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phenobarbital and Hepatic Encephalopathy

phenobarbital has been researched along with Hepatic Encephalopathy in 17 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure."7.71A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002)
"The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure."3.71A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002)
"This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h."1.27A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199014 (82.35)18.7374
1990's1 (5.88)18.2507
2000's2 (11.76)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rahman, TM1
Selden, AC1
Hodgson, HJ1
WARREN, KS1
SCHENKER, S1
Sarishvili, AG1
Mitagvariia, NP1
Azikuri, GSh1
Tsintsadze, TG1
Lazrishvili, IL1
Sagraves, R1
Bradberry, JC1
Derveaux, L1
Demedts, M1
Fevery, J1
Gyselen, A1
Puri, AS1
Sharma, BC1
Khan, EM1
Saraswat, VA1
Wilson, JT1
Kasantikul, V1
Harbison, R1
Martin, D1
Lesche, P1
Blume, U1
Scheibe, G1
Sussmann, P1
Schmidt, FW1
Bartels, M1
Okonek, S1
Miller, DJ1
Hickman, R3
Fratter, R1
Terblanche, J2
Saunders, SJ2
Patial, RK1
Sarin, R1
Patial, SB1
Alp, MH1
Ito, M1
Matsumoto, H1
Kikuchi, S1
Yachi, A1
Schwartz, GR1
Absolon, KB1
Carroll, AW1
Agostini, JC1
Goldbaum, LR1
Applebaum, ME1
Brachtel, D1
Thiel, H1
Zilly, W1
Richter, E1
van Leenhoff, JA1
Marin, GA1
Montoya, CA1
Sierra, JL1
Senior, JR1

Reviews

1 review available for phenobarbital and Hepatic Encephalopathy

ArticleYear
Death in an adolescent following an overdose of acetaminophen and phenobarbital.
    American journal of diseases of children (1960), 1978, Volume: 132, Issue:5

    Topics: Acetaminophen; Adolescent; Animals; Brain; Child; Diagnosis, Differential; Female; Gastric Lavage; H

1978

Trials

1 trial available for phenobarbital and Hepatic Encephalopathy

ArticleYear
Evaluation of corticosteroid and exchange-transfusion treatment of acute yellow-phosphorus intoxication.
    The New England journal of medicine, 1971, Jan-21, Volume: 284, Issue:3

    Topics: Adolescent; Adult; Child; Exchange Transfusion, Whole Blood; Female; Glucocorticoids; Hepatic Enceph

1971

Other Studies

15 other studies available for phenobarbital and Hepatic Encephalopathy

ArticleYear
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
    The Journal of surgical research, 2002, Volume: 106, Issue:2

    Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim

2002
DRUGS RELATED TO THE EXACERBATION OR AMELIORATION OF HEPATIC COMA AND THEIR EFFECTS ON AMMONIA TOXICITY.
    Clinical science, 1963, Volume: 25

    Topics: Acetazolamide; Ammonia; Ammonium Chloride; Arginine; Chlorothiazide; Cortisone; Formaldehyde; Glutam

1963
[Changes in emotional state and learning process disorders in rats with experimental hepatic encephalopathy].
    Georgian medical news, 2006, Issue:135

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Emotions; Hepatic Encephalopathy; Hypnotics and Se

2006
The effects of exchange transfusion on the pharmacokinetics of phenobarbital.
    Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:12

    Topics: Brain Edema; Child, Preschool; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Humans; Ki

1983
[Fulminating hepatitis caused by administration of isoniazid and rifampicin in a patient under chronic treatment with barbiturates].
    Nederlands tijdschrift voor geneeskunde, 1980, Jun-21, Volume: 124, Issue:25

    Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Hepatic

1980
Fatal fulminant hepatic failure due to sodium valproate in an adolescent.
    Indian pediatrics, 1994, Volume: 31, Issue:2

    Topics: Adolescent; Brain Diseases; Drug Therapy, Combination; Fatal Outcome; Hepatic Encephalopathy; Humans

1994
[Hemoperfusion by means of encapsuled charcoal for the treatment of exogenous and endogenous intoxications].
    Klinische Wochenschrift, 1976, Jun-01, Volume: 54, Issue:11

    Topics: Adsorption; Bromides; Charcoal; Diazepam; Heparin; Hepatic Encephalopathy; Humans; Parathion; Perfus

1976
An animal model of fulminant hepatic failure: a feasibility study.
    Gastroenterology, 1976, Volume: 71, Issue:1

    Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; He

1976
Halothane associated hepatitis and phenobarbitone.
    The Journal of the Association of Physicians of India, 1989, Volume: 37, Issue:7

    Topics: Adult; Anesthesia, Obstetrical; Chemical and Drug Induced Liver Injury; Drug Synergism; Female; Halo

1989
A predictable pathophysiological model of porcine hepatic failure.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1986, Volume: 18, Issue:5

    Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep

1986
[A comparative study of free amino acid levels in the serum and cerebral cortex in hepatic failure rats].
    No to shinkei = Brain and nerve, 1986, Volume: 38, Issue:1

    Topics: Acute Disease; Amino Acids; Ammonia; Animals; Blood-Brain Barrier; Carbon Tetrachloride; Cerebral Co

1986
Effect of phenobarbital on jaundice.
    The New England journal of medicine, 1967, Aug-17, Volume: 277, Issue:7

    Topics: Bilirubin; Enzyme Induction; Hepatic Encephalopathy; Humans; Jaundice; Phenobarbital

1967
Proceedings: experimental hepatic coma and lethal barbiturate intoxication response to total-body asanguineous hypothermic perfusion in dogs.
    The British journal of surgery, 1973, Volume: 60, Issue:11

    Topics: Ammonia; Animals; Dogs; Hepatic Encephalopathy; Hypothermia, Induced; Injections, Intravenous; Perfu

1973
[Relations between drug metabolizing liver enzyme system activity and disease course of experimental hepatic coma in animal experiment].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1973, Volume: 79

    Topics: Animals; Cytochrome P-450 Enzyme System; Guinea Pigs; Hepatic Encephalopathy; Hexobarbital; Liver; P

1973
Massive liver cell necrosis induced in the pig with carbon tetrachloride.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Jun-12, Volume: 48, Issue:28

    Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug

1974