phenobarbital has been researched along with Hypoxia in 62 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The most common cause of neonatal seizures is hypoxic encephalopathy, and here we show in an established model of neonatal hypoxia-induced seizures that the NKCC1 inhibitor, bumetanide, in combination with phenobarbital is significantly more effective than phenobarbital alone." | 7.79 | Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. ( Berry, G; Cleary, RT; Huynh, T; Jackson, M; Jensen, FE; Kahle, KT; Li, Y; Manning, SM; Rakhade, SN; Rotenberg, A; Sun, H; Talos, DM, 2013) |
| "Phenobarbital in anticonvulsant concentrations has been shown to lower cerebral blood flow (CBF) during hypertension and to reduce the incidence of intraventricular hemorrhage in newborn beagles after hypertensive insult." | 7.68 | Brain vasoactive effects of phenobarbital during hypertension and hypoxia in newborn pigs. ( Goddard-Finegold, J; Michael, LH, 1992) |
| "Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model." | 7.67 | Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. ( Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR, 1988) |
| "Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro." | 7.67 | Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986) |
| "Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0." | 7.66 | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 7.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| "Local cerebral blood flow (CBF) was measured in rats, using an autoradiographic technique with 14C-iodoantipyrine as diffusible tracer, in situations with low, normal and high flow rates (phenobarbital anesthesia, analgesia with 75% N2O, and hypoxia, respectively)." | 7.66 | Local versus regional cerebral blood flow in the rat at high (hypoxia) and low (phenobarbital anesthesia) flow rates. ( Abdul-Rahman, A; Dahlgren, N; Ingvar, M; Rehncrona, S; Siesjö, BK, 1979) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 7.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood." | 5.48 | Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. ( Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN, 2018) |
| "When halothane was administered with adequate oxygen the percentage of the cardiac output delivered to the hepatic artery significantly increased but there was no change in absolute blood flow to either the hepatic artery or portal vein." | 5.26 | Hepatic blood flow in phenobarbital-pretreated rats during halothane anesthesia and hypoxia. ( Daggy, BP; Ross, WT, 1981) |
| " The regulatory effect of muscone and its enantiomer on the neural system showed that they could prolong mouse hypoxia tolerance and dose-dependently enhance mouse spinal cord stimulation induced by strychnine nitrate." | 3.80 | Resolution and chiral recognition of muscone as well as actions on neural system. ( Bai, JY; Cheng, GF; Meng, Y; Xiao, Q; Xiao, X; Yin, DL; Zhang, S; Zhu, XY, 2014) |
| " The most common cause of neonatal seizures is hypoxic encephalopathy, and here we show in an established model of neonatal hypoxia-induced seizures that the NKCC1 inhibitor, bumetanide, in combination with phenobarbital is significantly more effective than phenobarbital alone." | 3.79 | Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. ( Berry, G; Cleary, RT; Huynh, T; Jackson, M; Jensen, FE; Kahle, KT; Li, Y; Manning, SM; Rakhade, SN; Rotenberg, A; Sun, H; Talos, DM, 2013) |
| "Phenobarbital in anticonvulsant concentrations has been shown to lower cerebral blood flow (CBF) during hypertension and to reduce the incidence of intraventricular hemorrhage in newborn beagles after hypertensive insult." | 3.68 | Brain vasoactive effects of phenobarbital during hypertension and hypoxia in newborn pigs. ( Goddard-Finegold, J; Michael, LH, 1992) |
| "To determine whether brief periods of hypoxia could produce hepatic injury, we pretreated Sprague-Dawley rats with phenobarbital, deprived them of food for 24 hr, and then exposed them to various hypoxic mixtures of nitrogen and oxygen for various lengths of time." | 3.67 | Brief periods of hypoxia can produce hepatic injury in rats. ( Cahalan, MK; Eger, EI; Eger, RR; Fassoulaki, A; Ferrell, LD; Harper, MH; Johnson, BH; Smuckler, EA, 1984) |
| "The antihypoxic effect of the newly-synthesized hydroxylamine barbiturate HB-7, compared with the effects of phenobarbital and pentobarbital, was studied in experiments on albino mice, using the following models of hypoxia: hypobaric, anoxic, asphyctic and haemic." | 3.67 | Antihypoxic effect of the hydroxylamine derivative HB-7. ( Georgiev, V; Getova, D, 1989) |
| "Hypoxia, phenobarbital induction, and halothane anesthesia have been implicated in the pathogenesis of hepatotoxicity in the rat model." | 3.67 | Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes. ( Costa, AK; Heffel, DF; Schieble, TM; Trudell, JR, 1988) |
| "Experimental factors implicated in the pathogenesis of halothane hepatotoxicity in the phenobarbital-hypoxia rat model were examined for direct effects on the energy status of isolated rat liver cells in vitro." | 3.67 | Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro. ( Albrecht, RF; Becker, GL; Hensel, P; Holland, AD; Miletich, DJ, 1986) |
| "A rat model of enflurane-associated hepatotoxicity was compared with the halothane-hypoxia (HH) model (adult male rats, phenobarbital induction, 1% halothane, 14% O2, for 2 hr)." | 3.67 | Comparison of the requirements for hepatic injury with halothane and enflurane in rats. ( Brown, BR; Gandolfi, AJ; Lind, RC; Sipes, IG, 1985) |
| "Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0." | 3.66 | Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983) |
| "Factors affecting halothane (H) hepatotoxicity were investigated in two animal models: 1) the phenobarbital-hypoxia model, and 2) the triiodothyronine (T3) model; in the latter we previously have shown that centrilobular necrosis occurs in T3 pretreated rats anesthetized with 1% H, in 21% oxygen for 2 h." | 3.66 | Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications. ( Phythyon, JM; Uetrecht, J; Wood, AJ; Wood, M, 1983) |
| " Halothane hepatotoxic was produced in all rat strains by exposing phenobarbital-pretreated rats to 1 per cent halothane under mild hypoxia (14 per cent oxygen, inspired) for 2 h." | 3.66 | Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains. ( Adams, JF; Cousins, MJ; Gourlay, GK; Hall, P, 1981) |
| "Local cerebral blood flow (CBF) was measured in rats, using an autoradiographic technique with 14C-iodoantipyrine as diffusible tracer, in situations with low, normal and high flow rates (phenobarbital anesthesia, analgesia with 75% N2O, and hypoxia, respectively)." | 3.66 | Local versus regional cerebral blood flow in the rat at high (hypoxia) and low (phenobarbital anesthesia) flow rates. ( Abdul-Rahman, A; Dahlgren, N; Ingvar, M; Rehncrona, S; Siesjö, BK, 1979) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 3.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood." | 1.48 | Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. ( Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN, 2018) |
| "Seizures are common during the neonatal period, often due to hypoxic-ischemic encephalopathy and may contribute to acute brain injury and the subsequent development of cognitive deficits and childhood epilepsy." | 1.42 | Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice. ( Boylan, GB; Dunleavy, M; Henshall, DC; Jimenez-Mateos, EM; Rodriguez-Alvarez, N; Waddington, JL, 2015) |
| "Sixty-three infants with neonatal seizures were studied in terms of etiology, seizure type, electroencephalograms, and outcome." | 1.27 | Neonatal seizures: a reappraisal. ( Nogen, AG, 1984) |
| "The physical stability and low blood solubility of the new inhaled anesthetic, I-653, imply that this agent produces limited or no toxic effects." | 1.27 | Studies of the toxicity of I-653, halothane, and isoflurane in enzyme-induced, hypoxic rats. ( Eger, EI; Ferrell, LD; Johnson, BH; Strum, DP, 1987) |
| "When halothane was administered with adequate oxygen the percentage of the cardiac output delivered to the hepatic artery significantly increased but there was no change in absolute blood flow to either the hepatic artery or portal vein." | 1.26 | Hepatic blood flow in phenobarbital-pretreated rats during halothane anesthesia and hypoxia. ( Daggy, BP; Ross, WT, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (75.81) | 18.7374 |
| 1990's | 5 (8.06) | 18.2507 |
| 2000's | 5 (8.06) | 29.6817 |
| 2010's | 5 (8.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kane, JM | 1 |
| Baron, BM | 1 |
| Dudley, MW | 1 |
| Sorensen, SM | 1 |
| Staeger, MA | 1 |
| Miller, FP | 1 |
| Dunn, R | 1 |
| Queenan, BN | 1 |
| Pak, DTS | 1 |
| Forcelli, PA | 1 |
| Quinlan, SMM | 1 |
| Rodriguez-Alvarez, N | 2 |
| Molloy, EJ | 1 |
| Madden, SF | 1 |
| Boylan, GB | 2 |
| Henshall, DC | 2 |
| Jimenez-Mateos, EM | 2 |
| Cleary, RT | 1 |
| Sun, H | 1 |
| Huynh, T | 1 |
| Manning, SM | 1 |
| Li, Y | 1 |
| Rotenberg, A | 1 |
| Talos, DM | 1 |
| Kahle, KT | 1 |
| Jackson, M | 1 |
| Rakhade, SN | 1 |
| Berry, G | 2 |
| Jensen, FE | 1 |
| Meng, Y | 1 |
| Xiao, Q | 1 |
| Bai, JY | 1 |
| Xiao, X | 1 |
| Zhang, S | 1 |
| Zhu, XY | 1 |
| Cheng, GF | 1 |
| Yin, DL | 1 |
| Dunleavy, M | 1 |
| Waddington, JL | 1 |
| Rekling, JC | 1 |
| CARPI, A | 1 |
| URSILLO, RC | 1 |
| BOVET, D | 1 |
| BAEDEKER, WD | 1 |
| Barac-Nieto, M | 1 |
| Constantinescu, A | 1 |
| Pina-Benabou, MH | 1 |
| Rozental, R | 1 |
| Maas, JW | 1 |
| Indacochea, RA | 1 |
| Muglia, LM | 1 |
| Tran, TT | 1 |
| Vogt, SK | 1 |
| West, T | 1 |
| Benz, A | 1 |
| Shute, AA | 1 |
| Holtzman, DM | 1 |
| Mennerick, S | 1 |
| Olney, JW | 1 |
| Muglia, LJ | 1 |
| Asimiadou, S | 1 |
| Bittigau, P | 1 |
| Felderhoff-Mueser, U | 1 |
| Manthey, D | 1 |
| Sifringer, M | 1 |
| Pesditschek, S | 1 |
| Dzietko, M | 1 |
| Kaindl, AM | 1 |
| Pytel, M | 1 |
| Studniarczyk, D | 1 |
| Mozrzymas, JW | 1 |
| Ikonomidou, C | 1 |
| King, LJ | 1 |
| Lowry, OH | 1 |
| Passonneau, JV | 1 |
| Venson, V | 1 |
| Bukowskyj, M | 1 |
| Nakatsu, K | 1 |
| Munt, PW | 1 |
| Nogen, AG | 1 |
| Fassoulaki, A | 1 |
| Eger, EI | 2 |
| Johnson, BH | 2 |
| Ferrell, LD | 2 |
| Smuckler, EA | 1 |
| Harper, MH | 1 |
| Eger, RR | 1 |
| Cahalan, MK | 1 |
| Benzi, G | 2 |
| Arrigoni, E | 2 |
| Agnoli, A | 1 |
| Raimondo, S | 2 |
| Fulle, D | 2 |
| Pastoris, O | 2 |
| Curti, D | 2 |
| Villa, RF | 2 |
| Siegers, CP | 1 |
| Frühling, A | 1 |
| Younes, M | 1 |
| Uetrecht, J | 1 |
| Wood, AJ | 1 |
| Phythyon, JM | 1 |
| Wood, M | 1 |
| Ross, WT | 2 |
| Daggy, BP | 2 |
| Gourlay, GK | 2 |
| Adams, JF | 1 |
| Cousins, MJ | 3 |
| Hall, P | 1 |
| Blösch, M | 1 |
| Ou, LC | 1 |
| Healey, J | 1 |
| Bonkowsky, HL | 1 |
| Sinclair, P | 1 |
| Alix, D | 1 |
| Riche, C | 1 |
| Bourin, M | 1 |
| Cortey, A | 1 |
| Monin, P | 1 |
| Hascoet, JM | 1 |
| Hamon, I | 1 |
| Vert, P | 1 |
| Hantson, P | 1 |
| Ziade, D | 1 |
| Evenepoel, M | 1 |
| Mahieu, P | 1 |
| Azarbayjani, F | 1 |
| Danielsson, BR | 1 |
| Starykh, EV | 1 |
| Fedin, AI | 1 |
| Oshino, N | 1 |
| Jamieson, D | 1 |
| Chance, B | 1 |
| Gorsky, BH | 1 |
| Cascorbi, HF | 1 |
| Abdul-Rahman, A | 1 |
| Dahlgren, N | 1 |
| Ingvar, M | 1 |
| Rehncrona, S | 1 |
| Siesjö, BK | 1 |
| McLain, GE | 1 |
| Sipes, IG | 2 |
| Brown, BR | 2 |
| Cardell, RR | 1 |
| Hägerdal, M | 1 |
| Welsh, FA | 1 |
| Keykhah, MM | 1 |
| Perez, E | 1 |
| Harp, JR | 1 |
| Widger, LA | 1 |
| Gandolfi, AJ | 2 |
| Van Dyke, RA | 1 |
| Goddard-Finegold, J | 1 |
| Michael, LH | 1 |
| Ruth, V | 1 |
| Virkola, K | 1 |
| Paetau, R | 1 |
| Raivio, KO | 1 |
| Getova, D | 1 |
| Georgiev, V | 1 |
| Knights, KM | 1 |
| Schieble, TM | 1 |
| Costa, AK | 1 |
| Heffel, DF | 1 |
| Trudell, JR | 1 |
| Strum, DP | 1 |
| Gelman, S | 1 |
| Becker, GL | 1 |
| Hensel, P | 1 |
| Holland, AD | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 1 |
| Plummer, JL | 1 |
| Hall, PM | 1 |
| Jenner, MA | 1 |
| Lind, RC | 1 |
| Onoe, T | 1 |
| Pincus, JH | 1 |
| Grove, I | 1 |
| Marino, BB | 1 |
| Glaser, GE | 1 |
| Sorbie, J | 1 |
| Hamilton, DL | 1 |
| Valberg, LS | 1 |
| Winston, JM | 1 |
| Creighton, JM | 1 |
| Roberts, RJ | 1 |
| Katzin, DB | 1 |
| Rubinstein, EH | 1 |
| Sonnenschein, RR | 1 |
| Thaler, MM | 1 |
| Roh, BL | 1 |
| Paulo, LG | 1 |
| Fisher, JW | 1 |
| Davies, RO | 1 |
| Lahiri, S | 1 |
| Kiese, M | 1 |
| Lenk, W | 1 |
| Snodgrass, GJ | 1 |
| Behrman, RE | 1 |
| Fisher, D | 1 |
| Paton, JB | 1 |
| Keller, J | 1 |
| Khaliq, SU | 1 |
| Kay, JM | 1 |
| Heath, D | 1 |
| Pelosi, G | 1 |
| Conti, F | 1 |
| Agliati, G | 1 |
| Wilhjelm, B | 1 |
| Langgård, H | 1 |
| Kraupp, O | 1 |
| Wilhjelm, BJ | 1 |
3 reviews available for phenobarbital and Hypoxia
| Article | Year |
|---|---|
Theophylline reassessed.
Topics: Acidosis; Aging; Allopurinol; Animals; Anti-Bacterial Agents; Breast Feeding; Bronchodilator Agents; | 1984 |
[Ultramicroscopic pathology of the liver].
Topics: Adenosine Triphosphatases; Aminopyrine; Animals; Bile; Cytoplasm; Glucose; Humans; Hypoxia; Lipoprot | 1968 |
In utero disease and the newborn infant.
Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Animals; Bilirubin; Birth Weight; Electrocardiograp | 1970 |
1 trial available for phenobarbital and Hypoxia
| Article | Year |
|---|---|
Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants.
Topics: Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Developmental Disabilities; Drug Adminis | 1988 |
58 other studies available for phenobarbital and Hypoxia
| Article | Year |
|---|---|
2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Gerbillinae; Hippocampus; Hypoxia | 1990 |
Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Hypoxia; Levetiracetam; M | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; E | 2018 |
Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Bumetanide; CA1 Region, Hippoca | 2013 |
Resolution and chiral recognition of muscone as well as actions on neural system.
Topics: Animals; Cycloparaffins; Dose-Response Relationship, Drug; Hippocampus; Hypoxia; Mice; Molecular Str | 2014 |
Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Cerebral Cortex; Electroencep | 2015 |
Neuroprotective effects of anticonvulsants in rat hippocampal slice cultures exposed to oxygen/glucose deprivation.
Topics: Acetates; Amines; Animals; Anticonvulsants; Carbamates; Carbamazepine; Cell Death; Cells, Cultured; | 2003 |
Local circulatory and metabolic factors influencing the cerebral vascular response to adrenaline in the dog.
Topics: Animals; Brain; Carbon Dioxide; Dogs; Epinephrine; Ergotamine; Humans; Hypoxia; Phenobarbital; Stryc | 1962 |
[THE EFFECT OF ANESTHESIA ON RESPIRATION AND RESPIRATORY IN METABOLISM RATS].
Topics: Anesthesia; Blood Gas Analysis; Heart; Hypoxia; Metabolism; Oximetry; Phenobarbital; Pregnanediones; | 1964 |
Hypoxic rise in cytosolic calcium and renal proximal tubule injury mediated by a nickel-sensitive pathway.
Topics: Animals; Calcium; Calcium Channel Blockers; Cytoplasm; Female; GABA Modulators; Humans; Hypoxia; Kid | 2004 |
Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain.
Topics: Adenylyl Cyclases; Anilides; Animals; Animals, Newborn; Behavior, Animal; Blotting, Western; Brain; | 2005 |
Protection with estradiol in developmental models of apoptotic neurodegeneration.
Topics: Animals; Animals, Newborn; Apoptosis; Bicuculline; Blotting, Western; Brain; Caenorhabditis elegans | 2005 |
Effects of convulsants on energy reserves in the cerebral cortex.
Topics: Animals; Centrifugation; Cerebral Cortex; Chlorpromazine; Electric Stimulation; Electroshock; Freezi | 1967 |
Neonatal seizures: a reappraisal.
Topics: Age Factors; Anticonvulsants; Electroencephalography; Female; Humans; Hypoxia; Infant, Newborn; Isch | 1984 |
Brief periods of hypoxia can produce hepatic injury in rats.
Topics: Animals; Enzyme Induction; Hypoxia; Liver Diseases; Oxygen; Phenobarbital; Rats; Rats, Inbred Strain | 1984 |
Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
Topics: Adenine Nucleotides; Aging; Animals; Dihydroergotoxine; Dogs; Female; Hypoxia; Lactates; Lactic Acid | 1982 |
Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Glutathione; Halothane; Hyperthyroidism; | 1983 |
Contrasting effects on halothane hepatotoxicity in the phenobarbital-hypoxia and triiodothyronine model: mechanistic implications.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fasting; Fluorides; Halothane; Hypoxia; Liver Disea | 1983 |
Hepatic blood flow in phenobarbital-pretreated rats during halothane anesthesia and hypoxia.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Cardiac Output; Halothane; Hypoxia; Liver | 1981 |
Genetic differences in reductive metabolism and hepatotoxicity of halothane in three rat strains.
Topics: Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Enzyme I | 1981 |
Metabolic changes induced by acute hypoxia on the synaptosomes from dog brain.
Topics: Adenine Nucleotides; Animals; Cerebral Cortex; Dogs; Female; Hypoxia; Lactates; Lactic Acid; Oxygen | 1981 |
Weight gain in young Mongolian gerbils (Meriones unguiculatus) of mothers treated with neurotropic substances, hypoxia or electroconvulsive shock.
Topics: Animals; Animals, Newborn; Body Weight; Central Nervous System Agents; Electroshock; Ethanol; Female | 1981 |
Hepatic cytochrome P-450 in chronically hypoxemic rats.
Topics: Animals; Cytochrome P-450 Enzyme System; Hemoglobins; Hypoxia; Liver; Male; Organ Size; Phenobarbita | 1980 |
[Concentrations of phenobarbital in the cerebrospinal fluid and blood of newborn infants].
Topics: Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Phenobarbital; Seizures | 1980 |
Effects of phenobarbital on cerebral blood flow during hypoxia.
Topics: Animals; Animals, Newborn; Brain; Hemodynamics; Hypoxia; Phenobarbital; Regional Blood Flow; Swine | 1994 |
Severe hypoxia and hypothermia following barbiturate poisoning.
Topics: Hemodynamics; Humans; Hypnotics and Sedatives; Hypothermia; Hypoxia; Male; Middle Aged; Phenobarbita | 1996 |
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac; | 1998 |
[The use of normobaric hypoxia in the therapy of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Humans; Hypoxia; Middle Aged; Oxygen; Oxygen Consumpti | 2002 |
The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver.
Topics: Aminopyrine; Animals; Body Weight; Catalase; Cytochrome c Group; Ethanol; Glycolates; Hydrogen Perox | 1975 |
Halothane hepatotoxicity and fluoride production in mice and rats.
Topics: Animals; Biotransformation; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Fluorides; | 1979 |
Local versus regional cerebral blood flow in the rat at high (hypoxia) and low (phenobarbital anesthesia) flow rates.
Topics: Anesthesia, General; Animals; Antipyrine; Autoradiography; Carbon Radioisotopes; Cerebrovascular Cir | 1979 |
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc | 1979 |
Hepatic necrosis caused by halothane and hypoxia in phenobarbital-treated rats.
Topics: Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Sys | 1979 |
Protective effects of combinations of hypothermia and barbiturates in cerebral hypoxia in the rat.
Topics: Animals; Brain; Carotid Arteries; Glucose; Halothane; Hypothermia, Induced; Hypoxia; Lactates; Ligat | 1978 |
Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents.
Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Halothane; Hypoxia; Lipid Metabolism; Li | 1976 |
Brain vasoactive effects of phenobarbital during hypertension and hypoxia in newborn pigs.
Topics: Animals; Animals, Newborn; Cerebrovascular Circulation; Hypertension; Hypoxia; Phenobarbital; Swine; | 1992 |
Antihypoxic effect of the hydroxylamine derivative HB-7.
Topics: Animals; Anticonvulsants; Asphyxia; Atmospheric Pressure; Hydroxylamines; Hypoxia; Mice; Pentobarbit | 1989 |
Changes in rat hepatic microsomal mixed function oxidase activity following exposure to halothane under various oxygen concentrations.
Topics: Alanine Transaminase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzy | 1987 |
Comparative toxicity of halothane, isoflurane, hypoxia, and phenobarbital induction in monolayer cultures of rat hepatocytes.
Topics: Animals; Cell Survival; Chemical and Drug Induced Liver Injury; Halothane; Hypoxia; In Vitro Techniq | 1988 |
Studies of the toxicity of I-653, halothane, and isoflurane in enzyme-induced, hypoxic rats.
Topics: Anesthetics; Animals; Desflurane; Enzyme Induction; Halothane; Hypoxia; Isoflurane; Kidney; Liver; L | 1987 |
Halothane hepatotoxicity--again?
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Guinea Pigs; Halothane; Humans; | 1986 |
Energy deficits in hepatocytes isolated from phenobarbital-treated or fasted rats and briefly exposed to halothane and hypoxia in vitro.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Animals; Energy Metabolism; Fas | 1986 |
Sex differences in halothane metabolism and hepatotoxicity in a rat model.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Biotransformation; Breath Tests; Chemical and | 1985 |
Comparison of the requirements for hepatic injury with halothane and enflurane in rats.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Temperature; Carbon Tetrachloride; Chemical | 1985 |
Studies on the mechanism of action of diphenylhydantoin.
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Crustacea; Cyanides; Hypoxia; Neurons; Oua | 1970 |
Effect of various factors on iron absorption in mice with X-linked anaemia.
Topics: Administration, Oral; Anemia, Hypochromic; Animals; Ascorbic Acid; Biological Transport; Body Weight | 1974 |
Alteration of carbon monoxide and hypoxic hypoxia-induced lethality following phenobarbital, chlorpromazine, or alcohol pretreatment.
Topics: Animals; Body Temperature; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; Chlorproma | 1974 |
Vagal control of heart rate during hypoxia in the cat.
Topics: Anesthesia; Animals; Blood Pressure; Cats; Cordotomy; Denervation; Glossopharyngeal Nerve; Heart; He | 1974 |
Neonatal hyperbilirubinemia.
Topics: Acidosis; Agar; Anemia, Hemolytic; Antibodies; Bilirubin; Blood Group Incompatibility; Blood Transfu | 1972 |
Metabolism of erythropoietin by isolated perfused livers of dogs treated with SKF 525-A.
Topics: Animals; Depression, Chemical; Dogs; Erythropoietin; Female; Hypoxia; Liver; Perfusion; Phenobarbita | 1972 |
Absence of carotid chemoreceptor response during hypoxic exercise in the cat.
Topics: Action Potentials; Anesthesia, General; Animals; Blood Pressure; Carbon Dioxide; Carotid Body; Cats; | 1973 |
Omega- and (omega-1)-hydroxylation of 4-chloropropionanilide in liver microsomes of rabbits treated with phenobarbital or 3-methylcholanthrene.
Topics: Acetophenones; Anilides; Animals; Carbon Monoxide; Chlorine; Drug Storage; Female; Hydroxylation; Hy | 1973 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Porta-pulmonary venous anastomoses in experimental cirrhosis of the liver in rats.
Topics: Animals; Arteries; Barium Sulfate; Carbon Tetrachloride; Coronary Vessels; Esophagus; Hypoxia; Liver | 1972 |
[Influence of hypoxia on the respiratory capacity of the brain of rats previously treated with luminal].
Topics: Animals; Brain Chemistry; Glucose; Humans; Hypoxia; Ketoglutaric Acids; Liver; Male; Oxygen Consumpt | 1968 |
Effects of phenobarbital, phenytoin, and anoxia on connective tissue of mice.
Topics: Animals; Collagen; Connective Tissue; Electrolytes; Fats; Hydroxyproline; Hypoxia; Liver; Mice; Phen | 1968 |
[Pharmacotherapy of states of deficient myocardial circulation. Pharmacologic aspects].
Topics: Anti-Arrhythmia Agents; Dipyridamole; Humans; Hypoxia; Myocardium; Papaverine; Phenobarbital; Vasodi | 1965 |
Effect of Tiomebumal upon resistance of mice to anoxia.
Topics: Amobarbital; Animals; Barbiturates; Brain; Carbon Dioxide; Hexobarbital; Hypoxia; Mice; Oxygen Consu | 1966 |