phenobarbital has been researched along with Folic Acid Deficiency in 34 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (91.18) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HANSEN, HA | 1 |
| NORDQVIST, P | 1 |
| SOURANDER, P | 1 |
| HAMFELT, A | 1 |
| KILLANDER, A | 1 |
| MALERS, E | 1 |
| DEVERDIER, CH | 1 |
| Billings, RE | 1 |
| Ravakhah, K | 1 |
| West, BC | 1 |
| Kishi, T | 1 |
| Fujita, N | 1 |
| Eguchi, T | 1 |
| Ueda, K | 1 |
| Schwaninger, M | 1 |
| Ringleb, P | 1 |
| Winter, R | 1 |
| Kohl, B | 1 |
| Fiehn, W | 1 |
| Rieser, PA | 1 |
| Walter-Sack, I | 1 |
| Botez, MI | 1 |
| Peyronnard, JM | 1 |
| Bérubé, L | 1 |
| Labrecque, R | 1 |
| Trimble, MR | 1 |
| Reynolds, EH | 9 |
| Eastham, RD | 1 |
| Jancar, J | 1 |
| Cameron, JD | 1 |
| Williams, DL | 1 |
| Spray, GH | 2 |
| Baylis, EM | 1 |
| Crowley, JM | 1 |
| Preece, JM | 1 |
| Sylvester, PE | 1 |
| Marks, V | 1 |
| Fehling, C | 1 |
| Jägerstad, M | 1 |
| Lindstrand, K | 1 |
| Westesson, AK | 1 |
| Taguchi, H | 2 |
| Gibberd, FB | 1 |
| Smith, DB | 1 |
| Racusen, LC | 1 |
| Loyning, Y | 1 |
| Henriksen, O | 1 |
| Burns, DG | 1 |
| Davis, RE | 1 |
| Woodliff, HJ | 1 |
| Preece, J | 1 |
| Johnson, AL | 1 |
| Chanarin, I | 1 |
| Milner, G | 1 |
| Matthews, DM | 2 |
| Pritchard, JA | 1 |
| Scott, DE | 1 |
| Whalley, PJ | 1 |
| Miller, DR | 1 |
| Gordon, N | 1 |
| Jensen, ON | 1 |
| Olesen, OV | 1 |
| Hallpike, JF | 1 |
| Phillips, BM | 1 |
1 review available for phenobarbital and Folic Acid Deficiency
| Article | Year |
|---|---|
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
2 trials available for phenobarbital and Folic Acid Deficiency
| Article | Year |
|---|---|
Influence of folic acid on blood-phenytoin levels.
Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Ph | 1971 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
32 other studies available for phenobarbital and Folic Acid Deficiency
| Article | Year |
|---|---|
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai | 1964 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy; | 1965 |
Interactions between folate metabolism, phenytoin metabolism, and liver microsomal cytochrome P450.
Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; In Vitro Techniques; Liver; Male; Microsomes, Live | 1984 |
Case report: subacute combined degeneration of the spinal cord from folate deficiency.
Topics: Adult; Erythrocyte Transfusion; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Spin | 1995 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Fe | 1997 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi | 1999 |
Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association.
Topics: Atrophy; Brain Diseases; Edema; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intesti | 1979 |
[Megaloblastic anemia caused by folic acid deficiency during treatment with barbiturates].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Middle Aged; Phenobarbital | 1977 |
Anticonvulsant drugs and mental symptoms: a review.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Folic Acid | 1976 |
Red cell folate and macrocytosis during long-term anticonvulsant therapy in non-anaemic mentally. Retarded epileptics.
Topics: Dose-Response Relationship, Drug; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid | 1975 |
Effect of some anticonvulsant drugs on depletion of folate in rats on a vitamin B12-deficient diet.
Topics: Animals; Dietary Proteins; Female; Folic Acid Deficiency; Formiminoglutamic Acid; Liver; Phenobarbit | 1976 |
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; M | 1967 |
The effect of anticonvulsant therapy upon the absorption of folates.
Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; | 1973 |
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. I. Clinical and nutritional study on megalobastic anemia due to anticonvulsants.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Diet; Epilepsy, Temporal Lobe; Folic Acid; Folic Acid De | 1971 |
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. 2. Investigations on patients receiving anticonvulsants and experimental study on the effect of diphenylhydantoin on the absorption of folic acid in rats.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Cell Nucleus; Depression, Chemical; Epithelial Cells; F | 1971 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug | 1970 |
Epilepsy.
Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T | 1969 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Clinical conference: megaloblastic anemia associated with anticonvulsant drugs.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Female; Folic Acid; Folic Acid Deficiency; Humans; Pheno | 1972 |
Folate metabolism and the anticonvulsant efficacy of phenobarbital.
Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital; | 1973 |
[Editorial: Antiepileptic agents--folic acid].
Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; P | 1973 |
Folate metabolism and anticonvulsant therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primi | 1974 |
Folate deficiency and anticonvulsant drugs.
Topics: Animals; Enzyme Induction; Female; Folic Acid; Folic Acid Deficiency; Liver; Male; Oxidoreductases; | 1972 |
Folic acid deficiency in patients receiving anticonvulsant drugs.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Folic Acid; Folic Acid De | 1971 |
Folate metabolism in epileptic and psychiatric patients.
Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum | 1971 |
Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.
Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Age | 1966 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, | 1971 |
Serum folate deficiency in children receiving anticonvulsant therapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocyte Coun | 1968 |
Folic acid deficiency from anticonvulsant therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Defic | 1968 |
Mental effects of anticonvulsants, and folic acid metabolism.
Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De | 1968 |
Folic acid and anticonvulsive drugs.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol | 1969 |
Reversible absorptive defects in anticonvulsant megaloblastic anaemia.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Blood; Female; FIGLU Test; Folic Acid Deficiency; Humans | 1965 |