phenobarbital has been researched along with Hypoxia-Ischemia, Brain in 43 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this open-label, dose finding, and feasibility phase 1/2 trial, we recruited full-term infants younger than 48 h who had hypoxic ischaemic encephalopathy and electrographic seizures not responding to a loading-dose of phenobarbital from eight neonatal intensive care units across Europe." | 9.20 | Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. ( Blennow, M; Boylan, GB; Chiron, C; Cross, JH; de Vries, LS; Hallberg, B; Hellström-Westas, L; Jullien, V; Livingstone, V; Mangum, B; Marlow, N; Murphy, B; Murray, D; Pons, G; Pressler, RM; Rennie, J; Swarte, R; Toet, MC; Vanhatalo, S; Zohar, S, 2015) |
| "Nineteen term asphyxiated newborns treated with mild whole body hypothermia, started within 6 h after birth and protracted for 72 h, received phenobarbital for clinical seizures." | 9.15 | Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia. ( Cavallaro, G; Donzelli, G; Favelli, F; Filippi, L; Fiorini, P; Guerrini, R; la Marca, G; Malvagia, S, 2011) |
| "The current study uses a population modeling approach to evaluate and quantify the impact of severity of asphyxia and hypoxic-ischemic encephalopathy (HIE) on the pharmacokinetics of phenobarbital in asphyxiated newborns treated with therapeutic hypothermia." | 8.12 | Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia. ( Hronová, K; Krekels, EH; Michaličková, D; Pokorná, P; Slanař, O; Tibboel, D; Völler, S, 2022) |
| "Many neonates with hypoxic ischemic encephalopathy and seizures do not respond to the first line antiepileptic drug, phenobarbital." | 7.91 | Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures. ( Dwivedi, D; Holland, K; Kline-Fath, B; Lin, N; Schapiro, M; Venkatesan, C, 2019) |
| "Phenobarbital is the first-line treatment of seizures in asphyxiated neonates; however, due to the high pharmacokinetic variability in this population, there is no consensus on the optimal dosage regimen." | 7.88 | Estimation of initial phenobarbital dosing in term neonates with moderate-to-severe hypoxic ischaemic encephalopathy following perinatal asphyxia. ( Hartinger, J; Pokorná, P; Šíma, M; Slanař, O, 2018) |
| "The objective of this study was to determine the efficacy and safety of levetiracetam in treatment of neonatal seizures due to hypoxic ischemic encephalopathy." | 7.85 | Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy. ( Schapiro, M; Thomas, C; Venkatesan, C; Young, S, 2017) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 7.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 5.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| "After identification of seizures, infants were treated with PHB or LEV at the discretion of treating physicians." | 5.48 | A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. ( Chanlaw, T; Cho, A; Garg, M; Hussain, SA; Rao, LM; Sankar, R; Zaki, T, 2018) |
| "To provide data on the incidence of seizures and response to anticonvulsant therapies, a cohort of 90 term infants with hypoxic-ischemic encephalopathy treated at our institution between January 1, 1995, and July 1, 1999, was reviewed." | 5.31 | Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde. ( Armstrong, DL; Battin, MR, 2001) |
| "In this open-label, dose finding, and feasibility phase 1/2 trial, we recruited full-term infants younger than 48 h who had hypoxic ischaemic encephalopathy and electrographic seizures not responding to a loading-dose of phenobarbital from eight neonatal intensive care units across Europe." | 5.20 | Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. ( Blennow, M; Boylan, GB; Chiron, C; Cross, JH; de Vries, LS; Hallberg, B; Hellström-Westas, L; Jullien, V; Livingstone, V; Mangum, B; Marlow, N; Murphy, B; Murray, D; Pons, G; Pressler, RM; Rennie, J; Swarte, R; Toet, MC; Vanhatalo, S; Zohar, S, 2015) |
| "Nineteen term asphyxiated newborns treated with mild whole body hypothermia, started within 6 h after birth and protracted for 72 h, received phenobarbital for clinical seizures." | 5.15 | Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia. ( Cavallaro, G; Donzelli, G; Favelli, F; Filippi, L; Fiorini, P; Guerrini, R; la Marca, G; Malvagia, S, 2011) |
| "Phenobarbital in the dose of 20 mg/kg IV given within six hours of life to term and near-term neonates with HIE, significantly decreased the incidence of neonatal seizures and was well tolerated." | 5.11 | A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy. ( Kumar, P; Narang, A; Singh, D, 2005) |
| "The current study uses a population modeling approach to evaluate and quantify the impact of severity of asphyxia and hypoxic-ischemic encephalopathy (HIE) on the pharmacokinetics of phenobarbital in asphyxiated newborns treated with therapeutic hypothermia." | 4.12 | Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia. ( Hronová, K; Krekels, EH; Michaličková, D; Pokorná, P; Slanař, O; Tibboel, D; Völler, S, 2022) |
| "Many neonates with hypoxic ischemic encephalopathy and seizures do not respond to the first line antiepileptic drug, phenobarbital." | 3.91 | Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures. ( Dwivedi, D; Holland, K; Kline-Fath, B; Lin, N; Schapiro, M; Venkatesan, C, 2019) |
| "Phenobarbital is the first-line treatment of seizures in asphyxiated neonates; however, due to the high pharmacokinetic variability in this population, there is no consensus on the optimal dosage regimen." | 3.88 | Estimation of initial phenobarbital dosing in term neonates with moderate-to-severe hypoxic ischaemic encephalopathy following perinatal asphyxia. ( Hartinger, J; Pokorná, P; Šíma, M; Slanař, O, 2018) |
| "The objective of this study was to determine the efficacy and safety of levetiracetam in treatment of neonatal seizures due to hypoxic ischemic encephalopathy." | 3.85 | Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy. ( Schapiro, M; Thomas, C; Venkatesan, C; Young, S, 2017) |
| "Infants with hypoxic ischemic encephalopathy and suspected seizures, all treated with phenobarbital." | 3.79 | Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia. ( Barks, JD; Bhatt-Mehta, V; Dillon, CH; Ng, CM; Shellhaas, RA, 2013) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 3.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Phenobarbital is an anticonvulsive drug widely used in newborns with hypoxic-ischemic encephalopathy." | 2.80 | Effect of co-medication on the pharmacokinetic parameters of phenobarbital in asphyxiated newborns. ( Hronová, K; Pokorná, P; Šíma, M; Slanař, O, 2015) |
| "The impact of seizure activity on the developing brain and the most effective way to manage these seizures remain surprisingly poorly understood, particularly in the era of therapeutic hypothermia." | 2.72 | Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions. ( Bennet, L; Cho, KHT; Davidson, JO; Drury, PP; Gunn, AJ; Lear, CA; McDouall, A; Zhou, KQ, 2021) |
| "Secondary or reperfusion injury is potentially amenable to neuroprotective strategies." | 2.42 | Brain injury in the term infant. ( Perlman, JM, 2004) |
| " With the current recommended dosage for phenobarbitone (40 mg/kg), we have noticed that babies are drowsier and their blood levels of phenobarbitone are more than the normal expected range." | 1.72 | Comparing the effect of different loading doses of phenobarbitone on serum phenobarbitone levels in babies with neonatal seizures and effect of therapeutic hypothermia on phenobarbitone levels. ( Kumar, M; Palaparthy, V; Rebekah, G; Thomas, N, 2022) |
| "To assess pharmacokinetics and clinical anti-epileptic effectiveness of phenobarbital and midazolam in asphyxiated neonates and to develop dosing guidelines." | 1.51 | Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia. ( Cools, F; de Haan, TR; Dijk, PH; Dijkman, KP; Egberts, TCG; Favié, LMA; Groenendaal, F; Huitema, ADR; Nuytemans, DHGM; Rademaker, CMA; Rijken, M; Simons, SHP; van Bel, F; van den Broek, MPH; van der Lee, JH; van Heijst, A; van Straaten, HLM; Zecic, A; Zonnenberg, IA, 2019) |
| "After identification of seizures, infants were treated with PHB or LEV at the discretion of treating physicians." | 1.48 | A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. ( Chanlaw, T; Cho, A; Garg, M; Hussain, SA; Rao, LM; Sankar, R; Zaki, T, 2018) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 1.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| "Research studies suggest that neonatal seizures, which are most commonly associated with hypoxic-ischemic injury, may contribute to brain injury and adverse neurologic outcome." | 1.46 | Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy. ( Raol, YH; Sampath, D; Valdez, R; White, AM, 2017) |
| "Phenobarbital was the most common initial medication for all gestational age groups, and failure to respond to an initial loading dose was 63% in both preterm and term neonates." | 1.46 | Seizures in Preterm Neonates: A Multicenter Observational Cohort Study. ( Abend, NS; Bonifacio, SL; Chang, T; Chu, CJ; Cilio, MR; Glass, HC; Massey, SL; Shellhaas, RA; Soul, JS; Tsuchida, TN; Wusthoff, CJ, 2017) |
| "None of the infants without clinical seizures showed electrographic seizures." | 1.43 | Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy. ( Bashir, RA; Bello-Espinosa, L; Buchhalter, J; Espinoza, L; Irvine, L; Mohammad, K; Vayalthrikkovil, S, 2016) |
| "After adjustment for seizure burden, neonates managed during the Neonatal Neurocritical Care Service era, on average, received 30 mg/kg less cumulative phenobarbital (95% confidence interval 15-46 mg/kg) and were on maintenance 5 fewer days (95% confidence interval 3-8 days) than those who were treated prior to implementation of the service." | 1.42 | Neonatal Neurocritical Care Service Is Associated With Decreased Administration of Seizure Medication. ( Bonifacio, SL; Glass, HC; Kuzniewicz, MW; McCulloch, CE; Wietstock, SO, 2015) |
| "He developed electrographic seizures for the first time during the warming phase, which continued in the hours after rewarming." | 1.38 | Recooling for rebound seizures after rewarming in neonatal encephalopathy. ( Kendall, GS; Mathieson, S; Meek, J; Rennie, JM, 2012) |
| "Very few respondents used pyridoxine to treat recurrent seizures that were historically linked to perinatal asphyxia and hypoxic-ischaemic encephalopathy." | 1.33 | Drug treatment of neonatal seizures by neonatologists and paediatric neurologists. ( Barr, P; Carmo, KB, 2005) |
| "Our infants suggest that neonatal seizures can also occur in infants with hypoxic ischemic encephalopathy without apparent neurological abnormalities." | 1.32 | Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities. ( Hayakawa, F; Kato, T; Kuno, K; Okumura, A; Sato, Y; Watanabe, K, 2003) |
| "To provide data on the incidence of seizures and response to anticonvulsant therapies, a cohort of 90 term infants with hypoxic-ischemic encephalopathy treated at our institution between January 1, 1995, and July 1, 1999, was reviewed." | 1.31 | Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde. ( Armstrong, DL; Battin, MR, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (20.93) | 29.6817 |
| 2010's | 29 (67.44) | 24.3611 |
| 2020's | 5 (11.63) | 2.80 |
| Authors | Studies |
|---|---|
| Palaparthy, V | 1 |
| Kumar, M | 1 |
| Rebekah, G | 1 |
| Thomas, N | 1 |
| Pokorná, P | 3 |
| Michaličková, D | 1 |
| Völler, S | 1 |
| Hronová, K | 2 |
| Tibboel, D | 1 |
| Slanař, O | 3 |
| Krekels, EH | 1 |
| Soul, JS | 2 |
| Bergin, AM | 1 |
| Stopp, C | 1 |
| Hayes, B | 1 |
| Singh, A | 1 |
| Fortuno, CR | 1 |
| O'Reilly, D | 1 |
| Krishnamoorthy, K | 1 |
| Jensen, FE | 1 |
| Rofeberg, V | 1 |
| Dong, M | 1 |
| Vinks, AA | 1 |
| Wypij, D | 1 |
| Staley, KJ | 1 |
| Deshpande, P | 1 |
| Jain, A | 2 |
| McNamara, PJ | 1 |
| Zhou, KQ | 1 |
| McDouall, A | 1 |
| Drury, PP | 1 |
| Lear, CA | 1 |
| Cho, KHT | 1 |
| Bennet, L | 1 |
| Gunn, AJ | 1 |
| Davidson, JO | 1 |
| Glass, HC | 3 |
| Shellhaas, RA | 2 |
| Tsuchida, TN | 1 |
| Chang, T | 1 |
| Wusthoff, CJ | 1 |
| Chu, CJ | 1 |
| Cilio, MR | 1 |
| Bonifacio, SL | 2 |
| Massey, SL | 1 |
| Abend, NS | 1 |
| Sampath, D | 1 |
| Valdez, R | 1 |
| White, AM | 1 |
| Raol, YH | 1 |
| Šíma, M | 2 |
| Hartinger, J | 1 |
| Krishna, S | 1 |
| Hutton, A | 1 |
| Aronowitz, E | 1 |
| Moore, H | 1 |
| Vannucci, SJ | 1 |
| Quinlan, SMM | 1 |
| Rodriguez-Alvarez, N | 1 |
| Molloy, EJ | 1 |
| Madden, SF | 1 |
| Boylan, GB | 3 |
| Henshall, DC | 1 |
| Jimenez-Mateos, EM | 1 |
| Rao, LM | 1 |
| Hussain, SA | 1 |
| Zaki, T | 1 |
| Cho, A | 1 |
| Chanlaw, T | 1 |
| Garg, M | 1 |
| Sankar, R | 1 |
| Dwivedi, D | 1 |
| Lin, N | 1 |
| Venkatesan, C | 2 |
| Kline-Fath, B | 1 |
| Holland, K | 1 |
| Schapiro, M | 2 |
| Favié, LMA | 1 |
| Groenendaal, F | 1 |
| van den Broek, MPH | 1 |
| Rademaker, CMA | 1 |
| de Haan, TR | 1 |
| van Straaten, HLM | 1 |
| Dijk, PH | 1 |
| van Heijst, A | 1 |
| Simons, SHP | 1 |
| Dijkman, KP | 1 |
| Rijken, M | 1 |
| Zonnenberg, IA | 1 |
| Cools, F | 1 |
| Zecic, A | 1 |
| van der Lee, JH | 1 |
| Nuytemans, DHGM | 1 |
| van Bel, F | 1 |
| Egberts, TCG | 1 |
| Huitema, ADR | 1 |
| Vergales, BD | 1 |
| Zanelli, SA | 1 |
| Matsumoto, JA | 1 |
| Goodkin, HP | 1 |
| Lake, DE | 1 |
| Moorman, JR | 1 |
| Fairchild, KD | 1 |
| Wietstock, SO | 1 |
| McCulloch, CE | 1 |
| Kuzniewicz, MW | 1 |
| Pressler, RM | 2 |
| Marlow, N | 2 |
| Blennow, M | 2 |
| Chiron, C | 2 |
| Cross, JH | 2 |
| de Vries, LS | 2 |
| Hallberg, B | 2 |
| Hellström-Westas, L | 2 |
| Jullien, V | 2 |
| Livingstone, V | 1 |
| Mangum, B | 2 |
| Murphy, B | 2 |
| Murray, D | 2 |
| Pons, G | 2 |
| Rennie, J | 2 |
| Swarte, R | 1 |
| Toet, MC | 2 |
| Vanhatalo, S | 1 |
| Zohar, S | 2 |
| Thoresen, M | 1 |
| Sabir, H | 1 |
| Spiers, H | 1 |
| Twesigomwe, G | 1 |
| Cartledge, P | 1 |
| Ramantani, G | 1 |
| Bashir, RA | 1 |
| Espinoza, L | 1 |
| Vayalthrikkovil, S | 1 |
| Buchhalter, J | 1 |
| Irvine, L | 1 |
| Bello-Espinosa, L | 1 |
| Mohammad, K | 1 |
| Young, S | 1 |
| Thomas, C | 1 |
| Filippi, L | 2 |
| la Marca, G | 2 |
| Fiorini, P | 2 |
| Poggi, C | 1 |
| Cavallaro, G | 2 |
| Malvagia, S | 2 |
| Pellegrini-Giampietro, DE | 1 |
| Guerrini, R | 2 |
| Barks, JD | 4 |
| Liu, YQ | 1 |
| Shangguan, Y | 2 |
| Silverstein, FS | 2 |
| Meyn, DF | 1 |
| Ness, J | 1 |
| Ambalavanan, N | 1 |
| Carlo, WA | 1 |
| Gathwala, G | 1 |
| Marwah, A | 1 |
| Gahlaut, V | 1 |
| Marwah, P | 1 |
| Favelli, F | 1 |
| Donzelli, G | 1 |
| Sarkar, S | 1 |
| Bapuraj, JR | 1 |
| Bhagat, I | 1 |
| Dechert, RE | 1 |
| Schumacher, RE | 1 |
| Donn, SM | 1 |
| Sant'Anna, G | 1 |
| Laptook, AR | 1 |
| Shankaran, S | 1 |
| Bara, R | 1 |
| McDonald, SA | 1 |
| Higgins, RD | 1 |
| Tyson, JE | 1 |
| Ehrenkranz, RA | 1 |
| Das, A | 1 |
| Goldberg, RN | 1 |
| Walsh, MC | 1 |
| Liu, Y | 1 |
| Kendall, GS | 1 |
| Mathieson, S | 1 |
| Meek, J | 1 |
| Rennie, JM | 1 |
| Ng, CM | 1 |
| Dillon, CH | 1 |
| Bhatt-Mehta, V | 1 |
| Poloyac, SM | 1 |
| Empey, PE | 1 |
| Sato, Y | 1 |
| Okumura, A | 1 |
| Kato, T | 1 |
| Hayakawa, F | 1 |
| Kuno, K | 1 |
| Watanabe, K | 1 |
| Singh, D | 2 |
| Kumar, P | 2 |
| Majumdar, S | 1 |
| Narang, A | 2 |
| Perlman, JM | 1 |
| Carmo, KB | 1 |
| Barr, P | 1 |
| Agarwal, R | 1 |
| Deorari, AK | 1 |
| Paul, VK | 1 |
| Stola, A | 1 |
| Perlman, J | 1 |
| Armstrong, DL | 1 |
| Battin, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NEMO1: An Open Label Exploratory Dose Finding and Pharmacokinetic Clinical Trial of Bumetanide for the Treatment of Neonatal Seizure Using Medication Off-patent[NCT01434225] | Phase 1/Phase 2 | 14 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Safety and Efficacy of Oral Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia: a Pilot Study of the Neonatal Neuroprotection of Asphyxiated Tuscan Infants (NeoNATI) Network[NCT01241019] | Phase 2 | 64 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for phenobarbital and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions.
Topics: Animals; Anticonvulsants; Brain; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Phenobarbita | 2021 |
Question 1: Phenobarbital for preventing mortality and morbidity in full-term newborns with perinatal asphyxia in a resource-poor setting.
Topics: Asphyxia Neonatorum; Humans; Hypnotics and Sedatives; Hypoxia-Ischemia, Brain; Infant, Newborn; Morb | 2015 |
Brain injury in the term infant.
Topics: Cell Death; Cerebral Infarction; Humans; Hypnotics and Sedatives; Hypothermia, Induced; Hypoxia-Isch | 2004 |
Post-resuscitation strategies to avoid ongoing injury following intrapartum hypoxia-ischemia.
Topics: Anticonvulsants; Blood Pressure; Female; Fetal Hypoxia; Fluid Therapy; Humans; Hyperglycemia; Hypogl | 2008 |
7 trials available for phenobarbital and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Topics: Anticonvulsants; Bumetanide; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; | 2021 |
Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.
Topics: Bumetanide; Drug Administration Schedule; Drug Synergism; Early Termination of Clinical Trials; Feas | 2015 |
Effect of co-medication on the pharmacokinetic parameters of phenobarbital in asphyxiated newborns.
Topics: Analgesics; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypoxia-I | 2015 |
Effect of high-dose phenobarbital on oxidative stress in perinatal asphyxia: an open label randomized controlled trial.
Topics: Asphyxia Neonatorum; Glutathione Peroxidase; Hospitals, Teaching; Humans; Hypoxia-Ischemia, Brain; I | 2011 |
Phenobarbital for neonatal seizures in hypoxic ischemic encephalopathy: a pharmacokinetic study during whole body hypothermia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Body Temperature; Humans; Hypothermia, Induced; Hypoxia-Ischem | 2011 |
Effect of phenobarbital on free radicals in neonates with hypoxic ischemic encephalopathy--a randomized controlled trial.
Topics: Anticonvulsants; Female; Free Radicals; Glutathione Peroxidase; Humans; Hypoxia-Ischemia, Brain; Inf | 2004 |
A randomized controlled trial of phenobarbital in neonates with hypoxic ischemic encephalopathy.
Topics: Anticonvulsants; Female; Free Radicals; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Nerv | 2005 |
32 other studies available for phenobarbital and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Comparing the effect of different loading doses of phenobarbitone on serum phenobarbitone levels in babies with neonatal seizures and effect of therapeutic hypothermia on phenobarbitone levels.
Topics: Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant; Infant, Newborn; Infant, Newborn, Dis | 2022 |
Severity parameters for asphyxia or hypoxic-ischemic encephalopathy do not explain inter-individual variability in the pharmacokinetics of phenobarbital in newborns treated with therapeutic hypothermia.
Topics: Adult; Asphyxia; Asphyxia Neonatorum; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, | 2022 |
Effect of Phenobarbitone on Amplitude-Integrated Electroencephalography in Neonates with Hypoxic-Ischemic Encephalopathy during Hypothermia.
Topics: Adolescent; Electroencephalography; Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Bra | 2020 |
Seizures in Preterm Neonates: A Multicenter Observational Cohort Study.
Topics: Anticonvulsants; Brain; Electroencephalography; Female; Gestational Age; Humans; Hypoxia-Ischemia, B | 2017 |
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease P | 2017 |
Estimation of initial phenobarbital dosing in term neonates with moderate-to-severe hypoxic ischaemic encephalopathy following perinatal asphyxia.
Topics: Asphyxia; Female; Gestational Age; Half-Life; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male | 2018 |
The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain Injuries; Disease Models, Animal | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; E | 2018 |
A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy.
Topics: Anticonvulsants; Electroencephalography; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Bra | 2018 |
Clinical, Neuroimaging, and Electrographic Predictors of Phenobarbital Failure in Newborns With Hypoxic Ischemic Encephalopathy and Seizures.
Topics: Anticonvulsants; Brain; Electroencephalography; Female; Humans; Hypoxia-Ischemia, Brain; Infant, New | 2019 |
Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Drug Interactions; Drug Therapy, Combination; Female; Humans; | 2019 |
Depressed heart rate variability is associated with abnormal EEG, MRI, and death in neonates with hypoxic ischemic encephalopathy.
Topics: Anticonvulsants; Body Temperature; Electroencephalography; Heart Rate; Humans; Hypothermia, Induced; | 2014 |
Neonatal Neurocritical Care Service Is Associated With Decreased Administration of Seizure Medication.
Topics: Cohort Studies; Electroencephalography; Female; Humans; Hypnotics and Sedatives; Hypothermia, Induce | 2015 |
Bumetanide for treatment of seizures in neonates.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Epilepsy: Neonatal seizures still lack safe and effective treatment.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Bumetanide for neonatal seizures-back from the cotside.
Topics: Bumetanide; Female; Humans; Hypoxia-Ischemia, Brain; Male; Phenobarbital; Seizures | 2015 |
Of Phenobarbital for Neonatal Seizures: Response Rate and Refractoriness Predictors.
Topics: Anticonvulsants; Electroencephalography; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Phenobarb | 2016 |
Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy.
Topics: Anticonvulsants; Brain; Cost of Illness; Electroencephalography; Female; Humans; Hypothermia, Induce | 2016 |
Levetiracetam for the Treatment of Seizures in Neonatal Hypoxic Ischemic Encephalopathy.
Topics: Adult; Anticonvulsants; Female; Follow-Up Studies; Humans; Hypothermia, Induced; Hypoxia-Ischemia, B | 2017 |
Topiramate concentrations in neonates treated with prolonged whole body hypothermia for hypoxic ischemic encephalopathy.
Topics: Asphyxia Neonatorum; Combined Modality Therapy; Drug Therapy, Combination; Female; Fructose; Humans; | 2009 |
Phenobarbital augments hypothermic neuroprotection.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Hypothe | 2010 |
Prophylactic phenobarbital and whole-body cooling for neonatal hypoxic-ischemic encephalopathy.
Topics: Anticonvulsants; Child, Preschool; Cold Temperature; Excitatory Amino Acid Antagonists; Female; Huma | 2010 |
Does phenobarbital improve the effectiveness of therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy?
Topics: Asphyxia Neonatorum; Brain; Combined Modality Therapy; Female; Humans; Hypothermia, Induced; Hypoxia | 2012 |
Phenobarbital and temperature profile during hypothermia for hypoxic-ischemic encephalopathy.
Topics: Anticonvulsants; Body Temperature; Cold Temperature; Female; Humans; Hypothermia, Induced; Hypoxia-I | 2012 |
Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model.
Topics: Animals; Animals, Newborn; Bumetanide; Disease Models, Animal; Drug Synergism; Hypothermia, Induced; | 2012 |
Recooling for rebound seizures after rewarming in neonatal encephalopathy.
Topics: Anticonvulsants; Combined Modality Therapy; Electroencephalography; Humans; Hypothermia, Induced; Hy | 2012 |
Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia.
Topics: Age Factors; Anticonvulsants; Body Temperature; Body Weight; Female; Humans; Hypothermia, Induced; H | 2013 |
Drug dosing during hypothermia: to adjust, or not to adjust, that is the question.
Topics: Anticonvulsants; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Male; Phenobarbital | 2013 |
Hypoxic ischemic encephalopathy associated with neonatal seizures without other neurological abnormalities.
Topics: Anticonvulsants; Brain; Electroencephalography; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Ma | 2003 |
Drug treatment of neonatal seizures by neonatologists and paediatric neurologists.
Topics: Anticonvulsants; Benzodiazepines; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infant, Newborn, | 2005 |
Post-resuscitation management of asphyxiated neonates.
Topics: Anticonvulsants; Asphyxia Neonatorum; Calcium; Cardiotonic Agents; Dobutamine; Drug Therapy, Combina | 2008 |
Pervasive seizures caused by hypoxic-ischemic encephalopathy: treatment with intravenous paraldehyde.
Topics: Anticonvulsants; Cohort Studies; Diazepam; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Infusio | 2001 |