phenobarbital has been researched along with Essential Tremor in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Essential Tremor: A relatively common disorder characterized by a fairly specific pattern of tremors which are most prominent in the upper extremities and neck, inducing titubations of the head. The tremor is usually mild, but when severe may be disabling. An autosomal dominant pattern of inheritance may occur in some families (i.e., familial tremor). (Mov Disord 1988;13(1):5-10)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors." | 3.88 | Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. ( Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kunisawa, N | 1 |
| Shimizu, S | 1 |
| Kato, M | 1 |
| Iha, HA | 1 |
| Iwai, C | 1 |
| Hashimura, M | 1 |
| Ogawa, M | 1 |
| Kawaji, S | 1 |
| Kawakita, K | 1 |
| Abe, K | 1 |
| Ohno, Y | 1 |
| Sampaio, C | 1 |
| Ferreira, J | 1 |
| Melmed, C | 1 |
| Moros, D | 1 |
| Rutman, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Efficacy and Safety of Taro Pharmaceuticals' Pro-Drug T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric Acid) in Patients With Essential Tremor: An Open-Label Dose Continuation Study[NCT00655278] | Phase 2 | 5 participants (Actual) | Interventional | 2007-08-31 | Terminated | ||
| Phase II Efficacy and Safety of Taro Pharmaceuticals' Pro-Drug T2000 (1,3-Dimethoxymethyl-5,5-Diphenyl-Barbituric Acid) In Patients With Myoclonus Dystonia: An Open Label Sequential Dose Escalation Study[NCT00506012] | Phase 2 | 5 participants (Anticipated) | Interventional | 2007-08-31 | Terminated (stopped due to Slow Recruitment of eligible patients) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenobarbital and Essential Tremor
| Article | Year |
|---|---|
Essential tremor.
Topics: Botulinum Toxins, Type A; Essential Tremor; Humans; Phenobarbital; Propranolol; Randomized Controlle | 2002 |
1 trial available for phenobarbital and Essential Tremor
| Article | Year |
|---|---|
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
1 other study available for phenobarbital and Essential Tremor
| Article | Year |
|---|---|
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbama | 2018 |