phenobarbital has been researched along with Hepatoblastoma in 4 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hepatoblastoma: A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We established a cell line (MHB-2) from a hepatoblastoma (HB) induced by diethylnitrosamine (DEN) and sodium phenobarbital (PB) in male B6C3F1 mice and examined the biological characteristics of MHB-2." | 3.70 | Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma. ( Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T, 2000) |
| "In previous studies, we found that male D2B6F1 mice fed phenobarbital (PB) for 53 weeks following N-nitrosodiethylamine (NDEA) initiation developed a high (70-80%) incidence of malignant hepatoblastomas." | 3.69 | Further evidence for promoter-dependent development of hepatoblastoma in the mouse. ( Diwan, BA; Henneman, JR; Rice, JM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gerloff, T | 1 |
| Geier, A | 1 |
| Roots, I | 1 |
| Meier, PJ | 1 |
| Gartung, C | 1 |
| Diwan, BA | 1 |
| Henneman, JR | 1 |
| Rice, JM | 1 |
| Sumida, A | 1 |
| Yamamoto, I | 1 |
| Zhou, Q | 1 |
| Morisaki, T | 1 |
| Azuma, J | 1 |
| Kobayashi, K | 1 |
| Sakairi, T | 1 |
| Goto, K | 1 |
| Tsuchiya, T | 1 |
| Sugimoto, J | 1 |
| Mutai, M | 1 |
4 other studies available for phenobarbital and Hepatoblastoma
| Article | Year |
|---|---|
Functional analysis of the rat bile salt export pump gene promoter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2002 |
Further evidence for promoter-dependent development of hepatoblastoma in the mouse.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatoblastoma; Liver Neoplasms, Experimental | 1995 |
Evaluation of induction of CYP3A mRNA using the HepG2 cell line and reverse transcription-PCR.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone | 1999 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver N | 2000 |