phenobarbital has been researched along with Jaundice in 34 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Jaundice: A clinical manifestation of HYPERBILIRUBINEMIA, characterized by the yellowish staining of the SKIN; MUCOUS MEMBRANE; and SCLERA. Clinical jaundice usually is a sign of LIVER dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Unconjugated hyperbilirubinemia as occurs in Gunn rats did not affect the plasma disappearance of sulfobromophthalein (BSP) or indocyanine green (ICG)." | 7.65 | Plasma disappearance of sulfobromophthalein or indocyanine green in unconjugated hyperbilirubinemia. ( Wise, KJ; Yeary, RA, 1975) |
| "The novobiocin and luminal test application increases the possibilities to differentiate premicrosome from postmicrosome jaundice and extends the knowledge on hyperbilirubinemia pathobiochemistry." | 7.65 | [Changes in the liver transport of bile pigments in certain forms of jaundice under the influence of novobiocin and luminal]. ( Avramova, K; Goranov, I, 1975) |
| " Patients with Crigglar-Najjar syndrome type II respond to phenobarbital therapy which decreases their chances of getting bilirubinemia by 60-70% in 3 weeks." | 3.88 | Crigler-Najjar Syndrome Type II Diagnosed in a Patient with Jaundice Since Birth. ( Ameer, A; Attiq, H; Imran, M; Liaqat, A; Shahid, A, 2018) |
| " In severely jaundiced patients (serum bilirubin concentrations greater than 140 mumol/l) a markedly decreased or absent uptake of 99mTc-EHIDA was observed." | 3.66 | The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. ( Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ, 1983) |
| "Salicylamide glucuronide (SAMG) in 0-6 and 6-12 hours-urine specimens was determined after oral administration of salicylamide in 7 normal volunteers (NV), in 51 cases of various liver diseases and hyperbilirubinemias, and in 19 cases after drug administration, to predict the in vivo drug metabolism in man and its change by drugs." | 3.65 | Salycylamide glucuronide formation in liver disease and its change by drugs. ( Adachi, Y; Wakisaka, G; Yamamoto, T, 1975) |
| " But enzyme induction can also lead to acute intermittent porphyrias and distrubances of the phosphorus-calcium metabolism." | 3.65 | [Liver metabolism of drugs (author's transl)]. ( Darnis, F, 1976) |
| "Unconjugated hyperbilirubinemia as occurs in Gunn rats did not affect the plasma disappearance of sulfobromophthalein (BSP) or indocyanine green (ICG)." | 3.65 | Plasma disappearance of sulfobromophthalein or indocyanine green in unconjugated hyperbilirubinemia. ( Wise, KJ; Yeary, RA, 1975) |
| "The novobiocin and luminal test application increases the possibilities to differentiate premicrosome from postmicrosome jaundice and extends the knowledge on hyperbilirubinemia pathobiochemistry." | 3.65 | [Changes in the liver transport of bile pigments in certain forms of jaundice under the influence of novobiocin and luminal]. ( Avramova, K; Goranov, I, 1975) |
| "Clinically apparent jaundice is unusual in patients with beta-thalassemia major." | 1.36 | Persistent jaundice in an infant with homozygous beta thalassemia due to co-inherited Crigler-Najjar syndrome. ( Aggarwal, V; Aneja, S; Fabiano, C; Sammarco, P; Seth, A; Sharma, S, 2010) |
| "Pruritus was a prominent symptom in five." | 1.30 | Nonsyndromic paucity of interlobular bile ducts: clinical and laboratory findings of 10 cases. ( Cağlar, M; Göğüş, S; Gürakan, F; Kale, G; Koçak, N; Yüce, A, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (88.24) | 18.7374 |
| 1990's | 2 (5.88) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liaqat, A | 1 |
| Shahid, A | 1 |
| Attiq, H | 1 |
| Ameer, A | 1 |
| Imran, M | 1 |
| Aggarwal, V | 1 |
| Seth, A | 1 |
| Sharma, S | 1 |
| Aneja, S | 1 |
| Sammarco, P | 1 |
| Fabiano, C | 1 |
| FOUTS, JR | 1 |
| Coenegracht, JM | 1 |
| Oei, TL | 1 |
| van Breda Vriesman, PJ | 1 |
| Iwańczak, F | 1 |
| Prandota, J | 1 |
| Puri, AS | 1 |
| Sharma, BC | 1 |
| Khan, EM | 1 |
| Saraswat, VA | 1 |
| Koçak, N | 1 |
| Gürakan, F | 1 |
| Yüce, A | 1 |
| Cağlar, M | 1 |
| Kale, G | 1 |
| Göğüş, S | 1 |
| Adachi, Y | 1 |
| Wakisaka, G | 1 |
| Yamamoto, T | 1 |
| Darnis, F | 3 |
| Margaria, E | 1 |
| Palieri Furlan, L | 1 |
| Marioni, A | 1 |
| Magro, M | 1 |
| Lovera, C | 1 |
| Oleĭnik, AN | 2 |
| Kirshenbaum, G | 1 |
| Lear, S | 1 |
| Way, LW | 1 |
| Nusinovici, V | 1 |
| Levy, VG | 1 |
| Caroli, J | 1 |
| Stiehl, A | 1 |
| Schmeisser, W | 1 |
| Eggstein, M | 1 |
| Maulbetsch, R | 1 |
| Dölle, W | 1 |
| Moreno, JA | 1 |
| Yeary, RA | 1 |
| Wise, KJ | 1 |
| Goranov, I | 1 |
| Avramova, K | 1 |
| Schwartz, GR | 1 |
| Sanbe, K | 1 |
| Kamegaya, K | 1 |
| Oda, M | 1 |
| Okazaki, I | 1 |
| Selye, H | 1 |
| Rundle, AT | 1 |
| Sudell, B | 1 |
| Ballow, M | 1 |
| Margolis, CZ | 1 |
| Schachtel, B | 1 |
| Hsia, YE | 1 |
| Perona, G | 1 |
| Corrocher, R | 1 |
| Frezza, M | 1 |
| Falezza, GC | 1 |
| Cellerino, R | 1 |
| Tiribelli, C | 1 |
| Fusaro, A | 1 |
| De Sandre, G | 1 |
| Shakun, NP | 1 |
| Espinoza, J | 1 |
| Barnafi, L | 1 |
| Schnaidt, E | 1 |
| Billing, BH | 1 |
| Black, M | 1 |
| Arias, IM | 1 |
| Gartner, LM | 1 |
| Cohen, M | 1 |
| Ezzer, JB | 1 |
| Levi, AJ | 1 |
| Henderson, PT | 1 |
| Rizzi, D | 1 |
| Pettinati, G | 1 |
| Serio, G | 1 |
| L'Abbate, M | 1 |
| Berglund, G | 1 |
| Hansson, L | 1 |
| Vikgren, P | 1 |
| Thompson, RP | 1 |
| Williams, R | 1 |
| Köhler, P | 1 |
| Mey, U | 1 |
5 reviews available for phenobarbital and Jaundice
| Article | Year |
|---|---|
[Effect of phenobarbital on the intrahepatic metabolism of bilirubin].
Topics: Animals; Bile; Bilirubin; Biological Transport, Active; Cytoplasm; Drug Evaluation; Drug Interaction | 1978 |
[Hepatic-cell enzyme induction using phenobarbital: applications to the treatment of jaundice].
Topics: Bile Acids and Salts; Bilirubin; Cholestasis; Chronic Disease; Enzyme Induction; Gilbert Disease; Hu | 1976 |
[Advances in the treatment of jaundice in the department of internal medicine].
Topics: Adrenal Cortex Hormones; Adult; Bilirubin; Cholestasis; Female; Humans; Hyperbilirubinemia; Jaundice | 1972 |
Bilirubin metabolism.
Topics: Bilirubin; Biological Transport, Active; Bone Marrow; Erythropoiesis; Glucuronates; Humans; Jaundice | 1969 |
Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency. Clinical, biochemical, pharmacologic and genetic evidence for heterogeneity.
Topics: Adolescent; Adult; Bile; Bile Pigments; Bilirubin; Child, Preschool; Female; Genes, Dominant; Genoty | 1969 |
29 other studies available for phenobarbital and Jaundice
| Article | Year |
|---|---|
Crigler-Najjar Syndrome Type II Diagnosed in a Patient with Jaundice Since Birth.
Topics: Adolescent; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyper | 2018 |
Persistent jaundice in an infant with homozygous beta thalassemia due to co-inherited Crigler-Najjar syndrome.
Topics: beta-Thalassemia; Crigler-Najjar Syndrome; Erythrocyte Transfusion; Fatal Outcome; GABA Modulators; | 2010 |
FACTORS AFFECTING HEPATIC MICROSOMAL ENZYME SYSTEMS INVOLVED IN DRUG METABOLISM.
Topics: Alloxan; Aminopyrine; Carcinoma, Hepatocellular; Chlordan; Chlorpromazine; Codeine; Hexobarbital; Ja | 1963 |
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans.
Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Ph | 1983 |
[Gilbert's syndrome. Diagnostic difficulties and successful use of the luminal test].
Topics: Adolescent; Bilirubin; Child; Diagnosis, Differential; Female; Gilbert Disease; Humans; Hyperbilirub | 1980 |
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans | 1994 |
Nonsyndromic paucity of interlobular bile ducts: clinical and laboratory findings of 10 cases.
Topics: Bile Ducts; Biopsy; Child, Preschool; Cholestasis; Cholestyramine Resin; Consanguinity; Female; Huma | 1997 |
Salycylamide glucuronide formation in liver disease and its change by drugs.
Topics: Adolescent; Adult; Aged; Barbiturates; Bilirubin; Child; Female; Gilbert Disease; Glucuronates; Hepa | 1975 |
[Liver metabolism of drugs (author's transl)].
Topics: Adult; Animals; Anticonvulsants; Biotransformation; Calcium; Child; Cushing Syndrome; Dicumarol; Dru | 1976 |
[Endogenous intoxications of pregnancy: jaundice of pregnancy].
Topics: Adult; Arginine; Bicarbonates; Cholestasis; Cholestyramine Resin; Dextrans; Fatty Liver; Female; Glu | 1979 |
Effect of phenobarbital on turnover of hepatic heme in rats.
Topics: Animals; Bilirubin; Heme; Jaundice; Liver; Male; Phenobarbital; Postoperative Complications; Rats | 1979 |
[Treatment of various forms of icterus or cholestasis with phenobarbital (author's transl)].
Topics: Adult; Anemia, Hemolytic; Cholangitis; Cholestasis; Crigler-Najjar Syndrome; Gilbert Disease; Humans | 1977 |
[A case of benign recurring intrahepatic cholestasis (Tygstrup-Summerskill and Walshe syndrome)].
Topics: Adult; Alkaline Phosphatase; Biopsy; Cholestasis; Cholestyramine Resin; Diet Therapy; Humans; Hyperb | 1977 |
[The liver and metabolism of drugs].
Topics: Biotransformation; Cushing Syndrome; Drug Antagonism; Enzyme Induction; Humans; Jaundice; Liver; Phe | 1976 |
[Use of phenobarbital in the management of pruritus associated with cholestatic jaundice of pregnancy].
Topics: Administration, Oral; Biliary Tract Diseases; Drug Evaluation; Female; Humans; Jaundice; Phenobarbit | 1975 |
Plasma disappearance of sulfobromophthalein or indocyanine green in unconjugated hyperbilirubinemia.
Topics: Animals; Bile Ducts; Bilirubin; Female; Genotype; Hyperbilirubinemia; Indocyanine Green; Jaundice; K | 1975 |
[Changes in the liver transport of bile pigments in certain forms of jaundice under the influence of novobiocin and luminal].
Topics: Bile; Biological Transport; Chronic Disease; Humans; Jaundice; Liver; Novobiocin; Phenobarbital; Pig | 1975 |
Effect of phenobarbital on jaundice.
Topics: Bilirubin; Enzyme Induction; Hepatic Encephalopathy; Humans; Jaundice; Phenobarbital | 1967 |
Prevention by catatoxic steroids of lithocholic acid-induced biliary concrements in the rat.
Topics: Animals; Bile Acids and Salts; Body Weight; Common Bile Duct; Female; Gallstones; Jaundice; Lithocho | 1972 |
Leucine aminopeptidase isoenzyme changes after treatment with anticonvulsant drugs.
Topics: Blood Protein Electrophoresis; Blood Proteins; Epilepsy; Humans; Isoenzymes; Jaundice; Leucyl Aminop | 1973 |
Progressive familial intrahepatic cholestasis.
Topics: Alkaline Phosphatase; Aspartate Aminotransferases; Bile Acids and Salts; Bile Ducts, Intrahepatic; C | 1973 |
Phenobarbitone of jaundice in haemolytic patients.
Topics: Adolescent; Adult; Agglutinins; Anemia, Hemolytic; Autoantibodies; Bilirubin; Cold Temperature; Fema | 1973 |
[Effect of drugs on bilirubin metabolism in the treatment of jaundice].
Topics: Bilirubin; Drug Evaluation; Drug-Related Side Effects and Adverse Reactions; Humans; Hyperbilirubine | 1973 |
The effect of phenobarbital on intrahepatic cholestasis of pregnancy.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Pro | 1974 |
[Induction of liver microsomal enzymes and its significance in the treatment of jaundice].
Topics: Animals; Bile Pigments; Bilirubin; Biotransformation; DDT; Enzyme Induction; Humans; Jaundice; Micro | 1971 |
[Reduction of indirect bilirubinemia after administration of phenylethylbarbituric acid in non-hemolytic chronic jaundice caused by glycuronyltransferase deficiency].
Topics: Adult; Chronic Disease; Glucuronates; Humans; Hyperbilirubinemia, Hereditary; Jaundice; Male; Metabo | 1970 |
[Phenemal treatment of icterus intermittens juvenilis].
Topics: Administration, Oral; Adult; Bilirubin; Humans; Hyperbilirubinemia; Jaundice; Male; Phenobarbital | 1971 |
Developments in jaundice.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Enzyme Induction; Female; | 1969 |
[Hemolysis due to disturbed drug detoxication in hepatopathies].
Topics: Anemia, Hemolytic; Bilirubin; Chronic Disease; Erythrocytes; Hemolysis; Heparin; Humans; Iron; Jaund | 1966 |