phenobarbital has been researched along with Hypocalcemia in 31 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hypocalcemia: Reduction of the blood calcium below normal. Manifestations include hyperactive deep tendon reflexes, Chvostek's sign, muscle and abdominal cramps, and carpopedal spasm. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of loss of seizure control due to hypocalcemia resulting from long-term treatment with phenytoin and phenobarbital." | 3.72 | Loss of seizure control due to anticonvulsant-induced hypocalcemia. ( Al-Busairi, WA; Al-Bustan, MA; Al-Mulla, FA; Ali, FE, 2004) |
| "Residents of an institution for the developmentally disabled in northwest Ohio receiving anticonvulsant therapy for six months or more with phenobarbital or phenytoin or both were studied for the prevalence of hypocalcemia and elevated alkaline phosphatase level." | 3.67 | Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy. ( Nordlund, DJ; Rodgers, LA; Schmitt, BP, 1984) |
| " Those seizures had been wrongly attributed to a primary epilepsy of a neurologic origin and a treatment with Phenobarbital had been instituted." | 3.66 | [Amicrobic pustulosis hypoparathyroidism epilepsy: treatment by 25-hydroxycholecalciferol]. ( Barthelme, D; Beurey, J; Chaulieu, Y; Vignaud, JM; Weber, M, 1980) |
| "He had seizures since the newborn period and he had been treated with phenobarbital but there was no favorable response to therapy." | 1.51 | Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions. ( Alan, B; Ceylaner, S; Kasapkara, CS; Kurt, ANÇ; Nergız, ME; Özlü, SG; Yılmaz, S, 2019) |
| "Subtle seizures are the commonest type of seizures occurring in the neonatal period." | 1.36 | Management of neonatal seizures. ( Agarwal, R; Deorari, A; Paul, VK; Sankar, JM, 2010) |
| " Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone." | 1.25 | Disturbance of calcium metabolism by anticonvulsant drugs. ( Richens, A; Rowe, DJ, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (80.65) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 1 (3.23) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Özlü, SG | 1 |
| Kasapkara, CS | 1 |
| Ceylaner, S | 1 |
| Nergız, ME | 1 |
| Alan, B | 1 |
| Yılmaz, S | 1 |
| Kurt, ANÇ | 1 |
| Awa, HD | 1 |
| Chelo, D | 1 |
| Kinkela, MN | 1 |
| Ndombo, PO | 1 |
| Formosa, N | 1 |
| Torpiano, J | 1 |
| Allgrove, J | 1 |
| Dattani, MT | 1 |
| Sankar, JM | 1 |
| Agarwal, R | 1 |
| Deorari, A | 1 |
| Paul, VK | 1 |
| Ali, FE | 1 |
| Al-Bustan, MA | 1 |
| Al-Busairi, WA | 1 |
| Al-Mulla, FA | 1 |
| Schmitt, BP | 1 |
| Nordlund, DJ | 1 |
| Rodgers, LA | 1 |
| Richards, GE | 1 |
| Brewer, ED | 1 |
| Conley, SB | 1 |
| Saldana, LR | 1 |
| Beurey, J | 1 |
| Weber, M | 1 |
| Barthelme, D | 1 |
| Vignaud, JM | 1 |
| Chaulieu, Y | 1 |
| Ammendola, A | 1 |
| Errico, ET | 1 |
| Iannaccone, S | 1 |
| Valerio, P | 1 |
| Tata, MR | 1 |
| Tillmann, F | 1 |
| Kruppa, E | 1 |
| Grün, R | 1 |
| Blaschke, S | 1 |
| Delling, G | 1 |
| Turner, TL | 1 |
| Cockburn, F | 2 |
| Forfar, JO | 1 |
| Maclay, E | 1 |
| Hadden, DR | 1 |
| McIlrath, EM | 1 |
| Nesbitt, GS | 1 |
| Hosking, DJ | 1 |
| Williams, A | 1 |
| Godwin-Austen, RB | 1 |
| Allison, SP | 1 |
| Friis, B | 1 |
| Sardemann, H | 1 |
| Holden, KR | 1 |
| Freeman, JM | 2 |
| Scheffner, D | 1 |
| Banister, A | 1 |
| Matin-Siddiqi, SA | 1 |
| Hatcher, GW | 1 |
| Vining, EP | 1 |
| Aryanpur, I | 1 |
| Farhoudi, A | 1 |
| Zangeneh, F | 1 |
| Sotaniemi, EA | 1 |
| Hakkarainen, HK | 1 |
| Puranen, JA | 1 |
| Lahti, RO | 1 |
| Kraft, D | 1 |
| von Herrath, D | 1 |
| Schaefer, K | 1 |
| Josephson, DA | 1 |
| Hahn, TJ | 1 |
| Hendin, BA | 1 |
| Scharp, CR | 1 |
| Haddad, JG | 1 |
| Volpe, J | 1 |
| Turner, T | 1 |
| Snodgrass, GJ | 1 |
| Ray, AK | 1 |
| Rao, DB | 1 |
| Harris, M | 1 |
| Jenkins, MV | 1 |
| Wills, MR | 1 |
| Viukari, NM | 1 |
| Kauko, K | 1 |
| Tammisto, P | 1 |
| Richens, A | 1 |
| Rowe, DJ | 1 |
| Schaaf, M | 1 |
| Payne, CA | 1 |
3 reviews available for phenobarbital and Hypocalcemia
| Article | Year |
|---|---|
Neonatal seizures and their treatment.
Topics: Anticonvulsants; Diazepam; Humans; Hypocalcemia; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 1975 |
Seizures which are not epilepsy.
Topics: Child, Preschool; Epilepsies, Partial; Fever; Humans; Hypocalcemia; Hypoglycemia; Infant; Infant, Ne | 1985 |
Neonatal Seizures.
Topics: Birth Injuries; Calcium; Congenital Abnormalities; Glucose; Humans; Hypocalcemia; Hypoglycemia; Infa | 1973 |
3 trials available for phenobarbital and Hypocalcemia
| Article | Year |
|---|---|
Magnesium therapy in neonatal tetany.
Topics: Administration, Oral; Calcium; Drug Evaluation; Humans; Hypocalcemia; Infant, Newborn; Infant, Newbo | 1977 |
Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Clinical Trials as Topic; Epilepsy; Ergocalci | 1972 |
Proceedings: Comparisons of phenobarbitone, magnesium sulphate, and calcium gluconate in treatment of neonatal hypocalcaemic convulsions.
Topics: Administration, Oral; Calcium; Clinical Trials as Topic; Gluconates; Humans; Hypocalcemia; Infant, N | 1974 |
25 other studies available for phenobarbital and Hypocalcemia
| Article | Year |
|---|---|
Mild hypotonia and recurrent seizures in an 8-month-old boy: Questions.
Topics: Calcium; Humans; Hypocalcemia; Infant; Magnesium; Male; Muscle Hypotonia; Phenobarbital; Seizures; T | 2019 |
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
Anticonvulsant treatment associated with intractable hypocalcaemia in a female child with hypoparathyroidism.
Topics: Anticonvulsants; Drug Interactions; Female; Humans; Hydroxycholecalciferols; Hypercalcemia; Hypocalc | 2015 |
Management of neonatal seizures.
Topics: Anticonvulsants; Benzodiazepines; Electroencephalography; Epilepsies, Myoclonic; Humans; Hypocalcemi | 2010 |
Loss of seizure control due to anticonvulsant-induced hypocalcemia.
Topics: Adult; Anticonvulsants; Humans; Hypocalcemia; Male; Phenobarbital; Phenytoin; Seizures; Vitamin D De | 2004 |
Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Calcium; Child; Female; Humans; Hypocalcemia; Male; Middle | 1984 |
Combined hypothyroidism and hypoparathyroidism in an infant after maternal 131I administration.
Topics: Carcinoma; Female; Humans; Hypocalcemia; Hypoparathyroidism; Hypothyroidism; Infant; Infant, Newborn | 1981 |
[Amicrobic pustulosis hypoparathyroidism epilepsy: treatment by 25-hydroxycholecalciferol].
Topics: Adolescent; Calcifediol; Diagnosis, Differential; Epilepsy; Humans; Hydroxycholecalciferols; Hypocal | 1980 |
[Epilepsy and hypocalcemia. Further considerations on a case].
Topics: Adult; Calcium; Epilepsy; Female; Goiter; Humans; Hypocalcemia; Hypoparathyroidism; Phenobarbital; P | 1981 |
[Increased fracture risk in a 67-year-old patient with hypocalcemia of unknown etiology].
Topics: Aged; Anticonvulsants; Biopsy; Bone and Bones; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Fe | 1999 |
Hypocalcaemia and secondary hyperparathyroidism in institutionalised mentally-retarded patients receiving anticonvulsant drugs: a survey of 292 patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hydroxycholecalci | 1978 |
Osteomalacia presenting as chorea.
Topics: Adolescent; Alkaline Phosphatase; Chorea; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; H | 1975 |
Neonatal hypocalcaemia after intrauterine exposure to anticonvulsant drugs.
Topics: Adult; Female; Humans; Hypocalcemia; Infant, Newborn; Infant, Newborn, Diseases; Male; Maternal-Feta | 1977 |
[Clinical picture and therapy of epilepsy in childhood].
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Hu | 1975 |
Treatment of hypernatraemic dehydration in infancy.
Topics: Bicarbonates; Body Weight; Dehydration; Gastroenteritis; Humans; Hyperglycemia; Hypernatremia; Hypoc | 1975 |
Congestive heart failure secondary to idiopathic hypoparathyroidism.
Topics: Adolescent; Calcium; Diagnostic Errors; Digoxin; Electrocardiography; Electroencephalography; Epilep | 1974 |
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D | 1972 |
[Anticonvulsants and vitamin D metabolism (author's transl)].
Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol | 1974 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Calcium metabolism in elderly epileptic patients during anticonvulsant therapy.
Topics: Aged; Alkaline Phosphatase; Calcium; Cerebrovascular Disorders; Drug Therapy, Combination; Epilepsy; | 1974 |
Phenytoin inhibition of parathyroid hormone induced bone resorption in vitro.
Topics: Animals; Bone Resorption; Calcium; Calcium Radioisotopes; Culture Media; Culture Techniques; Hypocal | 1974 |
Anticonvulsant hypocalcaemia.
Topics: Calcium; Epilepsy; Humans; Hypocalcemia; Phenobarbital; Phenytoin | 1972 |
Disturbance of calcium metabolism by anticonvulsant drugs.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Calcium Metabolism Disorders; Enzyme | 1970 |
Effect of diphenylhydantoin and phenobarbital on overt and latent tetany.
Topics: Adolescent; Adult; Aged; Blood; Calcium; Child; Drug Synergism; Female; Humans; Hypocalcemia; Hypopa | 1966 |