PRIMARY CARCINOMA OF THE BRONCHUS.
Topics: Adrenal Gland Neoplasms; Angiography; Bronchi; Bronchial Neoplasms; Chlorthalidone; Diagnosis, Diffe | 1964 |
Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
Topics: Anesthetics, Inhalation; Animals; Aryl Hydrocarbon Hydroxylases; Cysteine; Cytochrome P-450 CYP3A; D | 2004 |
New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.
Topics: Anesthetics, Inhalation; Animals; Biotransformation; GABA Modulators; Kidney Diseases; Kidney Functi | 2006 |
The effect of phenobarbital on chlorphentermine-induced lipidosis-like alterations in renal tissue of adult and newborn rats.
Topics: Animals; Animals, Newborn; Chlorphentermine; Drug Interactions; Kidney Diseases; Lipidoses; Male; Ph | 1981 |
Phenytoin and phenobarbital concentrations in renal insufficiency.
Topics: Humans; Kidney Diseases; Phenobarbital; Phenytoin | 1984 |
Mechanism of chloroform nephrotoxicity. IV. Phenobarbital potentiation of in vitro chloroform metabolism and toxicity in rabbit kidneys.
Topics: Animals; Chloroform; Cytochrome P-450 Enzyme System; Drug Synergism; Enzyme Induction; In Vitro Tech | 1984 |
Deuterated methoxyflurane anesthesia and renal function in Fischer 344 rats.
Topics: Anesthesia; Animals; Deuterium; Enzyme Induction; Fluorides; Kidney; Kidney Diseases; Male; Methoxyf | 1982 |
Urinary excretion of D-glucaric acid, an indicator of drug metabolizing enzyme activity, in patients with impaired renal function.
Topics: Adult; Aged; Female; Glomerular Filtration Rate; Glucaric Acid; Humans; Kidney Diseases; Male; Middl | 1980 |
Renal tubular function in patients receiving anticonvulsant therapy: a long-term study.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; | 2000 |
Gender differences in the potentiation of N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity by phenobarbital.
Topics: Animals; Female; Fungicides, Industrial; Hypnotics and Sedatives; Kidney Diseases; Male; Organ Size; | 2001 |
Effect of enzyme induction on nephrotoxicity of halothane-related compounds.
Topics: Anesthetics; Animals; Biotransformation; Enflurane; Environmental Exposure; Enzyme Induction; Fluori | 1977 |
beta-Cyclodextrin as an aid to peritoneal dialysis. Renal toxicity of beta-cyclodextrin in the rat.
Topics: Amylose; Animals; Blood Urea Nitrogen; Kidney Diseases; Peritoneal Dialysis; Phenobarbital; Rats; Ti | 1978 |
Influence of phenobarbital pretreatment on methoxyflurane and sodium fluoride nephropathy in Fischer 344 Rats.
Topics: Animals; Fluorides; Kidney Diseases; Male; Methoxyflurane; Phenobarbital; Rats; Rats, Inbred F344 | 1976 |
Effects of drugs on mushroom poisoning induced in the rat by Cortinarius speciosissimus.
Topics: Animals; Female; Kidney Diseases; Mushroom Poisoning; Phenobarbital; Phenylbutazone; Rats | 1976 |
Renal toxicity of l-alpha-acetylmethadol (LAAM) in the rat.
Topics: Animals; Hematuria; Kidney Diseases; Kidney Tubules; Methadone; Methadyl Acetate; Morphine; Naloxone | 1975 |
Nephrotoxicity of sodium dichromate depending on the route of administration.
Topics: Alanine Transaminase; Animals; Biotransformation; Blood Urea Nitrogen; Chromates; Chromium; Creatini | 1991 |
Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats.
Topics: Aging; Animals; Chromates; Chromium; Cromolyn Sodium; Female; Kidney; Kidney Diseases; Kidney Tubule | 1990 |
Acute effects of the antiepileptic succinimides on the urinary tract and potentiation of phensuximide-induced urotoxicity by phenobarbital.
Topics: Animals; Anticonvulsants; Drug Synergism; Ethosuximide; Kidney Diseases; Male; Phenobarbital; Rats; | 1990 |
Nephrotoxicity of butylated hydroxytoluene in phenobarbital-pretreated male rats.
Topics: Animals; Butylated Hydroxytoluene; In Vitro Techniques; Kidney; Kidney Diseases; Liver; Male; p-Amin | 1988 |
The role of drug metabolism in cyclosporine A nephrotoxicity.
Topics: Aminopyrine N-Demethylase; Animals; Cyclosporins; Cytochrome P-450 Enzyme System; Enzyme Induction; | 1986 |
Effect of phenobarbital and cimetidine on experimental cyclosporine nephrotoxicity: preliminary observations.
Topics: Animals; Cimetidine; Creatinine; Cyclosporins; Cytochrome P-450 Enzyme System; Drug Interactions; In | 1986 |
The etiology of methoxyflurane nephrotoxicity.
Topics: Animals; Fluorides; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Liver; Male; Methoxyflurane; | 1974 |
Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis.
Topics: Animals; Autoradiography; Bromine; Bronchial Diseases; Carbon Isotopes; Chemical and Drug Induced Li | 1973 |
Compensatory renal growth after unilateral ureteral obstruction.
Topics: Anesthesia, Intravenous; Animals; Carbon Isotopes; DNA; Hyperplasia; Hypertrophy; Kidney; Kidney Dis | 1973 |
[Kidney disease caused by analgesics].
Topics: Adult; Analgesics; Aspirin; Codeine; Female; Humans; Kidney Diseases; Male; Phenacetin; Phenobarbita | 1971 |
[Various problems on drug catabolism using labelled molecules].
Topics: Animals; Carbon Dioxide; Chromatography, Gas; Humans; Kidney Diseases; Methylation; Pharmaceutical P | 1968 |
Artificial kidney.
Topics: Adolescent; Adult; Child; Humans; Kidney Diseases; Kidneys, Artificial; Middle Aged; Phenobarbital | 1965 |