phenobarbital and Infant, Newborn, Diseases studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Infant, Newborn, Diseases: Diseases of newborn infants present at birth (congenital) or developing within the first month of birth. It does not include hereditary diseases not manifesting at birth or within the first 30 days of life nor does it include inborn errors of metabolism. Both HEREDITARY DISEASES and METABOLISM, INBORN ERRORS are available as general concepts.

Research Excerpts

Excerpt	Relevance	Reference
"Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures."	9.41	Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023)
"To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates."	9.17	Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. ( Chawla, D; Goel, SP; Pathak, G; Pathak, U; Upadhyay, A, 2013)
"Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM."	8.31	Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. ( Bättig, L; Cserpan, D; Dünner, C; Hagmann, C; Pisani, F; Ramantani, G; Rüegger, A; Schmitt, B, 2023)
"5 wk), 61 phenobarbital doses and 40 seizures were analyzed."	7.81	Phenobarbital and neonatal seizures affect cerebral oxygen metabolism: a near-infrared spectroscopy study. ( Barks, JD; Chervin, RD; Plegue, MA; Shellhaas, RA; Sokoloff, MD, 2015)
"Compare neurodevelopment after levetiracetam (LEV) and phenobarbital (PB) for neonatal seizures."	7.79	Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. ( Maitre, NL; Slaughter, JC; Smolinsky, C; Stark, AR, 2013)
" We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures."	7.66	Phenobarbital and diphenylhydantoin levels in neonates with seizures. ( MacDonald, H; Painter, MJ; Pippenger, C; Pitlick, W, 1978)
"Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures."	7.66	Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels. ( Boer, HR; Erkan, NV; Gal, P; Toback, J; Wells, TJ, 1982)
"High neonatal seizure burden is associated with worsened neurodevelopmental outcomes."	5.72	Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. ( Knox, A; Limjoco, J; Rajamanickam, V; Verwoerd, C, 2022)
"Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures."	5.41	Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023)
" These recommendations provide initial maintenance dosage guidelines, which should be adjusted according to plasma concentrations and clinical effects."	5.26	Phenobarbital maintenance dose requirements in treating neonatal seizures. ( Fischer, JH; Kriel, R; Lockman, LA; Zaske, D, 1981)
"A total of 26 neonates with seizures had an EEG while on phenobarbital therapy."	5.26	Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. ( Bickford, RB; Coen, RW; Scholl, ML; Staudt, F, 1982)
" The blood proportional to the dosage per kilogram, and was not related to weight or gestational age."	5.26	Phenobarbital dosage for control of neonatal seizures. ( Kriel, R; Lockman, LA; Thompson, T; Virnig, N; Zaske, D, 1979)
"Phenytoin was found in higher concentration in gray matter, whereas phenobarbital was equally distributed between gray and white matter."	5.26	Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. ( Abern, S; Barmada, M; Carter, G; Painter, MJ; Pippenger, C; Pitlick, W; Wasterlain, C, 1981)
"To compare the efficacy of phenobarbitone and phenytoin for treatment of neonatal seizures in term and near-term neonates."	5.17	Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. ( Chawla, D; Goel, SP; Pathak, G; Pathak, U; Upadhyay, A, 2013)
"Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM."	4.31	Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. ( Bättig, L; Cserpan, D; Dünner, C; Hagmann, C; Pisani, F; Ramantani, G; Rüegger, A; Schmitt, B, 2023)
"Neonatal seizures are difficult to diagnose and, when they are, tradition dictates first line treatment is phenobarbital."	3.96	Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach. ( Alix, JJP; Gossling, L; Hart, AR; Stavroulakis, T, 2020)
" As first-line drug phenobarbital was the most common choice, it was used in 79% of cases of acute symptomatic seizures, in 63% of structural epilepsy, in 42% of genetic epilepsies."	3.91	Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. ( Capovilla, G; Consonni, D; De Liso, P; Di Capua, M; Dilena, R; Falsaperla, R; Pisani, F; Pruna, D; Suppiej, A; Vitaliti, G, 2019)
"5 wk), 61 phenobarbital doses and 40 seizures were analyzed."	3.81	Phenobarbital and neonatal seizures affect cerebral oxygen metabolism: a near-infrared spectroscopy study. ( Barks, JD; Chervin, RD; Plegue, MA; Shellhaas, RA; Sokoloff, MD, 2015)
"Compare neurodevelopment after levetiracetam (LEV) and phenobarbital (PB) for neonatal seizures."	3.79	Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. ( Maitre, NL; Slaughter, JC; Smolinsky, C; Stark, AR, 2013)
" Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy."	3.68	Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990)
"Seventy-one neonates were observed for the relationship between phenobarbital plasma concentrations and elimination of seizures."	3.66	Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels. ( Boer, HR; Erkan, NV; Gal, P; Toback, J; Wells, TJ, 1982)
"Phenobarbital pharmacokinetics after intravenous injection were studied in 8 neonates with seizures."	3.66	Phenobarbital pharmacokinetics in neonates. ( Painter, M; Pippenger, C; Pitlick, W, 1978)
" We determined the plasma levels of phenobarbital and diphenylhydantoin following initial administration and during maintenance therapy in 59 neonates with seizures."	3.66	Phenobarbital and diphenylhydantoin levels in neonates with seizures. ( MacDonald, H; Painter, MJ; Pippenger, C; Pitlick, W, 1978)
"Two cases concerning newborn infants whose mothers used phencyclidine (PCP) during pregnancy are described."	3.66	Neonatal manifestations of maternal phencyclidine (PCP) abuse. ( Bosu, SK; Modaniou, HD; Strauss, AA, 1981)
"Clinical seizure control was noted."	3.11	Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial. ( Deshmukh, L; Joshi, A; Londhe, A; Susnerwala, S, 2022)
"Therapy for neonatal seizures should be prompt and tailored, based on semeiology, mirror of the underlying cause, and cEEG features."	2.82	Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options. ( Bedetti, L; Berardi, A; Casa Muttini, ED; Cavalleri, F; Ferrari, F; Guidotti, I; Lugli, L; Ori, L; Pugliese, M; Roversi, MF; Stefanelli, F, 2022)
"After 12 hours of seizure free period of the initial loading dose of phenobarbitone, one group received IV maintenance therapy and other 'no maintenance' (saline as placebo)."	2.82	Effect of Withholding Phenobarbitone Maintenance in Neonatal Seizures: A Randomized Controlled Trial. ( Gupta, P; Saxena, P; Sharma, S; Singh, A; Upadhyay, A; Vishnubatla, S, 2016)
"Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy."	2.82	Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022)
" Phenobarbital use should be monitored with serum drug levels and modification of recommended dosage regimens considered."	2.65	Opiate v CNS depressant therapy in neonatal drug abstinence syndrome. ( Doberczak, TM; Kandall, SR; Korts, DC; Mauer, KR; Strashun, RH, 1983)
" Further, this scoring system has been used by relating it to the dosage schedule of phenobarbital or paregoric as part of an ongoing research project designed to test the comparative usefulness of recommended treatments for neonates with abstinence symptoms."	2.64	Assessment and treatment of abstinence in the infant of the drug-dependent mother. ( Connaughton, JF; Emich, JP; Finnegan, LP; Kron, RE, 1975)
"Neonatal seizures can permanently disrupt neuronal development, induce synaptic reorganization, alter plasticity and "prime" the brain to increased damage from seizures later in life."	2.42	Neonatal seizures and their treatment. ( Boylan, GB; Rennie, JM, 2003)
"Treatment with phenobarbital (4 mg/kg/day, P."	2.38	[Benign familial neonatal convulsion: clinical features of the propositus and comparison with the previously reported cases]. ( Ishikawa, Y; Kibayashi, M; Minami, R; Okabe, M; Tachi, N; Wakai, S, 1990)
"It is the recommended drug for the treatment of seizures in term neonates."	2.37	[Phenobarbital in newborn infants. Overview]. ( Staudt, F, 1984)
" In order to rapidly achieve therapeutic levels, it is suggested that a loading dose of 8 to 10 mg per kg be administered for 2 days followed by reduction of dosage to a maintenance level of 5 to 6 mg per kg with frequent monitoring of plasma phenobarbital concentrations."	2.35	Phenobarbital plasma levels in neonates. ( Pippenger, CE; Rosen, TS, 1975)
" With the current recommended dosage for phenobarbitone (40 mg/kg), we have noticed that babies are drowsier and their blood levels of phenobarbitone are more than the normal expected range."	1.72	Comparing the effect of different loading doses of phenobarbitone on serum phenobarbitone levels in babies with neonatal seizures and effect of therapeutic hypothermia on phenobarbitone levels. ( Kumar, M; Palaparthy, V; Rebekah, G; Thomas, N, 2022)
"High neonatal seizure burden is associated with worsened neurodevelopmental outcomes."	1.72	Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. ( Knox, A; Limjoco, J; Rajamanickam, V; Verwoerd, C, 2022)
"Neonatal seizures are significant cause of neonatal mortality and morbidity."	1.72	Prevalence and predictors of adverse outcomes in neonatal seizures. ( Aggarwal, A; Banerjee, BD; Batra, P; Famra, K, 2022)
"Persistence of seizures and muscle twitching on phenobarbitone could either be due to a lack of response or a manifestation of drug toxicity."	1.51	Persistent Muscle Twitching With Phenobarbitone in a Preterm Neonate-Lack of Response or Manifestation of Toxicity? ( Dudeja, S; Dutta, S; Krishnamurthy, B; Pattanaik, S, 2019)
"Nineteen neonates had electrographic seizures and met the inclusion criteria for the study."	1.43	Short-Term Effects of Phenobarbitone on Electrographic Seizures in Neonates. ( Boylan, GB; Livingstone, V; Low, E; Mathieson, SR; Rennie, JM; Ryan, AC; Stevenson, NJ, 2016)
"In refractory seizures, the use of continuous lidocaine infusion is most common."	1.36	Approach to seizures in the neonatal period: a European perspective. ( Alberola, A; Blennow, M; Boronat, N; de Vries, LS; Greisen, G; Steggerda, S; Vento, M, 2010)
"Very few respondents used pyridoxine to treat recurrent seizures that were historically linked to perinatal asphyxia and hypoxic-ischaemic encephalopathy."	1.33	Drug treatment of neonatal seizures by neonatologists and paediatric neurologists. ( Barr, P; Carmo, KB, 2005)
"EEG seizures were recorded in seven patients, five of whom had experienced clinical seizures in the 24 hours prior to cassette EEG recording."	1.27	Cassette electroencephalography in the evaluation of neonatal seizures. ( Bridgers, SL; Ebersole, JS; Ehrenkranz, RA; Ment, LR; Silva, CG, 1986)
"Paraldehyde was given as a 200 mg/kg IV bolus followed by an infusion of 16 mg/kg/h (10 cases), or as a 400 mg/kg bolus (4 cases)."	1.27	Intravenous paraldehyde for seizure control in newborn infants. ( Butt, W; Koren, G; MacLeod, SM; Mayer, J; Pape, K; Rajchgot, P; Whyte, H, 1986)
"A total of 26 neonates with seizures had an EEG while on phenobarbital therapy."	1.26	Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. ( Bickford, RB; Coen, RW; Scholl, ML; Staudt, F, 1982)
"Phenobarbital was the initial drug of choice and phenytoin usually the second drug."	1.26	Neonatal seizures: a survey of current practice. ( Boer, HR; Gal, P, 1982)
" for therapeutic reasons, the elimination kinetics appeared to follow a two-compartment open model, with a significant difference in the therminal plasma half-life between premature (26."	1.26	Pharmacokinetics of furosemide in neonates. ( Broquaire, M; Legagneur, M; Morselli, PL; Vert, P, 1982)
"In order to find the optimal dosage schedule of phenobarbitone for neonatal convulsions, four groups of patients were studied."	1.26	Phenobarbitone dosage in neonatal convulsions. ( Goldsmith, R; Ouvrier, RA, 1982)
"All had central sleep apnea, three had hypoventilation, and none had obstructive apnea observed on polygraphic recordings."	1.26	Episodic complete airway obstruction in infants. ( Kelly, DH; Shannon, DC, 1981)
" These recommendations provide initial maintenance dosage guidelines, which should be adjusted according to plasma concentrations and clinical effects."	1.26	Phenobarbital maintenance dose requirements in treating neonatal seizures. ( Fischer, JH; Kriel, R; Lockman, LA; Zaske, D, 1981)
"Phenytoin was found in higher concentration in gray matter, whereas phenobarbital was equally distributed between gray and white matter."	1.26	Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. ( Abern, S; Barmada, M; Carter, G; Painter, MJ; Pippenger, C; Pitlick, W; Wasterlain, C, 1981)
" By administering the phenobarbital as an initial single loading dose and closely monitoring the blood levels, maintenance dosing could easily be adjusted for variables in infant metabolism and pharmacologic effect."	1.26	Management of neonatal narcotic abstinence utilizing a phenobarbital loading dose method. ( Finnegan, LP; Hopkins, LE; Mitros, TF, 1979)
"Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)."	1.26	Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979)
"Three infants are presented who had withdrawal symptoms after prolonged, intrauterine exposure to diazepam."	1.26	Withdrawal symptoms in neonates from intrauterine exposure to diazepam. ( Bhatt, K; Rementería, JL, 1977)
" It is suggested that reduction of methadone dosage in late pregnancy results in reduced incidence of withdrawal but must be carefully carried out."	1.26	Observation and treatment of neonatal narcotic withdrawal. ( Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F, 1977)
" The blood proportional to the dosage per kilogram, and was not related to weight or gestational age."	1.26	Phenobarbital dosage for control of neonatal seizures. ( Kriel, R; Lockman, LA; Thompson, T; Virnig, N; Zaske, D, 1979)
"Generalized motor seizures and myoclonic jerks were the predominant convulsive manifestations."	1.26	Neonatal seizures associated with narcotic withdrawal. ( Herzlinger, RA; Kandall, SR; Vaughan, HG, 1977)
" As expected, the chloramphenicol concentrations in the serum of the newborns was considerably higher than that of infants and small children with the same dosage of chloramphenicol."	1.26	Studies on the concentrations of chloramphenicol in the serum and cerebrospinal fluid of neonates, infants, and small children. Reciprocal reactions between chloramphenicol, penicillin and phenobarbitone. ( Pringsheim, W; Windorfer, A, 1977)

Research

Studies (186)

Authors

Clinical Trials (4)

Trial Overview

Trial Outcomes

Head Circumference Change at 2 Weeks

Timeframe	Studies, this research(%)	All Research%
pre-1990	157 (84.41)	18.7374
1990's	3 (1.61)	18.2507
2000's	3 (1.61)	29.6817
2010's	12 (6.45)	24.3611
2020's	11 (5.91)	2.80

Authors	Studies
Verwoerd, C	1
Limjoco, J	1
Rajamanickam, V	1
Knox, A	1
Susnerwala, S	1
Joshi, A	1
Deshmukh, L	1
Londhe, A	1
Guidotti, I	1
Lugli, L	1
Ori, L	1
Roversi, MF	1
Casa Muttini, ED	1
Bedetti, L	1
Pugliese, M	1
Cavalleri, F	1
Stefanelli, F	1
Ferrari, F	1
Berardi, A	1
Palaparthy, V	1
Kumar, M	1
Rebekah, G	1
Thomas, N	1
Bättig, L	3
Dünner, C	3
Cserpan, D	3
Rüegger, A	3
Hagmann, C	3
Schmitt, B	3
Pisani, F	5
Ramantani, G	3
Sortino, V	1
Praticò, A	1
Marino, S	1
Criscione, R	1
Ruggieri, M	1
Falsaperla, R	2
Gyandeep, G	1
Behura, SS	1
Sahu, SK	1
Panda, SK	1
Rao, S	1
Farhat, A	1
Rakshasbhuvankar, A	1
Athikarisamy, S	1
Ghosh, S	1
Nagarajan, L	1
Gossling, L	1
Alix, JJP	1
Stavroulakis, T	1
Hart, AR	1
Alix, V	1
James, M	1
Jackson, AH	1
Visintainer, PF	1
Singh, R	2
Famra, K	1
Batra, P	1
Aggarwal, A	1
Banerjee, BD	1
Krishnamurthy, B	1
Pattanaik, S	1
Dudeja, S	1
Dutta, S	2
Dilena, R	1
De Liso, P	1
Di Capua, M	1
Consonni, D	1
Capovilla, G	1
Suppiej, A	1
Vitaliti, G	1
Pruna, D	1
Pathak, G	1
Upadhyay, A	3
Pathak, U	1
Chawla, D	1
Goel, SP	1
Maitre, NL	1
Smolinsky, C	1
Slaughter, JC	1
Stark, AR	1
Sahu, JK	1
Lau, C	1
Watson, H	1
Cheong, J	1
Sokoloff, MD	1
Plegue, MA	1
Chervin, RD	1
Barks, JD	1
Shellhaas, RA	1
Low, E	1
Stevenson, NJ	1
Mathieson, SR	1
Livingstone, V	1
Ryan, AC	1
Rennie, JM	2
Boylan, GB	2
Saxena, P	1
Singh, A	1
Gupta, P	1
Sharma, S	1
Vishnubatla, S	1
Vento, M	1
de Vries, LS	1
Alberola, A	1
Blennow, M	1
Steggerda, S	1
Greisen, G	1
Boronat, N	1
GABURRO, D	1
PERESSINI, A	1
PAUL, SS	1
KAUR, P	1
GUPTA, S	1
JABBOUR, JT	1
DUNDON, S	1
HOLLAND, PD	1
ADAMS, EB	1
HOLLOWAY, R	1
THAMBIRAN, AK	2
HENDRICKSE, RG	1
SHERMAN, PM	1
Carmo, KB	1
Barr, P	1
Cooke, RW	4
Morgan, ME	4
Massey, RF	2
Hope, PL	1
Thorburn, RJ	1
Stewart, AL	1
Reynolds, EO	1
Donn, SM	1
Roloff, DW	1
Goldstein, GW	1
Gouyon, JB	1
Giroud, M	1
Staudt, F	2
Carin, I	1
Glass, L	3
Parekh, A	1
Solomon, N	1
Steigman, J	1
Wong, S	1
Finnegan, LP	8
Michael, H	2
Leifer, B	2
Desai, S	1
Bourin, M	3
Mouzard, A	1
Kergueris, MF	1
Le Normand, Y	1
Larousse, C	1
Mogorianu, PD	1
Kashkaval, LA	1
Majd, M	1
Reba, RC	1
Altman, RP	1
Alix, D	2
Riche, C	2
Guedes, Y	1
Parent, P	1
Curunet, M	1
Conan, G	1
Gouedard, H	1
Painter, MJ	3
Lockman, LA	3
Kandall, SR	4
Doberczak, TM	1
Mauer, KR	1
Strashun, RH	1
Korts, DC	1
Finer, NN	1
Robertson, CM	1
Peters, KL	1
Coward, JH	1
Dodson, WE	1
Bourgeois, BF	1
Ferrendelli, JA	1
Gal, P	3
Toback, J	1
Boer, HR	3
Erkan, NV	1
Wells, TJ	1
Fabris, C	1
Prandi, GM	1
Berardi, V	1
Santoro, MA	1
Martano, C	1
Mombrò, M	1
Siegel, SE	1
Moran, RG	1
Zenk, KE	1
Cohen, MS	1
Ostergaard, GZ	1
Pedersen, SE	1
Scholl, ML	1
Coen, RW	1
Bickford, RB	1
Vert, P	1
Broquaire, M	1
Legagneur, M	1
Morselli, PL	1
Ouvrier, RA	2
Goldsmith, R	2
Glade, G	1
Saccar, CL	1
Pereira, GR	1
Kelly, DH	1
Shannon, DC	1
Richards, GE	1
Brewer, ED	1
Conley, SB	1
Saldana, LR	1
Fischer, JH	1
Zaske, D	2
Kriel, R	2
Pippenger, C	3
Wasterlain, C	1
Barmada, M	1
Pitlick, W	3
Carter, G	1
Abern, S	1
Gomez, RC	1
Strauss, AA	1
Modaniou, HD	1
Bosu, SK	1
Yaffe, SJ	2
Morales, WJ	1
McBride, MC	1
Laroia, N	1
Guillet, R	1
Turner, TL	1
Cockburn, F	2
Forfar, JO	1
Buda, FB	1
Joyce, RP	1
Pettett, PG	1
Mitros, TF	1
Hopkins, LE	1
Neumann, LL	2
Cohen, SN	1
Andersen, G	1
Friis-Hansen, B	1
Ghodse, AH	1
Reed, JL	1
Mack, JW	1
Vassella, F	1
Halberstadt, E	1
Gerner, R	1
Manson, JI	1
Burstein, Y	1
Giardina, PJ	1
Rausen, AR	1
Siljestrom, K	1
Peterson, CM	1
Gupta, SM	1
Takkar, VP	1
Verma, AK	1
Thompson, T	1
Virnig, N	1
MacDonald, H	1
Painter, M	1
Purohit, DM	1
Madden, JD	2
Vesterhus, P	1
Johannessen, SI	1
Johnson, JD	1
Rementería, JL	1
Bhatt, K	1
Chappel, JN	1
Zuspan, F	1
Gumpel, J	1
Mejia, A	1
Davis, R	1
Windorfer, A	3
Pringsheim, W	1
Friis, B	1
Sardemann, H	1
Gupta, A	1
Chopra, K	1
Khalil, A	1
Herzlinger, RA	1
Vaughan, HG	1
Petrich, C	1
Voss, HV	1
Bretschneider, A	1
Göbel, U	1
Kron, RE	5
Connaughton, JF	2
Emich, JP	2
Pippenger, CE	1
Rosen, TS	1
Holden, KR	1
Freeman, JM	1
Mentsel', K	1
Shambakh, K	1
Grabosh, E	1
Erith, MJ	1
Kopelman, AE	1
Cohen, C	1
Zelson, C	3
Kaplan, SL	1
Litt, M	3
Phoenix, MD	2
Vargas, GC	1
Pildes, RS	1
Vidyasagar, D	1
Keith, LG	1
Lall, JC	1
Gupta, HL	1
Schambach, K	1
Menzel, K	1
Eng, D	1
Wakai, S	1
Tachi, N	1
Ishikawa, Y	1
Okabe, M	1
Minami, R	1
Kibayashi, M	1
Sutton, LR	1
Hinderliter, SA	1
De Carolis, S	1
De Carolis, MP	1
Caruso, A	1
Oliva, GC	1
Romagnoli, C	1
Ferrazzani, S	1
Muzii, U	1
Luciano, R	1
Mancuso, S	1
Bour, F	1
Malan, AF	1
Koren, G	1
Butt, W	1
Rajchgot, P	1
Mayer, J	1
Whyte, H	1
Pape, K	1
MacLeod, SM	1
Bridgers, SL	1
Ebersole, JS	1
Ment, LR	1
Ehrenkranz, RA	1
Silva, CG	1
Lennox-Buchthal, MA	1
Wilson, JT	2
Buist, NR	1
Campbell, JR	1
Castro, A	1
Pochedly, C	1
Ente, G	1
Hiller, HJ	1
Gladtke, E	1
Scheig, R	1
Harper, RG	3
Solish, GI	1
Purow, HM	1
Sang, E	1
Panepinto, WC	1
Lipsitz, PJ	1
Blatman, S	1
Volpe, J	1
Grossman, J	1
Tompkins, RL	1
Lombroso, CT	1
Turner, T	1
Ganendran, A	1
Reynolds, JW	1
Thaler, MM	1
Bleyer, WA	1
Marshall, RE	1
Kintzel, HW	3
Schwarze, R	2
Hinkel, GK	2
Götze, H	1
Sidiropoulos, D	1
Hess, FA	1
Berthelot, P	1
Gmyrek, D	2
Weh, L	2
Kalz, M	1
Bunke, H	2
Cario, WR	2
Lindenau, E	1
Neumann, R	1
Pietsch, I	1
Scigalla, P	1
Sima, K	1
Syllm-Rapoport, I	2
Lucey, JF	1
Händel, A	1
Hodr, R	1
Senkárcinová, V	1
Plesingerová, I	1
Cao, A	3
Falorni, A	3
Fracassini, F	3
Lungarotti, MS	1
Daberkow, H	1
Läuter, J	1
Saworra, H	1
Martinez, G	1
Snyder, RD	1
Rumack, BH	1
Walravens, PA	1
Sia, CG	1
Blenman, S	1
Gartner, LM	1
Snodgrass, GJ	1
Rothstein, P	1
Gould, JB	1
McNiel, JR	1
Stern, L	3
Chaudhuri, VP	1
Ghai, OP	1
Behrman, RE	1
Fisher, D	1
Paton, JB	1
Keller, J	1
Desmond, MM	1
Schwanecke, RP	1
Wilson, GS	1
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Kriss, JP	1

Trial	Enrollment	Study Type	Start Date	Status
The EAGLET Project: EEG vs aEEG to Improve the Diagnosis of neonataL Seizures and Epilepsy - a Randomised Trial[NCT05079971]	140 participants (Anticipated)	Interventional	2023-07-01	Recruiting
A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407]	55 participants (Actual)	Interventional	2017-04-20	Completed
Assessing the Effects of Auricular Acupressure on Newborn Behaviors and Withdrawal Signs in Newborns With Neonatal Abstinence Syndrome: A Pilot Study[NCT03890562]	12 participants (Actual)	Interventional	2019-09-04	Completed
Donor Human Milk for Infants With Neonatal Abstinence Syndrome[NCT02182973]	12 participants (Actual)	Observational	2014-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Change in head circumference from day 1 to day 14 (cm/wk) (NCT02182973)
Timeframe: 2 weeks

Percentage of Infants Achieving a GI Subscore >2 Over the Study Period

Intervention	cm/wk (Mean)
Donor Human Milk	0.4
Historical Control	0.6

Minimum score:0; Maximum score 13. Higher scores mean more GI distress (NCT02182973)
Timeframe: 2 weeks

Weight Change at 2 Weeks

Intervention	Percentage of participants (Number)
Donor Human Milk	39
Historical Controls	61

Change in weight from study day 1 to study day 14 (grams/day) Weight day 14 - weight day 1 divided by 14 (NCT02182973)
Timeframe: 2 weeks

Article	Year
Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options. Expert review of neurotherapeutics, 2022, Volume: 22, Issue:7 Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Disease	2022
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. Acta bio-medica : Atenei Parmensis, 2022, 12-16, Volume: 93, Issue:6 Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac	2022
Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. Seizure, 2023, Volume: 111 Topics: Aminoglycosides; Animals; Anticonvulsants; Bumetanide; Epilepsy; Hearing Loss; Humans; Infant; Infan	2023
Neonatal seizures and their treatment. Current opinion in neurology, 2003, Volume: 16, Issue:2 Topics: Anticonvulsants; Brain; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Neuronal Plas	2003
[Indications for phenobarbital in neonatal pathology]. Pediatrie, 1983, Volume: 38, Issue:6 Topics: Asphyxia Neonatorum; Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases; Jaundi	1983
[Phenobarbital in newborn infants. Overview]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1984, Volume: 132, Issue:4 Topics: Asphyxia Neonatorum; Brain Injuries; Cerebral Hemorrhage; Electroencephalography; Half-Life; Humans;	1984
[The newborn infant of the drug-dependent mother. Review of literature and personal case reports]. Minerva pediatrica, 1980, May-31, Volume: 32, Issue:10 Topics: Adult; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases	1980
Problems in the chemotherapy of cancer in the neonate. The American journal of pediatric hematology/oncology, 1981,Fall, Volume: 3, Issue:3 Topics: Age Factors; Antineoplastic Agents, Phytogenic; Blood Proteins; Glomerular Filtration Rate; Humans;	1981
An overview of perinatal clinical pharmacology. Clinics in laboratory medicine, 1981, Volume: 1, Issue:2 Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo	1981
Drug abuse in pregnancy: fetal ad neonatal effects. Drug therapeutics, 1982 Topics: Alcoholism; Birth Weight; Chlorpromazine; Diazepam; Female; Fetus; Humans; Infant, Newborn; Infant,	1982
Preparing the fetus for preterm birth. Bailliere's clinical obstetrics and gynaecology, 1993, Volume: 7, Issue:3 Topics: Chorioamnionitis; Female; Fetal Membranes, Premature Rupture; Genital Diseases, Female; Humans; Infa	1993
The neonatal narcotic withdrawal syndrome: a therapeutic challenge. Clinics in perinatology, 1975, Volume: 2, Issue:1 Topics: Barbiturates; Chlorpromazine; Diazepam; Humans; Infant Care; Infant, Newborn; Infant, Newborn, Disea	1975
The effect of maternal narcotic addiction on the newborn infant. Psychological medicine, 1977, Volume: 7, Issue:4 Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo	1977
[Epilepsies of infancy and early childhood (author's transl)]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1978, Jun-06, Volume: 67, Issue:23 Topics: Clonazepam; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Dise	1978
Neonatal nonhemolytic jaundice. The New England journal of medicine, 1975, Jan-23, Volume: 292, Issue:4 Topics: Bile Acids and Salts; Bile Ducts; Biliary Tract Diseases; Bilirubin; Brain Damage, Chronic; Breast F	1975
Phenobarbital plasma levels in neonates. Clinics in perinatology, 1975, Volume: 2, Issue:1 Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenobarbital; Pilot Projects; Sei	1975
Neonatal seizures and their treatment. Clinics in perinatology, 1975, Volume: 2, Issue:1 Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis	1975
[Benign familial neonatal convulsion: clinical features of the propositus and comparison with the previously reported cases]. No to hattatsu = Brain and development, 1990, Volume: 22, Issue:6 Topics: Adult; Child; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Ma	1990
Febrile convulsions. A reappraisal. Electroencephalography and clinical neurophysiology, 1973, Volume: 32 Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc	1973
Developmental pharmacology: a review of its application to clinical and basic science. Annual review of pharmacology, 1972, Volume: 12 Topics: Aging; Androgens; Aniline Compounds; Animals; Estrogens; Ethanol; Female; Fetus; Fluorosis, Dental;	1972
Adverse hematologic effects of drugs. Pediatric clinics of North America, 1972, Volume: 19, Issue:4 Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anti-Bacterial Agents; Anticonvulsants; Antidepressive Agents	1972
Neonatal Seizures. The New England journal of medicine, 1973, Aug-23, Volume: 289, Issue:8 Topics: Birth Injuries; Calcium; Congenital Abnormalities; Glucose; Humans; Hypocalcemia; Hypoglycemia; Infa	1973
The treatment of status epilepticus. Pediatrics, 1974, Volume: 53, Issue:4 Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases;	1974
[Stimulation of the microsomal enzyme system as a therapeutic principle in the newborn infant]. Medizinische Klinik, 1974, May-24, Volume: 69, Issue:21 Topics: Anticonvulsants; Blood Coagulation Disorders; Enzyme Induction; Female; Humans; Hyperbilirubinemia,	1974
The use of drugs in influencing human fetal metabolism. Clinical obstetrics and gynecology, 1974, Volume: 17, Issue:3 Topics: Adrenocortical Hyperfunction; Animals; Blood Transfusion, Intrauterine; Congenital Hypothyroidism; E	1974
Phenobarbital in the perinatal period. Pediatrics, 1969, Volume: 43, Issue:3 Topics: Animals; Animals, Newborn; Bilirubin; Chemical and Drug Induced Liver Injury; Drug Antagonism; Drug	1969
The control of hyperbilirubinemia in the newborn. Clinical obstetrics and gynecology, 1971, Volume: 14, Issue:3 Topics: Animals; Bilirubin; Enzyme Induction; Exchange Transfusion, Whole Blood; Food; Growth Disorders; Hum	1971
Neonatal hyperbilirubinemia--some new approaches--. Indian pediatrics, 1971, Volume: 8, Issue:11 Topics: Animals; Bilirubin; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Orotic A	1971
In utero disease and the newborn infant. Advances in pediatrics, 1970, Volume: 17 Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Animals; Bilirubin; Birth Weight; Electrocardiograp	1970

Article	Year
Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial. Hospital pediatrics, 2022, 07-01, Volume: 12, Issue:7 Topics: Adult; Anticonvulsants; Child; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases;	2022
Comparison between Phenobarbitone and Levetiracetam as the initial anticonvulsant in preterm neonatal seizures - a pilot randomized control trial in developing country setup. European journal of pediatrics, 2023, Volume: 182, Issue:5 Topics: Anticonvulsants; Developing Countries; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases;	2023
Phenobarbitone versus phenytoin for treatment of neonatal seizures: an open-label randomized controlled trial. Indian pediatrics, 2013, Volume: 50, Issue:8 Topics: Anticonvulsants; Electroencephalography; Female; Humans; India; Infant, Newborn; Infant, Newborn, Di	2013
Effect of Withholding Phenobarbitone Maintenance in Neonatal Seizures: A Randomized Controlled Trial. Indian pediatrics, 2016, Dec-15, Volume: 53, Issue:12 Topics: Anticonvulsants; Double-Blind Method; Female; Humans; India; Infant, Newborn; Infant, Newborn, Disea	2016
Phenobarbitone to prevent intraventricular haemorrhage. Lancet (London, England), 1981, Aug-22, Volume: 2, Issue:8243 Topics: Cerebral Hemorrhage; Cerebral Ventricles; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant,	1981
Failure of phenobarbitone to prevent neonatal intraventricular haemorrhage. Lancet (London, England), 1982, Mar-06, Volume: 1, Issue:8271 Topics: Cerebral Hemorrhage; Cerebral Ventricles; Clinical Trials as Topic; Double-Blind Method; Humans; Inf	1982
Phenobarbitone and neonatal intraventricular haemorrhage. Lancet (London, England), 1982, May-29, Volume: 1, Issue:8283 Topics: Cerebral Hemorrhage; Cerebral Ventricles; Clinical Trials as Topic; Humans; Infant, Newborn; Infant,	1982
Neonatal methadone withdrawal. Effect of two treatment regimens. American journal of diseases of children (1960), 1983, Volume: 137, Issue:12 Topics: Blood Pressure; Carbon Dioxide; Drug Administration Schedule; Female; Humans; Hydrogen-Ion Concentra	1983
Opiate v CNS depressant therapy in neonatal drug abstinence syndrome. American journal of diseases of children (1960), 1983, Volume: 137, Issue:4 Topics: Adult; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Prospective Studies	1983
Does phenobarbitone prevent periventricular hemorrhage in very low-birth-weight babies?: a controlled trial. Pediatrics, 1982, Volume: 70, Issue:2 Topics: Cerebral Hemorrhage; Clinical Trials as Topic; Humans; Infant, Low Birth Weight; Infant, Newborn; In	1982
Electrographic seizures in neonates correlate with poor neurodevelopmental outcome. Neurology, 2000, Aug-22, Volume: 55, Issue:4 Topics: Anticonvulsants; Asphyxia Neonatorum; Demography; Developmental Disabilities; Electroencephalography	2000
Magnesium therapy in neonatal tetany. Lancet (London, England), 1977, Feb-05, Volume: 1, Issue:8006 Topics: Administration, Oral; Calcium; Drug Evaluation; Humans; Hypocalcemia; Infant, Newborn; Infant, Newbo	1977
Assessment and treatment of abstinence in the infant of the drug-dependent mother. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2 Topics: Clinical Trials as Topic; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenoba	1975
Therapeutic trial of methocarbamol (Robinax) in tetanus neonatorum. Indian pediatrics, 1975, Volume: 12, Issue:6 Topics: Chlorpromazine; Drug Therapy, Combination; Humans; Infant, Newborn; Infant, Newborn, Diseases; Metho	1975
Antenatal phenobarbital in preventing intraventricular hemorrhage in premature newborns. Fetal therapy, 1988, Volume: 3, Issue:4 Topics: Cerebral Hemorrhage; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature;	1988
Proceedings: Comparisons of phenobarbitone, magnesium sulphate, and calcium gluconate in treatment of neonatal hypocalcaemic convulsions. Archives of disease in childhood, 1974, Volume: 49, Issue:3 Topics: Administration, Oral; Calcium; Clinical Trials as Topic; Gluconates; Humans; Hypocalcemia; Infant, N	1974
A controlled study of intramuscular meprobamate in neonatal tetanus. The Journal of tropical pediatrics and African child health, 1966, Volume: 12, Issue:1 Topics: Chlorpromazine; Clinical Trials as Topic; Humans; Infant, Newborn; Infant, Newborn, Diseases; Inject	1966
A double blind study of the effect of phenobarbitone on neonatal hyperbilirubinaemia and frequency of exchange transfusion. Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:6 Topics: Bilirubin; Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, N	1970
The course of the heroin withdrawal syndrome in newborn infants treated with phenobarbital or chlorpromazine. The Journal of pediatrics, 1969, Volume: 75, Issue:3 Topics: Chlorpromazine; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenobarbi	1969

Article	Year
Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. Journal of child neurology, 2022, Volume: 37, Issue:5 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2022
Comparing the effect of different loading doses of phenobarbitone on serum phenobarbitone levels in babies with neonatal seizures and effect of therapeutic hypothermia on phenobarbitone levels. Journal of tropical pediatrics, 2022, 08-04, Volume: 68, Issue:5 Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Infant, Newborn, Dis	2022
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. Pediatric neurology, 2023, Volume: 138 Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob	2023
Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach. BMC pediatrics, 2020, 01-28, Volume: 20, Issue:1 Topics: Anticonvulsants; Attitude of Health Personnel; Diagnostic Techniques and Procedures; Electroencephal	2020
Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital. Journal of child neurology, 2021, Volume: 36, Issue:1 Topics: Anticonvulsants; Child, Preschool; Cohort Studies; Female; Humans; Infant; Infant, Newborn; Infant,	2021
Prevalence and predictors of adverse outcomes in neonatal seizures. Journal of neonatal-perinatal medicine, 2022, Volume: 15, Issue:1 Topics: Female; Humans; Infant; Infant Mortality; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital;	2022
Persistent Muscle Twitching With Phenobarbitone in a Preterm Neonate-Lack of Response or Manifestation of Toxicity? Therapeutic drug monitoring, 2019, Volume: 41, Issue:3 Topics: Anticonvulsants; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Muscles; Phe	2019
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. Brain & development, 2019, Volume: 41, Issue:7 Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant,	2019
Anticonvulsants for neonates: high time we were seized of the matter. Indian pediatrics, 2013, Volume: 50, Issue:8 Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures	2013
Adverse neurodevelopmental outcomes after exposure to phenobarbital and levetiracetam for the treatment of neonatal seizures. Journal of perinatology : official journal of the California Perinatal Association, 2013, Volume: 33, Issue:11 Topics: Anticonvulsants; Child Development; Child, Preschool; Cohort Studies; Gestational Age; Humans; Infan	2013
Neonatal seizures: continued debate on phenobarbitone versus phenytoin. Indian pediatrics, 2013, Volume: 50, Issue:12 Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures	2013
Reply: To PMID 23502660. Indian pediatrics, 2013, Volume: 50, Issue:12 Topics: Anticonvulsants; Female; Humans; Infant, Newborn, Diseases; Male; Phenobarbital; Phenytoin; Seizures	2013
Poor neonatal adaptation following in-utero exposure to quetiapine and lamotrigine. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2015, Volume: 35, Issue:6 Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Hypothyroidism; Infant, Newborn; Infa	2015
Phenobarbital and neonatal seizures affect cerebral oxygen metabolism: a near-infrared spectroscopy study. Pediatric research, 2015, Volume: 78, Issue:1 Topics: Anticonvulsants; Brain; Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Di	2015
Short-Term Effects of Phenobarbitone on Electrographic Seizures in Neonates. Neonatology, 2016, Volume: 110, Issue:1 Topics: Anticonvulsants; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Monitor	2016
Approach to seizures in the neonatal period: a European perspective. Acta paediatrica (Oslo, Norway : 1992), 2010, Volume: 99, Issue:4 Topics: Anticonvulsants; Europe; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures	2010
[Therapy of convulsive states in the newborn]. Il Lattante, 1957, Volume: 28, Issue:1 Topics: Child; Chlorpromazine; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Se	1957
TETANUS IN CHILDREN IN DELHI. The Journal of tropical pediatrics and African child health, 1963, Volume: 9 Topics: Anti-Bacterial Agents; Child; Chlorpromazine; Humans; Immunization, Passive; India; Infant; Infant M	1963
THE INFANT WITH EPILEPSY. Southwestern medicine, 1963, Volume: 44 Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific	1963
LISTERIA MONOCYTOGENES MENINGITIS IN THE NEWBORN. Journal of the Irish Medical Association, 1964, Volume: 54 Topics: Chloramphenicol; Clinical Laboratory Techniques; Humans; Infant, Newborn; Infant, Newborn, Diseases;	1964
SOME MODIFICATIONS IN METHOD OF TREATING TETANUS NEONATORUM WITH INTERMITTENT POSITIVE-PRESSURE RESPIRATION. Archives of disease in childhood, 1964, Volume: 39 Topics: Biomedical Research; Chlorpromazine; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Mus	1964
THERAPEUTIC TRIAL OF DIAZEPAM IN TETANUS. Lancet (London, England), 1965, Apr-03, Volume: 1, Issue:7388 Topics: Child; Chlorpromazine; Diazepam; Drug Therapy; Humans; Infant; Infant, Newborn; Infant, Newborn, Dis	1965
Drug treatment of neonatal seizures by neonatologists and paediatric neurologists. Journal of paediatrics and child health, 2005, Volume: 41, Issue:7 Topics: Anticonvulsants; Benzodiazepines; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Newborn,	2005
Prevention of intraventricular haemorrhage by phenobarbitone. Lancet (London, England), 1981, Sep-05, Volume: 2, Issue:8245 Topics: Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital	1981
Phenobarbitone to prevent periventricular haemorrhage. Lancet (London, England), 1982, Jun-19, Volume: 1, Issue:8286 Topics: Cerebral Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intramuscular;	1982
An evaluation of neonatal abstinence treatment modalities. NIDA research monograph, 1984, Volume: 49 Topics: Central Nervous System Depressants; Diazepam; Drug Therapy, Combination; Humans; Infant, Newborn; In	1984
The use of phenobarbital in treating abstinence in newborns exposed in utero to psychoactive agents. NIDA research monograph, 1984, Volume: 49 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Narcotics; Phenobarbital; Psychotropic Drugs; Su	1984
Changes in phenobarbital concentrations in the cerebrospinal fluid and blood of the newborn. Developmental pharmacology and therapeutics, 1984, Volume: 7 Suppl 1 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Time Factors	1984
[Combined preparation of ergocalciferol and phenobarbital and its use in children]. Pediatriia, 1983, Issue:4 Topics: Drug Combinations; Ergocalciferols; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbita	1983
Hepatobiliary scintigraphy with 99mTc-PIPIDA in the evaluation of neonatal jaundice. Pediatrics, 1981, Volume: 67, Issue:1 Topics: Bile Ducts; Female; Gallbladder; Hepatitis; Humans; Imino Acids; Infant; Infant, Newborn; Infant, Ne	1981
[Phenobarbital in the newborn (author's transl)]. Archives francaises de pediatrie, 1982, Volume: 39, Issue:3 Topics: Administration, Oral; Brain Diseases; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Pr	1982
General principles of treatment: status epilepticus in neonates. Advances in neurology, 1983, Volume: 34 Topics: Diagnosis, Differential; Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital	1983
Phenobarbital dosage for neonatal seizures. Advances in neurology, 1983, Volume: 34 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Phenobarbital; Seizures	1983
Factors affecting outcome in hypoxic-ischemic encephalopathy in term infants. American journal of diseases of children (1960), 1983, Volume: 137, Issue:1 Topics: Adolescent; Adult; Brain Ischemia; Dexamethasone; Electroencephalography; Female; Follow-Up Studies;	1983
Phenobarbital and phenytoin in neonatal seizures. Neurology, 1982, Volume: 32, Issue:12 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Phenytoin; Seizures	1982
Efficacy of phenobarbital monotherapy in treatment of neonatal seizures -- relationship to blood levels. Neurology, 1982, Volume: 32, Issue:12 Topics: Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures	1982
Neonatal effects of maternal clomipramine treatment. Pediatrics, 1982, Volume: 69, Issue:2 Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Depressive Disorder; Female; Humans; Infant, Newborn;	1982
Early discontinuation of anticonvulsants after neonatal seizures: a preliminary report. Southern medical journal, 1982, Volume: 75, Issue:3 Topics: Child Development; Female; Follow-Up Studies; Growth; Humans; Infant, Newborn; Infant, Newborn, Dise	1982
Phenobarbital therapy in neonatal seizures and the prognostic value of the EEG. Neuropediatrics, 1982, Volume: 13, Issue:1 Topics: Electroencephalography; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Prematur	1982
Neonatal seizures: a survey of current practice. Clinical pediatrics, 1982, Volume: 21, Issue:8 Topics: Blood Glucose; Calcium; Diagnosis, Differential; Dose-Response Relationship, Drug; Electrolytes; Eva	1982
Pharmacokinetics of furosemide in neonates. European journal of clinical pharmacology, 1982, Volume: 22, Issue:1 Topics: Female; Furosemide; Gestational Age; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases;	1982
Phenobarbitone dosage in neonatal convulsions. Archives of disease in childhood, 1982, Volume: 57, Issue:9 Topics: Drug Administration Schedule; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Sei	1982
Cimetidine in pregnancy: apparent transient liver impairment in the newborn. American journal of diseases of children (1960), 1980, Volume: 134, Issue:1 Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cimetidine; Fema	1980
Episodic complete airway obstruction in infants. Pediatrics, 1981, Volume: 67, Issue:6 Topics: Airway Obstruction; Drug Therapy, Combination; Female; Humans; Infant; Infant, Newborn; Infant, Newb	1981
Combined hypothyroidism and hypoparathyroidism in an infant after maternal 131I administration. The Journal of pediatrics, 1981, Volume: 99, Issue:1 Topics: Carcinoma; Female; Humans; Hypocalcemia; Hypoparathyroidism; Hypothyroidism; Infant; Infant, Newborn	1981
Phenobarbital maintenance dose requirements in treating neonatal seizures. Neurology, 1981, Volume: 31, Issue:8 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Kinetics; Phenobarbital; Seizures	1981
Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution. Neurology, 1981, Volume: 31, Issue:9 Topics: Brain; Drug Therapy, Combination; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phe	1981
Neonatal tetanus. Virginia medical, 1980, Volume: 107, Issue:8 Topics: Chlorpromazine; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenobarbital; Tet	1980
Neonatal manifestations of maternal phencyclidine (PCP) abuse. Pediatrics, 1981, Volume: 68, Issue:4 Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Mater	1981
Clinical implications of perinatal pharmacology. European journal of clinical pharmacology, 1980, Volume: 18, Issue:1 Topics: Drug-Related Side Effects and Adverse Reactions; Female; Fetus; Humans; Infant, Newborn; Infant, New	1980
[Concentrations of phenobarbital in the cerebrospinal fluid and blood of newborn infants]. La Nouvelle presse medicale, 1980, Nov-15, Volume: 9, Issue:43 Topics: Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures	1980
Use of high dosage phenobarbital in the treatment of neonatal status epilepticus: a preliminary report. Military medicine, 1979, Volume: 144, Issue:7 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Status Epilepticus	1979
Management of neonatal narcotic abstinence utilizing a phenobarbital loading dose method. NIDA research monograph, 1979, Volume: 27 Topics: Administration, Oral; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Infant, New	1979
Hypercholesterolemia in the newborn: occurrence after anterpartum treatment with betamethasone-phenobarbital-ritodrine for the prevention of the respiratory distress syndrome. Pediatrics, 1978, Volume: 62, Issue:1 Topics: Betamethasone; Cholesterol; Female; Humans; Hypercholesterolemia; Infant, Newborn; Infant, Newborn,	1978
[Biochemical maturation of organs in the foetus and its induction (author's transl)]. Zeitschrift fur Geburtshilfe und Perinatologie, 1979, Volume: 183, Issue:1 Topics: Adaptation, Physiological; Enzyme Induction; Female; Fetus; Glucocorticoids; Humans; Hyaline Membran	1979
Management of the convulsing child. Australian family physician, 1979, Volume: 8, Issue:2 Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Infant, Newborn; Infant, Newborn, Disea	1979
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. The Journal of pediatrics, 1979, Volume: 94, Issue:6 Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant,	1979
A retrospective study of tetanus neonatorum and comparative assessment of diazepam in its treatment. Indian pediatrics, 1979, Volume: 16, Issue:4 Topics: Chlorpromazine; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methocar	1979
Phenobarbital dosage for control of neonatal seizures. Neurology, 1979, Volume: 29, Issue:11 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures	1979
Phenobarbitone dosage in the neonate--preliminary communication. Clinical and experimental neurology, 1977, Volume: 14 Topics: Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intramuscular; Injections, Intraveno	1977
Phenobarbital and diphenylhydantoin levels in neonates with seizures. The Journal of pediatrics, 1978, Volume: 92, Issue:2 Topics: Administration, Oral; Female; Half-Life; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infusio	1978
Phenobarbital pharmacokinetics in neonates. Clinical pharmacology and therapeutics, 1978, Volume: 23, Issue:3 Topics: Aging; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Kinetics; Models, Biol	1978
Management of narcotic withdrawal in neonates. The Journal of pediatrics, 1978, Volume: 92, Issue:6 Topics: Diazepam; Drug Therapy, Combination; Humans; Infant, Newborn; Infant, Newborn, Diseases; Narcotics;	1978
Problems pertaining to the care of newborn infants of drug-addicted women. The Journal of reproductive medicine, 1978, Volume: 20, Issue:6 Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P	1978
[Neonatal abstinence syndrome in children whose mothers were treated for epilepsy during pregnancy]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1978, Oct-20, Volume: 98, Issue:29 Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, D	1978
Withdrawal symptoms in neonates from intrauterine exposure to diazepam. The Journal of pediatrics, 1977, Volume: 90, Issue:1 Topics: Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Phenobarbital; Substance Withdra	1977
Observation and treatment of neonatal narcotic withdrawal. American journal of obstetrics and gynecology, 1977, Jan-15, Volume: 127, Issue:2 Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New	1977
Studies on the concentrations of chloramphenicol in the serum and cerebrospinal fluid of neonates, infants, and small children. Reciprocal reactions between chloramphenicol, penicillin and phenobarbitone. European journal of pediatrics, 1977, Jan-26, Volume: 124, Issue:2 Topics: Age Factors; Child, Preschool; Chloramphenicol; Drug Interactions; Humans; Infant; Infant, Newborn;	1977
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs. Archives of disease in childhood, 1977, Volume: 52, Issue:3 Topics: Adult; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Feta	1977
Tetanus neonatourm. Indian pediatrics, 1977, Volume: 14, Issue:3 Topics: Diazepam; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Tetanus	1977
Neonatal seizures associated with narcotic withdrawal. The Journal of pediatrics, 1977, Volume: 91, Issue:4 Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Pregnanc	1977
[Heroin withdrawal syndrome in newborns (author's transl]. Klinische Padiatrie, 1976, Volume: 188, Issue:6 Topics: Chloral Hydrate; Diazepam; Female; Heroin; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant	1976
[Prevention and conservative treatment of transitory hyperbilirubinemia in full-term and premature infants]. Voprosy okhrany materinstva i detstva, 1975, Volume: 20, Issue:1 Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases;	1975
Letter: Withdrawal symptoms in newborn infants of epileptic mothers. British medical journal, 1975, Jul-05, Volume: 3, Issue:5974 Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pheno	1975
Fetal addiction to pentazocine. Pediatrics, 1975, Volume: 55, Issue:6 Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pentazoc	1975
"Ground-glass" hepatocytes. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Aug-09, Volume: 49, Issue:34 Topics: Adult; Biopsy; Carrier State; Chemical and Drug Induced Liver Injury; Female; Hepatitis B; Hepatitis	1975
Neonatal abstinence syndrome: assessment and management. Addictive diseases, 1975, Volume: 2, Issue:1-2 Topics: Administration, Oral; Antidiarrheals; Central Nervous System; Diazepam; Digestive System; Female; He	1975
Acute management of neonatal addiction. Addictive diseases, 1975, Volume: 2, Issue:1-2 Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant	1975
The assessment of behavioral change in infants undergoing narcotic withdrawal: comparative data from clinical and objective methods. Addictive diseases, 1975, Volume: 2, Issue:1-2 Topics: Arousal; Attention; Central Nervous System; Female; Heroin Dependence; Humans; Infant, Newborn; Infa	1975
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings. Clinical pediatrics, 1975, Volume: 14, Issue:8 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet	1975
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin. International journal of clinical pharmacology and biopharmacy, 1975, Volume: 12, Issue:1-2 Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New	1975
[Clinical experiences using phenobarbital in the prevention of hyperbilirubinemia in mature newborn infants in a controlled study]. Zeitschrift fur arztliche Fortbildung, 1975, May-15, Volume: 69, Issue:10 Topics: Bilirubin; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Humans; Hyperbilirubinemia	1975
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior. The Journal of pediatrics, 1976, Volume: 88, Issue:4 Pt 1 Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob	1976
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. Clinical pediatrics, 1990, Volume: 29, Issue:2 Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas	1990
The electro-encephalogram in the term neonate. Case reports. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1986, Sep-27, Volume: 70, Issue:7 Topics: Cerebral Palsy; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Ph	1986
Intravenous paraldehyde for seizure control in newborn infants. Neurology, 1986, Volume: 36, Issue:1 Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intravenous; Male; Metabolic	1986
Cassette electroencephalography in the evaluation of neonatal seizures. Archives of neurology, 1986, Volume: 43, Issue:1 Topics: Apnea; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Se	1986
Congenital islet cell adenoma causing hypoglycemia in a newborn. Pediatrics, 1971, Volume: 47, Issue:3 Topics: Adenoma, Islet Cell; Blood Glucose; Glucose Tolerance Test; Humans; Hypoglycemia; Infant; Infant, Ne	1971
Infant of the addicted mother. The New England journal of medicine, 1973, Jun-28, Volume: 288, Issue:26 Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea	1973
[Withdrawal syndrome in a six-week-old infant treated with dihydrocodeine (author's transl)]. Deutsche medizinische Wochenschrift (1946), 1974, Jul-12, Volume: 99, Issue:28 Topics: Codeine; Dyspepsia; Female; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Morphinans;	1974
Neonatal jaundice. American family physician, 1974, Volume: 10, Issue:4 Topics: Albumins; Bile Ducts; Bilirubin; Breast Feeding; Crigler-Najjar Syndrome; Erythroblastosis, Fetal; E	1974
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants. Pediatrics, 1974, Volume: 54, Issue:3 Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma	1974
Newborn infants of mothers on methadone maintenance. New York state journal of medicine, 1974, Volume: 74, Issue:6 Topics: Body Weight; Camphor; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, D	1974
Group B beta-hemolytic streptococcal meningitis in mother and infant. The New England journal of medicine, 1974, Feb-14, Volume: 290, Issue:7 Topics: Adult; Ampicillin; Female; Gentamicins; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Me	1974
Intensive therapy in neonatal tetanus. Anaesthesia, 1974, Volume: 29, Issue:3 Topics: Body Temperature; Chloral Hydrate; Chlorpromazine; Diazepam; Electrocardiography; Humans; Hydrogen P	1974
Neonatal hyperbilirubinemia. Seminars in hematology, 1972, Volume: 9, Issue:2 Topics: Acidosis; Agar; Anemia, Hemolytic; Antibodies; Bilirubin; Blood Group Incompatibility; Blood Transfu	1972
Barbiturate withdrawal syndrome in a passively addicted infant. JAMA, 1972, Jul-10, Volume: 221, Issue:2 Topics: Cesarean Section; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Infant, Newborn; I	1972
[Prevention of transitory hyperbilirubinemia of the premature and mature newborn infants and of the hemolytic disease of the newborn by an enzyme induction combination: phenobarbital-nikethamide]. Schweizerische medizinische Wochenschrift, 1972, Sep-23, Volume: 102, Issue:38 Topics: Bilirubin; Enzyme Induction; Erythroblastosis, Fetal; Exchange Transfusion, Whole Blood; Female; Hum	1972
[Crigler-Naijar syndrome. Clinical, biochemical, morphologic and therapeutic aspects]. Helvetica paediatrica acta, 1972, Volume: 27, Issue:3 Topics: Bile; Bilirubin; Chromatography, Thin Layer; Clinical Enzyme Tests; Female; Glucuronates; Humans; Hy	1972
[Drug prevention of hyperbilirubinemia in newborn infants. 5. Cumulative effect of the combination of the inductors phenobarbital and nikethamide]. Das Deutsche Gesundheitswesen, 1972, Nov-23, Volume: 27, Issue:47 Topics: Drug Combinations; Drug Synergism; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Dis	1972
Rare diseases, old drug, new knowledge. Pediatrics, 1973, Volume: 51, Issue:6 Topics: Animals; Bilirubin; Epilepsy; Female; Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases	1973
[Prevention of toxic hyperbilirubinemia in premature and mature newborn infants by use of an enzyme-inducing combination: phenobarbital-nikethamide]. Helvetica paediatrica acta, 1973, Volume: 30 Topics: Drug Synergism; Enzyme Induction; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Dise	1973
[Effect of various drugs on serum bilirubin level in newborn infants]. Padiatrie und Padologie, 1973, Volume: 8, Issue:3 Topics: Bilirubin; Diazepam; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Meproba	1973
[Phenobarbital and hyperbilirubinemia of newborn infants with low birth weight. II]. Ceskoslovenska pediatrie, 1973, Volume: 28, Issue:7 Topics: Birth Weight; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Injections, In	1973
Phenobarbital effect on serum bilirubin levels in underweight infants. Helvetica paediatrica acta, 1973, Volume: 28, Issue:3 Topics: Bilirubin; Birth Weight; Diseases in Twins; Female; Gestational Age; Humans; Infant Nutrition Disord	1973
[Prevention of newborn infant hyperbilirubinemia by use of drugs. 8. Recommendation for the use of prevention in combination with a screening test for prognosis]. Kinderarztliche Praxis, 1973, Volume: 41, Issue:4 Topics: Birth Weight; Female; Gestational Age; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn,	1973
Transplacental passage of primidone. Neurology, 1973, Volume: 23, Issue:4 Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Maternal-Fetal	1973
Neonatal withdrawal following maternal ingestion of ethchlorvynol (Placidyl). Pediatrics, 1973, Volume: 52, Issue:5 Topics: Adult; Diagnosis, Differential; Ethchlorvynol; Female; Humans; Infant, Newborn; Infant, Newborn, Dis	1973
Observations on the sudden death of infants born to addicted mothers. Proceedings. National Conference on Methadone Treatment, 1973, Volume: 2 Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn;	1973
Late presentation of drug withdrawal symptoms in newborns. American journal of diseases of children (1960), 1974, Volume: 127, Issue:1 Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant,	1974
Seizures in newborn infants. Developmental medicine and child neurology, 1974, Volume: 16, Issue:1 Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant	1974
Narcotic withdrawal in the newborn infant. Journal of the National Medical Association, 1974, Volume: 66, Issue:2 Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate	1974
Born with a habit. Infants of drug-addicted mothers. Pediatric clinics of North America, 1974, Volume: 21, Issue:2 Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia	1974
Assisted respiration in the treatment of neonatal tetanus. Archives of disease in childhood, 1968, Volume: 43, Issue:228 Topics: Chlorpromazine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Intubation, Intratracheal; Pheno	1968
Maternal barbiturate utilization and neonatal withdrawal symptomatology. The Journal of pediatrics, 1972, Volume: 80, Issue:2 Topics: Anticonvulsants; Apgar Score; Barbiturates; Epilepsy; Female; Gestational Age; Heroin; Humans; Infan	1972
[Treatment of hyperbilirubinemia of the newborn with phenobarbital]. Minerva pediatrica, 1972, Jun-16, Volume: 24, Issue:22 Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital	1972
[Dangers and potential uses of enzyme stimulating medication on newborns and infants]. Padiatrie und Padologie, 1972, Volume: 7, Issue:3 Topics: Aminopyrine; Chloramphenicol; Drug Synergism; Enzyme Induction; Female; Humans; Infant; Infant, Newb	1972
Neonatal barbiturate withdrawal. JAMA, 1972, Sep-11, Volume: 221, Issue:11 Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Phenobarbital;	1972
Narcotic withdrawal in the newborn. American family physician, 1972, Volume: 6, Issue:1 Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, N	1972
[Evaluation of phenobarbitone treatment in neonatal hyperbilirubinemia]. Harefuah, 1971, Feb-15, Volume: 80, Issue:4 Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases;	1971
Observations on heroin and methadone withdrawal in the newborn. Pediatrics, 1971, Volume: 48, Issue:3 Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo	1971
[Phenobarbital treatment of transitory non-hemolytic and non-conjugated neonatal hyperbilirubinemia. Results observed in a selected group of cases]. La Clinica pediatrica, 1971, Volume: 53, Issue:9 Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital	1971
[Anticonvulsants. 5. Treatment of convulsions in the neonatal period]. Lakartidningen, 1971, Oct-18, Volume: 68 Topics: Diazepam; Electroencephalography; Humans; Infant, Newborn; Infant, Newborn, Diseases; Lidocaine; Phe	1971
Treatment of tetanus neonatorum. International anesthesiology clinics, 1966,Summer, Volume: 4, Issue:2 Topics: Humans; Humidity; Infant, Newborn; Infant, Newborn, Diseases; Injections, Intramuscular; Injections,	1966
[Detection and prognosis of the neonatal mal according to the electroclinical study of 150 cases]. Archives francaises de pediatrie, 1969, Volume: 26, Issue:10 Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Congenital Abnormalities; Electroencephalography; Ep	1969
[Phenobarbital in the treatment of hyperbilirubinemia of the newborn]. La Pediatria, 1969, Volume: 77, Issue:1 Topics: Bilirubin; Female; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, P	1969
Heroin withdrawal syndrome. The Journal of pediatrics, 1970, Volume: 76, Issue:3 Topics: Chlorpromazine; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal E	1970
[Experience in treatment of hyperbilirubinemia in the newborn with phenobarbital]. Minerva pediatrica, 1970, Mar-24, Volume: 22, Issue:12 Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature, Diseases;	1970
Effect of phenobarbital on hyperbilirubinemia and glucuronide formation in newborns. American journal of diseases of children (1960), 1970, Volume: 120, Issue:1 Topics: Bilirubin; Female; Glucuronates; Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Disea	1970
Pyridoxine dependency and penicillamine. Neurology, 1970, Volume: 20, Issue:1 Topics: Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Kidney Function Tests; Penicillamine; Ph	1970
[The influence of a short-time enzyme induction with phenobarbital on hyperbilirubinemia in premature newborns]. Das Deutsche Gesundheitswesen, 1970, Nov-19, Volume: 25, Issue:47 Topics: Bilirubin; Enzyme Induction; Glucosephosphate Dehydrogenase Deficiency; Humans; Hyperbilirubinemia;	1970
[Treatment of tetanus in the newborn]. Archivos argentinos de pediatria, 1970, Volume: 68, Issue:10 Topics: Chlorpromazine; Diazepam; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital;	1970
[New methods of treating hyperbilirubinemia in newborn infants]. L'union medicale du Canada, 1971, Volume: 100, Issue:3 Topics: Agar; Enzyme Induction; Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia; Infant, Newbo	1971
[Behavior of bilirubinemia in full-term newborn infants treated with phenobarbital]. Minerva pediatrica, 1971, Jun-23, Volume: 23, Issue:25 Topics: Humans; Hyperbilirubinemia; Infant, Newborn; Infant, Newborn, Diseases; Jaundice, Neonatal; Phenobar	1971
Clinical observations on tetanus. Journal of the Indian Medical Association, 1968, May-16, Volume: 50, Issue:10 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Child; Child, Preschool; Chlorpromazine; Female; Humans;	1968
Therapy in congenital hyperbilirubinemia: phenobarbital and diethylnicotinamide. Pediatrics, 1969, Volume: 44, Issue:1 Topics: Bilirubin; Child; Child, Preschool; Female; Humans; Hyperbilirubinemia, Hereditary; Infant; Infant,	1969
[Therapy of occasional convulsions in children and adolescents]. Munchener medizinische Wochenschrift (1950), 1969, Sep-05, Volume: 111, Issue:36 Topics: Adolescent; Age Factors; Anticonvulsants; Calcium; Child; Humans; Infant, Newborn; Infant, Newborn,	1969
Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder. Pediatrics, 1965, Volume: 36, Issue:6 Topics: Adolescent; Digoxin; Female; Humans; Hyperthyroidism; Infant; Infant, Newborn; Infant, Newborn, Dise	1965

phenobarbital and Infant, Newborn, Diseases