phenobarbital has been researched along with Glial Cell Tumors in 16 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation." | 7.88 | Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience. ( Britton, J; Clark, S; Hocker, S, 2018) |
| " The radiation dosage in each group was equal to 1702 ret." | 6.65 | The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980) |
| "The population pharmacokinetic model reported here was developed using data from 2 phase 2 trials of irinotecan for treatment of malignant glioma to quantify the impact of concomitant therapy with enzyme-inducing antiepileptic drugs (EIAEDs) on irinotecan pharmacokinetics." | 5.20 | Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure. ( Ames, MM; Berg, AK; Buckner, JC; Galanis, E; Jaeckle, KA; Reid, JM, 2015) |
| "Despite phenobarbital (PB) being a key component in status epilepticus (SE) treatment algorithms for decades, it has fallen out of favor compared to newer nonsedating medications due to potential for respiratory suppression and prolonged sedation." | 3.88 | Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience. ( Britton, J; Clark, S; Hocker, S, 2018) |
| " The radiation dosage in each group was equal to 1702 ret." | 2.65 | The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies. ( Bleehen, NM, 1980) |
| "Nervous system tumors were induced only in animals exposed to ENU." | 1.28 | Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea. ( Swenberg, JA; Walker, VE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hocker, S | 1 |
| Clark, S | 1 |
| Britton, J | 1 |
| Berg, AK | 1 |
| Buckner, JC | 1 |
| Galanis, E | 1 |
| Jaeckle, KA | 1 |
| Ames, MM | 1 |
| Reid, JM | 1 |
| MARX, GF | 1 |
| SCHEINBERG, L | 1 |
| ROMNEY, SL | 1 |
| Yumitori, K | 2 |
| Yamashita, J | 2 |
| Teraura, T | 2 |
| Handa, H | 2 |
| Nagashima, T | 1 |
| Matsutani, M | 1 |
| Kohono, T | 1 |
| Muraoka, K | 1 |
| Bleehen, NM | 1 |
| Geng, J | 2 |
| Strobel, HW | 2 |
| Lust, WD | 1 |
| Schwartz, JP | 1 |
| Passonneau, JV | 1 |
| Van Buren, JM | 1 |
| Ajmone-Marsan, C | 1 |
| Mutsuga, N | 1 |
| Sadowsky, D | 1 |
| Walker, VE | 1 |
| Swenberg, JA | 1 |
| Jou, TC | 1 |
| Wei, JW | 1 |
| Peng, TI | 1 |
| Rektor, I | 1 |
| Bednarík, J | 1 |
| Svejdová, M | 1 |
| Naito, M | 1 |
| Aoyama, H | 1 |
| Ito, A | 1 |
2 trials available for phenobarbital and Glial Cell Tumors
| Article | Year |
|---|---|
Quantification of the impact of enzyme-inducing antiepileptic drugs on irinotecan pharmacokinetics and SN-38 exposure.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Camptothecin; Carb | 2015 |
The Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies.
Topics: Brain Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Glioma; Head an | 1980 |
14 other studies available for phenobarbital and Glial Cell Tumors
| Article | Year |
|---|---|
Parenteral phenobarbital in status epilepticus revisited: Mayo Clinic experience.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Brain Waves; Electroencephalography; Female; Glasgow | 2018 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
[Treatment of brain tumor with phenobarbital and continuous infusion of ACNU into internal carotid artery].
Topics: Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Carotid Artery, Internal; Drug Therapy, Combina | 1983 |
[Effects of phenobarbital on the metabolism of ACNU in vivo].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Glioma; Male; Nimustine; Nitrosourea Compounds; Phe | 1983 |
[ACNU delivery to malignant tumor tissue and serum--route of administration and combined use of phenobarbital].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Brain; Brain Neoplasms; Child, Preschool; Drug Thera | 1983 |
Treatment of malignant brain tumours with ACNU and phenobarbital: continuous infusion of ACNU into internal carotid artery and systemic administration of phenobarbital.
Topics: Adult; Aged; Astrocytoma; Bone Marrow; Brain Neoplasms; Carotid Artery, Internal; Erythrocyte Count; | 1984 |
Identification of cytochromes P450 1A2, 2A1, 2C7, 2E1 in rat glioma C6 cell line by RT-PCR and specific restriction enzyme digestion.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benz(a)Anthracenes; Brain; Cell Line; Cytochr | 1993 |
Expression and induction of cytochrome P-450 1A1 and P-450 2D subfamily in the rat glioma C6 cell line.
Topics: Animals; Benz(a)Anthracenes; Brain Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Syste | 1997 |
Glycolytic metabolism in cultured cells of the nervous system. I. Glucose transport and metabolism in the C-6 glioma cell line.
Topics: Acetone; Biological Transport, Active; Cell Line; Fluoroacetates; Glioma; Glucose; Glycolysis; Hydro | 1975 |
Surgery of temporal lobe epilepsy.
Topics: Adolescent; Adult; Astrocytes; Brain Neoplasms; Cerebral Cortex; Child; Child, Preschool; Electroenc | 1975 |
Phenobarbital lacks promoting activity for neurogenic tumors in F344 rats transplacentally exposed to ethylnitrosourea.
Topics: Animals; Astrocytes; Ethylnitrosourea; Female; Gestational Age; Glioma; Male; Maternal-Fetal Exchang | 1989 |
[Effects of phenobarbital and phenytoin on the growth morphology and some ATPase activities of rat brain astrocytes derived from normal newborn cerebrum and C6 glioma cells in culture].
Topics: Adenosine Triphosphatases; Animals; Astrocytes; Brain; Cell Division; Cells, Cultured; Glioma; Pheno | 1988 |
[Anticonvulsants in the therapy of glioblastomas].
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Combined Modality Therapy; Drug Therapy, Com | 1986 |
Inhibitory effect of phenobarbital on the development of gliomas in WF rats treated neonatally with N-ethyl-N-nitrosourea.
Topics: Animals; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Glioma; Male; Nitrosourea Compo | 1985 |