phenobarbital has been researched along with Experimental Hepatoma in 440 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "This study was undertaken to investigate the influence of dietary vitamin A deficiency and type of diet on tetrachlorodibenzo-p-dioxin (TCDD)- and phenobarbital-induced liver tumor promotion in rats." | 7.68 | Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency. ( Ahlborg, UG; Busk, L; Flodström, S; Kronevi, T, 1991) |
| " sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype." | 7.67 | Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 5.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "We previously reported the contribution of constitutive androstane receptor (CAR) in cytotoxicity-related hepatocarcinogenesis induced by oxadiazon (OX) or acifluorfen (ACI), two pesticides categorized as protoporphyrinogen oxidase (PROTOX) inhibitors." | 3.85 | β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice. ( Ichimura, R; Inoue, K; Kodama, Y; Kuwata, K; Shibutani, M; Takahashi, M; Yoshida, M, 2017) |
| "Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia." | 3.76 | Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. ( Bower, CC; Elcombe, CR; Henderson, CJ; Plummer, SM; Rode, A; Ross, J; Scheer, N; Vogel, O; Wolf, CR, 2010) |
| " Following chronic treatment, altered hepatic foci and adenomas were classified as: small-cell, heterogeneous basophilic lesions (spontaneous or tetrachlorodibenzo-p-dioxin-induced); large-cell, homogeneous basophilic lesions (WY-14,643-induced); acidophilic lesions (phenobarbital- or chlordane-induced)." | 3.70 | Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice. ( Anderson, SP; Cattley, RC; Christensen, JG; Corton, JC; Fox, TR; Goldsworthy, TL; Gonzales, AJ; Healy, LN; Malarkey, DE; Romach, EH, 1999) |
| "In previous studies, we found that male D2B6F1 mice fed phenobarbital (PB) for 53 weeks following N-nitrosodiethylamine (NDEA) initiation developed a high (70-80%) incidence of malignant hepatoblastomas." | 3.69 | Further evidence for promoter-dependent development of hepatoblastoma in the mouse. ( Diwan, BA; Henneman, JR; Rice, JM, 1995) |
| "Naturally occurring basophilic foci (focal hepatocellular proliferative lesions) (FHPL) in the livers of aging female F344/NCr rats could not be promoted to grow or progress into tumors after phenobarbital (PB) exposure." | 3.68 | Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens. ( Henneman, JR; Ward, JM, 1990) |
| "This study was undertaken to investigate the influence of dietary vitamin A deficiency and type of diet on tetrachlorodibenzo-p-dioxin (TCDD)- and phenobarbital-induced liver tumor promotion in rats." | 3.68 | Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency. ( Ahlborg, UG; Busk, L; Flodström, S; Kronevi, T, 1991) |
| " Liver carcinogenesis was initiated by intraperitoneal injection of diethylnitrosamine (DEN) in male B6C3F1 mice at 100 or 200 mumol/kg body weight once a week for 10 weeks (total exposure 1000 or 2000 mumol/kg body weight)." | 3.68 | Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. ( Iatropoulos, MJ; Tokumo, K; Williams, GM, 1991) |
| "The ability of diethylnitrosamine (DENA) to initiate and phenobarbital to promote altered-hepatocyte foci and hepatocellular carcinomas in C3H and C3B6F1 (C3H x C57BL/6) mice was compared to the extent of cell proliferation." | 3.68 | Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation. ( Pereira, MA, 1993) |
| " sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype." | 3.67 | Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986) |
| "At exposures causing rodent liver tumors, PB has measurable effects on hepatocytes: PB inhibits cell-to-cell communication; PB induces enzymes, including P450 cytochromes; PB stimulates proliferation and inhibits apoptosis of hepatocytes in neoplastic foci." | 2.39 | Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. ( Ross, PM; Whysner, J; Williams, GM, 1996) |
| "Phenobarbital treated mice showed damped corticosterone levels and a less stable 24 hours activity rhythm as well as an increase in activity during the light phase, reminiscent of sleep disruption." | 1.62 | Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model. ( Ali, AAH; Hassan, SA; Jänicke, RU; Korf, HW; Pfeffer, M; Sohn, D; von Gall, C; Yassine, M, 2021) |
| " Overall, while chronic administration of the model CAR activator NaPB results in both hepatocellular adenoma and carcinoma in the low spontaneous liver tumour incidence C57BL/10J mouse strain, only 40 % of the liver tumours evaluated in this study had β-catenin mutations." | 1.56 | Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. ( Foster, A; Jones, HB; Kalaitzi, K; Lake, BG; Orton, TC; Sidaway, JE, 2020) |
| "Phenobarbital (PB) is a prototypical nongenotoxic carcinogen that activates the constitutive androstane receptor (CAR) resulting in rodent liver tumors." | 1.40 | Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway. ( Bhat, VS; Geter, DR; Gollapudi, BB; Hester, SD; Sura, R, 2014) |
| "Pretreatment with bicyclol showed a marked reduction in the above condition." | 1.38 | A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. ( Liu, G; Sun, H; Wei, H; Yu, L, 2012) |
| "A genetic basis of hepatocellular carcinoma (HCC) has been well-established and major signaling pathways, such as p53, Wnt-signaling, transforming growth factor-β (TGF-β) and Ras pathways, have been identified to be essential to HCC development." | 1.37 | Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis. ( Galle, PR; Hansen, T; Kanzler, S; Longerich, T; Maass, T; Mann, A; Schirmacher, P; Strand, D; Teufel, A; Thieringer, FR, 2011) |
| "Metofluthrin did not cause cytotoxicity or peroxisome proliferation." | 1.35 | Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. ( Deguchi, Y; Hirose, Y; Kawamura, S; Kushida, M; Nagahori, H; Nishioka, K; Okuno, Y; Sukata, T; Sumida, K; Tomigahara, Y; Uwagawa, S; Yamada, T, 2009) |
| " In summary, PB at a dose level which produces liver hypertrophy, a transient stimulation of replicative DNA synthesis and on chronic administration altered hepatic foci, three key events in the established mode of action for PB-induced rodent liver tumour formation, results in a significant increase in liver tumours in male C57BL/10 J mice." | 1.35 | Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse. ( Jones, HB; Lake, BG; Orton, TC, 2009) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 1.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| " PB produced a twofold increase in liver MF over controls after 27 weeks of treatment, but a similar increase was not observed with longer dosing times; at later time points, the MF in the PB groups was lower than that of the control group, suggesting that PB is not producing direct DNA damage in the liver." | 1.33 | Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice. ( de Boer, J; Fairchild, D; Glickman, B; Johnson, A; Kanazawa, N; Mirsalis, JC; Nguyen, T; Shimon, JA; Winegar, RA, 2005) |
| "Cyproterone acetate (CPA) is a synthetic antiandrogenic compound which is widely used in clinic but suspected to be hepatocarcinogenic." | 1.33 | Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration. ( Ferry, N; Pichard, V, 2005) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "Treatment with Curcumin (100 mg kg(-1)body wt) and Embelin (50 mg kg(-1)body wt) prevented the drop in hepatic glutathione antioxidant defense, decreased lipid peroxidation, minimized the histological alterations induced by DENA/PB, but showed toxic effects on the hematopoietic cells." | 1.33 | Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats. ( Bali, G; Sreepriya, M, 2006) |
| " Groups 3 and 5 were fed melatonin-containing diet for 20 wk, starting 1 wk after the last dosing of DEN." | 1.32 | Chemopreventive effects of melatonin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Rahman, KM; Sugie, S; Tanaka, T; Watanabe, T, 2003) |
| "Phenobarbital (PB) is an antiepileptic drug that promotes hepatocarcinogenesis in rodents when administered subsequent to an initiating carcinogen like N-nitrosodiethylamine (DEN)." | 1.31 | Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital. ( Buchmann, A; Gaunitz, F; Gebhardt, R; Kurek, R; Loeppen, S; Schneider, D; Schwarz, M, 2002) |
| "Phenobarbital (PB) is an antiepileptic drug which promotes hepatocarcinogenesis in rodents when administered subsequent to an initiating carcinogen like diethylnitrosamine (DEN)." | 1.31 | Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors. ( Aydinlik, H; Buchmann, A; Moennikes, O; Nguyen, TD; Schwarz, M, 2001) |
| ") for 6 weeks to female lambda/lacI transgenic rats caused a 4-fold increase in mutation frequency (MF) at the lacI gene locus in the livers of dosed animals compared with controls." | 1.31 | Tamoxifen mutagenesis and carcinogenesis in livers of lambda/lacI transgenic rats: selective influence of phenobarbital promotion. ( Davies, R; Fenwick, S; Smith, LL; Styles, JA; Walker, J; White, IN, 2001) |
| " We have examined the dose-response relationship of tamoxifen-induced DNA adducts in the liver and the subsequent increase in the development of liver cancer, with and without phenobarbital promotion." | 1.31 | Cumulative exposure to tamoxifen: DNA adducts and liver cancer in the rat. ( Carthew, P; Edwards, RE; Heydon, RT; Lee, PN; Martin, EA; Nolan, BM, 2001) |
| "In gene therapy for hepatocellular carcinoma (HCC), gene transfer is efficient for small tumors, but not for large tumors." | 1.31 | Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters. ( Eto, Y; Futagawa, Y; Ohashi, T; Okamoto, T; Shiba, H, 2001) |
| "Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative." | 1.30 | Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions. ( Bursch, W; Camus-Randon, AM; Grasl-Kraupp, B; Lang, MA; Rossmanith, W; Schulte-Hermann, R; Wastl, UM, 1998) |
| " The purpose of this work was to characterize the profile and dose-response relationship of microsomal enzyme induction following exposure to MX." | 1.30 | Induction and inhibition of mouse cytochrome P-450 2B enzymes by musk xylene. ( Caudill, D; Johnson, DR; Lehman-McKeeman, LD, 1997) |
| "Phenobarbital (PB) is a potent tumor promoter in rodent liver." | 1.29 | Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels. ( Boyer, IJ; De Souza, AT; Hankins, GR; Jirtle, RL; Mansbach, JM; Mills, JJ, 1996) |
| "Phenobarbital is an inducer of xenobiotic-metabolizing enzymes, such as cytochrome P-450, glutathione S-transferases (GSTs) and NAD(P)H:quinone reductase, as well as being a promoter of hepatocarcinogenesis." | 1.29 | Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression. ( Bergelson, S; Daniel, V; Pinkus, R, 1993) |
| "The dose-response characteristics of initiation of hepatocarcinogenesis by diethylnitrosamine (DEN) was investigated in the neonatal female rat by means of the quantitative stereologic estimation of altered hepatic foci (AHF) expressing multiple markers." | 1.29 | The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats. ( Dragan, YP; Pitot, HC; Xu, YH, 1993) |
| "As previously demonstrated, chronic administration of phenobarbital (0." | 1.29 | Modifications of liver bile acids pool during modulation of rat hepatocarcinogenesis by phenobarbital and nafenopin. ( Delzenne, NM; Roberfroid, M; Taper, HS, 1994) |
| "15 mumol/kg body weight on day 1 after birth) followed by chronic administration of phenobarbital-sodium (PB; 0." | 1.28 | Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules. ( Kunz, W; Scholz, W; Schütze, K; Schwarz, M, 1990) |
| "Barbital was also ineffective for maintenance of primary cultured hepatocytes but not toxic to the cells." | 1.28 | Influence of liver tumor promoters and structurally related chemicals on survival of normal adult rat hepatocytes in primary culture. ( Bai, L; Miyazaki, M; Sato, J, 1990) |
| " Dose-response experiments showed that the hepatocarcinogenic effects of long-term chlordecone administration became undetectable at concentrations in non-initiated rat liver in the same range as those measured in human biopsies taken from exposed workers who exhibited no liver effects." | 1.28 | Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence. ( Blanke, RV; Fitzgerald, R; Guzelian, PS; Sirica, AE; Wilkerson, CS; Wu, LL, 1989) |
| "The dose-response of phenobarbital (PB) promotion of hepatocarcinogenesis in rats was investigated." | 1.28 | Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine. ( Hayashi, Y; Maekawa, A; Matsushima, Y; Mitsumori, K; Ogasawara, H; Onodera, H, 1992) |
| "Tamoxifen was tested as an initiator at a single intragastric dose of 40 mg/kg, followed by promotion with 0." | 1.28 | Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis. ( Dragan, YP; Pitot, HC; Xu, YD, 1991) |
| " For phenobarbital and 2,3,7,8-tetrachloro-p-dioxin, PGST and GGT together scored 100% of the AHF; for 1-(phenylazo)-2-naphthol (CI solvent yellow 14) and chlorendic acid, PGST alone marked 90% of the AHF; after chronic administration of WY-14,643, ATP and G6Pase were the predominant markers." | 1.28 | An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay. ( Bawa, N; Campbell, HA; Dragan, YP; Hully, JR; Maronpot, RR; Pitot, HC; Rizvi, T; Xu, YH, 1991) |
| "Phenobarbital is a potent inducer of several liver-specific genes such as those encoding detoxication enzymes, including cytochromes P450." | 1.28 | Effect of phenobarbital on the glucocorticoid receptor in rat hepatoma cells. ( Beck, G; Chasserot-Golaz, S; Corcos, L; Venetianer, A, 1990) |
| " Four-day-old female F344/N rats were dosed with diethylnitrosamine (10 mg/kg)." | 1.28 | Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Duitsman, P; Hendrich, S; Jackson, A; Krueger, SK; Myers, RK, 1991) |
| "Ciprofibrate was fed in the diet at levels of 0%, 0." | 1.28 | Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis. ( Clark, TD; Glauert, HP, 1989) |
| "Phenobarbital (PB) promotes hepatic tumorigenesis when chronically administered to male B6C3F1 mice after initiation with diethylnitrosamine (DENA) at 30 days of age." | 1.28 | Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender. ( Klaunig, JE; Weghorst, CM, 1989) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| " A single administration of N-nitrosomorpholine (75 mg/kg, 24 h after partial hepatectomy) was used for initiation and chronic administration of phenobarbital (0." | 1.27 | Effects of N-nitrosomorpholine and phenobarbital on UDP-glucuronyltransferase in putative preneoplastic foci of rat liver. ( Bock, KW; Fischer, G; Ulrich, D, 1985) |
| "Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| " In the second experiment, the effect of chronic administration of PB and NAF given after I without S or after S without I was analyzed." | 1.27 | Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis. ( de Gerlache, J; Lans, M; Préat, V; Roberfroid, M; Taper, H, 1986) |
| " Chronic administration of dose levels of PB below 0." | 1.27 | The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration. ( Campbell, HA; Goldsworthy, T; Pitot, HC, 1984) |
| "Trichloroethylene was not found to induce GGT-positive foci under these conditions." | 1.27 | Trichloroethylene effects on the formation of enzyme-altered foci in rat liver. ( Couri, D; Milks, MM, 1984) |
| "025% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for two weeks combined with partial hepatectomy at the end of the first week and followed by long-term treatment with phenobarbital (PB) or 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from week 3 to week 86 resulted in dose-dependent development of liver and thyroid neoplastic and preneoplastic lesions." | 1.27 | Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion. ( Asamoto, M; Inoue, T; Ito, N; Nagao, M; Ogiso, T; Tsuda, H, 1988) |
| "The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment." | 1.27 | Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988) |
| " In contrast, only DEHP and BBS induced toxic renal lesions." | 1.27 | The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car ( Anderson, LM; Diwan, BA; Hagiwara, A; Lindsey, K; Ward, JM, 1988) |
| "Phenobarbital (PB) is known to be a promoter of liver tumorigenesis in rats and mice." | 1.27 | Effect of dietary phenobarbital on spontaneous hepatic tumorigenesis in germfree C3H/He male mice. ( Mitsuoka, T; Mizutani, T, 1988) |
| "Acetoxime was highly volatile and was not mutagenic in the Ames test under a variety of conditions." | 1.27 | Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone. ( Lawson, TA; Markin, RS; Mirvish, SS; Nickols, JG, 1988) |
| "A phenobarbital-mediated increase in enzyme protein and a concomitant enhancement of the corresponding mRNA was seen in hepatocytes of the centrilobular areas of the liver acinus." | 1.27 | Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization. ( Buchmann, A; Friedberg, T; Kunz, W; Peres, G; Schwarz, M; Waxman, DJ, 1987) |
| "Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil." | 1.27 | The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. ( Herren-Freund, SL; Khoury, MD; Olson, G; Pereira, MA, 1987) |
| "Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
| "The dose-response relationship was determined in rats for the enhancement by phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular carcinomas." | 1.27 | Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver. ( Herren-Freund, SL; Long, RE; Pereira, MA, 1986) |
| "A cell line derived from a Morris hepatoma, MH1C1, was examined for its in vitro expression of monooxygenases." | 1.27 | Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells. ( Bassi, AM; Chiarpotto, E; Dianzani, MU; Ferro, M; Marinari, UM; Nanni, G; Poli, G, 1984) |
| "The phenobarbital treatment became unnecessary when neoplastic nodules were present." | 1.27 | Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect. ( Barbason, H; Betz, EH; Rassenfosse, C, 1983) |
| " In subchronic studies, PB was administered in drinking water to 5-week-old male hamsters for periods of 8 or 16 weeks at dosage levels of 250, 500, or 1000 ppm." | 1.27 | Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters. ( Anderson, LM; Diwan, BA; Hagiwara, A; Rice, JM; Ward, JM, 1986) |
| " A simple two-stage model of rat hepatocarcinogenesis with a single ip dose of diethylnitrosamine (DEN) as the initiator and sodium phenobarbitone or ethanol given in the drinking-water for 12-18 months as the promoter was used to investigate dose-response relationships for initiation and promotion." | 1.27 | Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol. ( Driver, HE; McLean, AE, 1986) |
| "Pretreatment with phenobarbital led to a marked increase in binding of DES to kidney microsomes but not to liver microsomes from female hamsters and male and female rats." | 1.27 | Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity. ( Haaf, H; Metzler, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 188 (42.73) | 18.7374 |
| 1990's | 151 (34.32) | 18.2507 |
| 2000's | 60 (13.64) | 29.6817 |
| 2010's | 38 (8.64) | 24.3611 |
| 2020's | 3 (0.68) | 2.80 |
| Authors | Studies |
|---|---|
| Sidaway, JE | 1 |
| Orton, TC | 2 |
| Kalaitzi, K | 1 |
| Jones, HB | 2 |
| Foster, A | 1 |
| Lake, BG | 9 |
| Price, RJ | 2 |
| Scott, MP | 1 |
| Chatham, LR | 1 |
| Vardy, A | 1 |
| Osimitz, TG | 2 |
| Hassan, SA | 1 |
| Ali, AAH | 1 |
| Yassine, M | 1 |
| Sohn, D | 1 |
| Pfeffer, M | 1 |
| Jänicke, RU | 1 |
| Korf, HW | 1 |
| von Gall, C | 1 |
| El Miniawy, HM | 1 |
| Ahmed, KA | 1 |
| Mansour, SA | 1 |
| Khattab, MM | 1 |
| Mahmoud, AM | 1 |
| Zaki, AR | 1 |
| Hassan, ME | 1 |
| Mostafa-Hedeab, G | 1 |
| Kuwata, K | 2 |
| Inoue, K | 2 |
| Ichimura, R | 1 |
| Takahashi, M | 6 |
| Kodama, Y | 1 |
| Shibutani, M | 3 |
| Yoshida, M | 2 |
| Ho, J | 1 |
| Ware, M | 1 |
| Law, J | 1 |
| Nagaraj, A | 1 |
| Jain, S | 1 |
| Rios, J | 1 |
| Calderon, R | 1 |
| Toombs, B | 1 |
| Anderson, A | 1 |
| Bray, C | 1 |
| Curley, S | 1 |
| Corr, SJ | 1 |
| Gani, SA | 1 |
| Muhammad, SA | 1 |
| Kura, AU | 1 |
| Barahuie, F | 1 |
| Hussein, MZ | 1 |
| Fakurazi, S | 1 |
| Singh, Y | 1 |
| Braeuning, A | 4 |
| Schmid, A | 2 |
| Pichler, BJ | 2 |
| Schwarz, M | 13 |
| Saraswati, S | 1 |
| Alhaider, AA | 1 |
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18 reviews available for phenobarbital and Experimental Hepatoma
| Article | Year |
|---|---|
Report of ICPEMC Task Group 5 on the differentiation between genotoxic and non-genotoxic carcinogens.
Topics: Animals; Butylated Hydroxytoluene; Carcinogens; Cell Line; DDT; Dieldrin; Dioxins; Drug Evaluation, | 1984 |
NADPH cytochrome P-450 reductase and its role in the mixed function oxidase reaction.
Topics: Animals; Detergents; Electron Transport; Flavins; Hydroxylation; Kinetics; Liver Neoplasms, Experime | 1980 |
Negative selection in hepatic tumor promotion in relation to cancer risk assessment.
Topics: Animals; Carcinogens; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms, Experimental; | 1995 |
Receptor-mediated toxicity and implications for risk assessment.
Topics: Animals; Cell Division; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; D | 1994 |
Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Humans; Liver Neoplasms; Liver | 1995 |
The species specificity of dieldrin- or phenobarbital- induced hepatocarcinogenesis: case studies with implications for human health risk assessment.
Topics: Animals; Dieldrin; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Occupational Diseases; Oc | 1995 |
Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.
Topics: Animals; Biotransformation; Carcinogenicity Tests; Carcinogens; Cell Division; Enzyme Induction; Hum | 1996 |
AFP as a marker for liver cell injury: differentiation of tumor growth, hepatotoxicity, and carcinogenesis.
Topics: alpha-Fetoproteins; Animals; Carcinogens; Cell Division; Diagnosis, Differential; Humans; Liver; Liv | 1978 |
Liver tumour promotion by phenobarbital: comparison of rat and human studies.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Epilepsy; Humans; Liver Neoplasms; Liver Neoplasms, | 1992 |
Phenobarbital and related compounds: approaches to interspecies extrapolation.
Topics: Animals; Barbiturates; Carcinogens; Enzyme Induction; Humans; Liver; Liver Neoplasms, Experimental; | 1992 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Mouse liver tumors and microsomal enzyme-inducing drugs: experimental and clinical perspectives with phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Cell Communication; Cocarcinogenesis; DNA Damage; Humans; Liver | 1990 |
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; F | 1990 |
Species differences in enzymes controlling reactive epoxides.
Topics: Animals; Benzo(a)pyrene; DDT; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; Female; Hexachlor | 1987 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Initiation and promotion in hepatocarcinogenesis.
Topics: Animals; Carcinogens; Liver Neoplasms, Experimental; Mutagens; Phenobarbital | 1987 |
Genetics and epigenetics of neoplasia: facts and theories.
Topics: Age Factors; Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cul | 1985 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
422 other studies available for phenobarbital and Experimental Hepatoma
| Article | Year |
|---|---|
Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.
Topics: Adenoma; Animals; beta Catenin; Carcinoma, Hepatocellular; Constitutive Androstane Receptor; Female; | 2020 |
Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance.
Topics: Animals; Cell Size; Diet; DNA Replication; Gene Expression Regulation; Hepatocytes; Humans; Liver; L | 2020 |
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Topics: Activity Cycles; Animals; Behavior, Animal; Biomarkers; Carcinoma, Hepatocellular; Chronotherapy; Ci | 2021 |
In vivo antitumour potential of camel's milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Camelus; Carcinoma, Hepatocellular; Cisplatin; Dieth | 2017 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammat | 2017 |
β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice.
Topics: Animals; beta Catenin; Carcinogenesis; Carcinogens; Cell Proliferation; Constitutive Androstane Rece | 2017 |
Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Synergism; Female; Injections | 2018 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
Selective poisoning of Ctnnb1-mutated hepatoma cells in mouse liver tumors by a single application of acetaminophen.
Topics: Acetaminophen; Animals; beta Catenin; Carcinogens; Cell Proliferation; Cytochrome P-450 CYP2E1; Diet | 2013 |
Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase | 2013 |
Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Fem | 2014 |
Chemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
Topics: Animals; Cell Growth Processes; Diethylnitrosamine; DNA Damage; Immunohistochemistry; Lipids; Liver; | 2014 |
Cleistocalyx nervosum extract ameliorates chemical-induced oxidative stress in early stages of rat hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Diethylnitrosamine; Immunoenzyme Techniqu | 2014 |
Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver.
Topics: Animals; Cells, Cultured; Chimera; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; DNA Re | 2014 |
Superoxide deficiency attenuates promotion of hepatocarcinogenesis by cytotoxicity in NADPH oxidase knockout mice.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; Female; Liver; Liver Neoplasms, Experimental | 2015 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellul | 2015 |
Chemoprevention of Diethylnitrosamine-Initiated and Phenobarbital-Promoted Hepatocarcinogenesis in Rats by Sulfated Polysaccharides and Aqueous Extract of Ulva lactuca.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2015 |
Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells.
Topics: Animals; Carcinogens; Cell Line; Cell Movement; Clofibrate; Diethylnitrosamine; Epithelial Cells; Ge | 2016 |
The Mode of Action for Phenobarbital-Induced Rodent Liver Tumor Formation Is not Relevant for Humans: Recent Studies With Humanized Mice.
Topics: Animals; Chimera; Constitutive Androstane Receptor; Disease Models, Animal; Humans; Liver; Liver Neo | 2015 |
Model Systems for Understanding Mechanisms of Nongenotoxic Carcinogenesis: Response.
Topics: Animals; Humans; Liver Neoplasms, Experimental; Phenobarbital | 2015 |
Tumor promotion and inhibition by phenobarbital in livers of conditional Apc-deficient mice.
Topics: Adenomatous Polyposis Coli Protein; Animals; beta Catenin; Cell Proliferation; Hepatocytes; Immunohi | 2016 |
Therapeutic role of a synthesized calcium phosphate nanocomposite material on hepatocarcinogenesis in rats.
Topics: Animals; Calcium Phosphates; Diethylnitrosamine; DNA Fragmentation; Enzymes; Interferon-gamma; Inter | 2016 |
Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Diet; Enzyme Induction; Fumonisins; Glutat | 2008 |
Global liver proteomics of rats exposed for 5 days to phenobarbital identifies changes associated with cancer and with CYP metabolism.
Topics: Animals; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Liver; Liver Neoplasms, Experimenta | 2008 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Di | 2009 |
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
Topics: Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Constitutive Androstane Recep | 2009 |
Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Cyclopropanes; Cytochrome P-450 Enzym | 2009 |
Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors.
Topics: Animals; Cloning, Molecular; Constitutive Androstane Receptor; DNA Methylation; DNA, Neoplasm; Liver | 2009 |
Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse.
Topics: Animals; Body Weight; DNA Replication; Dose-Response Relationship, Drug; Female; Hepatocytes; Hypnot | 2009 |
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression Regulati | 2009 |
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, | 2009 |
Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Chlordan; Constitutive Androstane Recept | 2010 |
Resveratrol suppresses oxidative stress and inflammatory response in diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Chemical and Drug Induced Liver Injury; Diethylnitrosamine; Dose | 2010 |
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Blotting, Western; Carcinoma, Hepatocellular; Diethylni | 2011 |
Carcinogenic risk assessment: are there dose thresholds for carcinogens?
Topics: Animals; Carcinogens; Diethylnitrosamine; DNA Damage; Glutathione Transferase; Intestinal Neoplasms; | 2010 |
Chelidonium majus 30C and 200C in induced hepato-toxicity in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Hepatocellular; Chelidonium; Chromosome Ab | 2010 |
Anti-carcinogenic potentials of a plant extract (Hydrastis canadensis): I. Evidence from in vivo studies in mice (Mus musculus).
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Chromosome Aberrations; Female; Hydrastis; Lipid Pe | 2010 |
Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Glutathione S-Transferase pi; Immunohistochemistry; | 2011 |
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Topics: Animals; Anthocyanins; Anticarcinogenic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Prolifer | 2011 |
Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.
Topics: Animals; Cell Line, Tumor; Cell Movement; Constitutive Androstane Receptor; Disease Models, Animal; | 2011 |
Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; ATP-Binding Cassette Transporters; | 2011 |
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Cytokines; Diethylnitrosamine; Female; Gene Expression Regulation; | 2012 |
Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Constitutive Androstane Recep | 2011 |
Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.
Topics: Animals; Cell Cycle Proteins; Clofibrate; Cytochrome P-450 Enzyme System; DNA Damage; Down-Regulatio | 2011 |
Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Genetic Predisposition to Disease; Glycerol-3-Phosp | 2012 |
Quantitative analysis of the growth kinetics of chemically induced mouse liver tumors by magnetic resonance imaging.
Topics: Animal Use Alternatives; Animals; Cocarcinogenesis; Diethylnitrosamine; Early Detection of Cancer; I | 2012 |
A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Biphenyl Compounds; Body Weight; Cell Line; Di | 2012 |
β-Catenin loss in hepatocytes promotes hepatocellular cancer after diethylnitrosamine and phenobarbital administration to mice.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; Hepatocytes; Immunohistochemistry; Ligands; | 2012 |
The connection of β-catenin and phenobarbital in murine hepatocarcinogenesis: a critical discussion of Awuah et al., PLoS ONE 7(6):e39771, 2012.
Topics: Animals; beta Catenin; Carcinogens; Diethylnitrosamine; Hepatocytes; Liver Neoplasms, Experimental; | 2013 |
Mechanistic study on flumequine hepatocarcinogenicity focusing on DNA damage in mice.
Topics: Animals; Anti-Infective Agents; Carcinogenicity Tests; Carcinogens; Cell Line; Cell Nucleus; Comet A | 2002 |
Overexpression of glutamine synthetase is associated with beta-catenin-mutations in mouse liver tumors during promotion of hepatocarcinogenesis by phenobarbital.
Topics: Animals; beta Catenin; Cytoskeletal Proteins; Diethylnitrosamine; Glutamate-Ammonia Ligase; Liver Ne | 2002 |
Sodium selenite, dietary micronutrient, prevents the lymphocyte DNA damage induced by N-nitrosodiethylamine and phenobarbital promoted experimental hepatocarcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Dietary Supplements; Diethylnitrosamine; | 2003 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body | 2003 |
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism | 2003 |
Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors.
Topics: Animals; Biomarkers; Blood Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoproteins; H | 2003 |
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Alkylating Agents; Animals; Apoptosis; Cell Division; Cytochrome P-450 | 2003 |
[Effects of gardenal and chlorpromazine 4560 R. P. on histology of hepatomas induced by 2-acetamino fluorene].
Topics: Animals; Carcinoma, Hepatocellular; Chlorpromazine; Fluorenes; Histological Techniques; Liver Neopla | 1957 |
[Experimental hepatic cancers. III. Study of the hypothalamo-hypophysial influences of the use of chlorpromazine, levopromazine and phenobarbital and of non-specific stress].
Topics: Animals; Bile Ducts, Intrahepatic; Chlorpromazine; Hypothalamus; Liver Neoplasms, Experimental; Meth | 1962 |
Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III.
Topics: Acetylglucosamine; Animals; Apoptosis; Carbohydrate Sequence; Carcinogens; Cell Division; Diethylnit | 2003 |
Effect of dietary selenite on N-nitrosodiethylamine-induced and phenobarbital promoted multistage hepatocarcinogenesis in rat: reflection in some minerals.
Topics: Animals; Antineoplastic Agents; Carcinogens; Diet; Diethylnitrosamine; Iron; Liver; Liver Neoplasms, | 2003 |
Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital.
Topics: Animals; Apoptosis; Base Sequence; beta Catenin; Cell Division; Cytoskeletal Proteins; DNA Primers; | 2004 |
Chemopreventive effects of melatonin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylamines; Glutathione Transferase; Liver; Liver | 2003 |
1alpha, 25-dihydroxyvitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by phenobarbital.
Topics: Alkylating Agents; Animals; Anticonvulsants; Antioxidants; Carcinogens; Comet Assay; Diet; Diethylni | 2004 |
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Topics: Animals; Constitutive Androstane Receptor; Genotype; Liver Neoplasms, Experimental; Mice; Mice, Inbr | 2004 |
Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.
Topics: Animals; Carcinogens; Clone Cells; Diethylnitrosamine; Female; Gene Frequency; Liver; Liver Neoplasm | 2005 |
Chemoprevention of N-nitrosodiethylamine induced phenobarbitol promoted liver tumors in rat by extract of Indigofera aspalathoides.
Topics: Animals; Chemoprevention; Diethylnitrosamine; Drug Synergism; Indigofera; Liver Neoplasms, Experimen | 2005 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl | 2005 |
Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration.
Topics: Androgen Antagonists; Animals; Animals, Genetically Modified; beta-Galactosidase; Carcinogens; Cell | 2005 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Benzoquinones; Curcuma; Curcumin; Diethylnitrosamine; Li | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di | 2005 |
Absence of liver tumor-initiating activity of kojic acid in mice.
Topics: Animals; Carcinogenicity Tests; Cell Proliferation; gamma-Glutamyltransferase; Hepatocytes; Immunohi | 2006 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con | 2005 |
The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels.
Topics: alpha-Fetoproteins; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 2005 |
Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Benzoquinones; Blood Cell Count; Carcinoge | 2006 |
Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Glutathione S-Transfer | 2006 |
Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Glutathione S-Transferase pi; Hepat | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosi | 2006 |
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane | 2007 |
A mode of action for induction of liver tumors by Pyrethrins in the rat.
Topics: Animals; Cell Size; Cytochrome P-450 Enzyme System; DNA Replication; Female; Hepatocytes; Insecticid | 2007 |
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Carcinoma, Hepatocellular; Chr | 2007 |
Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Erythrocyte | 2007 |
Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation.
Topics: Animals; DNA Methylation; Gene Expression Regulation, Neoplastic; Liver Neoplasms, Experimental; Mic | 2008 |
Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with gamma-glutamyl transpeptidase activity during phenobarbital exposure.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Female; gamma-Glutamyltra | 1981 |
Changes in gamma-glutamyltransferase activity during N-2-fluorenylacetamide-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; gamma-Glutamyltransferase; Histocytochemistr | 1983 |
Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol.
Topics: Animals; Cell Line; Cell Separation; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase | 1983 |
Enhancement of NNM-induced carcinogenesis in the rat liver by phenobarbital: a combined morphological and enzyme histochemical approach.
Topics: Acyltransferases; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism; Liver; Live | 1983 |
Tumor promotion in rat liver.
Topics: Animals; Carcinogens; Cocarcinogenesis; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, | 1983 |
The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1984 |
Effect of coadministration of phenobarbital sodium on N-nitrosodiethylamine-induced gamma-glutamyltransferase-positive foci and hepatocellular carcinoma in rats.
Topics: Animals; Diethylnitrosamine; Drug Interactions; gamma-Glutamyltransferase; Liver; Liver Neoplasms, E | 1984 |
Effect of phenobarbital on the altered biochemical phenotypes expressed by hyperplastic liver nodules during hepatocarcinogenesis in the rat.
Topics: Animals; Cytochrome P-450 Enzyme System; Fructose-Bisphosphate Aldolase; gamma-Glutamyltransferase; | 1984 |
Effect of chronic phenobarbital administration on the gamma-glutamyl transpeptidase activity of hyperplastic liver lesions induced in rats by the Solt/Farber initiation: selection process of hepatocarcinogenesis.
Topics: Animals; gamma-Glutamyltransferase; Hyperplasia; Liver; Liver Neoplasms, Experimental; Male; Phenoba | 1984 |
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine | 1984 |
Promotion of hepatocarcinogenesis in vivo and in vitro.
Topics: Animals; Epidermal Growth Factor; gamma-Glutamyltransferase; In Vitro Techniques; Liver; Liver Neopl | 1983 |
The direct and indirect effects of promoters may depend upon the nature of the initiated cell.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DN | 1983 |
Trichloroethylene effects on the formation of enzyme-altered foci in rat liver.
Topics: Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Hepatectomy; Liver; Liver | 1984 |
Comparison of different models of rat liver carcinogenesis: conclusions from a systemic analysis.
Topics: 2-Acetylaminofluorene; Animals; Diet; gamma-Glutamyltransferase; Histocytochemistry; Liver; Liver Ne | 1984 |
Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
Topics: Adenosine Triphosphatases; Animals; Biotransformation; Carcinogens; Cocarcinogenesis; Dieldrin; Dose | 1983 |
Effect of phenobarbital administration on hepatocytes constituting the hyperplastic nodules induced in rat liver by 3'-methyl-4-dimethylaminoazobenzene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cytochrome P-450 Enzyme System; Ester | 1980 |
Complex, dynamically interacting host factors that affect the disposition of drugs and carcinogens.
Topics: Animals; Antipyrine; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Enzyme | 1982 |
Expression of cytochromes P-450 in rat hepatoma cells. Analysis by monoclonal antibodies specific for cytochromes P-450 from rat liver induced by 3-methylcholanthrene or phenobarbital.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Benz( | 1984 |
Induction of cytochrome P-450 isozymes in rat hepatoma-derived cell cultures.
Topics: Animals; Cell Line; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inducti | 1984 |
Drugs and environmental chemicals as promoters.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Li | 1984 |
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens.
Topics: Animals; Choline Deficiency; DNA; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Phen | 1984 |
Dose-response studies on promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis.
Topics: Animals; DDT; Dose-Response Relationship, Drug; Liver; Liver Neoplasms, Experimental; Male; Methyldi | 1984 |
Induction of cytochrome(s) P450-dependent drug metabolism in cultured MH1C1 hepatoma cells.
Topics: Animals; Biotransformation; Cell Line; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Cyto | 1984 |
Decrease in L-type pyruvate kinase activity in rat liver by some promoters of hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride Poisoning; Carcinogens; Diethylnitrosamine; Isoenzymes; Isomerism; Liv | 1984 |
Quantitative electron microscopic analysis of changes in peroxisomes and endoplasmic reticulum induced in mice during hepatocarcinogenesis by diethylnitrosamine promoted by di(2-ethylhexyl)phthalate or phenobarbital.
Topics: Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Endoplasmic Reticulum; Liver Neoplasms, Experim | 1984 |
An enhancing effect of the antihistaminic drug methapyrilene on rat liver carcinogenesis by previously administered N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Aminopyridines; Animals; Liver Neoplasms, Experimental; Male; Methapyrilene; | 1983 |
Carcinogenic effects induced in Wistar rats by combined treatment with technical-grade dichlorodiphenyltrichloroethane and sodium phenobarbital.
Topics: Animals; Body Weight; Cocarcinogenesis; DDT; Diet; Female; Liver Neoplasms, Experimental; Male; Phen | 1983 |
Evaluation of a human hepatoma cell line as a target cell in genetic toxicology.
Topics: Animals; Biotransformation; Cell Line; Cyclophosphamide; Humans; Liver Neoplasms, Experimental; Muta | 1983 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp | 1984 |
Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat hepatoma.
Topics: Animals; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrocortisone; Kinetics; Liver Neoplas | 1982 |
Phenobarbital as a promoter in the initiation/selection process of experimental rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimenta | 1983 |
Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver N | 1983 |
Dissimilar patterns of promotion by di(2-ethylhexyl)phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice.
Topics: Adenoma; Animals; Carcinogens; Diethylhexyl Phthalate; Diethylnitrosamine; Drug Synergism; Hyperplas | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Effect of phenobarbital on the carcinogenesis of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats.
Topics: Animals; Carcinogens; Drug Interactions; Drug Synergism; FANFT; Liver Neoplasms, Experimental; Male; | 1983 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Expression of the tumor aldehyde dehydrogenase phenotype during 2-acetylaminofluorene-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Cell Transformatio | 1982 |
Promotive effects of steroids and bile acids on hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Bile Acids and Salts; Carcinogens; Cortisone; Dexamethasone; Diethylnitrosamine; Ethinyl Es | 1982 |
Induction of aldehyde dehydrogenases during hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Diethylnitrosamine | 1982 |
Further studies on the increase in drug-metabolizing capacity adjacent to intrahepatic Morris hepatomas.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Liver Neoplasms, Experimental; | 1981 |
In vitro carcinogenesis of hepatocytes obtained from acetylaminofluorene-treated rat liver and promotion of their growth by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Drug Synergism; Epithelium; Liver; Liver Neoplasms, | 1980 |
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats.
Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; I | 1980 |
Induction of hepatocellular carcinoma in rat liver by initial treatment with benzo(a)pyrene after partial hepatectomy and promotion by phenobarbital.
Topics: Animals; Benzopyrenes; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats | 1980 |
Effects of varying the dietary concentration of phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Drug Synergism; | 1980 |
Growth characteristics and Ha-ras mutations of cell cultures isolated from chemically induced mouse liver tumours.
Topics: Animals; Cell Division; Codon; Diethylnitrosamine; Eosine Yellowish-(YS); Genes, ras; Liver Neoplasm | 1994 |
C-raf expression in early rat liver tumorigenesis after promotion with polychlorinated biphenyls or phenobarbital.
Topics: Animals; Blotting, Northern; Carcinogens; DNA; Female; Gene Expression; Histocytochemistry; Hydrogen | 1994 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans | 1995 |
Phenobarbital promotes the development of adenocarcinomas in the accessory sex glands of MNU-inoculated L-W rats.
Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Aging; Animals; Carcinogens; Drug Implants; Genital Ne | 1995 |
Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Female; Live | 1995 |
The in utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression of c-jun and c-myc oncogenes in primary neonatal rat hepatocytes.
Topics: Animals; Animals, Newborn; Biotechnology; Cells, Cultured; Dimethylnitrosamine; Female; Genes, jun; | 1993 |
Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; F | 1995 |
Evaluation of the xenobiotic biotransformation capability of six rodent hepatoma cell lines in comparison with rat hepatocytes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthofl | 1994 |
Further evidence for promoter-dependent development of hepatoblastoma in the mouse.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatoblastoma; Liver Neoplasms, Experimental | 1995 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease M | 1994 |
Correlation between S-adenosyl-L-methionine content and production of c-myc, c-Ha-ras, and c-Ki-ras mRNA transcripts in the early stages of rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; gamma-Glutamyltransferase; Gene Expression Regul | 1994 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transfe | 1994 |
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Topics: Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 1994 |
Simultaneous induction of liver cirrhosis and hepatocellular carcinomas in F-344 rats: establishment of a short hepatocarcinogenesis model.
Topics: Animals; Carbon Tetrachloride; Carcinogenicity Tests; Carcinogens; Diethylnitrosamine; Hepatectomy; | 1994 |
Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Down-Regulation; Gene Expression Regulation, Neoplast | 1994 |
Regulation of apolipoprotein A-I gene expression by phenobarbital in the human hepatocarcinoma cell line, Hep3B.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins E; Gene Expression Regulation; Humans; Liver Neoplasms, | 1994 |
Association between responsiveness to phenobarbital induction of CYP2B1/2 and 3A1 in rat hepatic hyperplastic nodules and their zonal origin.
Topics: Aflatoxin B1; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3 | 1993 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Synergistic effects of phenobarbital and thiourea on proliferative lesions in the rat liver.
Topics: Animals; Cell Division; Drug Synergism; Liver; Liver Neoplasms, Experimental; Lung; Male; Nitrosamin | 1994 |
Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital.
Topics: Animals; Liver; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; R | 1994 |
22-Oxa-1,25(OH)2vitamin D3, a synthetic analogue of vitamin D3, has no promoting activity in a rat liver medium-term bioassay.
Topics: Animals; Antineoplastic Agents; Calcitriol; Carcinogens; Diethylnitrosamine; Liver Neoplasms; Liver | 1994 |
Phenotypic alteration of hepatocellular foci in rats treated with clofibrate and phenobarbital.
Topics: Animals; Clofibrate; Glutathione Transferase; Liver Neoplasms; Liver Neoplasms, Experimental; Male; | 1994 |
Modifications of liver bile acids pool during modulation of rat hepatocarcinogenesis by phenobarbital and nafenopin.
Topics: Animals; Bile Acids and Salts; Liver; Liver Neoplasms, Experimental; Male; Nafenopin; Phenobarbital; | 1994 |
The initiation-promotion-progression model of rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Animals; Benzene; Biomarkers, Tumor; Cells, Cultured; Diethylnitrosamine; | 1993 |
The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.
Topics: Animals; Animals, Newborn; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1993 |
Intercellular communication in primary cultures of putative preneoplastic and 'normal' hepatocytes.
Topics: 2-Acetylaminofluorene; Animals; Cell Communication; Cells, Cultured; Diethylnitrosamine; gamma-Gluta | 1993 |
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; D | 1993 |
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Nucleus; Cyclooctanes; Dioxoles; Drugs, Chinese | 1994 |
Screening for p53 mutations in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Diethylnitrosamine; DNA, Neoplasm; DNA, Single-Stranded; Exons; Genes, p53; | 1994 |
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; D | 1994 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1994 |
DNA adduct formation of hepatocarcinogenic aromatic amines in rat liver: effect of cytochrome P450 inducers.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; Imidazoles; Liver; Live | 1994 |
Colocalized alterations in connexin32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Barbiturates; Carcinogens; Cell Communication; Connexins; Cy | 1994 |
The phenobarbital-induced transcriptional activation of cytochrome P-450 genes is blocked by the glucocorticoid-progesterone antagonist RU486.
Topics: Animals; Base Sequence; Cytochrome P-450 Enzyme System; Enzyme Activation; Gene Expression; Gene Exp | 1993 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; | 1993 |
Glutathione S-transferase isoenzyme patterns in different subtypes of enzyme-altered rat liver foci treated with the peroxisome proliferator nafenopin or with phenobarbital.
Topics: Adenoma; Aflatoxin B1; Animals; Carcinogens; Female; Glutathione Transferase; Isoenzymes; Liver; Liv | 1993 |
Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene-induced hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Arylsulfotransferase; Cytosol; Down-Regulation; Hydroxyacetylaminofl | 1994 |
Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Albumins; Animals; Female; Glutathione Transferase; Liver; Liver N | 1993 |
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver | 1993 |
An improved long-term culture of rat hepatocytes to detect liver tumour-promoting agents: results with phenobarbital.
Topics: Albumins; Animals; Blotting, Northern; Carcinogenicity Tests; Carcinogens; Cell Communication; Cell | 1993 |
Influence of orotic acid on multistage hepatocarcinogenesis in the rat: resistance of hepatocytes from nodules to the mitoinhibitory effects of orotic acid.
Topics: 1,2-Dimethylhydrazine; Animals; Anticarcinogenic Agents; Cells, Cultured; Dimethylhydrazines; DNA; D | 1993 |
Phenobarbital induction of AP-1 binding activity mediates activation of glutathione S-transferase and quinone reductase gene expression.
Topics: Acetylcysteine; Animals; Base Sequence; Chloramphenicol O-Acetyltransferase; Gene Expression; Glutat | 1993 |
Inhibitory effects of inhibitors of arachidonic acid metabolism on the evolution of rat liver preneoplastic foci into nodules and hepatocellular carcinomas with or without phenobarbital exposure.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspirin; Cyclooxygenase Inhibitors; Diethylnitrosamine; Li | 1993 |
Hepatic effects of dieldrin and phenobarbital in male B6C3F1 mice and Fisher 344 rats: species selective induction of DNA synthesis.
Topics: Animals; Dieldrin; Disease Susceptibility; DNA; Liver; Liver Neoplasms, Experimental; Male; Mice; Mi | 1995 |
Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Phenobarbital; Rats; | 1996 |
Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Anticarcinogenic Agents; Bile Acids and Salts; Body Weight; Carcinogens; Cyclooctanes; Deox | 1995 |
Sequence of the rat PB-inducible CYP2B1 promoter.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Binding Sites; Cell Line; Cytochrome P-450 En | 1996 |
Chemopreventive effects of taurine on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; L | 1996 |
Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diethylnitrosamine; Female; gamma-Glutam | 1995 |
Low expression of the WAF1/CIP1 gene product, p21, in enzyme-altered foci induced in rat liver by diethylnitrosamine or phenobarbital.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Diethylnitrosamine; Female; Gl | 1996 |
Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis.
Topics: Animals; Apoptosis; Carcinogens; Diethylnitrosamine; DNA; Dose-Response Relationship, Drug; Liver Ne | 1996 |
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver N | 1996 |
Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats.
Topics: Analysis of Variance; Animals; Autoradiography; Cytochrome P-450 Enzyme System; Dieldrin; DNA; Dose- | 1996 |
Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model.
Topics: Animals; Apoptosis; Cell Division; Cell Transformation, Neoplastic; Gene Expression Regulation, Neop | 1996 |
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
Topics: Albumins; Animals; Disease Models, Animal; Female; Genes, myc; Hepatocyte Growth Factor; Liver Neopl | 1996 |
Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.
Topics: Animals; Caprylates; Carcinogens; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Glut | 1996 |
Inhibitory effects of tea catechins, black tea extract and oolong tea extract on hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Catechin; Diethylnitrosamine; Drug Screening Assays, | 1996 |
Inhibitory effect of chlorophyllin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Carcinogens; Chlorophyllides; Diethylnitrosa | 1996 |
Induction and inhibition of mouse cytochrome P-450 2B enzymes by musk xylene.
Topics: Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Bacteria; Cytochrome P-450 CYP1A1; Cyt | 1997 |
[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].
Topics: Animals; Antithyroid Agents; Liver Neoplasms, Experimental; Lung Neoplasms; Male; Nitrosamines; Phen | 1996 |
Suppressive effects of S-methyl methanethiosulfonate on promotion stage of diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis model.
Topics: Animals; Anticarcinogenic Agents; Diethylnitrosamine; Lipid Peroxidation; Liver Neoplasms, Experimen | 1997 |
The effect of two periods of short-term fasting during the promotion stage of hepatocarcinogenesis in rats: the role of apoptosis and cell proliferation.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Fasting; Female; Glutathione Transferase; Live | 1997 |
Hepatic tumor induction in c-myc mono-transgenic and TGF-alpha/c-myc double-transgenic mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Liver Neoplasms, Experimental; Mice; Mice, Transgenic; Phe | 1997 |
Interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Gene Expression; Gene Expression Regulation, Neoplast | 1997 |
TGF-alpha sustains clonal expansion by promoter-dependent, chemically initiated rat hepatocytes.
Topics: Animals; Carcinogens; Cell Division; Cell Line; Dose-Response Relationship, Drug; Liver; Liver Neopl | 1997 |
Corn oil enhances gamma-glutamyl transpeptidase-positive foci development in the presence of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Carcinogens; Corn Oil; Dietary Fats, Unsaturated; Diethylnitrosamine; Dinoprost; Fatty Acid | 1997 |
Suppressive effect of irsogladine maleate on diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis in male F344 rats.
Topics: Animals; Antineoplastic Agents; Diethylnitrosamine; Glutathione Transferase; Immunohistochemistry; L | 1998 |
Progression of hepatic neoplasms is severely retarded in mice lacking the bisecting N-acetylglucosamine on N-glycans: evidence for a glycoprotein factor that facilitates hepatic tumor progression.
Topics: Acetylglucosamine; Animals; Carcinogens; Diethylnitrosamine; Disease Progression; Female; Genetic Ve | 1998 |
Attenuation of G1 checkpoint function by the non-genotoxic carcinogen phenobarbital.
Topics: Animals; Bleomycin; Carcinogens; Cell Cycle; Cells, Cultured; DNA; DNA Damage; G1 Phase; Liver; Live | 1998 |
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers, Tumor; Carcinogens; Cytochrome P-450 CYP2A6; Cyt | 1998 |
The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and gene expression in rat liver during the promotion stage.
Topics: Actins; Animals; Apoptosis; Cell Count; Cell Division; Cocarcinogenesis; Eating; Fasting; Female; Ge | 1998 |
Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dose-Response Relationship | 1998 |
Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Connexins; Cytochrome P-450 CYP2B1; Eating; Gap Ju | 1998 |
c-fos gene expression in rat liver is induced by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Gene Expression; Genes, fos; Liver; Liver Neoplasms, Ex | 1999 |
[Proliferating effect of cytochrome P-450 inducers in cultured hepatoma cells, expressing and not expressing cytochrome P-450].
Topics: Animals; Cell Division; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver Neoplasms, Experimen | 1999 |
Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Calcium-Calmodulin-Dependent Protein | 1999 |
Phenobarbital-induced cytoplasmic accumulation of beta1-integrin in rat liver enzyme altered foci; an immunohistological study.
Topics: Animals; Animals, Newborn; Bromodeoxyuridine; Carcinogens; Cytoplasm; Diethylnitrosamine; Female; Gl | 1998 |
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Temperature; Body Weight; Carcinogens; Circadian Rhythm; Diethylnitrosamine; Laparotom | 1999 |
2-(Allylthio)pyrazine inhibition of aflatoxin B1-induced hepatocarcinogenesis in rats.
Topics: Aflatoxin B1; Animals; Carcinogenicity Tests; DNA Adducts; DNA, Neoplasm; Enzyme Inhibitors; Glutath | 1999 |
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Topics: Adenoma; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinogens; Carcinoma; Carr | 1999 |
Inhibitory effect of Trianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diethylnitrosamine; Drinking Behavior; E | 1999 |
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Carcinogens; Diethylnitr | 1999 |
A conserved nuclear receptor consensus sequence (DR-4) mediates transcriptional activation of the chicken CYP2H1 gene by phenobarbital in a hepatoma cell line.
Topics: Animals; Base Sequence; Conserved Sequence; Cytochrome P-450 Enzyme System; Excitatory Amino Acid An | 2000 |
EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Barbiturates; Blotting, Northern; Blotting, Western; Carcino | 2000 |
New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice.
Topics: Alleles; Animals; Blotting, Northern; Blotting, Southern; Blotting, Western; Diethylnitrosamine; Dis | 2000 |
Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.
Topics: Animals; Apoptosis; bcl-X Protein; Carcinogens; Cell Transformation, Neoplastic; Crosses, Genetic; G | 2000 |
Further evidence for chemopreventive potential of beta-carotene against experimental carcinogenesis: diethylnitrosamine-initiated and phenobarbital-promoted hepatocarcinogenesis is prevented more effectively by beta-carotene than by retinoic acid.
Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; beta Carotene; Carcinogens; Diethylnitrosamine; | 2000 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg | 2000 |
Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.
Topics: 4-Butyrolactone; Aflatoxin B1; Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Catalyti | 2000 |
Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell Division; DNA; Eating; G | 2000 |
Tamoxifen mutagenesis and carcinogenesis in livers of lambda/lacI transgenic rats: selective influence of phenobarbital promotion.
Topics: Animals; Bacterial Proteins; Cell Division; Escherichia coli Proteins; Estrogen Antagonists; Female; | 2001 |
Mechanisms involved in the chemoprevention of flavonoids.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Chemoprevention; Cytosol; Diet; DNA; Fl | 2000 |
Alteration by phenobarbital of membrane-associated enzymes including gamma glutamyl transpeptidase in mouse liver neoplasms.
Topics: Adenosine Triphosphatases; Animals; Cell Membrane; Female; gamma-Glutamyltransferase; Glucose-6-Phos | 1980 |
Involvement of mu class glutathione S-transferase subunit M2 (rGST M2) levels in the initiation and promotion of hepatocellular carcinogenesis in old rats.
Topics: Aflatoxin B1; Aging; Animals; Carcinogens; Glutathione Transferase; Immunohistochemistry; Liver Neop | 2001 |
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Gene Dosage; Gene | 2001 |
Cumulative exposure to tamoxifen: DNA adducts and liver cancer in the rat.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; DNA; DNA Adducts; DNA Damage; Dose-Response | 2001 |
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Topics: Adenoviridae; Alkylating Agents; Animals; Anticonvulsants; beta-Galactosidase; Carcinoma, Hepatocell | 2001 |
Immunohistochemical characterization of hepatoblastomas in B6C3F1 mice treated with diethylnitrosamine and sodium phenobarbital.
Topics: Albumins; Alkylating Agents; alpha-Fetoproteins; Animals; Diethylnitrosamine; Immunohistochemistry; | 2001 |
Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of beta-catenin-mutated mouse liver tumors.
Topics: Animals; Base Sequence; beta Catenin; Carcinogens; Cell Division; Clone Cells; Cytoskeletal Proteins | 2001 |
Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosine; DNA; DNA Methylation; Genetic Predisposition to Di | 2002 |
Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphatases; Animals; Fluorenes; gamma-Glutamyltransferase; Glu | 1978 |
Promotion by dietary phenobarbital of hepatocarcinogenesis by 2-methyl-N,N-dimethyl-4-aminoazobenzene in the rat.
Topics: Animals; Drug Synergism; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; p-Dimet | 1979 |
Effects of phenobarbital and 3-methylcolanthrene treatment on microsomes of Morris hepatoma 3924-A, tumour-bearing and normal rat liver.
Topics: Aminopyrine N-Demethylase; Animals; Cell Membrane; Cytochrome P-450 Enzyme System; Cytochromes; Cyto | 1979 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Effect of phenobarbital, dichlorodiphenyltrichloroethane, and polychlorinated biphenyls on diethylnitrosamine-induced hepatocarcinogenesis.
Topics: Animals; DDT; Diethylnitrosamine; Drug Synergism; Enzyme Induction; Liver Neoplasms, Experimental; M | 1979 |
Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Diethylnitrosamine; Drug Synergism; Liver; Liver Neoplasms, Expe | 1978 |
Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions.
Topics: 2-Acetylaminofluorene; Animals; Iron; Liver Neoplasms, Experimental; Phenobarbital; Precancerous Con | 1978 |
A microsomal butyrylesterase appearing in rat livers during development, regeneration, and carcinogenesis, and after phenobarbital treatment.
Topics: Animals; Butyrates; Carboxylic Ester Hydrolases; Fetus; Isoenzymes; Liver Neoplasms, Experimental; L | 1979 |
[Accelerated microsomal DNA synthesis under the influence of xenobiotics and chemical carcinogens].
Topics: Animals; Benzopyrenes; Caffeine; Cell Nucleus; Cycloheximide; DNA; DNA, Mitochondrial; DNA, Neoplasm | 1979 |
The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse.
Topics: Age Factors; Animals; Azo Compounds; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Hep | 1979 |
Phenobarbital stimulation of cytochrome P-450 and aminopyrine N-demethylase in hyperplastic liver nodules during LD-ethionine carcinogenesis.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 Enzyme System; Ethionine; Hyperplasia; Liver Ne | 1978 |
The drug metabolism systems of liver and liver tumors: a comparison of activities and characteristics.
Topics: Animals; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Hydrocortisone; Kinetics; Liver Neop | 1978 |
The histology and development of hepatic nodules and carcinoma in C3H/He and C57BL/6 mice following chronic phenobarbitone administration.
Topics: Animals; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Ph | 1992 |
Effects of modifying agents on conformity of enzyme phenotype and proliferative potential in focal preneoplastic and neoplastic liver cell lesions in rats.
Topics: Adenosine Triphosphatases; Animals; Bromodeoxyuridine; Cell Division; Clofibrate; Diethylhexyl Phtha | 1992 |
Mitogen-induced liver hyperplasia does not substitute for compensatory regeneration during promotion of chemical hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Division; Diethylnitrosamine; gamma-Gluta | 1992 |
Threshold dose dependence in phenobarbital promotion of rat hepatocarcinogenesis initiated by diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathion | 1992 |
Modification of DENA-induced hepatocarcinogenesis by CCl4 cirrhosis. Comparison of the marker enzyme patterns.
Topics: Animals; Carbon Tetrachloride; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Drug Administrati | 1992 |
[Dose-response relationship of promotion by phenobarbital in rat two-stage hepatocarcinogenesis].
Topics: Administration, Oral; Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms | 1991 |
How the potency of the steroid RU486 is related to P450 activities induced by dexamethasone and phenobarbital in rat hepatoma cells.
Topics: Aminopyrine; Animals; Biotransformation; Cell Line; Cytochrome P-450 Enzyme System; Dexamethasone; E | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc | 1992 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Carcinoma, Hepatocellular; Chloroform; DNA, Neoplasm; Gene Expression Regulation, Neoplasti | 1991 |
Expression of the pp63 gene encoding the insulin receptor tyrosine kinase inhibitor in proliferating liver and in liver tumors.
Topics: alpha-2-HS-Glycoprotein; Animals; Cell Division; Crosses, Genetic; Female; Gene Expression; Glycopro | 1991 |
Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Biomarkers, Tumor; Carcinogens; Diethylnit | 1991 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans | 1991 |
[The expression of alpha 1-inhibitor 3 gene and some changes of its structure in rat hepatomas].
Topics: Acute-Phase Proteins; Animals; Diethylnitrosamine; DNA Transposable Elements; Female; Gene Expressio | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Fema | 1990 |
The appearance of hepatoma-associated chromosomal non-histone proteins in rat liver after a single dose of 3'-MDAB followed by treatment of phenobarbital.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cell Nucleus; Chromatin; Chromosomal Proteins, Non-H | 1990 |
Effect of rat developmental stage at initiation on the expression of biochemical markers during liver tumor promotion.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cytochrome P-450 Enzyme System; DNA; gamma-Glutamylt | 1990 |
Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Cytochrome Reductases; Deoxyguanosine; Dicumarol; | 1991 |
[Inhibitory effect of UFT on rat hepatocarcinogenesis induced by 3'-methyl-4-dimethylaminoazobenzene and phenobarbital promotion].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Liver Neoplasms, Experimental; Male; Methyl | 1991 |
Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Topics: Animals; Base Sequence; Blotting, Southern; Codon; Diethylnitrosamine; DNA; Gene Expression; Genes, | 1991 |
An ultrastructural study of spontaneous and phenobarbitone-induced nodules in the mouse liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Diseases; Liver Neoplasms, Experimenta | 1991 |
Effects of gomisin A on hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cyclooctanes; Dioxoles; Lignans; Liver Neoplasms, Exp | 1991 |
An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay.
Topics: Animals; Carcinogenicity Tests; Diet; Female; Liver; Liver Neoplasms, Experimental; Male; Molecular | 1991 |
Dealkylation of 7-methoxycoumarin as assay for measuring constitutive and phenobarbital-inducible cytochrome P450s.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Antibodies, Monoclonal; Cell Line; Cricetinae; Cytochrome P- | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liv | 1991 |
Quantitative stereological analysis of the effects of age and sex on multistage hepatocarcinogenesis in the rat by use of four cytochemical markers.
Topics: Adenosine Triphosphatases; Age Factors; Animals; Diethylnitrosamine; Female; gamma-Glutamyltransfera | 1990 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Proto-oncogene and gap-junction protein expression in rodent liver neoplasms.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gene Expression Re | 1990 |
Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver.
Topics: Aflatoxin B1; Aflatoxins; Animals; Body Weight; Carcinoma; Female; gamma-Glutamyltransferase; Liver; | 1990 |
Enhanced preneoplastic liver lesion development under 'selection pressure' conditions after administration of deoxycholic or lithocholic acid in the initiation phase in rats.
Topics: Animals; Body Weight; Deoxycholic Acid; gamma-Glutamyltransferase; Glutathione Transferase; Lithocho | 1990 |
Effect of phenobarbital on the glucocorticoid receptor in rat hepatoma cells.
Topics: Animals; Binding Sites; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Induction; Liver Neo | 1990 |
Increased susceptibility of aged rats to hepatocarcinogenesis by the peroxisome proliferator nafenopin and the possible involvement of altered liver foci occurring spontaneously.
Topics: Aging; Animals; Liver; Liver Neoplasms, Experimental; Male; Microbodies; Nafenopin; Phenobarbital; P | 1991 |
Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Analysis of Variance; Animals; Body Weight; Butylated Hydroxyanisole; Diethylnitrosamine; Eating; Li | 1991 |
Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
Topics: Animals; Binding, Competitive; Cell Transformation, Neoplastic; Diethylnitrosamine; Epidermal Growth | 1991 |
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1991 |
The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.
Topics: Animals; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; Liver; Liver Neoplasms, Exper | 1991 |
Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diet; Female; Liver; | 1991 |
Possible involvement of poly ADP-ribosylation in phenobarbital promotion of rat hepatocarcinogenesis.
Topics: Animals; Benzamides; Carcinogens; Diethylnitrosamine; Glutathione Transferase; Liver; Liver Neoplasm | 1990 |
[Expression of cellular oncogenes during hepatocarcinogenesis in rats].
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; Gene Expression Regulation, Neoplas | 1990 |
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; | 1990 |
Naturally-occurring age-dependent glutathione S-transferase pi immunoreactive hepatocytes in aging female F344 rat liver as potential promotable targets for non-genotoxic carcinogens.
Topics: Aging; Animals; Basophils; Eosinophils; Female; Glutathione Transferase; Immunoenzyme Techniques; Li | 1990 |
Phenobarbital enhances the formation of reactive oxygen in neoplastic rat liver nodules.
Topics: Acridines; Animals; Cytochrome P-450 Enzyme System; Diagnostic Imaging; Diethylnitrosamine; Female; | 1990 |
Modulatory interaction between initial clofibrate treatment and subsequent administration of 2-acetylaminofluorene or sodium phenobarbital on glutathione S-transferase positive lesion development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Clofibrate; Drug Interactions; Glutathione Transferase; | 1990 |
Structural and immunological identity of p65 tumor-associated factors from rat and mouse hepatocarcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Neoplasm; Biomarkers, Tumor; Carrier Proteins; Cocarcino | 1990 |
Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Enzyme Induction; Galactosamine; Glutathio | 1990 |
Correlation between medium-term liver bioassay system data and results of long-term testing in rats.
Topics: Animals; Butylated Hydroxyanisole; Butylhydroxybutylnitrosamine; Carcinogenicity Tests; Carcinogens; | 1990 |
Influence of liver tumor promoters and structurally related chemicals on survival of normal adult rat hepatocytes in primary culture.
Topics: Animals; Barbital; Butylated Hydroxytoluene; Carcinogens; Cell Survival; Cells, Cultured; DDT; DNA; | 1990 |
Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene.
Topics: Animals; Base Sequence; Cytochrome P-450 Enzyme System; Dexamethasone; DNA; Gene Expression Regulati | 1990 |
[An immunohistochemical and in situ hybridization study of carbamyl phosphate synthetase I in altered liver cells during carcinogenesis].
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Diethylnitrosamine; Female; Gene Expression; Immuno | 1990 |
The inhibition by methionine and choline of liver carcinoma formation in male C3H mice dosed with diethylnitrosamine and fed phenobarbital.
Topics: Animals; Choline; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Male; Methionine; Mice; | 1990 |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment | 1990 |
Modulation of neoplastic development: concepts and examples.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Enzyme Induction; Hepatectomy; Liver Ne | 1990 |
[Oncogenes and tumor promotion].
Topics: Animals; Bilirubin; Biliverdine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Gene | 1990 |
[Modification of the cellular cytoskeleton and hepatic tumor promotion].
Topics: Animals; Biliverdine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; L | 1990 |
[Role of junctional intercellular communication in hepatic carcinogenesis in rats].
Topics: Animals; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Intercellular Junctio | 1990 |
[Modulation of mRNAs P450 and hepatocarcinogenesis promotion].
Topics: Animals; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Liver Neoplasms, Expe | 1990 |
Pathogenesis of dimethylnitrosamine-induced hepatocellular cancer in hamster liver and lack of enhancement by phenobarbital.
Topics: Animals; Bile Ducts; Cricetinae; Dimethylnitrosamine; gamma-Glutamyltransferase; Histocytochemistry; | 1986 |
Effect of timing of partial hepatectomy on the induction of preneoplastic liver foci in rats given hepatocarcinogens.
Topics: 2-Acetylaminofluorene; Animals; gamma-Glutamyltransferase; Hepatectomy; Hexachlorocyclohexane; Liver | 1986 |
Comparison of gene expression in preneoplastic and neoplastic rat liver to adult, fetal, regenerating, and tumor-promoted liver.
Topics: Animals; Fetus; In Vitro Techniques; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; | 1988 |
Evaluation of chlordecone in a two-stage model of hepatocarcinogenesis: a significant sex difference in the hepatocellular carcinoma incidence.
Topics: Animals; Chlordecone; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Hepatectomy; Insecticid | 1989 |
Promotion of malignant 'embryonal' liver tumors by phenobarbital: increased incidence and shortened latency of hepatoblastomas in (DBA/2 x C57BL/6)F1 mice initiated with N-nitrosodiethylamine.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Crosses, Genetic; Diethylnitrosamine; Female; Hemang | 1989 |
Synergistic effects of low-dose hepatocarcinogens in induction of glutathione S-transferase P-positive foci in the rat liver.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Carbazoles; Carcinogens; Diethylnitrosamine; Drug Sy | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of rat hepatocarcinogenesis in a medium-term assay system: quantitation of glutathione S-transferase P-positive foci development.
Topics: 2-Acetylaminofluorene; Animals; Disease Susceptibility; Glutathione Transferase; Liver; Liver Neopla | 1989 |
Induction of cytochrome P450IA1 in mouse hepatoma cells by several chemicals. Phenobarbital and TCDD induce the same form of cytochrome P450.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Dioxins; Enzyme Induction; I | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans | 1989 |
Inhibition of promotion and persistent nodule growth by S-adenosyl-L-methionine in rat liver carcinogenesis: role of remodeling and apoptosis.
Topics: Adenosine; Animals; Deoxyadenosines; DNA; gamma-Glutamyltransferase; Liver Neoplasms, Experimental; | 1989 |
Differences between the promoting activities of the peroxisome proliferator WY-14,643 and phenobarbital in rat liver.
Topics: Adenosine Triphosphatases; Animals; Anticholesteremic Agents; Carcinogens; Diethylnitrosamine; gamma | 1989 |
Effect of the antihistamine, methapyrilene, as an initiator of hepatocarcinogenesis in female rats.
Topics: Adenosine Triphosphatases; Aminopyridines; Animals; Female; gamma-Glutamyltransferase; Glucose-6-Pho | 1989 |
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Body Weight; Diethyl | 1989 |
Effects of non-genotoxic hepatocarcinogens phenobarbital and nafenopin on phenotype and growth of different populations of altered foci in rat liver.
Topics: Aging; Animals; Carcinogenicity Tests; Carcinogens; Cell Survival; Female; gamma-Glutamyltransferase | 1989 |
Comparative study of diethylnitrosamine-initiated two-stage hepatocarcinogenesis in C3H, C57BL and BALB mice promoted by various hepatopromoters.
Topics: Animals; Clofibrate; Diethylnitrosamine; Ethinyl Estradiol; Liver; Liver Neoplasms, Experimental; Li | 1989 |
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Female; Genes, ras; Liver Neoplasms, Experimental; Male; | 1989 |
Over expression of proto-oncogenes: ki-ras, fos and myc in rat liver cells treated in vitro by two liver tumor promoters: phenobarbital and biliverdin.
Topics: Animals; Bilirubin; Biliverdine; Cell Line; Genes, ras; Liver; Liver Neoplasms, Experimental; Phenob | 1989 |
Amplification, rearrangements, and enhanced expression of c-myc in chemically induced rat liver tumors in vivo and in vitro.
Topics: Animals; Blotting, Northern; Blotting, Southern; Gene Amplification; Gene Expression Regulation, Neo | 1989 |
Synergistic promoter effect of diethylstilbesterol & phenobarbitone in diethylnitrosamine induced hepatic neoplasia in rats.
Topics: Animals; Diethylstilbestrol; Drug Synergism; Liver Neoplasms, Experimental; Male; Phenobarbital; Rat | 1989 |
Strain differences in hepatic tumor promotion by phenobarbital in diethylnitrosamine- and dimethylnitrosamine-initiated infant male mice.
Topics: Animals; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Drug Interactions; Liver Neoplasms, E | 1989 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; | 1989 |
The lectin binding characteristics of spontaneous and phenobarbitone induced hepatic lesions in C3H/He mice.
Topics: Animals; Cell Membrane; Lectins; Liver; Liver Neoplasms, Experimental; Membrane Glycoproteins; Mice; | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; L | 1989 |
Selective expression and induction of cytochrome P450PB and P450MC during the development of hereditary hepatitis and hepatoma of LEC rats.
Topics: Age Factors; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme Syst | 1989 |
Comparison of the effects of acute and subacute treatment of phenobarbital in different strains of mice.
Topics: Aminopyrine N-Demethylase; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; DNA; Do | 1989 |
Cell phenotype instability in preneoplastic foci of rat liver.
Topics: 5'-Nucleotidase; Adenosine Triphosphatases; Animals; Diethylnitrosamine; Glucose-6-Phosphatase; Live | 1988 |
Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyl | 1985 |
Phosphorylation of specific rat plasma membrane proteins during promotion of gamma-glutamyl transpeptidase-positive hepatic foci and inhibition by di(2-ethylhexyl)phthalate.
Topics: Animals; Chlorine; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experi | 1985 |
Effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Dietary Carbohydrates; DNA; Female; gamma-Glutamyltransferas | 1985 |
Effects of N-nitrosomorpholine and phenobarbital on UDP-glucuronyltransferase in putative preneoplastic foci of rat liver.
Topics: Adenosine Triphosphatases; Animals; Aryl Hydrocarbon Hydroxylases; gamma-Glutamyltransferase; Glucur | 1985 |
The effects of selenium on the emergence of aflatoxin B1-induced enzyme-altered foci in rat liver.
Topics: Aflatoxin B1; Aflatoxins; Animals; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; | 1985 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1985 |
Characterization of dimethylnitrosamine-induced focal and nodular lesions in the livers of newborn mice.
Topics: Animals; Animals, Newborn; Body Weight; Dimethylnitrosamine; Female; gamma-Glutamyltransferase; Hype | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, D | 1985 |
Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of gamma-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats.
Topics: Animals; Butylated Hydroxyanisole; Butylated Hydroxytoluene; gamma-Glutamyltransferase; Glutathione | 1985 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin | 1985 |
Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Separation; Cytochrome P-450 Enzyme System; Diethylnitr | 1985 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine.
Topics: Albumins; Animals; Female; gamma-Glutamyltransferase; Gene Expression Regulation; Liver; Liver Neopl | 1986 |
Promotion of 3'-methyl-4-dimethylaminoazobenzene-initiated adult rat liver cells to malignant state by phenobarbital in culture.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Epithelium; gamma-Glutamyltransferase; Liver; | 1986 |
Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis.
Topics: Animals; Butylated Hydroxytoluene; Cocarcinogenesis; DDT; gamma-Glutamyltransferase; Liver Neoplasms | 1986 |
Cholesterol synthesis and HMG CoA reductase activity during hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Cholesterol; Diethylnitrosamine; gamma-Glutamyltransferase; Hydroxym | 1986 |
Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment.
Topics: Aldehyde Dehydrogenase; Animals; Benzo(a)pyrene; Cell Division; Cell Line; Diethylnitrosamine; Enzym | 1986 |
Comparison of the biological effects of phenobarbital and nafenopin on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Diethylnitrosamine; gamma-Glutamyltransferase; Liver Ne | 1986 |
Facilitated expression of adaptive responses to phenobarbital in putative pre-stages of liver cancer.
Topics: Adaptation, Physiological; Animals; Cytochrome P-450 Enzyme System; DNA; Female; gamma-Glutamyltrans | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga | 1986 |
[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyper | 1987 |
The variations of S-adenosyl-L-methionine content modulate hepatocyte growth during phenobarbital promotion of diethylnitrosamine-induced rat liver carcinogenesis.
Topics: 2-Acetylaminofluorene; Adenosine; Animals; Cell Division; Deoxyadenosines; Diethylnitrosamine; gamma | 1987 |
Phenotypically selective promotion of diethylnitrosamine-initiated altered hepatocyte foci by dietary phenobarbital or a topically applied coal-derived organic mixture in male and female rats.
Topics: Administration, Topical; Animals; Coal; Cocarcinogenesis; Female; gamma-Glutamyltransferase; Iron; L | 1987 |
Factors influencing the initiation by gamma rays of hepatocarcinogenesis in the rat.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cells, Cultured; DNA Repair; Dose-Response Relations | 1987 |
Dietary effects on initiation and promotion of hepatocarcinogenesis in rat.
Topics: Animals; Body Weight; Diet; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; | 1988 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Femal | 1989 |
Phenobarbital promotion in diethylnitrosamine-initiated infant B6C3F1 mice: influence of gender.
Topics: Animals; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; Male; Mice; Phenobarbital; | 1989 |
Inhibition by dehydroepiandrosterone of liver preneoplastic foci formation in rats after initiation-selection in experimental carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Dehydroepiandrosterone; Diethylnitrosamine; Female; Liver; Liver Neo | 1987 |
Effects of phenobarbital and secondary bile acids on liver, gallbladder, and pancreas carcinogenesis initiated by N-nitrosobis (2-hydroxypropyl)amine in hamsters.
Topics: Adenoma, Bile Duct; Animals; Bile Acids and Salts; Cocarcinogenesis; Cricetinae; Deoxycholic Acid; E | 1986 |
Hydride transfer stereospecificity of rat liver aldehyde dehydrogenases.
Topics: Aldehyde Dehydrogenase; Animals; Isoenzymes; Liver; Liver Neoplasms, Experimental; Magnetic Resonanc | 1987 |
Quantitative relationship between initiation of hepatocarcinogenesis and induction of altered cell islands.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Benzopyrenes; Dimethylnitrosamine; DNA; | 1986 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Fem | 1986 |
Possible model of liver carcinogenesis using inhibitors of NAD+ ADP ribosyl transferase in rats.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms; Liver Neoplasms, Experimental; Male; NAD; Phenobarbita | 1986 |
Phenobarbital-dependent proliferation of putative initiated rat hepatocytes.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Cell Division; Cells, Cultured; Dimethy | 1988 |
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Hepatectomy; Liv | 1988 |
The influence of phenobarbital and butylated hydroxytoluene on the ploidy rate in rat hepatocarcinogenesis.
Topics: Animals; Butylated Hydroxytoluene; Carcinogens; Cell Nucleus; Liver; Liver Neoplasms, Experimental; | 1988 |
[Highly permeable contacts and electrical characteristics of the tissue of the normal liver and hepatomas. III. Absence of an effect of the tumor promoter phenobarbital on intercellular contacts in the mouse liver].
Topics: Animals; Carcinogens; Cell Membrane Permeability; Intercellular Junctions; Liver; Liver Neoplasms, E | 1988 |
The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.
Topics: Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; L | 1988 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship | 1988 |
The chronic hepatic or renal toxicity of di(2-ethylhexyl) phthalate, acetaminophen, sodium barbital, and phenobarbital in male B6C3F1 mice: autoradiographic, immunohistochemical, and biochemical evidence for levels of DNA synthesis not associated with car
Topics: Acetaminophen; Animals; Autoradiography; Barbital; Barbiturates; Diethylhexyl Phthalate; DNA; Immuno | 1988 |
Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.
Topics: Animals; Choline Deficiency; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Neoplasms, Experi | 1988 |
Enhancement of dimethylnitrosamine-initiated hepatocarcinogenesis in hamsters by subsequent administration of carbon tetrachloride but not phenobarbital or p,p'-dichlorodiphenyltrichloroethane.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Cricetinae; DDT; Dimethylnitrosamine; Liver Neoplas | 1987 |
Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital.
Topics: Age Factors; Animals; Carcinogens; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Phen | 1988 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; En | 1988 |
Effect of dietary phenobarbital on spontaneous hepatic tumorigenesis in germfree C3H/He male mice.
Topics: Animals; Diet; Germ-Free Life; Intestines; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C | 1988 |
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne | 1988 |
Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells.
Topics: Animals; Benz(a)Anthracenes; Cell Differentiation; Cytochrome P-450 Enzyme System; Dexamethasone; Ge | 1988 |
Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone.
Topics: Animals; Carcinogens; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Nitrosamines; Oxazolidin | 1988 |
[Metabolic characteristics of xenobiotics in the liver of tumor-bearing rats].
Topics: Aminopyrine; Aniline Compounds; Aniline Hydroxylase; Animals; Cytochrome b Group; Cytochrome P-450 E | 1987 |
[The use of a primary culture of liver cells from rat embryos subjected to transplacental exposure to N-nitrosodiethylamine for the study of hepatocarcinogenesis promoters].
Topics: Animals; Carcinogens; Cells, Cultured; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Ne | 1987 |
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Ma | 1986 |
The histopathology and biochemistry of phenobarbitone-induced liver nodules in C3H mice.
Topics: Animals; Diethylnitrosamine; Histocytochemistry; Liver; Liver Neoplasms, Experimental; Male; Mice; M | 1987 |
Dinitrotoluene isomer-specific hepatocarcinogenesis in F344 rats.
Topics: Animals; Body Weight; Carcinogens; Dinitrobenzenes; Epoxide Hydrolases; Isomerism; Liver; Liver Neop | 1987 |
Enhancement of the clonability of adult parenchymal hepatocytes with the liver tumor promoter phenobarbital.
Topics: Animals; Cell Division; DNA; Female; Hepatectomy; Liver; Liver Neoplasms, Experimental; Liver Transp | 1986 |
Development of cytochrome P-450-altered preneoplastic and neoplastic lesions during nitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Cell Differentiation; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Isoenzymes; Liver | 1987 |
Strain and species effects on the inhibition of hepatocyte intercellular communication by liver tumor promoters.
Topics: Animals; Carcinogens; Cell Communication; Cells, Cultured; Cocarcinogenesis; DDT; Dieldrin; Liver; L | 1987 |
Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Histocytochemistry; Liver Neoplas | 1987 |
Biochemical effects of two promoters of hepatocarcinogenesis in rats.
Topics: Alanine Transaminase; Animals; Butylated Hydroxytoluene; Carcinogens; Cytochrome P-450 Enzyme System | 1987 |
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
Topics: Acetates; Adenoma; Animals; Body Weight; Dichloroacetic Acid; Drug Synergism; Ethylnitrosourea; Live | 1987 |
Time course of dolichol and dolichyl phosphate during chemical carcinogenesis in rat liver.
Topics: Acyl Coenzyme A; Animals; Diethylnitrosamine; Diterpenes; Dolichol Phosphates; Dolichols; Hepatectom | 1987 |
[Characteristics of hepatocarcinogenesis after single exposure of synchronized cells of the regenerating liver to N-nitrosodiethylamine and subsequent administration of phenobarbital].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Liver Regenerat | 1987 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |
Carcinogenicity and cocarcinogenicity test of phenobarbital sodium in adult BALB/c mice.
Topics: Animals; Cocarcinogenesis; Female; Hydrazines; Liver Neoplasms, Experimental; Lung Neoplasms; Male; | 1986 |
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh | 1986 |
Induction by phenobarbital in McA-RH7777 rat hepatoma cells of a polycyclic hydrocarbon inducible cytochrome P450.
Topics: 2-Acetylaminofluorene; Animals; Aroclors; Cell Line; Chlorodiphenyl (54% Chlorine); Cloning, Molecul | 1986 |
Mechanism of organ specificity in nitrosamine carcinogenesis.
Topics: Animals; Carcinogens; Dimethylnitrosamine; Esophageal Neoplasms; Liver; Liver Neoplasms, Experimenta | 1986 |
Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Ex | 1986 |
Amplified response to phenobarbital promotion of hepatotumorigenesis in obese yellow Avy/A (C3H x VY) F-1 hybrid mice.
Topics: Adenoma; Animals; Body Weight; Hybridization, Genetic; Liver; Liver Neoplasms, Experimental; Male; M | 1986 |
Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital.
Topics: Adenoma; Animals; Body Weight; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Mu | 1986 |
Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats.
Topics: Animals; Esophageal Neoplasms; FANFT; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Mal | 1986 |
The phenotypic stability of altered hepatic foci: effects of withdrawal and subsequent readministration of phenobarbital.
Topics: Animals; Diet; Edible Grain; Female; Liver Neoplasms, Experimental; Phenobarbital; Phenotype; Precan | 1986 |
Anti-carcinogenic action of phenobarbital given simultaneously with diethylnitrosamine in the rat.
Topics: Animals; Diethylnitrosamine; Drug Interactions; Liver Neoplasms, Experimental; Male; Mitotic Index; | 1986 |
Promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis.
Topics: Animals; Cocarcinogenesis; DDT; Drug Interactions; Liver Neoplasms, Experimental; Male; Methyldimeth | 1986 |
Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters.
Topics: Aminopyrine N-Demethylase; Animals; Carcinogens; Cricetinae; Cytochrome P-450 Enzyme System; Diethyl | 1986 |
Influence of the duration and the delay of administration of phenobarbital on its modulating effect on rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Carcinogens; Drug Administration Schedule; Liv | 1987 |
Effect of phenobarbital on the content of RNA polymerase B regulatory factors during diethylnitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Neoplasm Proteins; Phenobarbital; | 1985 |
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Expe | 1985 |
Enhancement of hepatocarcinogenesis by sorbitan fatty acid ester, a liver pyruvate kinase activity-reducing substance.
Topics: Animals; Bile Ducts; Body Weight; Hemangioma; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; | 1985 |
N-Nitroso-N-methylurea initiation in multiple tissues for organ-specific tumor promotion in rats by phenobarbital.
Topics: Animals; Body Weight; Carcinogens; Female; Liver; Liver Neoplasms, Experimental; Male; Methylnitroso | 1985 |
An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Butylated Hydroxyanisole; Carcinogens; | 1985 |
Dose-response relationship for phenobarbitone promotion of liver tumours initiated by single dose dimethylnitrosamine.
Topics: Animals; Cytochrome P-450 Enzyme System; Diet; Dimethylnitrosamine; Dose-Response Relationship, Drug | 1986 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mic | 1986 |
Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; E | 1986 |
Effect of subsequent treatment of chloroform or phenobarbital on the incidence of liver and lung tumors initiated by ethylnitrosourea in 15 day old mice.
Topics: Animals; Chloroform; Cocarcinogenesis; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; L | 1985 |
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; | 1985 |
Effect of phenobarbital on the activity of RNA polymerase II during diethylnitrosamine-induced hepatocarcinogenesis in the rat.
Topics: Animals; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Nitrosamines; Phenobarbital; Rats; | 1985 |
Effect of phenobarbital and other liver monooxygenase modifiers on dimethylnitrosamine-induced alkylation of rat liver macromolecules.
Topics: Alkylation; Animals; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; DNA; Ethanol; Liver; Liver | 1985 |
Induction of epoxide hydrolase in cultured rat hepatocytes and hepatoma cell lines.
Topics: 2-Acetylaminofluorene; Animals; Cells, Cultured; Enzyme Induction; Epoxide Hydrolases; Hydroxyacetyl | 1985 |
Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity.
Topics: Animals; Cricetinae; Diethylstilbestrol; Female; In Vitro Techniques; Kidney; Kidney Neoplasms; Live | 1985 |
Effects of selenium supplementation on hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Org | 1985 |
Endogenous hepatic growth-modulating factors and effects of a choline-devoid diet and of phenobarbital on hepatocarcinogenesis in the rat.
Topics: Animals; Carbon Tetrachloride; Choline; Diet; DNA; Ethionine; Growth Substances; Liver; Liver Neopla | 1985 |