Page last updated: 2024-11-02

phenobarbital and Intellectual Disability

phenobarbital has been researched along with Intellectual Disability in 70 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Intellectual Disability: Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual has an intellectual disability. IQ scores between 70 and 79 are in the borderline range. Scores below 67 are in the disabled range. (from Joynt, Clinical Neurology, 1992, Ch55, p28)

Research Excerpts

ExcerptRelevanceReference
"A 28-year-old male developed total external ophthalmoplegia following oral administration of phenytoin."7.72Total external ophthalmoplegia induced by phenytoin: a case report and review of literature. ( Chaudhry, N; Puri, V, 2004)
"A 28-year-old male developed total external ophthalmoplegia following oral administration of phenytoin."3.72Total external ophthalmoplegia induced by phenytoin: a case report and review of literature. ( Chaudhry, N; Puri, V, 2004)
"An adult female with developmental disability was prescribed chlorpromazine for the target behaviors of aggression and self-injurious behavior (SIB), and she was prescribed phenobarbital for seizures."3.68A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy. ( Hanzel, TE; Harder, SR; Kalachnik, JE, 1992)
" The administration of daily phenobarbital did not reduce the frequency of epilepsy, in spite of a significant reduction in the incidence of recurrent febrile seizures."3.67Epilepsy and mental retardation following febrile seizures in childhood. ( Forsythe, A; Wolf, SM, 1989)
"However, seizures are not typical and the majority of them were seizure-free."1.51A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019)
"On VPA 1000 mg/d, the seizure frequency decreased significantly."1.37Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011)
"The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively."1.37Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011)
" Outcome did not depend on duration of barbiturate therapy, dosage or serum concentration, co-medication, reduction rate, degree of intellectual disability, or epilepsy syndrome."1.35Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability. ( Bocchicchio, M; Hauser, I; Horstmann, V; Huber, B; Jokeit, G; May, T; Meinert, T; Robertson, E; Schorlemmer, H; Schulz, L; Seidel, M; Wagner, W, 2009)
"Most patients have quiescent seizure disorders and can manage well on monotherapy."1.27Reduction of polypharmacy for epilepsy in an institution for the retarded. ( Bennett, HS; Dunlop, T; Ziring, P, 1983)
" Data were excluded for patients who required dosage adjustments because of toxicity or seizures."1.27Effect of influenza vaccine on serum anticonvulsant concentrations. ( Fidone, GS; Jann, MW, 1986)

Research

Studies (70)

TimeframeStudies, this research(%)All Research%
pre-199057 (81.43)18.7374
1990's6 (8.57)18.2507
2000's2 (2.86)29.6817
2010's4 (5.71)24.3611
2020's1 (1.43)2.80

Authors

AuthorsStudies
Kessi, M1
Chen, B1
Shan, LD1
Wang, Y1
Yang, L1
Yin, F1
He, F1
Peng, J1
Wang, G1
Mori, T1
Goji, A1
Toda, Y1
Ito, H1
Mori, K1
Kohmoto, T1
Imoto, I1
Kagami, S1
Maeda, S1
Tomoyasu, Y1
Higuchi, H1
Ishii-Maruhama, M1
Egusa, M1
Miyawaki, T1
Huber, B1
Bocchicchio, M1
Hauser, I1
Horstmann, V1
Jokeit, G1
May, T1
Meinert, T1
Robertson, E1
Schorlemmer, H1
Schulz, L1
Wagner, W1
Seidel, M1
Velizarova, R1
Gelisse, P1
Pageaux, GP1
Genton, P1
Crespel, A1
Visser, WE1
de Rijke, YB1
van Toor, H1
Visser, TJ1
KAHN, SB1
LISCHNER, H1
BAKER, L1
WILLIAMS, WJ1
NELSON, CT1
GROVES, R1
SCHLOESSER, PT1
DUNDAS, JB1
WILSKE, KR1
SHALIT, IE1
WILLKENS, RF1
DECKER, JL1
BAN, TA2
LEHMANN, HE1
Puri, V1
Chaudhry, N1
Pregelj, S1
Barkauskas, A1
Bennett, HS1
Dunlop, T1
Ziring, P1
Wallace, SJ1
Linnoila, M1
Viukari, M1
Vaisanen, K1
Auvinen, J1
Girgis, SS1
Staple, PH1
Miller, WA1
Sedransk, N1
Thompson, T1
Matarazzo, EB1
Schain, RJ2
Branford, D1
Collacott, RA1
Campbell, JJ1
McNamara, ME1
Maaswinkel-Mooij, PD1
Laan, LA1
Onkenhout, W1
Brouwer, OF1
Jaeken, J1
Poorthuis, BJ1
Hanson, JW1
Smith, DW1
Sieniawska, M1
Tolloczko, I1
Korniszewska, J1
Livingston, S1
Pauli, LL1
Pruce, I1
Kramer, II1
Maclay, E1
Hadden, DR1
McIlrath, EM1
Nesbitt, GS1
Jubiz, W1
Haussler, MR1
McCain, TA1
Tolman, KG1
Vose, GP1
Rawley, R1
Ashby, J1
Irmisch, B1
Pssler, J1
Richards, GB1
Mitchell, OC1
Speights, JL1
Van Buren, JM1
Ajmone-Marsan, C1
Mutsuga, N1
Sadowsky, D1
Eastham, RD1
Jancar, J1
Cameron, JD1
Chapel, JL1
Fahim, M1
Barden, HS1
Smith, E1
Curtis, JL1
Swicord, W1
Mayhew, LA1
Hanzel, TE2
Ferron, FR1
Kalachnik, JE2
Harder, SR2
Ferngren, H1
Akerström, I1
Rane, A1
Wolf, SM1
Forsythe, A1
Sheppard, LC1
Ballinger, BR1
Fenton, GW1
Jann, MW1
Fidone, GS1
Sandman, CA1
Barron, JL1
Parker, L1
Lennox-Buchthal, MA1
Duckett, S1
Cracco, J1
Lublin, F1
Scott, T1
Boucharlat, J1
Ledru, J1
Maître, A1
Arnould, JP1
Besnault, V1
Liu, MC1
St Jean, A1
Sterlin, C1
Noe, W1
Brenton, DP1
Cusworth, DC1
Hartley, S1
Lumley, S1
Kuzemko, JA1
Annegers, JF1
Elveback, LR1
Hauser, WA1
Kurland, LT1
Holdsworth, L1
Whitmore, K1
Greene, NM1
Falcetti, JP1
Omenn, GS1
Cordes, CK1
Lifshitz, F1
Maclaren, NK1
Carroll, HG1
Abel, GG1
Partington, MW1
Tu, JB1
Wong, CY1
Robinson, RJ1
Soyka, LF1
Houben, PF1
Hommes, OR1
Knaven, PJ1
Matti, N1
Viukari, A1
Tammisto, P2
Viukari, NM1
Edmundson, WF1
Davies, JE1
Maceo, A1
Morgade, C1
Tripp, JH1
Joseph, MC1
Reay, HA1
Gillen, HW1
Pippinger, CE1
Martin, AJ1
Reynolds, EH1
Buchanan, RA1
Heffelfinger, JC1
Weiss, CF1

Reviews

3 reviews available for phenobarbital and Intellectual Disability

ArticleYear
Febrile convulsions: diagnosis, treatment, and prognosis.
    Pediatric annals, 1979, Volume: 8, Issue:3

    Topics: Child; Epilepsy; Humans; Infant; Intellectual Disability; Intelligence; Meningitis; Phenobarbital; P

1979
Febrile convulsions. A reappraisal.
    Electroencephalography and clinical neurophysiology, 1973, Volume: 32

    Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc

1973
Genetic approaches to the syndrome of minimal brain dysfunction.
    Annals of the New York Academy of Sciences, 1973, Feb-28, Volume: 205

    Topics: Amphetamine; Attention Deficit Disorder with Hyperactivity; Child; Dextroamphetamine; Diseases in Tw

1973

Trials

1 trial available for phenobarbital and Intellectual Disability

ArticleYear
Clinical studies with propericiazine (R.P. 8909).
    Diseases of the nervous system, 1967, Volume: 28, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin

1967

Other Studies

66 other studies available for phenobarbital and Intellectual Disability

ArticleYear
Genotype-phenotype correlations of STXBP1 pathogenic variants and the treatment choices for STXBP1-related disorders in China.
    BMC medical genomics, 2023, 03-07, Volume: 16, Issue:1

    Topics: Adrenocorticotropic Hormone; China; Female; Genetic Association Studies; Humans; Intellectual Disabi

2023
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
    Brain & development, 2019, Volume: 41, Issue:10

    Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam

2019
Independent predictors of delay in emergence from general anesthesia.
    Anesthesia progress, 2015,Spring, Volume: 62, Issue:1

    Topics: Adult; Ambulatory Care; Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Anesthetic

2015
Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability.
    Seizure, 2009, Volume: 18, Issue:2

    Topics: Anticonvulsants; Barbiturates; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Intellectual

2009
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
    Seizure, 2011, Volume: 20, Issue:6

    Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H

2011
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
    Clinical endocrinology, 2011, Volume: 75, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy,

2011
MEGALOBLASTIC ANEMIA ASSOCIATED WITH THE INGESTION OF PHENOBARBITAL AND PRIMIDONE. REPORT OF A CASE IN A SIX-YEAR-OLD CHILD.
    Pediatrics, 1963, Volume: 32

    Topics: Anemia, Aplastic; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; Barbiturates; Ca

1963
CONVULSIONS.
    Archives of dermatology, 1964, Volume: 89

    Topics: Black People; Diagnosis, Differential; Epilepsy; Humans; Intellectual Disability; Phenobarbital; Phe

1964
A STATE PROGRAM TO CONTROL PHENYLKETONURIA.
    The American journal of nursing, 1964, Volume: 64

    Topics: Adolescent; Blood; Child; Diet; Diet Therapy; Genetics, Medical; Humans; Infant; Intellectual Disabi

1964
LOWE'S SYNDROME.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Acidosis; Albuminuria; Alkalies; Anti-Bacterial Agents; Blood; Bone Diseases; Calcium; Cataract; Chi

1964
FINDINGS SUGGESTIVE OF SYSTEMIC LUPUS ERYTHEMATOSUS IN SUBJECTS ON CHRONIC ANTICONVULSANT THERAPY.
    Arthritis and rheumatism, 1965, Volume: 8

    Topics: Anticonvulsants; Barbiturates; Drug Therapy; Intellectual Disability; Lupus Erythematosus, Systemic;

1965
SKIN PIGMENTATION, A RARE SIDE EFFECT OF CHLORPROMAZINE.
    Canadian Psychiatric Association journal, 1965, Volume: 10

    Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Diagnosis, Differential; Drug Therapy; Epilepsy; Eye

1965
Total external ophthalmoplegia induced by phenytoin: a case report and review of literature.
    Neurology India, 2004, Volume: 52, Issue:3

    Topics: Adult; Anticonvulsants; Humans; Intellectual Disability; Male; Ophthalmoplegia; Phenobarbital; Pheny

2004
Thioridazine in the treatment of mentally retarded children. (A four-year retroactive evaluation).
    Canadian Psychiatric Association journal, 1967, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child Behavior Disorders; Child, Preschool; Evaluat

1967
Reduction of polypharmacy for epilepsy in an institution for the retarded.
    Developmental medicine and child neurology, 1983, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Huma

1983
Febrile convulsions: their significance for later intellectual development and behaviour.
    Journal of child psychology and psychiatry, and allied disciplines, 1984, Volume: 25, Issue:1

    Topics: Child; Child Behavior Disorders; Child Development; Child, Preschool; Female; Follow-Up Studies; Hum

1984
Effect of anticonvulsants on plasma haloperidol and thioridazine levels.
    The American journal of psychiatry, 1980, Volume: 137, Issue:7

    Topics: Adult; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Female; Haloperidol; Humans; Intellectual

1980
Dental root abnormalities and gingival overgrowth in epileptic patients receiving anticonvulsant therapy.
    Journal of periodontology, 1980, Volume: 51, Issue:8

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Intellectual Disability; M

1980
[Antiepileptic therapy and its eventual risks].
    Revista do Hospital das Clinicas, 1981, Volume: 36, Issue:4

    Topics: Child; Female; Humans; Intellectual Disability; Learning Disabilities; Phenobarbital; Risk

1981
Phenobarbital in neurologically handicapped children.
    The Journal of pediatrics, 1981, Volume: 98, Issue:1

    Topics: Brain Damage, Chronic; Child; Humans; Intellectual Disability; Nervous System Diseases; Phenobarbita

1981
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
    Journal of intellectual disability research : JIDR, 1994, Volume: 38 ( Pt 6)

    Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi

1994
A case of phenobarbital behavioral toxicity presenting as a menstrually related mood disorder.
    The Journal of clinical psychiatry, 1993, Volume: 54, Issue:11

    Topics: Adult; Depressive Disorder; Diagnosis, Differential; Epilepsy; Female; Humans; Intellectual Disabili

1993
Adenylosuccinase deficiency presenting with epilepsy in early infancy.
    Journal of inherited metabolic disease, 1997, Volume: 20, Issue:4

    Topics: Anticonvulsants; Epilepsy, Generalized; Female; Humans; Infant; Intellectual Disability; Phenobarbit

1997
The fetal hydantoin syndrome.
    The Journal of pediatrics, 1975, Volume: 87, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di

1975
[Case of idiopathic hypoparathyroidism].
    Pediatria polska, 1975, Volume: 50, Issue:3

    Topics: Child; Cholecalciferol; Humans; Hypoparathyroidism; Intellectual Disability; Male; Phenobarbital

1975
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
    Pediatrics, 1979, Volume: 63, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec

1979
Problems with the use of conventional anticonvulsant drugs in mentally retarded individuals.
    Brain & development, 1979, Volume: 1, Issue:2

    Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Cognition; Epilepsy; Humans; Intellec

1979
Hypocalcaemia and secondary hyperparathyroidism in institutionalised mentally-retarded patients receiving anticonvulsant drugs: a survey of 292 patients.
    The Ulster medical journal, 1978, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hydroxycholecalci

1978
Plasma 1,25-dihydroxyvitamin D levels in patients receiving anticonvulsant drugs.
    The Journal of clinical endocrinology and metabolism, 1977, Volume: 44, Issue:4

    Topics: Adult; Alkaline Phosphatase; Calcium; Dihydroxycholecalciferols; Humans; Hydroxycholecalciferols; In

1977
Skeletal status in mentally retarded patients on anticonvulsive therapy.
    Growth, 1977, Volume: 41, Issue:3

    Topics: Absorptiometry, Photon; Adolescent; Adult; Anticonvulsants; Bone Development; Child; Female; Humans;

1977
[Experiences with premedication in the ambulatory stomatological treatment of difficult children].
    Stomatologie der DDR, 1976, Volume: 26, Issue:4

    Topics: Child; Child, Exceptional; Dental Care; Dentist-Patient Relations; Diazepam; Humans; Intellectual Di

1976
Effects of phenobarbital on intra-aural muscle reflexes in retarded children.
    Eye, ear, nose & throat monthly, 1975, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Audiometry; Auditory Threshold; Female; Humans; Intellectual Disability; Male; Mu

1975
Surgery of temporal lobe epilepsy.
    Advances in neurology, 1975, Volume: 8

    Topics: Adolescent; Adult; Astrocytes; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Electroenc

1975
Red cell folate and macrocytosis during long-term anticonvulsant therapy in non-anaemic mentally. Retarded epileptics.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Dose-Response Relationship, Drug; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid

1975
The clinical application of laboratory animal experimental findings: treatment of hypersexualized behavior in a male.
    International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2

    Topics: Adolescent; Androgens; Female; Humans; Hydroxylation; Intellectual Disability; Male; Microsomes, Liv

1975
Bone mineral in mentally retarded patients receiving long-term anticonvulsive therapy.
    Growth, 1975, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Bone and Bones; Child; Female; Humans;

1975
Letter: Effects of medication of plasma vitamin A concentrations.
    Clinical chemistry, 1976, Volume: 22, Issue:5

    Topics: Humans; Intellectual Disability; Isosorbide Dinitrate; Phenobarbital; Phenytoin; Thioridazine; Vitam

1976
Phenobarbital exacerbation of self-injurious behavior.
    The Journal of nervous and mental disease, 1992, Volume: 180, Issue:11

    Topics: Acute Disease; Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hu

1992
A case of phenobarbital exacerbation of a preexisting maladaptive behavior partially suppressed by chlorpromazine and misinterpreted as chlorpromazine efficacy.
    Research in developmental disabilities, 1992, Volume: 13, Issue:4

    Topics: Adult; Aggression; Chlorpromazine; Diagnosis, Differential; Dose-Response Relationship, Drug; Epilep

1992
Mono- or polypharmacotherapy in institutionalized epileptic children with severe mental retardation? A team approach for optimizing antiepileptic therapy.
    Acta paediatrica Scandinavica, 1991, Volume: 80, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Evaluation Studies as Topic

1991
Epilepsy and mental retardation following febrile seizures in childhood.
    Acta paediatrica Scandinavica, 1989, Volume: 78, Issue:2

    Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Intellectual Disability; Phenobarbital; Recurrenc

1989
Anticonvulsant medication in a mental handicap hospital: 1972-1982.
    The British journal of psychiatry : the journal of mental science, 1987, Volume: 150

    Topics: Anticonvulsants; Carbamazepine; Female; Hospitals, Psychiatric; Humans; Intellectual Disability; Mal

1987
Effect of influenza vaccine on serum anticonvulsant concentrations.
    Clinical pharmacy, 1986, Volume: 5, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Influenza Vaccines; Inf

1986
Disregulation of hypothalamic-pituitary-adrenal axis in the mentally retarded.
    Pharmacology, biochemistry, and behavior, 1985, Volume: 23, Issue:1

    Topics: Adult; Depressive Disorder; Dexamethasone; Hospitalization; Humans; Hydrocortisone; Hypothalamo-Hypo

1985
Electron microscopical diagnosis of lipidosis with the use of rectal biopsy.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:5

    Topics: Adolescent; Aggression; Biopsy; Chlorpromazine; Epilepsy; Gait; Humans; Inclusion Bodies; Intellectu

1974
[Anti-epileptic treatment supervision in an Medico-Pedagogic-Institute for average mental retardation].
    Annales medico-psychologiques, 1974, Volume: 1, Issue:3

    Topics: Adolescent; Child; Child, Institutionalized; Electroencephalography; Epilepsy; Epilepsy, Absence; Ep

1974
Clinical experience with sulthiame (Ospolot).
    The British journal of psychiatry : the journal of mental science, 1966, Volume: 112, Issue:487

    Topics: Adolescent; Adult; Anticonvulsants; Brain Damage, Chronic; Epilepsy, Temporal Lobe; Female; Humans;

1966
Argininosuccinicaciduria: clinical, metabolic and dietary study.
    Journal of mental deficiency research, 1974, Volume: 18, Issue:0

    Topics: Affective Symptoms; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginase; Arginine; Ataxia; Child

1974
Do anticonvulsants have a teratogenic effect?
    Archives of neurology, 1974, Volume: 31, Issue:6

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital

1974
A study of children with epilepsy attending ordinary schools. I: their seizure patterns, progress and behaviour in school.
    Developmental medicine and child neurology, 1974, Volume: 16, Issue:6

    Topics: Adolescent; Aggression; Attention; Child; Child Behavior Disorders; Child, Preschool; Colitis, Ulcer

1974
A program of general anesthesia for dental care of mentally retarded patients.
    Oral surgery, oral medicine, and oral pathology, 1974, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Anesthesia, General; Child; Dental Care; Evaluation Studies as Topic; Halothane;

1974
Chronic drug intoxication causing pseudoretardation in a young child.
    Journal of the American Academy of Child Psychiatry, 1973, Volume: 12, Issue:2

    Topics: Child; Child Development; Child, Preschool; Female; Humans; Iatrogenic Disease; Infant; Intellectual

1973
Vitamin D-dependent rickets in institutionalized, mentally retarded children receiving long-term anticonvulsant therapy. I. A survey of 288 patients.
    The Journal of pediatrics, 1973, Volume: 83, Issue:4

    Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Child, Preschool; Female; Humans;

1973
Chronic gasoline inhalation.
    Southern medical journal, 1973, Volume: 66, Issue:12

    Topics: Adolescent; Delirium; Humans; Intellectual Disability; Lead; Male; Movement Disorders; Petroleum; Ph

1973
Blood serotonin levels in severe mental retardation.
    Developmental medicine and child neurology, 1973, Volume: 15, Issue:5

    Topics: Age Factors; Blood Pressure; Child; Child, Preschool; Defecation; Diazepam; Diet; Female; Humans; Hy

1973
Febrile convulsions.
    Guy's Hospital reports, 1973, Volume: 122, Issue:1-2

    Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Epilepsy, Temporal Lobe; Female; Fever of Unknown

1973
Drug interactions. 3. Therapeutic implications of enzyme induction.
    Pediatrics, 1972, Volume: 50, Issue:3

    Topics: Age Factors; Child; Child, Preschool; Drug Interactions; Drug Synergism; Enzyme Induction; Epilepsy;

1972
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q.
    Epilepsia, 1971, Volume: 12, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Human

1971
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
    Behavioral neuropsychiatry, 1969, Volume: 1, Issue:8

    Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra

1969
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
    Behavioral neuropsychiatry, 1969, Volume: 1, Issue:8

    Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra

1969
Drug and environmental effects on DDT residues in human blood.
    Southern medical journal, 1970, Volume: 63, Issue:12

    Topics: Adult; DDT; Environment; Female; Humans; Intellectual Disability; Male; Phenobarbital; Phenytoin; Ra

1970
A new neurocutaneous syndrome (skin, eye, brain and heart syndrome).
    Proceedings of the Royal Society of Medicine, 1971, Volume: 64, Issue:1

    Topics: Aortic Coarctation; Child, Preschool; Electroencephalography; Eye Diseases; Female; Heart Diseases;

1971
Low specific gravity syndrome.
    Clinical chemistry, 1968, Volume: 14, Issue:5

    Topics: Adult; Anticonvulsants; Calcium; Chlorides; Chronic Disease; Creatinine; Epilepsy; Female; Humans; I

1968
The tuberous sclerosis complex.
    Scottish medical journal, 1968, Volume: 13, Issue:9

    Topics: Adult; Epilepsy; Female; Fluorescence; Hamartoma; Humans; Intellectual Disability; Intracranial Pres

1968
Mental effects of anticonvulsants, and folic acid metabolism.
    Brain : a journal of neurology, 1968, Volume: 91, Issue:2

    Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De

1968
The effect of phenobarbital on diphenylhydantoin metabolism in children.
    Pediatrics, 1969, Volume: 43, Issue:1

    Topics: Child; Child, Preschool; Drug Synergism; Humans; Intellectual Disability; Phenobarbital; Phenytoin

1969