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phenobarbital and Folic Acid Deficiency

phenobarbital has been researched along with Folic Acid Deficiency in 34 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Folic Acid Deficiency: A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199031 (91.18)18.7374
1990's3 (8.82)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
HANSEN, HA1
NORDQVIST, P1
SOURANDER, P1
HAMFELT, A1
KILLANDER, A1
MALERS, E1
DEVERDIER, CH1
Billings, RE1
Ravakhah, K1
West, BC1
Kishi, T1
Fujita, N1
Eguchi, T1
Ueda, K1
Schwaninger, M1
Ringleb, P1
Winter, R1
Kohl, B1
Fiehn, W1
Rieser, PA1
Walter-Sack, I1
Botez, MI1
Peyronnard, JM1
Bérubé, L1
Labrecque, R1
Trimble, MR1
Reynolds, EH9
Eastham, RD1
Jancar, J1
Cameron, JD1
Williams, DL1
Spray, GH2
Baylis, EM1
Crowley, JM1
Preece, JM1
Sylvester, PE1
Marks, V1
Fehling, C1
Jägerstad, M1
Lindstrand, K1
Westesson, AK1
Taguchi, H2
Gibberd, FB1
Smith, DB1
Racusen, LC1
Loyning, Y1
Henriksen, O1
Burns, DG1
Davis, RE1
Woodliff, HJ1
Preece, J1
Johnson, AL1
Chanarin, I1
Milner, G1
Matthews, DM2
Pritchard, JA1
Scott, DE1
Whalley, PJ1
Miller, DR1
Gordon, N1
Jensen, ON1
Olesen, OV1
Hallpike, JF1
Phillips, BM1

Reviews

1 review available for phenobarbital and Folic Acid Deficiency

ArticleYear
Cerebrospinal folate levels in epileptics and their response to folate therapy.
    Nutrition reviews, 1974, Volume: 32, Issue:3

    Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def

1974

Trials

2 trials available for phenobarbital and Folic Acid Deficiency

ArticleYear
Influence of folic acid on blood-phenytoin levels.
    Lancet (London, England), 1971, Jan-09, Volume: 1, Issue:7689

    Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Ph

1971
Cerebrospinal folate levels in epileptics and their response to folate therapy.
    Nutrition reviews, 1974, Volume: 32, Issue:3

    Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def

1974

Other Studies

32 other studies available for phenobarbital and Folic Acid Deficiency

ArticleYear
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
    Acta medica Scandinavica, 1964, Volume: 176

    Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai

1964
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
    Acta medica Scandinavica, 1965, Volume: 177

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy;

1965
Interactions between folate metabolism, phenytoin metabolism, and liver microsomal cytochrome P450.
    Drug-nutrient interactions, 1984, Volume: 3, Issue:1

    Topics: Animals; Diet; Folic Acid; Folic Acid Deficiency; In Vitro Techniques; Liver; Male; Microsomes, Live

1984
Case report: subacute combined degeneration of the spinal cord from folate deficiency.
    The American journal of the medical sciences, 1995, Volume: 310, Issue:5

    Topics: Adult; Erythrocyte Transfusion; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Spin

1995
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
    Journal of the neurological sciences, 1997, Volume: 145, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Fe

1997
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
    Epilepsia, 1999, Volume: 40, Issue:3

    Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi

1999
Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association.
    Applied neurophysiology, 1979, Volume: 42, Issue:3

    Topics: Atrophy; Brain Diseases; Edema; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intesti

1979
[Megaloblastic anemia caused by folic acid deficiency during treatment with barbiturates].
    Semaine des hopitaux. Therapeutique, 1977, Volume: 53, Issue:9

    Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Folic Acid Deficiency; Humans; Middle Aged; Phenobarbital

1977
Anticonvulsant drugs and mental symptoms: a review.
    Psychological medicine, 1976, Volume: 6, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Folic Acid

1976
Red cell folate and macrocytosis during long-term anticonvulsant therapy in non-anaemic mentally. Retarded epileptics.
    The British journal of psychiatry : the journal of mental science, 1975, Volume: 126

    Topics: Dose-Response Relationship, Drug; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid

1975
Effect of some anticonvulsant drugs on depletion of folate in rats on a vitamin B12-deficient diet.
    British journal of haematology, 1976, Volume: 33, Issue:2

    Topics: Animals; Dietary Proteins; Female; Folic Acid Deficiency; Formiminoglutamic Acid; Liver; Phenobarbit

1976
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
    Lancet (London, England), 1967, May-20, Volume: 1, Issue:7499

    Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; M

1967
The effect of anticonvulsant therapy upon the absorption of folates.
    Clinical science, 1973, Volume: 44, Issue:6

    Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans;

1973
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. I. Clinical and nutritional study on megalobastic anemia due to anticonvulsants.
    Acta medicinae Okayama, 1971, Volume: 25, Issue:5

    Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Diet; Epilepsy, Temporal Lobe; Folic Acid; Folic Acid De

1971
Clinical and experimental studies on folic acid deficiency due to anticonvulsants. 2. Investigations on patients receiving anticonvulsants and experimental study on the effect of diphenylhydantoin on the absorption of folic acid in rats.
    Acta medicinae Okayama, 1971, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Cell Nucleus; Depression, Chemical; Epithelial Cells; F

1971
Iatrogenic disorders in epilepsy.
    Modern trends in neurology, 1970, Volume: 5, Issue:0

    Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug

1970
Epilepsy.
    British medical journal, 1969, Nov-01, Volume: 4, Issue:5678

    Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T

1969
Iatrogenic nutritional effects of anticonvulsants.
    The Proceedings of the Nutrition Society, 1974, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch

1974
Clinical conference: megaloblastic anemia associated with anticonvulsant drugs.
    Journal of the Tennessee Medical Association, 1972, Volume: 65, Issue:9

    Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Female; Folic Acid; Folic Acid Deficiency; Humans; Pheno

1972
Folate metabolism and the anticonvulsant efficacy of phenobarbital.
    Archives of neurology, 1973, Volume: 28, Issue:1

    Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital;

1973
[Editorial: Antiepileptic agents--folic acid].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1973, Jun-30, Volume: 93, Issue:18

    Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; P

1973
Folate metabolism and anticonvulsant therapy.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:1

    Topics: Anticonvulsants; Blood-Brain Barrier; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; Primi

1974
Folate deficiency and anticonvulsant drugs.
    British medical journal, 1972, Apr-15, Volume: 2, Issue:5806

    Topics: Animals; Enzyme Induction; Female; Folic Acid; Folic Acid Deficiency; Liver; Male; Oxidoreductases;

1972
Folic acid deficiency in patients receiving anticonvulsant drugs.
    The Medical journal of Australia, 1971, Nov-20, Volume: 2, Issue:21

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Female; Folic Acid; Folic Acid De

1971
Folate metabolism in epileptic and psychiatric patients.
    Journal of neurology, neurosurgery, and psychiatry, 1971, Volume: 34, Issue:6

    Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum

1971
Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.
    Epilepsia, 1966, Volume: 7, Issue:4

    Topics: Adult; Anemia, Macrocytic; Female; Folic Acid Deficiency; Humans; Male; Mental Disorders; Middle Age

1966
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
    American journal of obstetrics and gynecology, 1971, Feb-01, Volume: 109, Issue:3

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia,

1971
Serum folate deficiency in children receiving anticonvulsant therapy.
    Pediatrics, 1968, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocyte Coun

1968
Folic acid deficiency from anticonvulsant therapy.
    Developmental medicine and child neurology, 1968, Volume: 10, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Defic

1968
Mental effects of anticonvulsants, and folic acid metabolism.
    Brain : a journal of neurology, 1968, Volume: 91, Issue:2

    Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De

1968
Folic acid and anticonvulsive drugs.
    Archives of neurology, 1969, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol

1969
Reversible absorptive defects in anticonvulsant megaloblastic anaemia.
    Journal of clinical pathology, 1965, Volume: 18, Issue:5

    Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Blood; Female; FIGLU Test; Folic Acid Deficiency; Humans

1965