phenobarbital has been researched along with Hepatic Encephalopathy in 17 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
Excerpt | Relevance | Reference |
---|---|---|
"The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
"The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
"This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h." | 1.27 | A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (82.35) | 18.7374 |
1990's | 1 (5.88) | 18.2507 |
2000's | 2 (11.76) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Rahman, TM | 1 |
Selden, AC | 1 |
Hodgson, HJ | 1 |
WARREN, KS | 1 |
SCHENKER, S | 1 |
Sarishvili, AG | 1 |
Mitagvariia, NP | 1 |
Azikuri, GSh | 1 |
Tsintsadze, TG | 1 |
Lazrishvili, IL | 1 |
Sagraves, R | 1 |
Bradberry, JC | 1 |
Derveaux, L | 1 |
Demedts, M | 1 |
Fevery, J | 1 |
Gyselen, A | 1 |
Puri, AS | 1 |
Sharma, BC | 1 |
Khan, EM | 1 |
Saraswat, VA | 1 |
Wilson, JT | 1 |
Kasantikul, V | 1 |
Harbison, R | 1 |
Martin, D | 1 |
Lesche, P | 1 |
Blume, U | 1 |
Scheibe, G | 1 |
Sussmann, P | 1 |
Schmidt, FW | 1 |
Bartels, M | 1 |
Okonek, S | 1 |
Miller, DJ | 1 |
Hickman, R | 3 |
Fratter, R | 1 |
Terblanche, J | 2 |
Saunders, SJ | 2 |
Patial, RK | 1 |
Sarin, R | 1 |
Patial, SB | 1 |
Alp, MH | 1 |
Ito, M | 1 |
Matsumoto, H | 1 |
Kikuchi, S | 1 |
Yachi, A | 1 |
Schwartz, GR | 1 |
Absolon, KB | 1 |
Carroll, AW | 1 |
Agostini, JC | 1 |
Goldbaum, LR | 1 |
Applebaum, ME | 1 |
Brachtel, D | 1 |
Thiel, H | 1 |
Zilly, W | 1 |
Richter, E | 1 |
van Leenhoff, JA | 1 |
Marin, GA | 1 |
Montoya, CA | 1 |
Sierra, JL | 1 |
Senior, JR | 1 |
1 review available for phenobarbital and Hepatic Encephalopathy
Article | Year |
---|---|
Death in an adolescent following an overdose of acetaminophen and phenobarbital.
Topics: Acetaminophen; Adolescent; Animals; Brain; Child; Diagnosis, Differential; Female; Gastric Lavage; H | 1978 |
1 trial available for phenobarbital and Hepatic Encephalopathy
Article | Year |
---|---|
Evaluation of corticosteroid and exchange-transfusion treatment of acute yellow-phosphorus intoxication.
Topics: Adolescent; Adult; Child; Exchange Transfusion, Whole Blood; Female; Glucocorticoids; Hepatic Enceph | 1971 |
15 other studies available for phenobarbital and Hepatic Encephalopathy
Article | Year |
---|---|
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.
Topics: Acetazolamide; Ammonia; Ammonium Chloride; Arginine; Chlorothiazide; Cortisone; Formaldehyde; Glutam | 1963 |
[Changes in emotional state and learning process disorders in rats with experimental hepatic encephalopathy].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Emotions; Hepatic Encephalopathy; Hypnotics and Se | 2006 |
The effects of exchange transfusion on the pharmacokinetics of phenobarbital.
Topics: Brain Edema; Child, Preschool; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Humans; Ki | 1983 |
[Fulminating hepatitis caused by administration of isoniazid and rifampicin in a patient under chronic treatment with barbiturates].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Hepatic | 1980 |
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans | 1994 |
[Hemoperfusion by means of encapsuled charcoal for the treatment of exogenous and endogenous intoxications].
Topics: Adsorption; Bromides; Charcoal; Diazepam; Heparin; Hepatic Encephalopathy; Humans; Parathion; Perfus | 1976 |
An animal model of fulminant hepatic failure: a feasibility study.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; He | 1976 |
Halothane associated hepatitis and phenobarbitone.
Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halo | 1989 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep | 1986 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co | 1986 |
Effect of phenobarbital on jaundice.
Topics: Bilirubin; Enzyme Induction; Hepatic Encephalopathy; Humans; Jaundice; Phenobarbital | 1967 |
Proceedings: experimental hepatic coma and lethal barbiturate intoxication response to total-body asanguineous hypothermic perfusion in dogs.
Topics: Ammonia; Animals; Dogs; Hepatic Encephalopathy; Hypothermia, Induced; Injections, Intravenous; Perfu | 1973 |
[Relations between drug metabolizing liver enzyme system activity and disease course of experimental hepatic coma in animal experiment].
Topics: Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Hepatic Encephalopathy; Hexobarbital; Liver; P | 1973 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |