phenobarbital has been researched along with Infant, Premature, Diseases in 108 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levetiracetam can be a good and safe choice for treatment of neonatal seizures in preterm infants." | 7.88 | Efficacy of levetiracetam for neonatal seizures in preterm infants. ( Han, JY; Lee, IG; Moon, CJ; Sung, IK; Youn, YA, 2018) |
| "The transplacental and elimination pharmacokinetics of phenobarbital administered antenatally was analyzed in both mothers and infants as part of a study evaluating the efficacy of antenatally administered phenobarbital in the prevention of neonatal intracerebral hemorrhage." | 7.67 | Pharmacokinetic basis for antenatal dosing of phenobarbital for the prevention of neonatal intracerebral hemorrhage. ( Cepeda, EE; Ilagan, N; Kauffman, RE; Shankaran, S, 1986) |
| "Polygraphic recordings were performed in seven preterm infants who had been given phenobarbital (phenobarbitone) to evaluate its effect on neonatal sleep behavior and on the incidence of neurogenic apnea and/or bradycardia." | 7.65 | Rapid eye movement sleep, apnea, and cardiac slowing influenced by phenobarbital administration in the neonate. ( Albani, M; Gabriel, M, 1977) |
| "A total of 26 neonates with seizures had an EEG while on phenobarbital therapy." | 5.26 | Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. ( Bickford, RB; Coen, RW; Scholl, ML; Staudt, F, 1982) |
| "The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years." | 5.09 | Does perinatal phenobarbital exposure affect developmental outcome at age 2? ( Belden, B; Hoffman, EL; Jones, AM; O'Connor, M; Thorp, JA, 1999) |
| "Levetiracetam can be a good and safe choice for treatment of neonatal seizures in preterm infants." | 3.88 | Efficacy of levetiracetam for neonatal seizures in preterm infants. ( Han, JY; Lee, IG; Moon, CJ; Sung, IK; Youn, YA, 2018) |
| "The transplacental and elimination pharmacokinetics of phenobarbital administered antenatally was analyzed in both mothers and infants as part of a study evaluating the efficacy of antenatally administered phenobarbital in the prevention of neonatal intracerebral hemorrhage." | 3.67 | Pharmacokinetic basis for antenatal dosing of phenobarbital for the prevention of neonatal intracerebral hemorrhage. ( Cepeda, EE; Ilagan, N; Kauffman, RE; Shankaran, S, 1986) |
| "Polygraphic recordings were performed in seven preterm infants who had been given phenobarbital (phenobarbitone) to evaluate its effect on neonatal sleep behavior and on the incidence of neurogenic apnea and/or bradycardia." | 3.65 | Rapid eye movement sleep, apnea, and cardiac slowing influenced by phenobarbital administration in the neonate. ( Albani, M; Gabriel, M, 1977) |
| "Phenobarbital was compared to no intervention or placebo." | 3.01 | Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants. ( Bruschettini, M; Odd, DE; Romantsik, O; Smit, E, 2023) |
| " Mean cumulative dosage of ch was 643." | 2.78 | Treatment of neonatal abstinence syndrome in preterm and term infants. ( Dabek, MT; Englert, S; Poeschl, J; Ruef, P, 2013) |
| "Women in preterm labor ( < 35 weeks' gestation) were assigned to control and treatment groups." | 2.68 | Antenatal phenobarbital therapy and neonatal outcome. I: Effect on intracranial hemorrhage. ( Bedard, MP; Cepeda, E; Johnson, S; Kazzi, SN; Mariona, F; Muran, G; Poland, R; Shankaran, S, 1996) |
| " Therefore phenobarbitone does not have seem to have any significant effect on cerebral haemodynamics up to a dosage of 20 mg/kg, so that there is no apparent effect on the risk of cerebral haemorrhage." | 2.66 | [Doppler flow velocities in cerebral arteries in relation to intravenous phenobarbital in premature infants weighing between 500 and 1,500 g]. ( Jorch, G; Michel, E; Rabe, H; Rickers, E; Stöhr, G; Süllwald, A, 1988) |
| "Phenobarbital-treated infants were over eight times more likely to experience IVH than were untreated infants." | 2.66 | Effect of phenobarbital on motor activity and intraventricular hemorrhage in preterm infants with respiratory disease weighing less than 1500 grams. ( Marshall, RE; Miller, RH; Moore, JA; Porter, FL, 1985) |
| "The phenobarbital-treated infants who bled, however, were also significantly larger and more mature than control infants who bled." | 2.65 | Effect of prophylactic phenobarbital on intraventricular hemorrhage in high-risk infants. ( Bedard, MP; Dayal, B; Pantoja, A; Poland, RL; Shankaran, S; Slovis, TL, 1984) |
| "Phenobarbital (PB) has been used at several pediatric centers for prophylaxis against neonatal hyperbilirubinemia." | 2.65 | Phenobarbital prophylaxis for hyperbilirubinemia in preterm infants. A controlled study of bilirubin disappearance and infant behavior. ( Boréus, LO; Wallin, A, 1984) |
| "Phenobarbital has been suggested as a safe treatment that stabilises blood pressure and may protect against free radicals." | 2.49 | Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants. ( Odd, D; Smit, E; Whitelaw, A, 2013) |
| "Phenobarbital has been suggested as a safe treatment that stabilises blood pressure and may protect against free radicals." | 2.44 | Postnatal phenobarbital for the prevention of intraventricular hemorrhage in preterm infants. ( Odd, D; Whitelaw, A, 2007) |
| "Chloral hydrate (100mg/kg) was given orally for the induction of moderate to deep sedation 15 minutes before OSC; then the operative field was infiltrated with 1% lidocaine." | 1.39 | Central venous cutdown in neonates: feasibility as a bedside procedure without general anesthesia. ( Hong, SM; Lee, HS; Moon, SB, 2013) |
| "The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG." | 1.29 | Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. ( Blennow, G; Hellström-Westas, L; Lindroth, M; Rosén, I; Svenningsen, NW, 1995) |
| "Seizures were classified as subtle, multifocal clonic, generalized tonic, focal clonic, and myoclonic." | 1.27 | Seizures in the neonatal intensive care unit of the 1980s. Types, Etiologies, Timing. ( Calciolari, G; Perlman, JM; Volpe, JJ, 1988) |
| " Qualitative and quantitative differences in pharmacokinetics and pharmacodynamics of drugs should be considered before dosage regimens can be established." | 1.27 | [Peculiarities of drug therapy in childhood]. ( Kusenbach, G; Reinhardt, D, 1986) |
| " At the moment, xanthines are the drugs of choice, since they are both effective and safe, provided dosage is adjusted to each patient." | 1.26 | [Drug treatment of apnoea in premature infants (author's transl)]. ( Klethi, J; Mack, G; Messer, J; Willard, D, 1981) |
| "A total of 26 neonates with seizures had an EEG while on phenobarbital therapy." | 1.26 | Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. ( Bickford, RB; Coen, RW; Scholl, ML; Staudt, F, 1982) |
| "Phenobarbital was the initial drug of choice and phenytoin usually the second drug." | 1.26 | Neonatal seizures: a survey of current practice. ( Boer, HR; Gal, P, 1982) |
| " As expected, the chloramphenicol concentrations in the serum of the newborns was considerably higher than that of infants and small children with the same dosage of chloramphenicol." | 1.26 | Studies on the concentrations of chloramphenicol in the serum and cerebrospinal fluid of neonates, infants, and small children. Reciprocal reactions between chloramphenicol, penicillin and phenobarbitone. ( Pringsheim, W; Windorfer, A, 1977) |
| "A neonate treated initially with oxacillin intravenously for two weeks and who was receiving phenobarbital for a seizure disorder subsequently failed to achieve therapeutic levels of orally administered dicloxacillin, even when the dosage was as high as 175 mg/kg/day." | 1.26 | Subtherapeutic dicloxacillin levels in a neonate: possible mechanisms. ( Hegyi, T; Schwartz, GJ; Spitzer, A, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (69.44) | 18.7374 |
| 1990's | 16 (14.81) | 18.2507 |
| 2000's | 10 (9.26) | 29.6817 |
| 2010's | 6 (5.56) | 24.3611 |
| 2020's | 1 (0.93) | 2.80 |
| Authors | Studies |
|---|---|
| Romantsik, O | 1 |
| Smit, E | 2 |
| Odd, DE | 1 |
| Bruschettini, M | 1 |
| Han, JY | 1 |
| Moon, CJ | 1 |
| Youn, YA | 1 |
| Sung, IK | 1 |
| Lee, IG | 1 |
| Dabek, MT | 1 |
| Poeschl, J | 1 |
| Englert, S | 1 |
| Ruef, P | 1 |
| Hong, SM | 1 |
| Lee, HS | 1 |
| Moon, SB | 1 |
| Odd, D | 2 |
| Whitelaw, A | 5 |
| Hall, ES | 1 |
| Wexelblatt, SL | 1 |
| Crowley, M | 1 |
| Grow, JL | 1 |
| Jasin, LR | 1 |
| Klebanoff, MA | 1 |
| McClead, RE | 1 |
| Meinzen-Derr, J | 1 |
| Mohan, VK | 1 |
| Stein, H | 1 |
| Walsh, MC | 1 |
| Crowther, CA | 4 |
| Crosby, DD | 1 |
| Henderson-Smart, DJ | 4 |
| Crowther, C | 1 |
| Henderson-Smart, D | 1 |
| Scher, MS | 1 |
| Alvin, J | 1 |
| Gaus, L | 1 |
| Minnigh, B | 1 |
| Painter, MJ | 1 |
| Chen, HJ | 1 |
| Wu, SM | 1 |
| Levene, M | 2 |
| Willard, D | 1 |
| Mack, G | 1 |
| Messer, J | 1 |
| Klethi, J | 1 |
| Donn, SM | 3 |
| Roloff, DW | 3 |
| Goldstein, GW | 3 |
| Hope, PL | 1 |
| Stewart, AL | 1 |
| Thorburn, RJ | 1 |
| Whitehead, MD | 1 |
| Reynolds, EO | 1 |
| Lowe, D | 1 |
| Placzek, M | 1 |
| Dubowitz, L | 1 |
| Lary, S | 1 |
| Bedard, MP | 2 |
| Shankaran, S | 4 |
| Slovis, TL | 1 |
| Pantoja, A | 1 |
| Dayal, B | 1 |
| Poland, RL | 1 |
| Wallin, A | 1 |
| Boréus, LO | 1 |
| Bjerre, I | 1 |
| Hellström-Westas, L | 2 |
| Rosén, I | 2 |
| Svenningsen, N | 1 |
| Alix, D | 1 |
| Riche, C | 1 |
| Guedes, Y | 1 |
| Parent, P | 1 |
| Curunet, M | 1 |
| Conan, G | 1 |
| Bourin, M | 1 |
| Gouedard, H | 1 |
| Toback, JW | 1 |
| Wiriyathian, S | 1 |
| Kaojarern, S | 1 |
| Rosenfeld, CR | 1 |
| Staudt, F | 1 |
| Scholl, ML | 1 |
| Coen, RW | 1 |
| Bickford, RB | 1 |
| Boer, HR | 1 |
| Gal, P | 1 |
| Wimberley, PD | 1 |
| Lou, HC | 1 |
| Pedersen, H | 1 |
| Hejl, M | 1 |
| Lassen, NA | 1 |
| Friis-Hansen, B | 1 |
| Forest, MG | 1 |
| Lecoq, A | 1 |
| Salle, B | 1 |
| Bertrand, J | 1 |
| Blennow, G | 1 |
| Lindroth, M | 1 |
| Svenningsen, NW | 1 |
| Thorp, JA | 4 |
| Ferrette-Smith, D | 2 |
| Gaston, LA | 1 |
| Johnson, J | 2 |
| Yeast, JD | 1 |
| Meyer, B | 1 |
| Abdel-Rahman, AM | 1 |
| Rosenberg, AA | 1 |
| De Lia, JE | 1 |
| Billman, D | 1 |
| Parriott, J | 1 |
| Meyer, BA | 1 |
| Cohen, GR | 1 |
| Leviton, A | 4 |
| Kuban, KC | 4 |
| Pagano, M | 3 |
| Allred, EN | 2 |
| Van Marter, L | 1 |
| Mas-Muñoz, RL | 1 |
| Udaeta-Mora, E | 1 |
| Barrera-Reyes, RH | 1 |
| Rivera-Rueda, MA | 1 |
| Morales-Suárez, M | 1 |
| Cepeda, E | 1 |
| Muran, G | 1 |
| Mariona, F | 1 |
| Johnson, S | 1 |
| Kazzi, SN | 1 |
| Poland, R | 1 |
| McKenzie, DR | 1 |
| Papile, LA | 1 |
| Wright, LL | 1 |
| Ehrenkranz, RA | 1 |
| Mele, L | 1 |
| Lemons, JA | 1 |
| Korones, SB | 1 |
| Stevenson, DK | 1 |
| Donovan, EF | 1 |
| Stoll, BJ | 1 |
| Fanaroff, AA | 1 |
| Oh, W | 1 |
| Tholl, DA | 1 |
| Miller, TQ | 1 |
| Henderson, WG | 1 |
| Myers, TF | 1 |
| O'Connor, M | 1 |
| Jones, AM | 1 |
| Hoffman, EL | 1 |
| Belden, B | 1 |
| Gabriel, M | 2 |
| Albani, M | 2 |
| Daskalova, E | 1 |
| Tsankova, TS | 1 |
| Menzel, K | 3 |
| Linke, M | 1 |
| Schambach, K | 1 |
| Töpke, B | 1 |
| Edel'shteĭn, EA | 1 |
| Bondarenko, ES | 1 |
| Mumladze, TA | 1 |
| Windorfer, A | 1 |
| Pringsheim, W | 1 |
| Michaelis, L | 1 |
| Schwartz, GJ | 1 |
| Hegyi, T | 2 |
| Spitzer, A | 1 |
| Mentsel', K | 1 |
| Shambakh, K | 1 |
| Grabosh, E | 1 |
| Garrettson, LK | 1 |
| Fenton, T | 1 |
| Strassfeld, R | 1 |
| Wolff, M | 1 |
| Iyer, P | 1 |
| Shann, F | 1 |
| Krishnamoorthy, KS | 1 |
| Sullivan, KF | 2 |
| Hakeem, VF | 1 |
| Wallace, SJ | 1 |
| Ruth, V | 1 |
| Virkola, K | 1 |
| Paetau, R | 1 |
| Raivio, KO | 1 |
| Volpe, JJ | 3 |
| Jorch, G | 1 |
| Rickers, E | 1 |
| Rabe, H | 1 |
| Stöhr, G | 1 |
| Süllwald, A | 1 |
| Michel, E | 1 |
| Perlman, JM | 2 |
| Wilschanski, M | 1 |
| Kaplan, M | 1 |
| Calciolari, G | 1 |
| Kauffman, RE | 2 |
| Anwar, M | 1 |
| Kadam, S | 1 |
| Hiatt, IM | 1 |
| Lhermitte, M | 1 |
| Houdret, N | 1 |
| Broly, F | 1 |
| Roussel, P | 1 |
| Carpentier, C | 1 |
| Zaoui, C | 1 |
| Lequien, P | 1 |
| Goddard-Finegold, J | 1 |
| Mizrahi, EM | 1 |
| Brown, ER | 1 |
| Krishnamoorthy, K | 1 |
| Baglivo, J | 1 |
| Allred, E | 1 |
| Cepeda, EE | 1 |
| Ilagan, N | 1 |
| Morales, WJ | 1 |
| Koerten, J | 1 |
| Reinhardt, D | 1 |
| Kusenbach, G | 1 |
| Marosvári, I | 1 |
| Neubauer, K | 1 |
| Porter, FL | 1 |
| Marshall, RE | 1 |
| Moore, JA | 1 |
| Miller, RH | 1 |
| Walker, W | 1 |
| Hughes, MI | 1 |
| Barton, M | 1 |
| Yeung, CY | 1 |
| Field, CE | 1 |
| Rosanelli, K | 1 |
| Török, J | 1 |
| Ostrow, JD | 1 |
| Kintzel, HW | 5 |
| Schwarze, R | 4 |
| Hinkel, GK | 4 |
| Händel, A | 2 |
| Braun, W | 1 |
| Cao, A | 3 |
| Falorni, A | 3 |
| Fracassini, F | 3 |
| Lungarotti, MS | 1 |
| Orbeck, H | 1 |
| Heringová, A | 1 |
| Jirsová, V | 1 |
| Polácek, K | 1 |
| Wennberg, RP | 1 |
| Scholz, E | 1 |
| Gagyi, D | 1 |
| Frank, K | 1 |
| Dortmann, A | 1 |
| Haupt, H | 1 |
| Küster, F | 1 |
| Blackburn, MG | 1 |
| Orzalesi, MM | 1 |
| Pigram, P | 1 |
| Chevrel, B | 1 |
| Hecht, Y | 1 |
| Svirsky, S | 1 |
| Tomer, A | 1 |
| Metze, H | 1 |
| Vaisman, S | 1 |
| Ebensperger, I | 1 |
| Hering, E | 1 |
| Severi, F | 1 |
| Marchi, A | 1 |
| Colombo, A | 1 |
| Zwacka, G | 2 |
| Frenzel, J | 2 |
| Monod, N | 1 |
| Dreyfus-Brisac, C | 1 |
| Sfaello, Z | 1 |
| Mastrantonio, P | 1 |
| Theile, H | 1 |
| Reich, J | 1 |
| Vest, M | 1 |
| Signer, E | 1 |
| Weisser, K | 1 |
| Olafsson, A | 1 |
| O'Leary, JA | 1 |
| Feldman, M | 1 |
| Switzer, HE | 1 |
| Lucey, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome[NCT02851303] | Phase 4 | 61 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
| Randomized Clinical Trial of Antenatal Phenobarbital in the Prevention of Neonatal Intracranial Hemorrhage[NCT00009620] | Phase 3 | 610 participants (Actual) | Interventional | 1993-02-28 | Completed | ||
| Follow-up Visit of High Risk Infants[NCT00009633] | 68,000 participants (Anticipated) | Observational | 1993-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Assessed through chart review of discharge summary documentation of method of infant feeding at time of discharge (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 5 |
| Methadone | 5 |
Number of days in hospital after birth (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 17.9 |
| Methadone | 16.1 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | days (Mean) |
|---|---|
| Morphine | 14.7 |
| Methadone | 12.8 |
clonidine (NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 1 |
| Methadone | 0 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 11 |
| Methadone | 6 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Morphine | 0 |
| Methadone | 3 |
(NCT02851303)
Timeframe: assessed at hospital discharge, approximately 7-30 days
| Intervention | morphine equivalents mg (Mean) |
|---|---|
| Morphine | 9.86 |
| Methadone | 33.0 |
18 reviews available for phenobarbital and Infant, Premature, Diseases
| Article | Year |
|---|---|
Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Female; Humans; Hydrocephalus; Infant; Infant, Newborn; Infant, Premature; Infa | 2023 |
Postnatal phenobarbital for the prevention of intraventricular haemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Excitatory Amino Acid Antagonists; Humans; Infant, Newborn | 2013 |
Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage.
Topics: Central Nervous System Agents; Cerebral Hemorrhage; Cerebral Ventricles; Female; Humans; Infant, New | 2010 |
Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage.
Topics: Central Nervous System Agents; Cerebral Hemorrhage; Cerebral Ventricles; Female; Humans; Infant, New | 2003 |
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; | 2007 |
Postnatal phenobarbital for the prevention of intraventricular hemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Excitatory Amino Acid Antagonists; Humans; Infant, Newborn | 2007 |
Prevention of intraventricular hemorrhage in the premature infant.
Topics: Animals; Cerebral Hemorrhage; Cerebral Ventricles; Clinical Trials as Topic; Fetal Diseases; Humans; | 1994 |
Meta-analysis of phenobarbital usage for prevention of intraventricular hemorrhage in premature infants: factors related to variation in outcome.
Topics: Birth Weight; Cerebral Hemorrhage; Cerebral Ventricles; Double-Blind Method; Female; Gestational Age | 1994 |
Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage.
Topics: Central Nervous System Agents; Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Prematu | 2000 |
Postnatal phenobarbitone for the prevention of intraventricular hemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Excitatory Amino Acid Antagonists; Humans; Infant, Newborn | 2000 |
Postnatal phenobarbitone for the prevention of intraventricular hemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Excitatory Amino Acid Antagonists; Humans; Infant, Newborn | 2001 |
Phenobarbital prior to preterm birth for preventing neonatal periventricular haemorrhage.
Topics: Central Nervous System Agents; Cerebral Hemorrhage; Cerebral Ventricles; Female; Humans; Infant, New | 2001 |
Intraventricular hemorrhage in the premature infant--current concepts. Part II.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Combined Modality Therapy; Echoencephalography; Ethamsylat | 1989 |
Prevention of neonatal intraventricular hemorrhage.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Cerebrovascular Circulation; Ethamsylate; Humans; Indometh | 1987 |
Therapeutic interventions to prevent intracerebral hemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Cerebrovascular Circulation; Clinical Trials as Topic; Ethamsylate; Humans; Ind | 1986 |
[Hyperbilirubinemia in premature infants during 1948-1973 (evaluation and therapy of physiological jaundice in newborn infants of low birth weight during the past 25 years)].
Topics: Adrenal Cortex Hormones; Birth Weight; Brain Diseases; Exchange Transfusion, Whole Blood; Gestationa | 1973 |
Photochemical and biochemical basis of the treatment of neonatal jaundice.
Topics: Animals; Bile; Bile Acids and Salts; Bilirubin; Erythroblastosis, Fetal; Eye Injuries; Female; Fetal | 1972 |
What to do when the infant is jaundiced.
Topics: Animals; Bilirubin; Diagnosis, Differential; Erythroblastosis, Fetal; Erythropoiesis; Exchange Trans | 1971 |
29 trials available for phenobarbital and Infant, Premature, Diseases
| Article | Year |
|---|---|
Treatment of neonatal abstinence syndrome in preterm and term infants.
Topics: Adult; Analgesics, Opioid; Chloral Hydrate; Dose-Response Relationship, Drug; Drug Administration Sc | 2013 |
Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use.
Topics: Anticonvulsants; Electroencephalography; Evoked Potentials; Female; Gestational Age; Humans; Infant, | 2003 |
Prevention of intraventricular haemorrhage in preterm infants by phenobarbitone. A controlled trial.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Clinical Trials as Topic; Female; Humans; Infant, Low Birt | 1981 |
Phenobarbitone for prevention of periventricular haemorrhage in very low birth-weight infants. A randomised double-blind trial.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Clinical Trials as Topic; Double-Blind Method; Evaluation | 1983 |
Effect of prophylactic phenobarbital on intraventricular hemorrhage in high-risk infants.
Topics: Cerebral Hemorrhage; Clinical Trials as Topic; Humans; Infant, Newborn; Infant, Premature, Diseases; | 1984 |
Phenobarbital prophylaxis for hyperbilirubinemia in preterm infants. A controlled study of bilirubin disappearance and infant behavior.
Topics: Bilirubin; Child Behavior; Clinical Trials as Topic; Hematocrit; Humans; Infant, Newborn; Infant, Pr | 1984 |
Further observations on the use of phenobarbital to prevent neonatal intracranial hemorrhage.
Topics: Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Premature, Diseases; Phenobarbital | 1982 |
Combined antenatal vitamin K and phenobarbital therapy for preventing intracranial hemorrhage in newborns less than 34 weeks' gestation.
Topics: Adolescent; Adult; Algorithms; Cerebral Hemorrhage; Double-Blind Method; Drug Therapy, Combination; | 1995 |
Antepartum vitamin K and phenobarbital for preventing intraventricular hemorrhage in the premature newborn: a randomized, double-blind, placebo-controlled trial.
Topics: Cerebral Hemorrhage; Diseases in Twins; Double-Blind Method; Humans; Infant, Newborn; Infant, Premat | 1994 |
Antepartum vitamin K and phenobarbital for preventing intraventricular hemorrhage in the premature newborn: a randomized, double-blind, placebo-controlled trial.
Topics: Cerebral Hemorrhage; Double-Blind Method; Female; Humans; Infant, Newborn; Infant, Premature, Diseas | 1994 |
Antenatal corticosteroids appear to reduce the risk of postnatal germinal matrix hemorrhage in intubated low birth weight newborns.
Topics: Cerebral Hemorrhage; Glucocorticoids; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Pre | 1993 |
[The effect of phenobarbital on the severity of intraventricular hemorrhage].
Topics: Cerebral Hemorrhage; Ependyma; Female; Humans; Incidence; Infant, Newborn; Infant, Premature; Infant | 1993 |
Antenatal phenobarbital therapy and neonatal outcome. I: Effect on intracranial hemorrhage.
Topics: Administration, Oral; Adult; Anticonvulsants; Birth Weight; Cerebral Hemorrhage; Female; Gestational | 1996 |
The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants.
Topics: Adult; Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, D | 1997 |
The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants.
Topics: Adult; Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, D | 1997 |
The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants.
Topics: Adult; Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, D | 1997 |
The effect of antenatal phenobarbital therapy on neonatal intracranial hemorrhage in preterm infants.
Topics: Adult; Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, D | 1997 |
Does perinatal phenobarbital exposure affect developmental outcome at age 2?
Topics: Adult; Anticonvulsants; Central Nervous System Depressants; Cerebral Hemorrhage; Chi-Square Distribu | 1999 |
[Dynamic changes in the level of serum bilirubin in newborn infants treated with enzyme inducers].
Topics: Bilirubin; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Enzyme Induction; G | 1977 |
The epidemiology of germinal matrix hemorrhage during the first half-day of life.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Cross-Sectional Studies; Echoencephalography; Ependyma; Hu | 1991 |
Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants.
Topics: Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Developmental Disabilities; Drug Adminis | 1988 |
[Doppler flow velocities in cerebral arteries in relation to intravenous phenobarbital in premature infants weighing between 500 and 1,500 g].
Topics: Birth Weight; Blood Flow Velocity; Cerebrovascular Circulation; Echoencephalography; Humans; Infant, | 1988 |
Therapeutic interventions to prevent intracerebral hemorrhage in preterm infants.
Topics: Cerebral Hemorrhage; Cerebrovascular Circulation; Clinical Trials as Topic; Ethamsylate; Humans; Ind | 1986 |
Phenobarbitone prophylaxis of intraventricular haemorrhage.
Topics: Cerebral Hemorrhage; Clinical Trials as Topic; Humans; Infant, Newborn; Infant, Premature, Diseases; | 1986 |
Respiratory complications in low-birth-weight infants who received phenobarbital.
Topics: Cerebral Hemorrhage; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature, Diseases; | 1987 |
Prevention of intraventricular hemorrhage in very low birth weight infants by maternally administered phenobarbital.
Topics: Administration, Oral; Cerebral Hemorrhage; Female; Fetal Monitoring; Fetal Organ Maturity; Humans; I | 1986 |
Effect of phenobarbital on motor activity and intraventricular hemorrhage in preterm infants with respiratory disease weighing less than 1500 grams.
Topics: Apgar Score; Cerebral Hemorrhage; Cerebral Ventricles; Humans; Infant, Low Birth Weight; Infant, New | 1985 |
Phenobarbitone therapy in neonatal hyperbilirubinaemia.
Topics: Asian People; Bilirubin; Blood Group Incompatibility; Clinical Trials as Topic; Exchange Transfusion | 1969 |
[Current problems in the hyperbilirubinemia of premature infants].
Topics: Bilirubin; Birth Weight; Clinical Trials as Topic; Enzyme Induction; Humans; Hyperbilirubinemia, Her | 1972 |
[The effect of phenobarbitol treatment on hyperbilirubinemia and albumin binding capacity in premature infants].
Topics: Bilirubin; Birth Weight; Clinical Trials as Topic; Enzyme Induction; Exchange Transfusion, Whole Blo | 1971 |
[The influence of combined therapy with orotic acid and phenobarbital on the level of serum bilirubin in premature infants].
Topics: Bilirubin; Birth Weight; Drug Combinations; Drug Synergism; Humans; Infant, Newborn; Infant, Prematu | 1972 |
A double blind study of the effect of phenobarbitone on neonatal hyperbilirubinaemia and frequency of exchange transfusion.
Topics: Bilirubin; Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, N | 1970 |
62 other studies available for phenobarbital and Infant, Premature, Diseases
| Article | Year |
|---|---|
Efficacy of levetiracetam for neonatal seizures in preterm infants.
Topics: Anticonvulsants; Birth Weight; Brain; Female; Gestational Age; Humans; Infant, Newborn; Infant, Prem | 2018 |
Central venous cutdown in neonates: feasibility as a bedside procedure without general anesthesia.
Topics: Administration, Oral; Anesthesia, Local; Anesthetics, Local; Catheterization, Central Venous; Chlora | 2013 |
A multicenter cohort study of treatments and hospital outcomes in neonatal abstinence syndrome.
Topics: Adult; Clinical Protocols; Female; Humans; Hypnotics and Sedatives; Infant, Newborn; Infant, Prematu | 2014 |
Prenatal phenobarbital before very-preterm birth and neurodevelopmental outcome.
Topics: Cerebral Hemorrhage; Clinical Trials as Topic; Humans; Infant, Newborn; Infant, Premature, Diseases; | 2002 |
[Early diagnosis, prophylaxis and treatment of intraventricular hemorrhage in premature infants].
Topics: Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; I | 2003 |
[Drug treatment of apnoea in premature infants (author's transl)].
Topics: Apnea; Chemoreceptor Cells; Doxapram; Humans; Infant, Newborn; Infant, Premature, Diseases; Neurotra | 1981 |
Phenobarbitone in neonatal intraventricular haemorrhage.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Child, Preschool; Follow-Up Studies; Humans; Infant; Infan | 1981 |
Failure of phenobarbitone to prevent intraventricular haemorrhage in small preterm infants.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Humans; Infant, Newborn; Infant, Premature, Diseases; Phen | 1982 |
Monitoring of cerebral function after severe asphyxia in infancy.
Topics: Asphyxia; Asphyxia Neonatorum; Brain; Brain Damage, Chronic; Electroencephalography; Electrophysiolo | 1983 |
[Phenobarbital in the newborn (author's transl)].
Topics: Administration, Oral; Brain Diseases; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Pr | 1982 |
Intravenous medications administered orally to neonates.
Topics: Administration, Oral; Aminophylline; Humans; Infant, Newborn; Infant, Premature, Diseases; Phenobarb | 1983 |
Dilantin toxicity in a preterm infant: persistent bradycardia and lethargy.
Topics: Bradycardia; Dose-Response Relationship, Drug; Heart; Humans; Infant, Newborn; Infant, Premature, Di | 1982 |
Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG.
Topics: Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Prematur | 1982 |
Neonatal seizures: a survey of current practice.
Topics: Blood Glucose; Calcium; Diagnosis, Differential; Dose-Response Relationship, Drug; Electrolytes; Eva | 1982 |
Hypertensive peaks in the pathogenesis of intraventricular hemorrhage in the newborn. Abolition by phenobarbitone sedation.
Topics: Blood Pressure; Cerebral Hemorrhage; Female; Humans; Hypertension; Infant, Newborn; Infant, Prematur | 1982 |
Does neonatal phenobarbital treatment affect testicular and adrenal functions and steroid binding in plasma in infancy?
Topics: Adrenal Glands; Androstenedione; Humans; Hydrocortisone; Hydroxyprogesterones; Infant, Newborn; Infa | 1981 |
Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period.
Topics: Anticonvulsants; Diazepam; Drug Administration Schedule; Electroencephalography; Humans; Infant, Low | 1995 |
Antenatal phenobarbital therapy and neonatal income.
Topics: Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases | 1997 |
Rapid eye movement sleep, apnea, and cardiac slowing influenced by phenobarbital administration in the neonate.
Topics: Apnea; Female; Heart Rate; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Phenobarbital | 1977 |
[Comparative studies of the effect of hyperalimentation and preventive phenobarbital on transient hyperbilirubinemia in premature infants].
Topics: Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Parenteral Nutrition; Pare | 1977 |
[Lesions of the nervous system in premature children with "conjugated" jaundices].
Topics: Apnea; Eye Manifestations; Face; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neo | 1979 |
Studies on the concentrations of chloramphenicol in the serum and cerebrospinal fluid of neonates, infants, and small children. Reciprocal reactions between chloramphenicol, penicillin and phenobarbitone.
Topics: Age Factors; Child, Preschool; Chloramphenicol; Drug Interactions; Humans; Infant; Infant, Newborn; | 1977 |
[Phenobarbital treatment in premature infants with continuous blood level control].
Topics: Age Factors; Body Weight; Half-Life; Humans; Infant, Newborn; Infant, Premature, Diseases; Monitorin | 1977 |
Subtherapeutic dicloxacillin levels in a neonate: possible mechanisms.
Topics: Administration, Oral; Arthritis, Infectious; Dicloxacillin; Dose-Response Relationship, Drug; Drug T | 1976 |
[Prevention and conservative treatment of transitory hyperbilirubinemia in full-term and premature infants].
Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; | 1975 |
Phenobarbital disposition in the neonate.
Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature, Diseases; Phenobarbital; Seizures; S | 1975 |
Maternal toxemia is associated with reduced incidence of germinal matrix hemorrhage in premature babies.
Topics: Cerebral Hemorrhage; Cerebral Palsy; Double-Blind Method; Female; Humans; Hypertension; Infant, Newb | 1992 |
Antenatal phenobarbital to prevent intraventricular hemorrhage.
Topics: Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Phenob | 1991 |
EEG monitoring of therapy for neonatal seizures.
Topics: Anticonvulsants; Chloral Hydrate; Clonazepam; Diazepam; Drug Therapy, Combination; Electroencephalog | 1990 |
Phenobarbital increases aminophylline requirement in premature infants.
Topics: Aminophylline; Apnea; Humans; Infant, Newborn; Infant, Premature, Diseases; Phenobarbital; Seizures | 1988 |
Seizures in the neonatal intensive care unit of the 1980s. Types, Etiologies, Timing.
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Epilepsy; Female; Gestational Age; Humans; Infant, L | 1988 |
Simultaneous administration of caffeine and phenobarbitone in infants with apnea.
Topics: Apnea; Caffeine; Drug Therapy, Combination; Half-Life; Humans; Infant; Infant, Newborn; Infant, Prem | 1987 |
Understanding and preventing perinatal, intracerebral, peri- and intraventricular hemorrhage.
Topics: Blood Pressure; Brain; Cerebral Hemorrhage; Cerebral Ventricles; Cerebrovascular Circulation; Electr | 1987 |
Prevention of intraventricular hemorrhage with phenobarbital therapy: now what?
Topics: Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Premature, Diseases; Phenobarbital; Prospectiv | 1986 |
Pharmacokinetic basis for antenatal dosing of phenobarbital for the prevention of neonatal intracerebral hemorrhage.
Topics: Cerebral Hemorrhage; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Infant, Premature, Dis | 1986 |
[Peculiarities of drug therapy in childhood].
Topics: Apnea; Biological Availability; Biotransformation; Caffeine; Child; Child, Preschool; Dexamethasone; | 1986 |
Treatment of neonatal hyperbilirubinaemia with flumecinolone, a new enzyme inducing drug.
Topics: Benzhydryl Compounds; Bilirubin; Combined Modality Therapy; Glucuronosyltransferase; Hematoma; Human | 1985 |
Barbiturate and hyperbilirubinaemia of prematurity.
Topics: Barbiturates; Bilirubin; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neo | 1969 |
[Prevention of transitory hyperbilirubinemia of the premature and mature newborn infants and of the hemolytic disease of the newborn by an enzyme induction combination: phenobarbital-nikethamide].
Topics: Bilirubin; Enzyme Induction; Erythroblastosis, Fetal; Exchange Transfusion, Whole Blood; Female; Hum | 1972 |
[Prevention of hyperbilirubinemia in premature infants using a combination of two enzyme inductors: phenobarbitol and nikethamide].
Topics: Enzyme Induction; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature; Infant, Premature, | 1972 |
[Results of icterus prevention using phenobarbital in 1500 newborn and premature infants].
Topics: Bilirubin; Female; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonatal; Male; P | 1972 |
[Prevention of toxic hyperbilirubinemia in premature and mature newborn infants by use of an enzyme-inducing combination: phenobarbital-nikethamide].
Topics: Drug Synergism; Enzyme Induction; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Dise | 1973 |
Phenobarbital effect on serum bilirubin levels in underweight infants.
Topics: Bilirubin; Birth Weight; Diseases in Twins; Female; Gestational Age; Humans; Infant Nutrition Disord | 1973 |
Neonatal hyperthyroidism.
Topics: Adult; Body Weight; Breast Diseases; Diarrhea; Digitalis Glycosides; Female; Graves Disease; Humans; | 1973 |
[Effect of phenobarbital on neonatal jaundice].
Topics: Bilirubin; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Jaundice, Neonat | 1973 |
An enzyme inductor combination for the prevention of hyperbilirubinemia in premature infants.
Topics: Administration, Oral; Bilirubin; Depression, Chemical; Dose-Response Relationship, Drug; Drug Therap | 1974 |
[Therapeutic and preventive values of phenobarbital in the prevention and treatment of neonatal jaundice].
Topics: ABO Blood-Group System; Administration, Oral; Bilirubin; Birth Weight; Blood Group Incompatibility; | 1971 |
Barbiturate treatment of neonatal icterus.
Topics: Bilirubin; Birth Weight; Factor V; Factor VII; Hematocrit; Humans; Infant, Newborn; Infant, Prematur | 1972 |
The combined effect of phototherapy and phenobarbital on serum bilirubin levels of premature infants.
Topics: Bilirubin; Diseases in Twins; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice, Neonat | 1972 |
[Neonatal jaundice due to hepatic immaturity. Physiopathology and treatment. Role of enzyme inductors].
Topics: Bilirubin; Ethanol; Exchange Transfusion, Whole Blood; Humans; Infant, Newborn; Infant, Premature, D | 1971 |
[Evaluation of phenobarbitone treatment in neonatal hyperbilirubinemia].
Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; | 1971 |
[Therapy of hyperbilirubinemia in premature and newborn infants using phenobarbital and light therapy].
Topics: Bilirubin; Enzyme Induction; Exchange Transfusion, Whole Blood; Humans; Infant, Newborn; Infant, Pre | 1971 |
[Hyperbilirubinemia in newborn infants and phenobarbital. II. Newborn infants of low weight].
Topics: Female; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature, Diseases; Male; Phenobarbita | 1971 |
[Effects of luminal treatment on neonatal hyperbilirubinemia in premature infants].
Topics: Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Infan | 1971 |
[The influence of short time phenobarbital treatment on neonatal jaundice].
Topics: Age Factors; Bilirubin; Birth Weight; Humans; Infant, Newborn; Infant, Premature, Diseases; Jaundice | 1971 |
[Detection and prognosis of the neonatal mal according to the electroclinical study of 150 cases].
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Congenital Abnormalities; Electroencephalography; Ep | 1969 |
[Phenobarbital in the treatment of hyperbilirubinemia of the newborn].
Topics: Bilirubin; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, P | 1969 |
[Experience in treatment of hyperbilirubinemia in the newborn with phenobarbital].
Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases; | 1970 |
[Effect of phenobarbital on the bilirubin level in premature infants].
Topics: Administration, Oral; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Premature, Diseases; Inje | 1970 |
[The influence of a short-time enzyme induction with phenobarbital on hyperbilirubinemia in premature newborns].
Topics: Bilirubin; Enzyme Induction; Glucosephosphate Dehydrogenase Deficiency; Humans; Hyperbilirubinemia; | 1970 |
P henobarbital-Dilantin treatment of the intrauterine patient.
Topics: Enzyme Induction; Epilepsy; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Infant, Newborn | 1970 |
Phototherapy of jaundice 1969.
Topics: ABO Blood-Group System; Adolescent; Age Factors; Bilirubin; Birth Weight; Blood Group Incompatibilit | 1970 |