phenobarbital has been researched along with Kernicterus in 24 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Kernicterus: A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sodium phenobarbital and various hormones, compounds capable of hepatic enzyme induction, were given to an infant boy with congenital, nonhemolytic, unconjugated, hyperbilirubinemia and severe kernicterus for prolonged periods between the ages of 2 and 25 months to determine their effect on serum bilirubin concentrations." | 7.65 | Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus. ( Crigler, JF; Gold, NI, 1969) |
| "A 37-year-old mother with CNS type II was treated with phenobarbital during her pregnancy and her bilirubin levels were monitored." | 4.85 | Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature. ( Koelbl, H; Kohlschmidt, N; Passuello, V; Puhl, AG; Skala, C; Steiner, E; Wirth, S, 2009) |
| "An understanding of the pathophysiologic factors causing kernicterus, the determination of infants at greatest risk for developing kernicterus, even the cornerstone of therapy for kernicterus--controlling the bilirubin level--are in a current (and continuous) state of revision." | 4.76 | Kernicterus 1980: problems and practices viewed from the perspective of the practicing clinician. ( Harper, RG; Kierney, CM; Sia, CG, 1980) |
| " The limited bilirubin binding capacity of human serum albumin, and the fact that kernicterus can occur once the serum unconjugated bilirubin concentration exceeds this capacity, makes the assessment of non-albumin bound free bilirubin valuable in cases of severe neonatal hyperbilirubinemia." | 3.65 | The albumin binding of unconjugated bilirubin in serum. ( Dextraze, P; Diamond, I; Griffiths, WC, 1975) |
| "Sodium phenobarbital and various hormones, compounds capable of hepatic enzyme induction, were given to an infant boy with congenital, nonhemolytic, unconjugated, hyperbilirubinemia and severe kernicterus for prolonged periods between the ages of 2 and 25 months to determine their effect on serum bilirubin concentrations." | 3.65 | Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus. ( Crigler, JF; Gold, NI, 1969) |
| ""Kernicterus" is a term currently used to describe bilirrubin induced brain injury in the neuro-pathological studies." | 1.38 | [Neurological dysfunction induced by bilirrubin]. ( Campistol, J; Cazorla, AG; Cusí, V; Galvez, H; Iriondo, M; Málaga, I, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (83.33) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Passuello, V | 1 |
| Puhl, AG | 1 |
| Wirth, S | 1 |
| Steiner, E | 1 |
| Skala, C | 1 |
| Koelbl, H | 1 |
| Kohlschmidt, N | 1 |
| Campistol, J | 1 |
| Galvez, H | 1 |
| Cazorla, AG | 1 |
| Málaga, I | 1 |
| Iriondo, M | 1 |
| Cusí, V | 1 |
| Smits-Wintjens, VE | 1 |
| Walther, FJ | 1 |
| Lopriore, E | 1 |
| Harper, RG | 1 |
| Sia, CG | 1 |
| Kierney, CM | 1 |
| Jansen, PL | 1 |
| Lathe, GH | 1 |
| Gupta, JM | 1 |
| McCrae, WM | 1 |
| Griffiths, WC | 1 |
| Diamond, I | 1 |
| Dextraze, P | 1 |
| Thomas, CR | 1 |
| Jährig, K | 1 |
| Stenger, R | 1 |
| Meisel, P | 1 |
| Scheig, R | 1 |
| Mauer, AM | 1 |
| Maisels, MJ | 1 |
| Juszczyk, J | 1 |
| Grauaug, A | 1 |
| Windorfer, A | 1 |
| Mihailova, K | 1 |
| Pringsheim, W | 1 |
| Wennberg, RP | 1 |
| von Brücke, FT | 1 |
| Ballowitz, L | 1 |
| Natzschka, J | 1 |
| Murano, G | 1 |
| Di Toro, R | 1 |
| Arias, IM | 1 |
| Gartner, LM | 1 |
| Cohen, M | 1 |
| Ben-Ezzer, J | 1 |
| Levi, AJ | 1 |
| Crigler, JF | 1 |
| Gold, NI | 1 |
| Ertel, IJ | 1 |
| Newton, WA | 1 |
10 reviews available for phenobarbital and Kernicterus
| Article | Year |
|---|---|
Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature.
Topics: Adult; Bilirubin; Crigler-Najjar Syndrome; Female; Hearing Disorders; Humans; Infant; Infant, Newbor | 2009 |
Rhesus haemolytic disease of the newborn: Postnatal management, associated morbidity and long-term outcome.
Topics: Albumins; Anemia, Neonatal; Cholestasis; Fluid Therapy; Humans; Hydrops Fetalis; Hyperbilirubinemia, | 2008 |
Kernicterus 1980: problems and practices viewed from the perspective of the practicing clinician.
Topics: Bilirubin; Brain Diseases; Exchange Transfusion, Whole Blood; Humans; Infant; Infant, Newborn; Kerni | 1980 |
Diagnosis and management of Crigler-Najjar syndrome.
Topics: Animals; Bilirubin; Child; Crigler-Najjar Syndrome; Female; Humans; Kernicterus; Liver Transplantati | 1999 |
Neonatal bilirubin metabolism in relation to jaundice.
Topics: Agar; Animals; Bilirubin; Breast Feeding; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Jaund | 1976 |
[Pathogenesis of bilirubin encephalopathy and subsequent therapeutic consequences].
Topics: Blood-Brain Barrier; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Kernicterus; Phenobarbital | 1989 |
Neonatal jaundice--prevention & management.
Topics: Albumins; Bilirubin; Blood Transfusion, Intrauterine; Erythrocytes; Exchange Transfusion, Whole Bloo | 1972 |
Bilirubin; on understanding and influencing its metabolism in the newborn infant.
Topics: Bile Pigments; Bilirubin; Exchange Transfusion, Whole Blood; Female; Fetus; Heme; Humans; Hyperbilir | 1972 |
[Effects of drugs and other biological and physical factors on bilirubin metabolism in man].
Topics: Animals; Antigens, Bacterial; Bilirubin; Depression, Chemical; Enzyme Induction; Fasting; Female; Fe | 1973 |
What to do when the infant is jaundiced.
Topics: Animals; Bilirubin; Diagnosis, Differential; Erythroblastosis, Fetal; Erythropoiesis; Exchange Trans | 1971 |
14 other studies available for phenobarbital and Kernicterus
| Article | Year |
|---|---|
[Neurological dysfunction induced by bilirrubin].
Topics: Age of Onset; Autopsy; Electroencephalography; Evoked Potentials, Auditory; Exchange Transfusion, Wh | 2012 |
Neonatal jaundice.
Topics: Exchange Transfusion, Whole Blood; Humans; Infant, Newborn; Jaundice, Neonatal; Kernicterus; Phenoba | 1977 |
Kernicterus in the newborn.
Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Kernicterus; Phenobarbital; Phototherapy | 1976 |
The albumin binding of unconjugated bilirubin in serum.
Topics: Adult; Bilirubin; Binding, Competitive; Charcoal; Dextrans; Humans; Kernicterus; Methods; Phenobarbi | 1975 |
Routine phenobarbital for prevention of neonatal hyperbilirubinemia.
Topics: Costs and Cost Analysis; Female; Hospitalization; Humans; Infant, Newborn; Jaundice, Neonatal; Kerni | 1976 |
Neonatal jaundice.
Topics: Albumins; Bile Ducts; Bilirubin; Breast Feeding; Crigler-Najjar Syndrome; Erythroblastosis, Fetal; E | 1974 |
The management of jaundice in the newborn.
Topics: Agar; Diagnosis, Differential; Erythroblastosis, Fetal; Exchange Transfusion, Whole Blood; Female; G | 1972 |
[Does drug therapy increase the dangers of bilirubin encephalopathy during the newborn period?].
Topics: Ampicillin; Bilirubin; Blood; Carbenicillin; Cephalothin; Child, Preschool; Colistin; Diazepam; Eryt | 1973 |
[Luminal therapy in the prevention of icterus of the newborn caused by Rh incompatibility].
Topics: Bilirubin; Endoplasmic Reticulum; Enzyme Induction; Erythroblastosis, Fetal; Female; Humans; Infant, | 1970 |
[Hyperbilirubinemia in newborn infants. Experimental principles of phototheray and enzyme induction].
Topics: Animals; Bilirubin; Enzyme Induction; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Kernicter | 1971 |
[On the "rebound" of bilirubin in the newborn after exchange transfusion].
Topics: Bilirubin; Brain Diseases; Erythroblastosis, Fetal; Exchange Transfusion, Whole Blood; Female; Human | 1969 |
Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency: evidence for genetic heterogeneity.
Topics: Adolescent; Adult; Bile; Bilirubin; Child; Child, Preschool; Female; Genes, Dominant; Genes, Recessi | 1968 |
Effect of sodium phenobarbital on bilirubin metabolism in an infant with congenital, nonhemolytic, unconjugated hyperbilirubinemia, and kernicterus.
Topics: Bilirubin; Carbon Isotopes; Crystallization; Growth Hormone; Humans; Hyperbilirubinemia, Hereditary; | 1969 |
Therapy in congenital hyperbilirubinemia: phenobarbital and diethylnicotinamide.
Topics: Bilirubin; Child; Child, Preschool; Female; Humans; Hyperbilirubinemia, Hereditary; Infant; Infant, | 1969 |