phenobarbital has been researched along with Hypercapnia in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although results obtained in baboons and rats have demonstrated that the fatty acid cyclo-oxygenase inhibitor indomethacin reduces cerebral blood flow (CBF) under control conditions and markedly attenuates the CBF response to hypercapnia, nonconfirmatory results have been obtained in rabbits and cats." | 3.66 | Effects of indomethacin on cerebral blood flow and oxygen consumption in barbiturate-anesthetized Normocapnic and hypercapnic rats. ( Dahlgren, N; Siesjö, BK, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dahlgren, N | 1 |
| Siesjö, BK | 3 |
| MacMillan, V | 1 |
| Messeter, K | 1 |
| Pontén, U | 1 |
3 other studies available for phenobarbital and Hypercapnia
| Article | Year |
|---|---|
Effects of indomethacin on cerebral blood flow and oxygen consumption in barbiturate-anesthetized Normocapnic and hypercapnic rats.
Topics: Anesthetics; Animals; Brain; Cerebrovascular Circulation; Hypercapnia; Indomethacin; Nitrous Oxide; | 1981 |
The effect of phenobarbitone anaesthesia upon some organic phosphates, glycolytic metabolites and citric acid cycle-associated intermediates of the rat brain.
Topics: Adenine Nucleotides; Anesthesia, General; Animals; Brain; Carbon Dioxide; Citric Acid Cycle; Depress | 1973 |
The influence of deep barbiturate anesthesia upon the regulation of extra- and intracellular pH in the rat brain during hypercapnia.
Topics: Acid-Base Equilibrium; Anesthesia, General; Animals; Brain; Cerebrospinal Fluid; Halothane; Hydrogen | 1972 |