phenobarbital has been researched along with Glioma in 16 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation." | 7.88 | Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience. ( Britton, J; Clark, S; Hocker, S, 2018) |
| " The radiation dosage in each group was equal to 1702 ret." | 6.65 | The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980) |
| "The population pharmacokinetic model reported here was developed using data from 2 phase 2 trials of irinotecan for treatment of malignant glioma to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics." | 5.20 | Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure. ( Ames, MM; Berg, AK; Buckner, JC; Galanis, E; Jaeckle, KA; Reid, JM, 2015) |
| "Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation." | 3.88 | Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience. ( Britton, J; Clark, S; Hocker, S, 2018) |
| " The radiation dosage in each group was equal to 1702 ret." | 2.65 | The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980) |
| "Nervous system tumors were induced only in animals exposed to ENU." | 1.28 | Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea. ( Swenberg, JA; Walker, VE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hocker, S | 1 |
| Clark, S | 1 |
| Britton, J | 1 |
| Berg, AK | 1 |
| Buckner, JC | 1 |
| Galanis, E | 1 |
| Jaeckle, KA | 1 |
| Ames, MM | 1 |
| Reid, JM | 1 |
| MARX, GF | 1 |
| SCHEINBERG, L | 1 |
| ROMNEY, SL | 1 |
| Yumitori, K | 2 |
| Yamashita, J | 2 |
| Teraura, T | 2 |
| Handa, H | 2 |
| Nagashima, T | 1 |
| Matsutani, M | 1 |
| Kohono, T | 1 |
| Muraoka, K | 1 |
| Bleehen, NM | 1 |
| Geng, J | 2 |
| Strobel, HW | 2 |
| Lust, WD | 1 |
| Schwartz, JP | 1 |
| Passonneau, JV | 1 |
| Van Buren, JM | 1 |
| Ajmone-Marsan, C | 1 |
| Mutsuga, N | 1 |
| Sadowsky, D | 1 |
| Walker, VE | 1 |
| Swenberg, JA | 1 |
| Jou, TC | 1 |
| Wei, JW | 1 |
| Peng, TI | 1 |
| Rektor, I | 1 |
| Bednarík, J | 1 |
| Svejdová, M | 1 |
| Naito, M | 1 |
| Aoyama, H | 1 |
| Ito, A | 1 |
2 trials available for phenobarbital and Glioma
| Article | Year |
|---|---|
Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carb | 2015 |
The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies.
Topics: Brain Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Glioma; Head an | 1980 |
14 other studies available for phenobarbital and Glioma
| Article | Year |
|---|---|
Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Brain Waves; Electroencephalography; Female; Glasgow | 2018 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
[Treatment of brain tumor with phenobarbital and continuous infusion of ACNU into internal carotid artery].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carotid Artery, Internal; Drug Therapy, Combina | 1983 |
[Effects of phenobarbital on the metabolism of ACNU in vivo].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Glioma; Male; Nimustine; Nitrosourea Compounds; Phe | 1983 |
[ACNU delivery to malignant tumor tissue and serum--route of administration and combined use of phenobarbital].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain; Brain Neoplasms; Child, Preschool; Drug Thera | 1983 |
Treatment of malignant brain tumours with ACNU and phenobarbital: continuous infusion of ACNU into internal carotid artery and systemic administration of phenobarbital.
Topics: Adult; Aged; Astrocytoma; Bone Marrow; Brain Neoplasms; Carotid Artery, Internal; Erythrocyte Count; | 1984 |
Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benz(a)Anthracenes; Brain; Cell Line; Cytochr | 1993 |
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Topics: Animals; Benz(a)Anthracenes; Brain Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Syste | 1997 |
Glycolytic metabolism in cultured cells of the nervous system. I. Glucose transport and metabolism in the C-6 glioma cell line.
Topics: Acetone; Biological Transport, Active; Cell Line; Fluoroacetates; Glioma; Glucose; Glycolysis; Hydro | 1975 |
Surgery of temporal lobe epilepsy.
Topics: Adolescent; Adult; Astrocytes; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Electroenc | 1975 |
Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea.
Topics: Animals; Astrocytes; Ethylnitrosourea; Female; Gestational Age; Glioma; Male; Maternal-Fetal Exchang | 1989 |
[Effects of phenobarbital and phenytoin on the growth morphology and some ATPase activities of rat brain astrocytes derived from normal newborn cerebrum and C6 glioma cells in culture].
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Cell Division; Cells, Cultured; Glioma; Pheno | 1988 |
[Anticonvulsants in the therapy of glioblastomas].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Combined Modality Therapy; Drug Therapy, Com | 1986 |
Inhibitory effect of phenobarbital on the development of gliomas in WF rats treated neonatally with N-ethyl-N-nitrosourea.
Topics: Animals; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Glioma; Male; Nitrosourea Compo | 1985 |