phenobarbital has been researched along with Heart Failure in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He developed many annular skin eruptions and peripheral eosinophilia due to reactions against phenobarbital." | 7.70 | Eosinophilic myocarditis associated with toxicodermia caused by phenobarbital. ( Arima, M; Kanoh, T; Kasuya, H; Kawai, S; Matsuda, S; Okada, R; Sunayama, S; Yamasaki, A, 1998) |
| " He developed many annular skin eruptions and peripheral eosinophilia due to reactions against phenobarbital." | 3.70 | Eosinophilic myocarditis associated with toxicodermia caused by phenobarbital. ( Arima, M; Kanoh, T; Kasuya, H; Kawai, S; Matsuda, S; Okada, R; Sunayama, S; Yamasaki, A, 1998) |
| " Based on the available data it seems that one may postulate the following conclusions: (1) that the distribution factors as well as changes in drug elimination capacities seem to play a role, perhaps with differing relative importance, during each of the maturational periods; (2) that the physicochemical properties of a drug and its dosage, as well as changes in the volume of distribution in children, in the course of certain disease states may have a significant effect on kinetics of drug disposition in the body; (3) that systemic clearance, a model independent parameter, rather than elimination half-life, a hybrid pharmacokinetic parameter, more accurately reflects elimination of some drugs from the body; (4) that each drug and every clinical situation may require the evaluation of the direct effect on pharmacokinetic processes, since general principles may not always apply; (5) that drug disposition studies should also be performed, if possible, on patients under actual clinical situations and receiving the usual therapeutic regime, and (6) that the half-life of colistin is independent of postnatal age which should serve as a warning not to generalize about drug excretion in the young infant." | 2.37 | Clinical pharmacokinetics of changes in drug elimination in children. ( Prandota, J, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| DE MICHELI, E | 1 |
| PARENTI, B | 1 |
| FINEBERG, SK | 1 |
| MACKENZIE, GJ | 1 |
| PASCUAL, S | 1 |
| Wimmer, H | 1 |
| Spesshardt, K | 1 |
| Risler, T | 1 |
| Seipel, L | 1 |
| Miano, A | 1 |
| Casadei, G | 1 |
| Biasini, G | 1 |
| Arima, M | 1 |
| Kanoh, T | 1 |
| Yamasaki, A | 1 |
| Matsuda, S | 1 |
| Kasuya, H | 1 |
| Sunayama, S | 1 |
| Kawai, S | 1 |
| Okada, R | 1 |
| Prandota, J | 1 |
| Aryanpur, I | 1 |
| Farhoudi, A | 1 |
| Zangeneh, F | 1 |
1 review available for phenobarbital and Heart Failure
| Article | Year |
|---|---|
Clinical pharmacokinetics of changes in drug elimination in children.
Topics: Adult; Anti-Bacterial Agents; Brain Injuries; Child; Child, Preschool; Colistin; Cystic Fibrosis; Di | 1985 |
8 other studies available for phenobarbital and Heart Failure
| Article | Year |
|---|---|
[The combination of meprobamate and phenylethylmalonylurea in therapy].
Topics: Arteriosclerosis; Heart Failure; Humans; Hypertension; Hyperthyroidism; Meprobamate; Myocardial Infa | 1963 |
MASSIVE OBESITY AND WATER RETENTION.
Topics: Diet, Reducing; Diuretics; Edema; Heart Failure; Humans; Obesity; Phenmetrazine; Phenobarbital | 1964 |
PAROXYSMAL VENTRICULAR TACHYCARDIA.
Topics: Coronary Disease; Diagnosis; Digitalis Glycosides; Electrocardiography; Heart Failure; Hydrocortison | 1964 |
[The treatment of heart diseases from various causes with the combination preparation Spasmo-Guttacor].
Topics: Coronary Disease; Heart Failure; Humans; Papaverine; Phenobarbital; Plants, Medicinal; Quinidine | 1966 |
[Controlled digitalis therapy].
Topics: Cholestyramine Resin; Digitalis Glycosides; Digitoxin; Digoxin; Dose-Response Relationship, Drug; Dr | 1983 |
Cardiac failure in pseudohypoparathyroidism.
Topics: Anticonvulsants; Child, Preschool; Heart Failure; Humans; Male; Phenobarbital; Pseudohypoparathyroid | 1981 |
Eosinophilic myocarditis associated with toxicodermia caused by phenobarbital.
Topics: Adult; Drug Eruptions; Eosinophilia; Heart Failure; Humans; Hypnotics and Sedatives; Male; Myocardit | 1998 |
Congestive heart failure secondary to idiopathic hypoparathyroidism.
Topics: Adolescent; Calcium; Diagnostic Errors; Digoxin; Electrocardiography; Electroencephalography; Epilep | 1974 |