phenobarbital has been researched along with Intracranial Hemorrhages in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Intracranial Hemorrhages: Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 7.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "In this retrospective study, we tested the following hypotheses: rates of severe intraventricular hemorrhage (SIVH) and early neonatal survival are similar among extremely low birth weight (ELBW) infants treated with combination prophylaxis of phenobarbital and indomethacin compared with phenobarbital alone or no prophylaxis; and rates of patent ductus arteriosus (PDA) and necrotizing enterocolitis (NEC) are similar among indomethacin-exposed and nonexposed ELBW infants." | 3.73 | Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant. ( Ekekezie, II; Mundy, DC; Okah, FA, 2005) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 3.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Infants with intracranial hemorrhage (23%) had significantly lower mental developmental index and psychomotor developmental index scores than infants with no intracranial hemorrhage, independent of antenatal phenobarbital exposure." | 2.70 | Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure. ( Donovan, EF; Ehrenkranz, RA; Fanaroff, AA; Korones, SB; Lemons, JA; Mele, L; Oh, W; Papile, LA; Shankaran, S; Stevenson, DK; Stoll, BJ; Verter, J; Wright, LL, 2002) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Secondary or reperfusion injury is potentially amenable to neuroprotective strategies." | 2.42 | Brain injury in the term infant. ( Perlman, JM, 2004) |
| "Phenobarbital was the most common initial medication for all gestational age groups, and failure to respond to an initial loading dose was 63% in both preterm and term neonates." | 1.46 | Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. ( Abend, NS; Bonifacio, SL; Chang, T; Chu, CJ; Cilio, MR; Glass, HC; Massey, SL; Shellhaas, RA; Soul, JS; Tsuchida, TN; Wusthoff, CJ, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Soul, JS | 2 |
| Bergin, AM | 1 |
| Stopp, C | 1 |
| Hayes, B | 1 |
| Singh, A | 1 |
| Fortuno, CR | 1 |
| O'Reilly, D | 1 |
| Krishnamoorthy, K | 1 |
| Jensen, FE | 1 |
| Rofeberg, V | 1 |
| Dong, M | 1 |
| Vinks, AA | 1 |
| Wypij, D | 1 |
| Staley, KJ | 1 |
| Glass, HC | 1 |
| Shellhaas, RA | 1 |
| Tsuchida, TN | 1 |
| Chang, T | 1 |
| Wusthoff, CJ | 1 |
| Chu, CJ | 1 |
| Cilio, MR | 1 |
| Bonifacio, SL | 1 |
| Massey, SL | 1 |
| Abend, NS | 1 |
| Olivier-Gougenheim, L | 1 |
| Freychet, C | 1 |
| Collardeau-Frachon, S | 1 |
| Roure-Sobas, C | 1 |
| Di Filippo, S | 1 |
| Riva, R | 1 |
| Lega, JC | 1 |
| Belot, A | 1 |
| Wilson, KL | 1 |
| Alexander, JM | 1 |
| Shankaran, S | 1 |
| Papile, LA | 1 |
| Wright, LL | 1 |
| Ehrenkranz, RA | 1 |
| Mele, L | 1 |
| Lemons, JA | 1 |
| Korones, SB | 1 |
| Stevenson, DK | 1 |
| Donovan, EF | 2 |
| Stoll, BJ | 1 |
| Fanaroff, AA | 1 |
| Oh, W | 1 |
| Verter, J | 1 |
| Chen, HJ | 1 |
| Wu, SM | 1 |
| Okah, FA | 1 |
| Mundy, DC | 1 |
| Ekekezie, II | 1 |
| Perlman, JM | 1 |
| McCain, GC | 1 |
| Gartside, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Clinical Trial of Antenatal Phenobarbital in the Prevention of Neonatal Intracranial Hemorrhage[NCT00009620] | Phase 3 | 610 participants (Actual) | Interventional | 1993-02-28 | Completed | ||
| Follow-up Visit of High Risk Infants[NCT00009633] | 68,000 participants (Anticipated) | Observational | 1993-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenobarbital and Intracranial Hemorrhages
| Article | Year |
|---|---|
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Brain injury in the term infant.
Topics: Cell Death; Cerebral Infarction; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Hypoxia-Isch | 2004 |
3 trials available for phenobarbital and Intracranial Hemorrhages
| Article | Year |
|---|---|
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Topics: Anticonvulsants; Bumetanide; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; | 2021 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Preterm infant behavioral and heart rate responses to antenatal phenobarbital.
Topics: Analysis of Variance; Female; Heart Rate; Humans; Hypnotics and Sedatives; Infant Behavior; Infant, | 1999 |
4 other studies available for phenobarbital and Intracranial Hemorrhages
| Article | Year |
|---|---|
Seizures in Preterm Neonates: A Multicenter Observational Cohort Study.
Topics: Anticonvulsants; Brain; Electroencephalography; Female; Gestational Age; Humans; Hypoxia-Ischemia, B | 2017 |
A quest for Q fever.
Topics: Brain; Child; Doxycycline; Female; Humans; Hydroxychloroquine; Intracranial Aneurysm; Intracranial H | 2019 |
[Early diagnosis, prophylaxis and treatment of intraventricular hemorrhage in premature infants].
Topics: Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; I | 2003 |
Combining phenobarbital and indomethacin to improve early neonatal outcomes in the extremely low birth weight infant.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Therapy, Combination; Enterocolitis, | 2005 |