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phenobarbital and Hypotension

phenobarbital has been researched along with Hypotension in 21 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels."9.08Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998)
"Phenobarbital sodium (PhS) has been used in anticonvulsant concentrations in premature newborns in attempts to prevent peri- and intraventricular hemorrhages (PIVH)."5.29Phenobarbital and cerebral blood flow during hypotension in newborn pigs. ( Contant, CF; Goddard-Finegold, J; Martin, CG; Michael, LH; Yamashita, Y, 1993)
"We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels."5.08Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998)
"Pentobarbital is standard treatment for refractory status epilepticus (SE) and is almost uniformly effective, but the morbidity of treatment and the mortality of refractory SE are high."3.69Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. ( Drislane, FW; Krishnamurthy, KB, 1996)
"Enuresis is a common problem often treated effectively with imipramine hydrochloride."3.66Treatment of imipramine overdose in children. ( Cromie, WJ; Greene, AS, 1981)
"Phenobarbital has been shown to be an effective adjunctive therapy for AWS, reducing benzodiazepine use, in the emergency department."1.56Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit. ( Lam, SW; Nguyen, TA, 2020)
"Phenobarbital sodium (PhS) has been used in anticonvulsant concentrations in premature newborns in attempts to prevent peri- and intraventricular hemorrhages (PIVH)."1.29Phenobarbital and cerebral blood flow during hypotension in newborn pigs. ( Contant, CF; Goddard-Finegold, J; Martin, CG; Michael, LH; Yamashita, Y, 1993)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199015 (71.43)18.7374
1990's3 (14.29)18.2507
2000's1 (4.76)29.6817
2010's0 (0.00)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Staidle, A1
Geier, C1
Nguyen, TA1
Lam, SW1
KROGSGAARD, AR2
KFOGSGAARD, AR1
MEDVEDEV, Ia1
ROVINA, AK1
OSTAPENKO, GI1
SEKIYA, A1
VAUGHANWILLIAMS, EM1
Lal, R1
Faiz, S1
Garg, RK1
Baweja, KS1
Guntupalli, J1
Finkel, KW1
Griffith, PA1
Karp, HR1
Greene, AS1
Cromie, WJ1
Yamashita, Y1
Goddard-Finegold, J1
Contant, CF1
Martin, CG1
Michael, LH1
Krishnamurthy, KB1
Drislane, FW1
Stecker, MM1
Kramer, TH1
Raps, EC1
O'Meeghan, R1
Dulaney, E1
Skaar, DJ1
Boldyrev, AI1
Fleĭs, EP1
Vaĭntrub, MIa1
Diehl, LW1
Bosl, R1
Shideman, JR1
Meyer, RM1
Buselmeier, TJ1
von Hartitzsch, B1
Kjellstrand, CM1
López, C1
Jiménez, W1
Arroyo, V1
La Villa, G1
Gaya, J1
Clària, J1
Rivera, F1
Rodés, J1
Tsueda, K1
Jean-Francois, J1
Richter, RW1
Ponessa, JT1
De Boer, B1
Sheffer, AL1
Bell, DS1
Nilsson, L1

Trials

1 trial available for phenobarbital and Hypotension

ArticleYear
Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings.
    Epilepsia, 1998, Volume: 39, Issue:1

    Topics: Adult; Aged; Barbiturates; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combinati

1998

Other Studies

20 other studies available for phenobarbital and Hypotension

ArticleYear
Phenobarbital and/or benzodiazepines for recurrent alcohol withdrawal: A self-controlled, retrospective cohort study.
    The American journal of emergency medicine, 2022, Volume: 54

    Topics: Alcoholism; Benzodiazepines; Humans; Hypotension; Phenobarbital; Retrospective Studies; Substance Wi

2022
Phenobarbital and symptom-triggered lorazepam versus lorazepam alone for severe alcohol withdrawal in the intensive care unit.
    Alcohol (Fayetteville, N.Y.), 2020, Volume: 82

    Topics: Adult; Aged; Alcoholism; Central Nervous System Agents; Drug Therapy, Combination; Ethanol; Female;

2020
[Effect of reserpine in lowering blood pressure compared with phenemal and placebo; preliminary study].
    Ugeskrift for laeger, 1956, Oct-04, Volume: 118, Issue:40

    Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypotension; Phenobarbital; Reserpine

1956
[Effect of reserpine in lowering blood pressure compared with phenemal and placebo; preliminary study].
    Ugeskrift for laeger, 1956, Oct-04, Volume: 118, Issue:40

    Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypotension; Phenobarbital; Reserpine

1956
[Effect of reserpine in lowering blood pressure compared with phenemal and placebo; preliminary study].
    Ugeskrift for laeger, 1956, Oct-04, Volume: 118, Issue:40

    Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypotension; Phenobarbital; Reserpine

1956
[Effect of reserpine in lowering blood pressure compared with phenemal and placebo; preliminary study].
    Ugeskrift for laeger, 1956, Oct-04, Volume: 118, Issue:40

    Topics: Blood Pressure; Blood Pressure Determination; Humans; Hypotension; Phenobarbital; Reserpine

1956
Hypotensive effect of reserpine compared with phenobarbital and placebo.
    Acta medica Scandinavica, 1957, Jun-05, Volume: 157, Issue:5

    Topics: Humans; Hypertension; Hypotension; Phenobarbital; Reserpine

1957
[ANESTHESIA IN OPERATIONS FOR AORTIC COARCTATION].
    Vestnik khirurgii imeni I. I. Grekova, 1964, Volume: 92

    Topics: Adolescent; Anesthesia; Anesthesia, Intravenous; Aortic Coarctation; Blood Transfusion; Child; Elect

1964
CENTRAL AND PERIPHRAL ACTIONS OF PRONETHALOL.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Arrhythmias, Cardiac; Blood Pressure; Chloroform; Electrocardiography; Epinephrine; Ethanolamines; E

1965
Use of continuous venovenous hemodiafiltration in a case of severe phenobarbital poisoning.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2006, Volume: 48, Issue:2

    Topics: Coma; Drug Overdose; Hemodiafiltration; Humans; Hypnotics and Sedatives; Hypotension; Male; Middle A

2006
Lorazepam in therapy for status epilepticus.
    Annals of neurology, 1980, Volume: 7, Issue:5

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Apnea; Drug Therapy, Combination; Humans; Hypotension; Loraz

1980
Treatment of imipramine overdose in children.
    Urology, 1981, Volume: 18, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschool; Coma; Diazepam; Drug Administrat

1981
Phenobarbital and cerebral blood flow during hypotension in newborn pigs.
    Pediatric research, 1993, Volume: 33, Issue:6

    Topics: Animals; Animals, Newborn; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Hypoten

1993
Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus.
    Epilepsia, 1996, Volume: 37, Issue:9

    Topics: Adult; Anesthetics, Intravenous; Electroencephalography; Humans; Hypotension; Infusions, Intravenous

1996
[Neurologic complications following medical treatment of epileptic patients].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1979, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey

1979
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1977, Jun-24, Volume: 119, Issue:25

    Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T

1977
Effects and complications of high efficiency dialysis.
    Nephron, 1975, Volume: 15, Issue:2

    Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypote

1975
Role of altered systemic hemodynamics in the blunted renal response to atrial natriuretic peptide in rats with cirrhosis and ascites.
    Journal of hepatology, 1989, Volume: 9, Issue:2

    Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Hemodynamics; Hypotension; Infus

1989
Cardiac standstill in tetanus: review of seven consecutive cases.
    International surgery, 1973, Volume: 58, Issue:9

    Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Arrest; Heroin Dependence; Humans; H

1973
The effect of reserpine and syrosingopine upon pentobarbital depression.
    Archives internationales de pharmacodynamie et de therapie, 1966, Volume: 164, Issue:1

    Topics: Animals; Blood Pressure; Body Temperature; Central Nervous System; Drug Synergism; Hypotension; Hypo

1966
Treatment of anaphylaxis.
    Postgraduate medicine, 1973, Volume: 53, Issue:4

    Topics: Anaphylaxis; Desensitization, Immunologic; Diphenhydramine; Drug Hypersensitivity; Ephedrine; Epinep

1973
Dangers of treatment of status epilepticus with diazepam.
    British medical journal, 1969, Jan-18, Volume: 1, Issue:5637

    Topics: Adolescent; Adult; Aged; Cheyne-Stokes Respiration; Child; Diazepam; Drug Antagonism; Epilepsies, Pa

1969
The influence of barbiturate anaesthesia upon the energy state and upon acid-base parameters of the brain in arterial hypotension and in asphyxia.
    Acta neurologica Scandinavica, 1971, Volume: 47, Issue:2

    Topics: Acid-Base Equilibrium; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anest

1971