phenobarbital has been researched along with Hepatitis in 26 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hepatitis: INFLAMMATION of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice." | 8.31 | Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models. ( Fujino, C; Hayashi, K; Katsura, T; Kubo, Y; Kuzu, T; Ueshima, S, 2023) |
| "Pharmacokinetics of methohexital were studied in patients with acute hepatitis and after a treatment period either with "essential phospholipids" or phenobarbital." | 7.66 | [Methohexital clearance in patients with acute hepatitis (author's transl)]. ( Breimer, DD; Gallenkamp, H; Heusler, H; Richter, E; Zilly, W, 1979) |
| " Group 1 (n = 48), group 2 (n = 29), and group 3 (n = 18) received phenobarbital at the dosage of 5 mg/kg/day for at least 5 days, less than 5 mg/kg/day or less than 5 days, and no premedication, respectively." | 5.32 | The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. ( Charearnrad, P; Chongsrisawat, V; Poovorawan, Y; Tepmongkol, S, 2003) |
| " Phenobarbital was administered once as a CYP inducer in the carbon tetrachloride-induced hepatitis model mice." | 4.31 | Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models. ( Fujino, C; Hayashi, K; Katsura, T; Kubo, Y; Kuzu, T; Ueshima, S, 2023) |
| "Pharmacokinetics of methohexital were studied in patients with acute hepatitis and after a treatment period either with "essential phospholipids" or phenobarbital." | 3.66 | [Methohexital clearance in patients with acute hepatitis (author's transl)]. ( Breimer, DD; Gallenkamp, H; Heusler, H; Richter, E; Zilly, W, 1979) |
| "Serum squalene levels did not change in patients with acute hepatitis, chronic active hepatitis and liver cirrhosis, but were significantly reduced in patients with intra- and extrahepatic cholestasis." | 3.66 | Serum squalene levels in hepatobiliary diseases. ( Hirayama, C; Ikawa, S; Yamanishi, Y, 1978) |
| "Salicylamide glucuronide (SAMG) in 0-6 and 6-12 hours-urine specimens was determined after oral administration of salicylamide in 7 normal volunteers (NV), in 51 cases of various liver diseases and hyperbilirubinemias, and in 19 cases after drug administration, to predict the in vivo drug metabolism in man and its change by drugs." | 3.65 | Salycylamide glucuronide formation in liver disease and its change by drugs. ( Adachi, Y; Wakisaka, G; Yamamoto, T, 1975) |
| " Except for the patients with cholestatic hepatitis, in whom marked cholestasis was virtually the only abnormality in liver biopsy specimens, serum bilirubin and bile acid concentrations were diminished during therapy, the hepatic clearance of sulfobromophthalein and 131-I-rose bengal was variably enhanced, and there was relief from pruritus." | 3.65 | Phenobarbital effects in cholestatic liver diseases. ( Bloomer, JR; Boyer, JL, 1975) |
| " Group 1 (n = 48), group 2 (n = 29), and group 3 (n = 18) received phenobarbital at the dosage of 5 mg/kg/day for at least 5 days, less than 5 mg/kg/day or less than 5 days, and no premedication, respectively." | 1.32 | The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. ( Charearnrad, P; Chongsrisawat, V; Poovorawan, Y; Tepmongkol, S, 2003) |
| "Phenobarbital was administered to 22 patients before imaging." | 1.29 | Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice. ( Ben-Haim, S; Brown, BP; Johnson, J; Kao, SC; Seabold, JE; Tran, D, 1995) |
| "Antipyrine has been used as a model drug to investigate the effects of liver disease on drug metabolism in man." | 1.25 | Determinants of serum antipyrine half-lives in patients with liver disease. ( Branch, RA; Herbert, CM; Read, AE, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (88.46) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Fujino, C | 1 |
| Kuzu, T | 1 |
| Kubo, Y | 1 |
| Hayashi, K | 1 |
| Ueshima, S | 1 |
| Katsura, T | 1 |
| Charearnrad, P | 1 |
| Chongsrisawat, V | 1 |
| Tepmongkol, S | 1 |
| Poovorawan, Y | 1 |
| SVEC, F | 1 |
| HLAVAYOVA, E | 1 |
| DITTERTOVA, V | 1 |
| KUTT, H | 1 |
| WINTERS, W | 1 |
| SCHERMAN, R | 1 |
| MCDOWELL, F | 1 |
| HERDSON, PB | 1 |
| GARVIN, PJ | 1 |
| JENNINGS, RB | 1 |
| WELTON, DG | 1 |
| DUBOIS, EL | 1 |
| Sotaniemi, EA | 1 |
| Pelkonen, RO | 1 |
| Puukka, M | 1 |
| Majd, M | 1 |
| Reba, RC | 1 |
| Altman, RP | 1 |
| Ben-Haim, S | 1 |
| Seabold, JE | 1 |
| Kao, SC | 1 |
| Johnson, J | 1 |
| Tran, D | 1 |
| Brown, BP | 1 |
| Adachi, Y | 1 |
| Wakisaka, G | 1 |
| Yamamoto, T | 1 |
| Schenker, S | 1 |
| Hoyumpa, AM | 1 |
| Wilkinson, GR | 1 |
| Stiehl, A | 1 |
| Richter, E | 1 |
| Gallenkamp, H | 1 |
| Heusler, H | 1 |
| Zilly, W | 1 |
| Breimer, DD | 1 |
| Yamanishi, Y | 1 |
| Ikawa, S | 1 |
| Hirayama, C | 1 |
| Johnson, JD | 1 |
| Loginov, AS | 1 |
| Bloomer, JR | 1 |
| Boyer, JL | 1 |
| Nusinovici, V | 2 |
| Levy, VG | 2 |
| Caroli, J | 2 |
| De Oya, JC | 2 |
| Del Río, A | 2 |
| Noya, M | 2 |
| Villanueva, A | 1 |
| Greene, NM | 1 |
| Falcetti, JP | 1 |
| Branch, RA | 1 |
| Herbert, CM | 1 |
| Read, AE | 1 |
| Amar, AB | 1 |
| Okuda, K | 1 |
| Abe, H | 1 |
| Gladtke, E | 1 |
4 reviews available for phenobarbital and Hepatitis
| Article | Year |
|---|---|
The effect of parenchymal liver disease on the disposition and elimination of sedatives and analgesics.
Topics: Analgesics; Anti-Anxiety Agents; Barbiturates; Diazepam; Half-Life; Hepatitis; Humans; Hypnotics and | 1975 |
Disturbances of bile acid metabolism in cholestasis.
Topics: Bile Acids and Salts; Bile Ducts; Cholestasis; Cholestyramine Resin; Deoxycholic Acid; Disease Model | 1977 |
Neonatal nonhemolytic jaundice.
Topics: Bile Acids and Salts; Bile Ducts; Biliary Tract Diseases; Bilirubin; Brain Damage, Chronic; Breast F | 1975 |
[Recent progress in the study of liver diseases].
Topics: Adrenal Cortex Hormones; Anesthesia, Inhalation; Bilirubin; Biological Transport; Chemical and Drug | 1971 |
22 other studies available for phenobarbital and Hepatitis
| Article | Year |
|---|---|
Attenuation of phenobarbital-induced cytochrome P450 expression in carbon tetrachloride-induced hepatitis in mice models.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Gene Expressi | 2023 |
The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome.
Topics: Biliary Atresia; Excitatory Amino Acid Antagonists; Female; Hepatitis; Humans; Infant; Infant, Newbo | 2003 |
[ON THE PROBLEM OF THE PHARMACOLOGY AND TOXICOLOGY OF 6-AZAURACIL RIBOSIDE].
Topics: Acetylcholine; Blood Pressure; Cats; Heart; Hepatitis; Hepatitis A; Ileum; Nucleosides; Pharmacology | 1963 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis | 1964 |
FINE STRUCTURAL CHANGES IN RAT LIVER INDUCED BY PHENOBARBITAL.
Topics: Chemical and Drug Induced Liver Injury; Electrons; Hepatitis; Liver; Microscopy; Microscopy, Electro | 1964 |
Exfoliative dermatitis and hepatitis due to phenobarbital.
Topics: Barbital; Dermatitis; Dermatitis, Exfoliative; Hepatitis; Hepatitis A; Phenobarbital; Viral Vaccines | 1950 |
Toxic hepatic necrosis associated with taking dilantin, tridione and phenobarbital; report of a case.
Topics: Aged; Barbital; Hepatitis; Humans; Hydantoins; Liver; Liver Diseases; Phenobarbital; Phenytoin; Trim | 1950 |
Measurement of hepatic drug-metabolizing enxyme activity in man. Comparison of three different assays.
Topics: Adult; Aged; Antipyrine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Glucaric Acid; He | 1980 |
Hepatobiliary scintigraphy with 99mTc-PIPIDA in the evaluation of neonatal jaundice.
Topics: Bile Ducts; Female; Gallbladder; Hepatitis; Humans; Imino Acids; Infant; Infant, Newborn; Infant, Ne | 1981 |
Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice.
Topics: Aniline Compounds; Biliary Atresia; Cholestasis, Intrahepatic; Female; Glycine; Hepatitis; Humans; I | 1995 |
Salycylamide glucuronide formation in liver disease and its change by drugs.
Topics: Adolescent; Adult; Aged; Barbiturates; Bilirubin; Child; Female; Gilbert Disease; Glucuronates; Hepa | 1975 |
[Methohexital clearance in patients with acute hepatitis (author's transl)].
Topics: Acute Disease; Adolescent; Adult; Aged; Female; Hepatitis; Humans; Infusions, Parenteral; Male; Meth | 1979 |
Serum squalene levels in hepatobiliary diseases.
Topics: Acute Disease; Adult; Azathioprine; Biliary Tract Diseases; Cholestasis; Cholesterol; Cholestyramine | 1978 |
[Treatment of chronic diseases of the liver].
Topics: Adrenal Cortex Hormones; Chronic Disease; Hepatitis; Humans; Liver Cirrhosis; Liver Diseases; Phenob | 1977 |
Phenobarbital effects in cholestatic liver diseases.
Topics: Adult; Bile Ducts, Intrahepatic; Bilirubin; Chenodeoxycholic Acid; Child; Child, Preschool; Cholangi | 1975 |
[Letter: Treatment of cholestatic hepatitis by enzyme inductors].
Topics: Cholestasis; Enzyme Induction; Glutethimide; Hepatitis; Humans; Phenobarbital | 1976 |
Phenobarbitone in posthepatitic unconjugated hyperbilirubinaemia.
Topics: Adult; Hepatitis; Humans; Hyperbilirubinemia; Male; Phenobarbital | 1970 |
A program of general anesthesia for dental care of mentally retarded patients.
Topics: Adolescent; Adult; Anesthesia, General; Child; Dental Care; Evaluation Studies as Topic; Halothane; | 1974 |
Determinants of serum antipyrine half-lives in patients with liver disease.
Topics: Adult; Alkaline Phosphatase; Antipyrine; Aspartate Aminotransferases; Bilirubin; Half-Life; Hepatiti | 1973 |
[Acholangic cholestatic hepatitis evolving towards xanthomatosis and cirrhosis].
Topics: Bile Ducts; Bilirubin; Biopsy; Blood Proteins; Cholestasis; Female; Glutethimide; Hepatitis; Humans; | 1973 |
[Phenobarbital treatment of indirect hyperbilirubinemia states in various hepatic diseases].
Topics: Administration, Oral; Hepatitis; Humans; Hyperbilirubinemia; Hyperbilirubinemia, Hereditary; Liver C | 1972 |
[Acetonemic vomiting].
Topics: Abdomen, Acute; Acidosis; Brain Neoplasms; Child, Preschool; Diabetic Coma; Diagnosis, Differential; | 1969 |