phenobarbital has been researched along with Heroin Dependence in 23 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Heroin Dependence: Strong dependence or addiction, both physiological and emotional, upon HEROIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)." | 1.26 | Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979) |
| " It is suggested that reduction of methadone dosage in late pregnancy results in reduced incidence of withdrawal but must be carefully carried out." | 1.26 | Observation and treatment of neonatal narcotic withdrawal. ( Chappel, JN; Davis, R; Gumpel, J; Madden, JD; Mejia, A; Zuspan, F, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (95.65) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, SJ | 1 |
| Wang, RI | 1 |
| Fabris, C | 1 |
| Prandi, GM | 1 |
| Berardi, V | 1 |
| Santoro, MA | 1 |
| Martano, C | 1 |
| Mombrò, M | 1 |
| Ghodse, AH | 1 |
| Reed, JL | 1 |
| Mack, JW | 1 |
| Burstein, Y | 1 |
| Giardina, PJ | 1 |
| Rausen, AR | 1 |
| Kandall, SR | 2 |
| Siljestrom, K | 1 |
| Peterson, CM | 1 |
| Madden, JD | 1 |
| Chappel, JN | 1 |
| Zuspan, F | 1 |
| Gumpel, J | 1 |
| Mejia, A | 1 |
| Davis, R | 1 |
| Finnegan, LP | 3 |
| Connaughton, JF | 1 |
| Kron, RE | 3 |
| Emich, JP | 1 |
| Zelson, C | 2 |
| Kaplan, SL | 1 |
| Litt, M | 2 |
| Phoenix, MD | 1 |
| Vargas, GC | 1 |
| Pildes, RS | 1 |
| Vidyasagar, D | 1 |
| Keith, LG | 1 |
| Woody, GE | 1 |
| O'Brien, CP | 1 |
| Greenstein, R | 1 |
| Kattner, E | 1 |
| Wesson, DR | 1 |
| Smith, DE | 1 |
| Lerner, SE | 1 |
| Kettner, VR | 1 |
| Tsueda, K | 1 |
| Jean-Francois, J | 1 |
| Richter, RW | 1 |
| Harper, RG | 2 |
| Solish, GI | 1 |
| Purow, HM | 1 |
| Sang, E | 1 |
| Panepinto, WC | 1 |
| Blatman, S | 1 |
| Sia, CG | 1 |
| Blenman, S | 1 |
| Gartner, LM | 1 |
| Glass, L | 2 |
| Rothstein, P | 1 |
| Gould, JB | 1 |
| Evans, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Randomized Comparative Effectiveness Clinical Trial of Buprenorphine vs. Methadone for the Treatment of Opioid Dependence in Pregnancy.[NCT03098407] | 55 participants (Actual) | Interventional | 2017-04-20 | Completed | |||
| Assessing the Effects of Auricular Acupressure on Newborn Behaviors and Withdrawal Signs in Newborns With Neonatal Abstinence Syndrome: A Pilot Study[NCT03890562] | 12 participants (Actual) | Interventional | 2019-09-04 | Completed | |||
| Donor Human Milk for Infants With Neonatal Abstinence Syndrome[NCT02182973] | 12 participants (Actual) | Observational | 2014-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in head circumference from day 1 to day 14 (cm/wk) (NCT02182973)
Timeframe: 2 weeks
| Intervention | cm/wk (Mean) |
|---|---|
| Donor Human Milk | 0.4 |
| Historical Control | 0.6 |
Minimum score:0; Maximum score 13. Higher scores mean more GI distress (NCT02182973)
Timeframe: 2 weeks
| Intervention | Percentage of participants (Number) |
|---|---|
| Donor Human Milk | 39 |
| Historical Controls | 61 |
Change in weight from study day 1 to study day 14 (grams/day) Weight day 14 - weight day 1 divided by 14 (NCT02182973)
Timeframe: 2 weeks
| Intervention | grams/day (Mean) |
|---|---|
| Donor Human Milk | 19.1 |
| Historical Control | 20.5 |
4 reviews available for phenobarbital and Heroin Dependence
| Article | Year |
|---|---|
[The newborn infant of the drug-dependent mother. Review of literature and personal case reports].
Topics: Adult; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1980 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
Narcotic poisoning of children (1) through accidental ingestion of methadone and (2) in utero.
Topics: Administration, Oral; Apgar Score; Birth Weight; Child; Child Care; Female; Gestational Age; Heroin | 1974 |
19 other studies available for phenobarbital and Heroin Dependence
| Article | Year |
|---|---|
Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.
Topics: Adult; Biotransformation; Female; Heroin Dependence; Humans; Male; Methadone; Phenobarbital; Substan | 1984 |
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, | 1979 |
Observation and treatment of neonatal narcotic withdrawal.
Topics: Diazepam; Drug Therapy, Combination; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1977 |
Neonatal abstinence syndrome: assessment and management.
Topics: Administration, Oral; Antidiarrheals; Central Nervous System; Diazepam; Digestive System; Female; He | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
The assessment of behavioral change in infants undergoing narcotic withdrawal: comparative data from clinical and objective methods.
Topics: Arousal; Attention; Central Nervous System; Female; Heroin Dependence; Humans; Infant, Newborn; Infa | 1975 |
Effect of maternal heroin addiction on 67 liveborn neonates. Withdrawal symptoms, small body size, and small head circumference were frequent findings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Birth Weight; Blood Glucose; Cephalomet | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1975 |
Misuse and abuse of diazepam: an increasingly common medical problem.
Topics: Adult; Diazepam; Drug Prescriptions; Heroin Dependence; Humans; Legislation, Drug; Male; Methadone; | 1975 |
Treatment of polydrug users in San Francisco.
Topics: Adult; Aftercare; Alcoholism; Ambulatory Care; Anti-Anxiety Agents; California; Crisis Intervention; | 1974 |
Cardiac standstill in tetanus: review of seven consecutive cases.
Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Arrest; Heroin Dependence; Humans; H | 1973 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea | 1973 |
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma | 1974 |
Treatment of neonatal withdrawal syndrome.
Topics: Chlorpromazine; Diazepam; Heroin Dependence; Humans; Infant, Newborn; Methadone; Opium; Phenobarbita | 1973 |
Observations on the sudden death of infants born to addicted mothers.
Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn; | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Narcotic withdrawal in the newborn.
Topics: Birth Weight; Chlorpromazine; Cocaine; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, N | 1972 |