phenobarbital has been researched along with Experimental Leukemia in 7 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital pretreatment reduced CPA and phosphoramide mustard CXT (concentration x time) by 66+% and 27+%, respectively." | 1.26 | Effect of phenobarbital on plasma levels of cyclophosphamide and its metabolites in the mouse. ( Alberts, DS; Chen, HS; Peng, YM; Struck, RF, 1978) |
| " Dose-response curves with and without phenobarbital pretreatment showed a constant 90% (1-log) reduction in the toxicity of cyclophosphamide to leukemic colony-forming units, whereas enzyme induction had no effect on the toxicity of the drug to normal bone marrow colony-forming units." | 1.26 | The effect of phenobarbital on cyclophosphamide antitumor activity. ( Alberts, DS; van Daalen Wetters, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dorr, RT | 1 |
| Alberts, DS | 3 |
| Belitskiĭ, GA | 1 |
| Bukhman, VM | 1 |
| Konopleva, IA | 1 |
| Peng, YM | 1 |
| Chen, HS | 1 |
| Struck, RF | 1 |
| van Daalen Wetters, T | 1 |
| Lijinsky, W | 1 |
| Kovatch, RM | 1 |
| Thomas, BJ | 1 |
| Bogush, TA | 1 |
| Sitdikova, SM | 1 |
| Syrkin, AB | 1 |
| Goldenberg, GJ | 1 |
7 other studies available for phenobarbital and Experimental Leukemia
| Article | Year |
|---|---|
Cimetidine enhancement of cyclophosphamide antitumour activity.
Topics: Animals; Cimetidine; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Guanidines; Leukem | 1982 |
[Change of toxic and antineoplastic properties of ftorafur by means of action on nonspecific microsomal oxidase].
Topics: Animals; Drug Antagonism; Drug Synergism; Enzyme Induction; Fluorouracil; Leukemia, Experimental; Me | 1979 |
Effect of phenobarbital on plasma levels of cyclophosphamide and its metabolites in the mouse.
Topics: Animals; Chromatography, Thin Layer; Cyclophosphamide; Drug Interactions; Kinetics; Leukemia, Experi | 1978 |
The effect of phenobarbital on cyclophosphamide antitumor activity.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cyclophosphamide; Dose-Response Relationship, Drug; Drug In | 1976 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
[Effect of the induction and inhibition of liver monooxygenases on the toxic and therapeutic action of vincristine].
Topics: Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug | 1986 |
Drug-induced stimulation of nitrogen mustard and choline transport and other systems in L5178Y lymphoblasts in vitro.
Topics: Amino Acids; Aminoisobutyric Acids; Aminolevulinic Acid; Animals; Atropine; Biological Transport; Ce | 1974 |