Page last updated: 2024-11-02

phenobarbital and Hyperthyroidism

phenobarbital has been researched along with Hyperthyroidism in 22 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Hyperthyroidism: Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.

Research Excerpts

ExcerptRelevanceReference
"Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0."7.66Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983)
"Halothane hepatotoxicity was observed after exposing hyperthyroid rats to 0."3.66Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model. ( Frühling, A; Siegers, CP; Younes, M, 1983)
"1 In order to study the relative contribution of hepatic drug metabolizing enzymes and hepatic blood flow to the clearance of drugs in the hyperthyroid state, the disposition kinetics of two model compounds (antipyrine and propranolol) were examined in thyroid-fed dogs as compared to euthyroid and phenobarbitone-pretreated animals."3.66Absence of changes in drug disposition and catecholamine sensitivity in the hyperthyroid dog. ( Ishizaki, T; Tawara, K, 1980)
"The prevalence of unrecognized primary hypothyroidism and hyperthyroidism was 5·2% and 2·8%, respectively."1.37Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study. ( de Rijke, YB; van Toor, H; Visser, TJ; Visser, WE, 2011)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199020 (90.91)18.7374
1990's0 (0.00)18.2507
2000's1 (4.55)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Visser, WE1
de Rijke, YB1
van Toor, H1
Visser, TJ1
DE MICHELI, E1
PARENTI, B1
Siegers, CP1
Frühling, A1
Younes, M1
Ishizaki, T1
Tawara, K1
Surks, M1
Hosek, B1
Misustová, J1
Pospísil, M1
Marselos, M1
Puhakainen, E1
Rantanen, T1
Ibarra, JD1
Gilliland, PF1
Petty, FC1
Roberts, JW1
Peake, RL1
Crile, G1
Galen, RS1
Mounié, J1
Goudonnet, H1
Serrar, M1
Escousse, A1
Truchot, RC1
Smith, AC1
Roberts, SM1
James, RC1
Berman, LM1
Harbison, RD2
Horiguchi, T1
Björkhem, I1
Danielsson, H1
Gerdes, H1
Littmann, KP1
Joseph, K1
Mahlstedt, J1
Herzfeld, R1
Orbeck, H1
Heffron, WA1
Appenzeller, O1
Bettman, JW1
Daroff, RB1
Sanders, MD1
Hoyt, WF1
Rivlin, RS1
Wagner, HN1
Becker, BA1
Sunshine, P1
Kusumoto, H1
Kriss, JP1
Schindler, H1

Reviews

1 review available for phenobarbital and Hyperthyroidism

ArticleYear
Hydroxylations in biosynthesis and metabolism of bile acids.
    Molecular and cellular biochemistry, 1974, Sep-30, Volume: 4, Issue:2

    Topics: Acetates; Animals; Bile Acids and Salts; Biliary Tract Diseases; Carbon Monoxide; Carbon Radioisotop

1974

Other Studies

21 other studies available for phenobarbital and Hyperthyroidism

ArticleYear
Thyroid status in a large cohort of patients with mental retardation: the TOP-R (Thyroid Origin of Psychomotor Retardation) study.
    Clinical endocrinology, 2011, Volume: 75, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Cross-Sectional Studies; Drug Therapy,

2011
[The combination of meprobamate and phenylethylmalonylurea in therapy].
    Gazzetta medica italiana, 1963, Volume: 122

    Topics: Arteriosclerosis; Heart Failure; Humans; Hypertension; Hyperthyroidism; Meprobamate; Myocardial Infa

1963
Halothane hepatotoxicity in hyperthyroid rats as compared to the phenobarbital-hypoxia model.
    Toxicology and applied pharmacology, 1983, Jun-30, Volume: 69, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Fluorides; Glutathione; Halothane; Hyperthyroidism;

1983
Absence of changes in drug disposition and catecholamine sensitivity in the hyperthyroid dog.
    British journal of pharmacology, 1980, Volume: 71, Issue:1

    Topics: Animals; Antipyrine; Catecholamines; Dogs; Female; Heart Rate; Hyperthyroidism; Kinetics; Male; Phar

1980
Neonatal hyperthyroidism.
    Thyroid : official journal of the American Thyroid Association, 2002, Volume: 12, Issue:4

    Topics: Endocrinology; History, 20th Century; Humans; Hyperthyroidism; Infant, Newborn; Phenobarbital

2002
The toxic and protective effects of 5-methoxytryptamine and cystamine in mice in the state of hyperthyroidism and its recovery.
    Strahlentherapie, 1979, Volume: 155, Issue:2

    Topics: 5-Methoxytryptamine; Animals; Cystamine; Drug Interactions; Hyperthyroidism; Male; Mice; Phenobarbit

1979
The hepatic glucuronate pathway in the rat after treatment with 3,3',5-triiodothyronine and phenobarbital.
    Acta pharmacologica et toxicologica, 1976, Volume: 38, Issue:3

    Topics: Animals; Glucuronates; Glucuronidase; Glucuronosyltransferase; Hyperthyroidism; Male; Microsomes, Li

1976
Treatment of hyperthyroidism. Panel discussion.
    Postgraduate medicine, 1975, Volume: 57, Issue:7

    Topics: Adolescent; Adult; Child; Female; Guanethidine; Humans; Hyperthyroidism; Iodine Radioisotopes; Male;

1975
The enzyme diagnosis of myocardial infarction.
    Human pathology, 1975, Volume: 6, Issue:2

    Topics: Angiography; Aspartate Aminotransferases; Cardiac Surgical Procedures; Chlorpromazine; Clinical Enzy

1975
[Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Volume: 182, Issue:3

    Topics: Animals; Cholesterol, Dietary; Cytochrome P-450 Enzyme System; Hyperthyroidism; Male; Microsomes, Li

1988
Comparison of covalent binding from halothane metabolism in hepatic microsomes from phenobarbital-induced and hyperthyroid rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 1988, Volume: 18, Issue:8

    Topics: Animals; Chemical and Drug Induced Liver Injury; Glutathione; Halothane; Hyperthyroidism; Lipid Meta

1988
[Clinical study on determination of blood thyroid hormone levels using the protein binding test--free thyroxine index in young children].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1971, Volume: 75, Issue:9

    Topics: Age Factors; Androgens; Antithyroid Agents; Child; Child, Preschool; Down Syndrome; Dwarfism, Pituit

1971
[Lithium therapy of thyrotoxicosis. Clinical experiences and results with a new therapeutic principle].
    Deutsche medizinische Wochenschrift (1946), 1973, Aug-24, Volume: 98, Issue:34

    Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Hyperthyroidism; Iodine Radioisotopes; Lithium; Long

1973
[Treatment of heart rhythm disorders in general practice].
    Hippokrates, 1969, Feb-28, Volume: 40, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Synergism; Electrocardiography; Histamine H1 Antagonists; Hu

1969
Neonatal hyperthyroidism.
    Acta paediatrica Scandinavica, 1973, Volume: 62, Issue:3

    Topics: Adult; Body Weight; Breast Diseases; Diarrhea; Digitalis Glycosides; Female; Graves Disease; Humans;

1973
Choreoathetosis in hyperthyroidism: a manifestation of a hyperadrenergic state.
    Transactions of the American Neurological Association, 1970, Volume: 95

    Topics: Adult; Chorea; Female; Humans; Hyperthyroidism; Phenobarbital; Prednisone; Propranolol; Propylthiour

1970
Edema of the optic disc in hyperthyroidism without exophathalmos. A fluorescein angiographic study of its resolution.
    American journal of ophthalmology, 1968, Volume: 66, Issue:4

    Topics: Adolescent; Cerebrospinal Fluid; Exophthalmos; Female; Fluoresceins; Fluoroscopy; Fundus Oculi; Huma

1968
Anemia in hyperthyroidism.
    Annals of internal medicine, 1969, Volume: 70, Issue:3

    Topics: Adolescent; Adult; Aged; Anemia; Erythrocyte Aging; Female; Humans; Hyperthyroidism; Iron; Male; Mid

1969
Barbiturate mortality in hypothyroid and hyperthyroid rats.
    Journal of pharmaceutical sciences, 1969, Volume: 58, Issue:2

    Topics: Amobarbital; Animals; Barbiturates; Basal Metabolism; Body Temperature; Body Weight; Hexobarbital; H

1969
Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder.
    Pediatrics, 1965, Volume: 36, Issue:6

    Topics: Adolescent; Digoxin; Female; Humans; Hyperthyroidism; Infant; Infant, Newborn; Infant, Newborn, Dise

1965
[Psychotropic drugs in the treatment of hyperthyroidism and states of marginal autonomic dysfunction].
    Medizinische Klinik, 1966, Jan-14, Volume: 61, Issue:2

    Topics: Diazepam; Dysautonomia, Familial; Ergotamine; Humans; Hyperthyroidism; Phenobarbital

1966