phenobarbital has been researched along with Hypertrophy in 37 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phenobarbital treatment of experimental animals induces cytochrome P450 enzymes, and thus acts as a growth stimulus to the liver with both hyperplasia and hypertrophy; cessation results in reversion of liver to normal size with apoptosis playing a role." | 7.69 | Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice. ( Alison, MR; Edwards, RJ; Horgan, M; Sarraf, CE, 1997) |
| "Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat." | 7.68 | Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. ( Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW, 1991) |
| "Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes." | 5.31 | Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. ( Gallavan, RH; Goodman, JI; Jean, PA; Kolesar, GB; McKim, JM; Meeker, LS; Meeks, RG; Schoonhoven, R; Swenberg, JA; Wilga, PC, 2001) |
| "In the case of PB treatment, the hepatomegaly was found to be partly due to hypertrophy and partly to hyperplasia after 2 weeks of treatment." | 5.30 | The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. ( Carthew, P; Edwards, RE; Nolan, BM, 1998) |
| "Phenobarbital (PB) is a non-genotoxic liver tumor promoter used extensively in initiation-promotion protocols." | 5.30 | Phenobarbital promotes liver growth in c-myc/TGF-alpha transgenic mice by inducing hypertrophy and inhibiting apoptosis. ( Sanders, S; Thorgeirsson, SS, 1999) |
| "Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia." | 3.76 | Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. ( Bower, CC; Elcombe, CR; Henderson, CJ; Plummer, SM; Rode, A; Ross, J; Scheer, N; Vogel, O; Wolf, CR, 2010) |
| " Phenobarbital caused follicular cell hypertrophy and hyperplasia in the thyroid and centrilobular hypertrophy in the liver, without effects on serum triiodotyronine (T(3)), thyroxine (T(4)) levels." | 3.74 | Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats. ( Coelho-Palermo Cunha, G; van Ravenzwaay, B, 2007) |
| " The induction characteristics of SK&F 86002 were compared to those of the classical inducer, phenobarbital, and morphological features of both SK&F 86002 and phenobarbital induced hepatocellular hypertrophy were quantitated." | 3.68 | Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat. ( Howard, MO; Newton, JF; Qualls, CW; Schwartz, LW; Ventre, JR; Yodis, LA, 1991) |
| "Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phenobarbital (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism and the thyroid hypertrophy and follicular cell adenomas which it produces in this strain of rat." | 3.68 | Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat. ( Deluca, JG; Germershausen, JI; Gerson, RJ; Gordon, LR; Grossman, SJ; MacDonald, JS; Majka, JA; Smith, PF; Wang, RW, 1991) |
| " We induced cirrhosis with hypertrophy in rats by simultaneous treatment with CCl4 and phenobarbital (PB) and devised a hierarchy of structure applicable to the sampling and morphometric analysis of untreated and PB-treated control livers and of cirrhotic livers." | 3.66 | A morphometric analysis of the hypertrophy of experimental liver cirrhosis. ( Buschmann, RJ; Ryoo, JW, 1983) |
| "6) activity, measured as [14C]delta1 -pyrroline formation from [14C]putrescine, was studied in homogenates of rat kidney during compensatory hypertrophy after unilateral nephrectomy." | 3.66 | Induction of diamine oxidase activity in rat kidney during compensatory hypertrophy. ( Desiderio, MA; Perin, A; Sessa, A, 1982) |
| "Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes." | 1.31 | Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. ( Gallavan, RH; Goodman, JI; Jean, PA; Kolesar, GB; McKim, JM; Meeker, LS; Meeks, RG; Schoonhoven, R; Swenberg, JA; Wilga, PC, 2001) |
| "In the case of PB treatment, the hepatomegaly was found to be partly due to hypertrophy and partly to hyperplasia after 2 weeks of treatment." | 1.30 | The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. ( Carthew, P; Edwards, RE; Nolan, BM, 1998) |
| "Phenobarbital (PB) is a non-genotoxic liver tumor promoter used extensively in initiation-promotion protocols." | 1.30 | Phenobarbital promotes liver growth in c-myc/TGF-alpha transgenic mice by inducing hypertrophy and inhibiting apoptosis. ( Sanders, S; Thorgeirsson, SS, 1999) |
| "The phenobarbital-induced increase in the phospholipid and cytochrome P-450 content of the microsomes, as well as in the activities of microsomal reduced nicotinamide-adenine dinucleotide phosphate-cytochrome c reductase and N-demethylase, was correlated with the morphometric data on the endoplasmic reticulum." | 1.25 | Correlated morphometric and biochemical studies on the liver cell. II. Effects of phenobarbital on rat hepatocytes. ( Hess, R; Stäubli, W; Weibel, ER, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (59.46) | 18.7374 |
| 1990's | 8 (21.62) | 18.2507 |
| 2000's | 5 (13.51) | 29.6817 |
| 2010's | 2 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asaoka, Y | 1 |
| Togashi, Y | 1 |
| Mutsuga, M | 1 |
| Imura, N | 1 |
| Miyoshi, T | 1 |
| Miyamoto, Y | 1 |
| Ross, J | 1 |
| Plummer, SM | 1 |
| Rode, A | 1 |
| Scheer, N | 1 |
| Bower, CC | 1 |
| Vogel, O | 1 |
| Henderson, CJ | 1 |
| Wolf, CR | 1 |
| Elcombe, CR | 1 |
| Amacher, DE | 1 |
| Adler, R | 1 |
| Herath, A | 1 |
| Townsend, RR | 1 |
| Peffer, RC | 1 |
| Moggs, JG | 1 |
| Pastoor, T | 1 |
| Currie, RA | 1 |
| Wright, J | 1 |
| Milburn, G | 1 |
| Waechter, F | 1 |
| Rusyn, I | 1 |
| Coelho-Palermo Cunha, G | 1 |
| van Ravenzwaay, B | 1 |
| Kunz, HW | 1 |
| Tennekes, HA | 1 |
| Port, RE | 1 |
| Schwartz, M | 1 |
| Lorke, D | 1 |
| Schaude, G | 3 |
| Ryoo, JW | 1 |
| Buschmann, RJ | 1 |
| Desiderio, MA | 1 |
| Sessa, A | 1 |
| Perin, A | 1 |
| Kunz, W | 1 |
| Schwarz, M | 1 |
| Tennekes, H | 1 |
| Aduri, PR | 1 |
| Patil, SB | 1 |
| Sarraf, CE | 1 |
| Horgan, M | 1 |
| Edwards, RJ | 1 |
| Alison, MR | 1 |
| Grossman, HJ | 1 |
| Grossman, VL | 1 |
| Bhathal, PS | 1 |
| Carthew, P | 1 |
| Edwards, RE | 1 |
| Nolan, BM | 1 |
| Sanders, S | 1 |
| Thorgeirsson, SS | 1 |
| Hood, A | 1 |
| Hashmi, R | 1 |
| Klaassen, CD | 1 |
| Tsuchiya, Y | 1 |
| Ohno, H | 1 |
| Satoh, H | 1 |
| Sugawara, T | 1 |
| Kajimura, T | 1 |
| Nomura, M | 1 |
| McKim, JM | 1 |
| Kolesar, GB | 1 |
| Jean, PA | 1 |
| Meeker, LS | 1 |
| Wilga, PC | 1 |
| Schoonhoven, R | 1 |
| Swenberg, JA | 1 |
| Goodman, JI | 1 |
| Gallavan, RH | 1 |
| Meeks, RG | 1 |
| Hutterer, F | 1 |
| Dressler, K | 1 |
| Greim, H | 1 |
| Czygan, P | 1 |
| Schaffner, F | 1 |
| Popper, H | 1 |
| Manen, CA | 1 |
| Costa, M | 1 |
| Sipes, IG | 1 |
| Russell, DH | 1 |
| Fort, L | 1 |
| Taper, HS | 1 |
| Brucher, JM | 1 |
| Wright, AS | 1 |
| Akintonwa, DA | 1 |
| Wooder, MF | 1 |
| Drew, R | 1 |
| Priestly, BG | 1 |
| Staneva-Stoĭcheva, D | 1 |
| Krustev, L | 1 |
| Kitova, E | 1 |
| Capron, JP | 1 |
| Dumont, M | 1 |
| Feldmann, G | 1 |
| Erlinger, S | 1 |
| Owen, NV | 1 |
| Griffing, WJ | 1 |
| Hoffman, DG | 1 |
| Gibson, WR | 1 |
| Kiplinger, GF | 1 |
| Böhm, N | 1 |
| Moser, B | 1 |
| Sindgi, SB | 1 |
| Rao, MA | 1 |
| Howard, MO | 1 |
| Schwartz, LW | 1 |
| Newton, JF | 1 |
| Qualls, CW | 1 |
| Yodis, LA | 1 |
| Ventre, JR | 1 |
| Smith, PF | 1 |
| Grossman, SJ | 1 |
| Gerson, RJ | 1 |
| Gordon, LR | 1 |
| Deluca, JG | 1 |
| Majka, JA | 1 |
| Wang, RW | 1 |
| Germershausen, JI | 1 |
| MacDonald, JS | 1 |
| Muirhead, E | 1 |
| Byers, LW | 1 |
| Capdevila, J | 1 |
| Brooks, B | 1 |
| Pitcock, JA | 1 |
| Brown, P | 1 |
| Dowell, R | 1 |
| de Camargo, JL | 1 |
| Punyarit, P | 1 |
| Newberne, PM | 1 |
| Harrison, GG | 1 |
| Smith, JS | 1 |
| Schulte-Hermann, R | 1 |
| Thom, R | 1 |
| Schlicht, I | 1 |
| Koransky, W | 1 |
| Stäubli, W | 1 |
| Hess, R | 1 |
| Weibel, ER | 1 |
| Gollan, JL | 1 |
| Huang, SN | 1 |
| Billing, BH | 1 |
| Sherlock, S | 1 |
| Paulson, DF | 1 |
| Fraley, EE | 1 |
| Siess, M | 1 |
| Vogell, W | 1 |
| Niessing, J | 1 |
1 review available for phenobarbital and Hypertrophy
| Article | Year |
|---|---|
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
36 other studies available for phenobarbital and Hypertrophy
| Article | Year |
|---|---|
Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice.
Topics: Animals; Cell Nucleus; Clofibrate; Hepatocytes; Hepatomegaly; Hypertrophy; Image Processing, Compute | 2016 |
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Chlordan; Constitutive Androstane Recept | 2010 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor.
Topics: Administration, Oral; Animals; Antigens, Differentiation; Aryl Hydrocarbon Hydroxylases; Cell Prolif | 2007 |
Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats.
Topics: Animals; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Hyperplasia; Hypertrophy; Iodine Radioi | 2007 |
Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
Topics: Adenosine Triphosphatases; Animals; Biotransformation; Carcinogens; Cocarcinogenesis; Dieldrin; Dose | 1983 |
A morphometric analysis of the hypertrophy of experimental liver cirrhosis.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Connective Tissue; Hepatomegaly; Hypertroph | 1983 |
Induction of diamine oxidase activity in rat kidney during compensatory hypertrophy.
Topics: Acetaldehyde; Amine Oxidase (Copper-Containing); Animals; Cycloheximide; Dactinomycin; Enzyme Induct | 1982 |
Ovarian sensitivity to exogenous gonadotrophins in phenobarbital treated unilaterally ovariectomized albino rats.
Topics: Animals; Estrus; Female; Follicle Stimulating Hormone; Hypertrophy; Lipid Metabolism; Luteinizing Ho | 1994 |
Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice.
Topics: Animals; Apoptosis; fas Receptor; Hyperplasia; Hypertrophy; Immunoenzyme Techniques; Liver; Male; Mi | 1997 |
The effect of hepatocyte enlargement on the hemodynamic characteristics of the isolated perfused rat liver preparation.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Hypertrophy; Hypotonic Solutions; In Vitro T | 1998 |
The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital.
Topics: Animals; Cell Count; Cell Nucleus; Hepatomegaly; Hyperplasia; Hypertrophy; Hypnotics and Sedatives; | 1998 |
Phenobarbital promotes liver growth in c-myc/TGF-alpha transgenic mice by inducing hypertrophy and inhibiting apoptosis.
Topics: Animals; Apoptosis; bcl-X Protein; Carcinogens; Cell Division; Diet; Gene Expression Regulation; Gen | 1999 |
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Topics: Animals; Cell Count; Cell Division; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Hyperplasia; H | 1999 |
Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats.
Topics: Animals; Calcium Channel Blockers; Female; Glucuronosyltransferase; Hyperplasia; Hypertrophy; Liver; | 2000 |
Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.
Topics: Animals; Bromodeoxyuridine; DNA; Female; Hepatomegaly; Hyperplasia; Hypertrophy; Inhalation Exposure | 2001 |
Effect of cyclic AMP on the phenobarbital induced increase in cytochrome P-450 and hypertrophy of the endoplasmic reticulum of the rat liver.
Topics: Animals; Biotransformation; Body Weight; Bucladesine; Cyclic AMP; Cytochrome P-450 Enzyme System; Cy | 1975 |
Further evidence of cyclic AMP-mediated hypertrophy as a prerequisite of drug-specific enzyme induction.
Topics: Animals; Cyclic AMP; Enzyme Induction; Hypertrophy; Liver; Male; Methylcholanthrene; Mice; Mice, Inb | 1978 |
Morphological alterations and focal deficiency of the histochemical activity of acid and alkaline nucleases in rat liver after chronic administration of phenobarbital.
Topics: Animals; Deoxyribonucleases; Endoplasmic Reticulum; Glycogen; Hypertrophy; Liver; Male; Phenobarbita | 1977 |
Studies on the interactions of dieldrin with mammalian liver cells at the subcellular level.
Topics: Animals; Carcinogens; Dieldrin; DNA; Dogs; Endoplasmic Reticulum; Hyperplasia; Hypertrophy; Liver; M | 1977 |
Failure of hypoactive hypertrophic smooth endoplasmic reticulum to produce cholestasis in rats.
Topics: Animals; Cholestasis; Cobalt; Endoplasmic Reticulum; Hypertrophy; Lithocholic Acid; Liver Function T | 1978 |
[Morphological changes in the liver of rats treated with phenobarbital, methylphenobarbital and their N-substituted morpholinoethyl derivatives].
Topics: Animals; Hypertrophy; Liver; Male; Mephobarbital; Phenobarbital; Rats; Time Factors | 1977 |
Barbiturate-induced choleresis: possible independence from microsomal enzyme induction.
Topics: Animals; Barbital; Barbiturates; Bile; Bile Acids and Salts; Cytochrome P-450 Enzyme System; Endopla | 1977 |
Dichlorophenobarbital-induced centrilobular hypertrophy of hepatocytes and enzyme induction in the rat.
Topics: Animals; Enzyme Induction; Hypertrophy; Liver; Microsomes, Liver; Phenobarbital; Rats | 1975 |
[Reversible hyperplasia and hypertrophy of the mouse liver during functional phenobarbital load].
Topics: Animals; Hyperplasia; Hypertrophy; Liver Diseases; Mice; Phenobarbital | 1975 |
Retardation of ovarian compensatory hypertrophy by barbiturates in albino rats.
Topics: Animals; Barbital; Barbiturates; Castration; Depression, Chemical; Female; Hypertrophy; Ovary; Pheno | 1975 |
Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cytoch | 1991 |
Studies on the mechanism of simvastatin-induced thyroid hypertrophy and follicular cell adenoma in the rat.
Topics: Adenoma; Animals; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy; Liver; Lovast | 1991 |
Effect of cytochrome P-450 induction and inhibition on the antihypertensive function of the kidney.
Topics: Animals; Blood Pressure; Clofibric Acid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 1987 |
Early stages of nodular transformation of the B6C3F1 mouse liver induced by choline deficiency.
Topics: Animals; Choline Deficiency; Hepatectomy; Hypertrophy; Liver; Male; Mice; Mice, Inbred Strains; Orga | 1985 |
Massive lethal hepatic necrosis in rats anesthetized with fluroxene, after microsomal enzyme induction.
Topics: Anesthesia, Inhalation; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 1973 |
[Number and "ploidy" of liver cell nuclei under the influence of substances alien to the body. Analysis by means of an electronic particle counter].
Topics: Animals; Cell Nucleus; Electronics; Female; Hepatomegaly; Hexachlorocyclohexane; Hyperplasia; Hypert | 1968 |
Correlated morphometric and biochemical studies on the liver cell. II. Effects of phenobarbital on rat hepatocytes.
Topics: Animals; Cell Membrane; Cytochromes; Cytoplasm; Cytoplasmic Granules; Electron Transport Complex IV; | 1969 |
Proceedings: Prolonged survival in the Crigler-Najjar syndrome: ultrastructural and dietary studies.
Topics: Bilirubin; Cell Membrane; Crigler-Najjar Syndrome; Endoplasmic Reticulum; Glucose; Golgi Apparatus; | 1974 |
Compensatory renal growth after unilateral ureteral obstruction.
Topics: Anesthesia, Intravenous; Animals; Carbon Isotopes; DNA; Hyperplasia; Hypertrophy; Kidney; Kidney Dis | 1973 |
[Histological, histochemical and electron microscopical findings in foreign substance induced liver hypertrophy in white mice].
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Endoplasmic Reticulum; Halothane; Hyper | 1967 |