phenobarbital has been researched along with Hepatic Encephalopathy in 17 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h." | 1.27 | A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (82.35) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rahman, TM | 1 |
| Selden, AC | 1 |
| Hodgson, HJ | 1 |
| WARREN, KS | 1 |
| SCHENKER, S | 1 |
| Sarishvili, AG | 1 |
| Mitagvariia, NP | 1 |
| Azikuri, GSh | 1 |
| Tsintsadze, TG | 1 |
| Lazrishvili, IL | 1 |
| Sagraves, R | 1 |
| Bradberry, JC | 1 |
| Derveaux, L | 1 |
| Demedts, M | 1 |
| Fevery, J | 1 |
| Gyselen, A | 1 |
| Puri, AS | 1 |
| Sharma, BC | 1 |
| Khan, EM | 1 |
| Saraswat, VA | 1 |
| Wilson, JT | 1 |
| Kasantikul, V | 1 |
| Harbison, R | 1 |
| Martin, D | 1 |
| Lesche, P | 1 |
| Blume, U | 1 |
| Scheibe, G | 1 |
| Sussmann, P | 1 |
| Schmidt, FW | 1 |
| Bartels, M | 1 |
| Okonek, S | 1 |
| Miller, DJ | 1 |
| Hickman, R | 3 |
| Fratter, R | 1 |
| Terblanche, J | 2 |
| Saunders, SJ | 2 |
| Patial, RK | 1 |
| Sarin, R | 1 |
| Patial, SB | 1 |
| Alp, MH | 1 |
| Ito, M | 1 |
| Matsumoto, H | 1 |
| Kikuchi, S | 1 |
| Yachi, A | 1 |
| Schwartz, GR | 1 |
| Absolon, KB | 1 |
| Carroll, AW | 1 |
| Agostini, JC | 1 |
| Goldbaum, LR | 1 |
| Applebaum, ME | 1 |
| Brachtel, D | 1 |
| Thiel, H | 1 |
| Zilly, W | 1 |
| Richter, E | 1 |
| van Leenhoff, JA | 1 |
| Marin, GA | 1 |
| Montoya, CA | 1 |
| Sierra, JL | 1 |
| Senior, JR | 1 |
1 review available for phenobarbital and Hepatic Encephalopathy
| Article | Year |
|---|---|
Death in an adolescent following an overdose of acetaminophen and phenobarbital.
Topics: Acetaminophen; Adolescent; Animals; Brain; Child; Diagnosis, Differential; Female; Gastric Lavage; H | 1978 |
1 trial available for phenobarbital and Hepatic Encephalopathy
| Article | Year |
|---|---|
Evaluation of corticosteroid and exchange-transfusion treatment of acute yellow-phosphorus intoxication.
Topics: Adolescent; Adult; Child; Exchange Transfusion, Whole Blood; Female; Glucocorticoids; Hepatic Enceph | 1971 |
15 other studies available for phenobarbital and Hepatic Encephalopathy
| Article | Year |
|---|---|
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.
Topics: Acetazolamide; Ammonia; Ammonium Chloride; Arginine; Chlorothiazide; Cortisone; Formaldehyde; Glutam | 1963 |
[Changes in emotional state and learning process disorders in rats with experimental hepatic encephalopathy].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Emotions; Hepatic Encephalopathy; Hypnotics and Se | 2006 |
The effects of exchange transfusion on the pharmacokinetics of phenobarbital.
Topics: Brain Edema; Child, Preschool; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Humans; Ki | 1983 |
[Fulminating hepatitis caused by administration of isoniazid and rifampicin in a patient under chronic treatment with barbiturates].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Hepatic | 1980 |
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans | 1994 |
[Hemoperfusion by means of encapsuled charcoal for the treatment of exogenous and endogenous intoxications].
Topics: Adsorption; Bromides; Charcoal; Diazepam; Heparin; Hepatic Encephalopathy; Humans; Parathion; Perfus | 1976 |
An animal model of fulminant hepatic failure: a feasibility study.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; He | 1976 |
Halothane associated hepatitis and phenobarbitone.
Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halo | 1989 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep | 1986 |
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co | 1986 |
Effect of phenobarbital on jaundice.
Topics: Bilirubin; Enzyme Induction; Hepatic Encephalopathy; Humans; Jaundice; Phenobarbital | 1967 |
Proceedings: experimental hepatic coma and lethal barbiturate intoxication response to total-body asanguineous hypothermic perfusion in dogs.
Topics: Ammonia; Animals; Dogs; Hepatic Encephalopathy; Hypothermia, Induced; Injections, Intravenous; Perfu | 1973 |
[Relations between drug metabolizing liver enzyme system activity and disease course of experimental hepatic coma in animal experiment].
Topics: Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Hepatic Encephalopathy; Hexobarbital; Liver; P | 1973 |
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug | 1974 |