phenobarbital has been researched along with Hyperplasia in 62 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phenobarbital treatment of experimental animals induces cytochrome P450 enzymes, and thus acts as a growth stimulus to the liver with both hyperplasia and hypertrophy; cessation results in reversion of liver to normal size with apoptosis playing a role." | 7.69 | Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice. ( Alison, MR; Edwards, RJ; Horgan, M; Sarraf, CE, 1997) |
| "Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes." | 5.31 | Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. ( Gallavan, RH; Goodman, JI; Jean, PA; Kolesar, GB; McKim, JM; Meeker, LS; Meeks, RG; Schoonhoven, R; Swenberg, JA; Wilga, PC, 2001) |
| "In the case of PB treatment, the hepatomegaly was found to be partly due to hypertrophy and partly to hyperplasia after 2 weeks of treatment." | 5.30 | The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. ( Carthew, P; Edwards, RE; Nolan, BM, 1998) |
| " This study reports five cases of pediatric patients (6 to 12-years-old) diagnosed with Fanconi anemia (FA) after HSCT who presented similar oral mucosal lesions associated with the use of cyclosporine, phenobarbital and amlodipine." | 4.02 | A case series of medication-related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia. ( Ballardin, BS; Bonfim, CMS; Carvalho Torres-Pereira, C; Coracin, FL; Mobile, RZ; Ribeiro, LL; Schussel, JL, 2021) |
| "Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia." | 3.76 | Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. ( Bower, CC; Elcombe, CR; Henderson, CJ; Plummer, SM; Rode, A; Ross, J; Scheer, N; Vogel, O; Wolf, CR, 2010) |
| " Phenobarbital caused follicular cell hypertrophy and hyperplasia in the thyroid and centrilobular hypertrophy in the liver, without effects on serum triiodotyronine (T(3)), thyroxine (T(4)) levels." | 3.74 | Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats. ( Coelho-Palermo Cunha, G; van Ravenzwaay, B, 2007) |
| " injection of nitrosomethylurea (NMU) in 3-day-old rats orally treated with the pesticide mancozeb (MZ), the flavonoid quercetin (Q) or in combination (MZ-Q) induces hyperplasia, atypical acinar cell proliferation and carcinoma in situ (CIS) in the pancreas." | 3.73 | Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats. ( Barotto, NN; Bongiovanni, GA; Díaz, MP; Eynard, AR; Valentich, MA, 2006) |
| "Two-stage carcinogenesis of mouse skin papillomas induced by 7,12-dimethylbenz[alpha]anthracene and 12-O-tetradecanoylphorbol 13-acetate, and mouse hepatic tumors induced by N-nitrosodiethylamine and phenobarbital, were inhibited by lantadenes." | 3.69 | Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors. ( Inada, A; Nakanishi, T; Nishino, H; Sharma, OP; Tokuda, H, 1997) |
| "Hyperplasia of the rat liver can be induced by cyproterone acetate (CPA)." | 3.67 | Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia. ( Bursch, W; Lauer, B; Schulte-Hermann, R; Taper, HS, 1985) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes." | 1.31 | Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. ( Gallavan, RH; Goodman, JI; Jean, PA; Kolesar, GB; McKim, JM; Meeker, LS; Meeks, RG; Schoonhoven, R; Swenberg, JA; Wilga, PC, 2001) |
| "In the case of PB treatment, the hepatomegaly was found to be partly due to hypertrophy and partly to hyperplasia after 2 weeks of treatment." | 1.30 | The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. ( Carthew, P; Edwards, RE; Nolan, BM, 1998) |
| " The public health implication of this lack of linearity in the low-dose area of the dose-response curve raises the question of whether low doses of carcinogens will reduce cancer risk." | 1.30 | Can the concept of hormesis Be generalized to carcinogenesis? ( Baldwin, LA; Calabrese, EJ, 1998) |
| "Phenobarbital sodium (PB) was administered at dietary levels of 0 (control), 8, 30, 125 and 500 ppm to groups of 20 male F344/DuCrj rats for 104 weeks." | 1.30 | Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. ( Fukushima, S; Funae, Y; Hagiwara, A; Ito, N; Masuda, C; Miyata, E; Sano, M; Shirai, T; Tamano, S, 1999) |
| "Phenobarbital (PB) is an effective growth stimulator of hepatic hyperplastic nodules developed with diethylnitrosamine and 2-acetylaminofluorene plus partial hepatectomy (the Solt-Farber model), but it does not apparently stimulate the growth of preneoplastic lesions produced with aflatoxin B1 (AFB)." | 1.28 | Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats. ( Chen, ZY; Eaton, DL, 1991) |
| " At a dosage of 0." | 1.27 | Liver cell hyperplasia: on the suitability of using the metaphase-arrest technique. ( Alabi, JA; Alison, MR, 1984) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "The incidence of thyroid adenomas and cancers was 20% (4/20) and 10% (2/20) in rats treated with DHPN alone." | 1.27 | Effects of castration before and after treatment with N-bis (2-hydroxypropyl)-nitrosamine (DHPN) on the development of thyroid tumors in rats treated with DHPN followed by phenobarbital. ( Hashimoto, H; Hiasa, Y; Katoh, Y; Kitahori, Y; Konishi, N; Minami, S; Murata, Y; Ohshima, M; Sakaguchi, Y; Shimoyama, T, 1987) |
| "Amount of cytochrome P-450 in hepatoma tissues also showed similar values as that in hyperplastic nodules." | 1.26 | Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. ( Fukumoto, Y; Noda, K; Okita, K; Takemoto, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (61.29) | 18.7374 |
| 1990's | 14 (22.58) | 18.2507 |
| 2000's | 5 (8.06) | 29.6817 |
| 2010's | 3 (4.84) | 24.3611 |
| 2020's | 2 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Phoon, YP | 1 |
| Chivukula, IV | 1 |
| Tsoi, YL | 1 |
| Kanatani, S | 1 |
| Uhlén, P | 1 |
| Kuiper, R | 1 |
| Lendahl, U | 1 |
| Ballardin, BS | 1 |
| Mobile, RZ | 1 |
| Coracin, FL | 1 |
| Ribeiro, LL | 1 |
| Bonfim, CMS | 1 |
| Schussel, JL | 1 |
| Carvalho Torres-Pereira, C | 1 |
| Ross, J | 1 |
| Plummer, SM | 1 |
| Rode, A | 1 |
| Scheer, N | 1 |
| Bower, CC | 1 |
| Vogel, O | 1 |
| Henderson, CJ | 1 |
| Wolf, CR | 1 |
| Elcombe, CR | 1 |
| Bishayee, A | 1 |
| Barnes, KF | 1 |
| Bhatia, D | 1 |
| Darvesh, AS | 1 |
| Carroll, RT | 1 |
| Saito, K | 1 |
| Moore, R | 1 |
| Negishi, M | 1 |
| Valentich, MA | 1 |
| Eynard, AR | 1 |
| Barotto, NN | 1 |
| Díaz, MP | 1 |
| Bongiovanni, GA | 1 |
| Coelho-Palermo Cunha, G | 1 |
| van Ravenzwaay, B | 1 |
| Sirica, AE | 2 |
| Jicinsky, JK | 2 |
| Vinje, EJ | 1 |
| Cihla, HP | 1 |
| Heyer, EK | 1 |
| Vinarchuk, MP | 2 |
| Kononenko, LI | 2 |
| Bykorez, AI | 2 |
| Kaneko, A | 1 |
| Dempo, K | 1 |
| Kaku, T | 1 |
| Yokoyama, S | 1 |
| Satoh, M | 1 |
| Mori, M | 1 |
| Onoé, T | 1 |
| Hasegawa, R | 3 |
| Tatematsu, M | 5 |
| Tsuda, H | 2 |
| Shirai, T | 2 |
| Hagiwara, A | 4 |
| Ito, N | 10 |
| Alabi, JA | 1 |
| Alison, MR | 2 |
| Ward, JM | 1 |
| Rice, JM | 1 |
| Creasia, D | 1 |
| Lynch, P | 1 |
| Riggs, C | 1 |
| Nakanishi, K | 5 |
| Fukushima, S | 4 |
| Tamano, S | 2 |
| Shibata, M | 1 |
| Cameron, R | 1 |
| Imaida, K | 2 |
| Takano, T | 1 |
| Chen, ZY | 3 |
| Liu, YF | 1 |
| He, CY | 1 |
| White, CC | 1 |
| Eaton, DL | 3 |
| Murkofsky, RL | 1 |
| Glover, SE | 1 |
| Miller, RT | 1 |
| Popp, JA | 1 |
| Cattley, RC | 1 |
| Sarraf, CE | 1 |
| Horgan, M | 1 |
| Edwards, RJ | 1 |
| Fletcher, K | 1 |
| Orton, TC | 1 |
| Chipman, JK | 1 |
| Strain, AJ | 1 |
| Inada, A | 1 |
| Nakanishi, T | 1 |
| Tokuda, H | 1 |
| Nishino, H | 1 |
| Sharma, OP | 1 |
| Carthew, P | 1 |
| Edwards, RE | 1 |
| Nolan, BM | 1 |
| Calabrese, EJ | 1 |
| Baldwin, LA | 1 |
| Kolaja, KL | 1 |
| Hood, AM | 1 |
| Klaassen, CD | 2 |
| Miyata, E | 1 |
| Sano, M | 1 |
| Masuda, C | 1 |
| Funae, Y | 1 |
| Hood, A | 1 |
| Hashmi, R | 1 |
| Tsuchiya, Y | 1 |
| Ohno, H | 1 |
| Satoh, H | 1 |
| Sugawara, T | 1 |
| Kajimura, T | 1 |
| Nomura, M | 1 |
| McKim, JM | 1 |
| Kolesar, GB | 1 |
| Jean, PA | 1 |
| Meeker, LS | 1 |
| Wilga, PC | 1 |
| Schoonhoven, R | 1 |
| Swenberg, JA | 1 |
| Goodman, JI | 1 |
| Gallavan, RH | 1 |
| Meeks, RG | 1 |
| Ikeda, T | 1 |
| Nishikawa, A | 1 |
| Son, HY | 1 |
| Nakamura, H | 1 |
| Miyauchi, M | 1 |
| Imazawa, T | 1 |
| Kimura, S | 1 |
| Hirose, M | 2 |
| Pitot, HC | 1 |
| Pugh, TD | 1 |
| Goldfarb, S | 1 |
| Murasaki, G | 2 |
| Miyata, Y | 2 |
| Shinohara, Y | 1 |
| Okita, K | 1 |
| Noda, K | 1 |
| Fukumoto, Y | 1 |
| Takemoto, T | 1 |
| Wright, AS | 1 |
| Akintonwa, DA | 1 |
| Wooder, MF | 1 |
| Butler, WH | 1 |
| Feo, F | 1 |
| Canuto, RA | 1 |
| Garcea, R | 1 |
| Brossa, O | 1 |
| Caselli, GC | 1 |
| Crampton, RF | 1 |
| Gray, TJ | 1 |
| Grasso, P | 1 |
| Parke, DV | 1 |
| Nievel, JG | 1 |
| Anderson, J | 1 |
| Bray, PF | 1 |
| Böhm, N | 1 |
| Moser, B | 1 |
| Ledda-Columbano, GM | 1 |
| Coni, P | 1 |
| Curto, M | 1 |
| Giacomini, L | 1 |
| Faa, G | 1 |
| Sarma, DS | 1 |
| Columbano, A | 1 |
| Shibata, MA | 1 |
| Takahashi, S | 1 |
| Cater, KC | 1 |
| Gandolfi, AJ | 1 |
| Sipes, IG | 1 |
| Bursch, W | 1 |
| Taper, HS | 1 |
| Lauer, B | 1 |
| Schulte-Hermann, R | 2 |
| Greaves, P | 1 |
| Irisarri, E | 1 |
| Monro, AM | 1 |
| Hiasa, Y | 1 |
| Kitahori, Y | 1 |
| Katoh, Y | 1 |
| Ohshima, M | 1 |
| Konishi, N | 1 |
| Shimoyama, T | 1 |
| Sakaguchi, Y | 1 |
| Hashimoto, H | 1 |
| Minami, S | 1 |
| Murata, Y | 1 |
| Estadella, MD | 1 |
| Pujol, MJ | 1 |
| Domingo, J | 1 |
| Yamada, K | 1 |
| Tsukidate, K | 1 |
| Taki, T | 1 |
| Katayama, K | 1 |
| Sato, T | 1 |
| Thorpe, E | 1 |
| Walker, AI | 1 |
| Thom, R | 1 |
| Schlicht, I | 1 |
| Koransky, W | 1 |
| Pandhi, PN | 1 |
| Baum, R | 1 |
| Tyler, FH | 1 |
| West, CD | 1 |
| Jubiz, W | 1 |
| Meikle, AW | 1 |
| Koff, RS | 1 |
| Davidson, LJ | 1 |
| Gordon, G | 1 |
| Sabesin, SM | 1 |
| Gollan, JL | 1 |
| Huang, SN | 1 |
| Billing, BH | 1 |
| Sherlock, S | 1 |
| Paulson, DF | 1 |
| Fraley, EE | 1 |
| Riede, UN | 1 |
| Torhorst, J | 1 |
| Rohr, HP | 1 |
62 other studies available for phenobarbital and Hyperplasia
| Article | Year |
|---|---|
Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes.
Topics: Animals; Cell Transformation, Neoplastic; Epithelial Cells; Female; Hyperplasia; Mammary Glands, Ani | 2020 |
A case series of medication-related fibrovascular hyperplasia following hematopoietic stem cell transplantation for Fanconi anemia.
Topics: Amlodipine; Calcium Channel Blockers; Child; Cyclosporine; Fanconi Anemia; Female; Granuloma, Pyogen | 2021 |
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Chlordan; Constitutive Androstane Recept | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chromatin Immunoprecipitation; Constitutive Androstane | 2013 |
Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats.
Topics: Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Carcinoma in Situ; Disease Models, Animal | 2006 |
Standardization of the perchlorate discharge assay for thyroid toxicity testing in rats.
Topics: Animals; beta-Naphthoflavone; Chlorodiphenyl (54% Chlorine); Hyperplasia; Hypertrophy; Iodine Radioi | 2007 |
Effect of phenobarbital on the altered biochemical phenotypes expressed by hyperplastic liver nodules during hepatocarcinogenesis in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Fructose-Bisphosphate Aldolase; gamma-Glutamyltransferase; | 1984 |
Effect of chronic phenobarbital administration on the gamma-glutamyl transpeptidase activity of hyperplastic liver lesions induced in rats by the Solt/Farber initiation: selection process of hepatocarcinogenesis.
Topics: Animals; gamma-Glutamyltransferase; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Phenoba | 1984 |
[Histochemical appearance of gamma-glutamyltranspeptidase in the rat liver after transplacental exposure to diethylnitrosamine and postnatal administration of phenobarbital].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Histo | 1984 |
Effect of phenobarbital administration on hepatocytes constituting the hyperplastic nodules induced in rat liver by 3'-methyl-4-dimethylaminoazobenzene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cytochrome P-450 Enzyme System; Ester | 1980 |
Induction of hyperplastic liver nodules in hepatectomized rats treated with 3'-methyl-4-dimethylaminoazobenzene, benzo[a]pyrene or phenobarbital before or after exposure to N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Benzopyrenes; Carbon Tetrachloride; Hepatectomy; Hyp | 1982 |
Liver cell hyperplasia: on the suitability of using the metaphase-arrest technique.
Topics: Animals; Colchicine; Histological Techniques; Hyperplasia; Kinetics; Liver; Liver Regeneration; Male | 1984 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Induction of hyperplastic liver nodules by phenobarbital in rats initiated with N-butyl-N-(4-hydroxybutyl) nitrosamine.
Topics: Animals; Butylhydroxybutylnitrosamine; Drug Synergism; Hyperplasia; Liver; Liver Neoplasms; Male; Ne | 1980 |
Promotive effects of ethinyl estradiol in hepatocarcinogenesis initiated by diethylnitrosamine in male rats.
Topics: Animals; Diethylnitrosamine; Drug Synergism; Ethinyl Estradiol; Hyperplasia; Liver Neoplasms; Male; | 1981 |
Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Dose-Response Relationship, Drug; Dr | 1980 |
Inhibition of cell proliferation by ciprofibrate in glutathione S-transferase P1-1-positive rat hepatic hyperplastic nodules.
Topics: Animals; Cell Division; Clofibric Acid; Cytochrome P-450 Enzyme System; DNA; Fibric Acids; gamma-Glu | 1994 |
Association between responsiveness to phenobarbital induction of CYP2B1/2 and 3A1 in rat hepatic hyperplastic nodules and their zonal origin.
Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3 | 1993 |
Effect of regeneration and hyperplasia on levels of DNA base oxidation in rat liver.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carbon Tetrachloride; Cell Division; Deoxyguanosine; Hyperplas | 1993 |
Reversal of phenobarbital-induced hyperplasia and hypertrophy in the livers of lpr mice.
Topics: Animals; Apoptosis; fas Receptor; Hyperplasia; Hypertrophy; Immunoenzyme Techniques; Liver; Male; Mi | 1997 |
The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors.
Topics: Animals; Cell Division; Cell Separation; Cells, Cultured; DNA Replication; Drug Synergism; Epidermal | 1997 |
Anti-tumor promoting activities of lantadenes on mouse skin tumors and mouse hepatic tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; | 1997 |
The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital.
Topics: Animals; Cell Count; Cell Nucleus; Hepatomegaly; Hyperplasia; Hypertrophy; Hypnotics and Sedatives; | 1998 |
Can the concept of hormesis Be generalized to carcinogenesis?
Topics: Animals; Caffeic Acids; Carcinogenicity Tests; Carcinogens; Cell Division; Dioxins; DNA Ligases; Dos | 1998 |
The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16alpha-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-beta1 expression.
Topics: Animals; Apoptosis; Enzyme Induction; Glucuronosyltransferase; Hyperplasia; Male; Phenobarbital; Pre | 1999 |
Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diet; Dose-Respo | 1999 |
Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy.
Topics: Animals; Cell Count; Cell Division; Chlorodiphenyl (54% Chlorine); Enzyme Activation; Hyperplasia; H | 1999 |
Thyroid hypertrophic effect of semotiadil fumarate, a new calcium antagonist, in rats.
Topics: Animals; Calcium Channel Blockers; Female; Glucuronosyltransferase; Hyperplasia; Hypertrophy; Liver; | 2000 |
Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.
Topics: Animals; Bromodeoxyuridine; DNA; Female; Hepatomegaly; Hyperplasia; Hypertrophy; Inhalation Exposure | 2001 |
Synergistic effects of high-dose soybean intake with iodine deficiency, but not sulfadimethoxine or phenobarbital, on rat thyroid proliferation.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Female; Glycine max; Hyper | 2001 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu | 1978 |
Sequential quantitative studies on hyperplastic nodules in the liver of rats treated with carcinogenic chemicals.
Topics: 2-Acetylaminofluorene; Animals; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Hexachlo | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplas | 1976 |
Studies on the interactions of dieldrin with mammalian liver cells at the subcellular level.
Topics: Animals; Carcinogens; Dieldrin; DNA; Dogs; Endoplasmic Reticulum; Hyperplasia; Hypertrophy; Liver; M | 1977 |
Long-term effects of phenobarbitone-Na on male Fischer rats.
Topics: Animals; Hyperplasia; Liver; Liver Diseases; Liver Neoplasms; Male; Neoplasms, Experimental; Phenoba | 1978 |
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Ethionine; Hyperplasia; Liver Ne | 1978 |
Long-term studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene.
Topics: Animals; Butylated Hydroxytoluene; Chemical and Drug Induced Liver Injury; Cresols; Diet; Enzyme Ind | 1977 |
Biochemical changes in liver and blood underlying parenchymal damage of rat liver induced by a dose-dependent effect of drugs before and after development of liver enlargement and nodular hyperplasia.
Topics: Animals; Butylated Hydroxytoluene; Coumarins; Cresols; Female; Hyperplasia; Liver; Phenobarbital; Pr | 1976 |
[Reversible hyperplasia and hypertrophy of the mouse liver during functional phenobarbital load].
Topics: Animals; Hyperplasia; Hypertrophy; Liver Diseases; Mice; Phenobarbital | 1975 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Gluta | 1992 |
Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats.
Topics: 2-Acetylaminofluorene; Aflatoxin B1; Alkylation; Animals; Cytochrome P-450 Enzyme System; Diethylnit | 1991 |
Enhancing effects of sodium phenobarbital and N,N-dibutylnitrosamine on tumor development in a rat wide-spectrum organ carcinogenesis model.
Topics: Animals; Carcinogens; Hyperplasia; Male; Neoplasms, Experimental; Nitrosamines; Organ Specificity; P | 1990 |
Characterization of dimethylnitrosamine-induced focal and nodular lesions in the livers of newborn mice.
Topics: Animals; Animals, Newborn; Body Weight; Dimethylnitrosamine; Female; gamma-Glutamyltransferase; Hype | 1985 |
Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia.
Topics: Animals; Cell Survival; Cyproterone; Cyproterone Acetate; Deoxyribonucleases; DNA; Female; Hyperplas | 1985 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyper | 1987 |
Effects of castration before and after treatment with N-bis (2-hydroxypropyl)-nitrosamine (DHPN) on the development of thyroid tumors in rats treated with DHPN followed by phenobarbital.
Topics: Animals; Body Weight; Gonadal Steroid Hormones; Hyperplasia; Male; Nitrosamines; Orchiectomy; Organ | 1987 |
Proliferative response of putative preneoplastic hepatocytes to triiodothyronine, aminoacids, glucagon and heparine.
Topics: Amino Acids; Animals; Cell Division; Diethylnitrosamine; Glucagon; Heparin; Hyperplasia; Liver Neopl | 1988 |
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectom | 1987 |
The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, -BHC and -BHC.
Topics: Administration, Oral; Animals; DDT; Dieldrin; Female; Hepatomegaly; Hexachlorocyclohexane; Hyperplas | 1973 |
[Number and "ploidy" of liver cell nuclei under the influence of substances alien to the body. Analysis by means of an electronic particle counter].
Topics: Animals; Cell Nucleus; Electronics; Female; Hepatomegaly; Hexachlorocyclohexane; Hyperplasia; Hypert | 1968 |
Effect of fasting and of phenobarbital on the distribution and latency of glucose-6-phosphatase in microsomal sub-fractions of rat liver.
Topics: Animals; Endoplasmic Reticulum; Fasting; Glucose-6-Phosphatase; Hyperplasia; Male; Microsomes, Liver | 1970 |
Dilantin and metyrapone: a clinically significant example of enzyme induction.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R | 1970 |
D-galactosamine hepatotoxicity. 3. Normoactive smooth endoplasmic reticulum and modification by phenobarbital.
Topics: Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Endoplasmic Reti | 1973 |
Proceedings: Prolonged survival in the Crigler-Najjar syndrome: ultrastructural and dietary studies.
Topics: Bilirubin; Cell Membrane; Crigler-Najjar Syndrome; Endoplasmic Reticulum; Glucose; Golgi Apparatus; | 1974 |
Compensatory renal growth after unilateral ureteral obstruction.
Topics: Anesthesia, Intravenous; Animals; Carbon Isotopes; DNA; Hyperplasia; Hypertrophy; Kidney; Kidney Dis | 1973 |
Focal proliferation of the smooth endoplasmic reticulum in the cells of the straight part of the proximal kidney tubule.
Topics: Animals; Aspirin; Cell Aggregation; Cytoplasmic Granules; Endoplasmic Reticulum; Hydrocarbons, Bromi | 1973 |