phenobarbital has been researched along with Epilepsy in 1523 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures." | 9.41 | Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023) |
| "To investigate the current status of epilepsy treatment and the efficacy and adverse effects of phenobarbital therapy in rural areas of Northern China." | 9.24 | Current status of epilepsy treatment and efficacy of standard phenobarbital therapy in rural areas of Northern China. ( Lin, W; Luo, N; Wang, Z; Yu, J, 2017) |
| "Imepitoin was tested as a combination treatment with phenobarbital in an open-label mono-centre cohort study in dogs with drug-resistant epilepsy." | 9.24 | Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy. ( Keefe, T; Kostic, D; Löscher, W; Neßler, J; Rundfeldt, C; Tipold, A, 2017) |
| "To evaluate the efficacy of Levetiracetam in the management of neonatal seizures." | 9.22 | Efficacy of Levetiracetam in neonatal seizures: a systematic review. ( Hussain, AM; Sharma, D; Sharma, SS, 2022) |
| "To study the impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate (TPM) and phenobarbital (PB)." | 9.22 | Comparison of impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate and phenobarbital. ( Deng, XQ; Huang, XX; Wang, MG; Wang, YY; Yao, D; Zhang, T, 2016) |
| "To assess tolerability and short-term efficacy of oral administration of pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with poorly controlled suspected idiopathic epilepsy." | 9.14 | Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy. ( Badgley, BL; Cerda-Gonzalez, S; Cooper, JJ; Dewey, CW; Ducoté, JM; Lavely, JA; Levine, JM; Packer, RA; Silver, GM, 2009) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "Patients with convulsive epilepsy were identified at primary care level and provided with phenobarbital monotherapy." | 9.12 | Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. ( Bell, GS; Dai, XY; de Boer, HM; Hong, Z; Ma, GY; Prilipko, L; Sander, JW; Wang, TP; Wang, WZ; Wu, JZ; Yang, B; Yuan, CL, 2006) |
| "To compare the behavioural side effects associated with two commonly used antiepilepsy drugs-phenobarbital and carbamazepine-in children in Bangladesh." | 9.12 | Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. ( Banu, SH; Ferdousi, S; Jahan, M; Khan, NZ; Koli, UK; Neville, B, 2007) |
| "The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy." | 9.10 | Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002) |
| "To determine the efficacy of pyridoxine in treating seizures, 90 infants and children with recurrent convulsions primarily due to acute infectious diseases were enrolled in the present study." | 9.08 | Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. ( Bai, AN; Cao, YM; Chui, W; Gao, DY; Ge, ZL; Jiao, FY; Li, HR; Lieu, NS; Liu, SB; Liu, ZY; Takuma, Y; Wu, S; Zhang, XK, 1997) |
| "Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy." | 9.06 | Progabide for refractory partial epilepsy: a controlled add-on trial. ( Schmidt, D; Utech, K, 1986) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 9.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| "This article reviews the current position of phenobarbital using articles published since 2000 and speculates on its likely future contribution to epilepsy care." | 8.88 | Current position of phenobarbital in epilepsy and its future. ( Brodie, MJ; Kwan, P, 2012) |
| "Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM." | 8.31 | Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. ( Bättig, L; Cserpan, D; Dünner, C; Hagmann, C; Pisani, F; Ramantani, G; Rüegger, A; Schmitt, B, 2023) |
| "To investigate caregivers' assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy." | 8.31 | Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy. ( Gristina, BR; Muñana, KR; Nettifee, JA; Waldron, RJ, 2023) |
| "Phenobarbital (PB) q12h is the most common treatment recommendation for cats with recurrent epileptic seizures." | 8.31 | Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy. ( De Decker, S; Mojarradi, A; Van Meervenne, S, 2023) |
| "The aim of this study was to explore the compliance of epilepsy patients in the Phenobarbital Epilepsy Management Project in a rural area of China and its influencing factors, so as to provide the basis for further strategies." | 8.02 | Researching on the compliance of epilepsy patients of the Phenobarbital Epilepsy Management Project in a rural area of China: A retrospective study. ( Feng, XL; Luo, BA; Qin, LL, 2021) |
| "Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult." | 8.02 | Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021) |
| "This study aims to compare the neurocognitive outcome in term infants who were treated using phenobarbital (PB) and levetiracetam (LEV) monotherapy for neonatal clinical seizures." | 7.96 | Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures. ( Akbay, S; Akkaya Inal, M; Arican, P; Cavusoglu, D; Gencpinar, P; Mete Atasever, N; Olgac Dundar, N; Tekgul, H, 2020) |
| "Phenobarbital and sodium valproate are broad spectrum and inexpensive antiepileptic drugs that are used to treat convulsive epilepsy." | 7.91 | Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. ( Li, J; Li, N; Lin, W; Yang, D; Zhao, D, 2019) |
| "This article presents an additional case of concomitant topiramate and phenobarbital administration that resulted in 8 hospital admissions for hypothermia that resolved after discontinuation of phenobarbital." | 7.91 | Recurrent Admissions for Hypothermia From Concomitant Topiramate and Phenobarbital: A Case Report. ( Mutch, AM, 2019) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 7.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "The aim of this study was to evaluate changes in epileptic seizures (ES) frequency and semiology in antiepileptic-medication (AEM)-naïve dogs with idiopathic epilepsy (DIE) after initiation of imepitoin (IMP) or phenobarbital (PB) monotherapy." | 7.91 | Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy. ( Barnett, CR; De Risio, L; Stabile, F; van Dijk, J, 2019) |
| "Neonatal seizures are treated with phenobarbital and prolonged treatment does not prevent postneonatal epilepsy." | 7.88 | Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures. ( Beatty, CW; Gust, J; Hamiwka, L; Natarajan, N, 2018) |
| "To compare the effectiveness of levetiracetam vs phenobarbital for nonsyndromic infantile epilepsy." | 7.88 | Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. ( Berg, AT; Chu, CJ; Coryell, J; Gaillard, WD; Grinspan, ZM; Keator, C; Knupp, KG; Kossoff, EH; Loddenkemper, T; Millichap, J; Mytinger, JR; Novotny, EJ; Ryan, N; Shellhaas, RA; Sullivan, JE; Valencia, I; Wirrell, EC; Wusthoff, C, 2018) |
| "Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin." | 7.85 | Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency. ( Bhatti, SFM; Broeckx, BJG; Martlé, V; Royaux, E; Stee, K; Van Ham, L, 2017) |
| "To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis." | 7.83 | Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016) |
| "Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children." | 7.83 | The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)." | 7.81 | Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 7.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "We report a stillborn, GA/LMP = 37 weeks, delivered by an epileptic woman, who received in the first four months of pregnancy phenobarbital (PH) 0." | 7.79 | Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy. ( Brailoiu, CG; Cernea, N; Tica, AA; Tica, OS; Tica, VI, 2013) |
| "To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [(11)C]quinidine and [(11)C]laniquidar." | 7.79 | [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness. ( de Lange, EC; Eriksson, J; Koepp, M; Labots, M; Lammertsma, AA; Potschka, H; Rongen, M; Russmann, V; Schuit, R; Seeger, N; Syvänen, S; van Kooij, R; Verbeek, J; Voskuyl, RA; Windhorst, AD; Zellinger, C, 2013) |
| "-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy." | 7.79 | High frequency of a single nucleotide substitution (c.-6-180T>G) of the canine MDR1/ABCB1 gene associated with phenobarbital-resistant idiopathic epilepsy in Border Collie dogs. ( Chang, HS; Kohyama, M; Kushida, K; Mizukami, K; Rahman, MM; Uddin, MM; Yabuki, A; Yamato, O, 2013) |
| "To evaluate the long-term outcome of phenobarbital treatment for convulsive epilepsy in rural China, and to explore factors associated with overall seizure outcomes." | 7.79 | Long-term outcome of phenobarbital treatment for epilepsy in rural China: a prospective cohort study. ( Dai, X; de Boer, HM; Ding, D; Hong, Z; Kwan, P; Li, S; Ma, G; Sander, JW; Wang, T; Wang, W; Wu, J; Yang, B; Yang, H; Yuan, C, 2013) |
| "Phenobarbital is an effective treatment for epilepsy but concerns remain over its potential neurocognitive toxicity." | 7.78 | Cognitive and mood effects of phenobarbital treatment in people with epilepsy in rural China: a prospective study. ( Bell, GS; de Boer, HM; Ding, D; Hong, Z; Kwan, P; Li, S; Lin, W; Sander, JW; Sun, J; Thompson, PJ; Wang, W; Wu, J; Wu, Q; Yu, P; Zhang, Q; Zhao, Q; Zhou, D, 2012) |
| "We investigated the effectiveness of intravenous injection of phenobarbital (PB) in patients referred to Himeji Red Cross Hospital, Hyogo, Japan, with benign convulsions with mild gastroenteritis (CwG) between November 2009 and June 2011." | 7.78 | [Intravenous injection of phenobarbital for benign convulsions with mild gastroenteritis]. ( Ban, H; Takami, Y, 2012) |
| "An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)." | 7.78 | Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012) |
| "The failure of the maximum tolerated dosage to improve seizure control in dogs with phenobarbital-resistant epilepsy argues against the suitability of verapamil add-on treatment to overcome pharmacoresistance." | 7.77 | Add-on treatment with verapamil in pharmacoresistant canine epilepsy. ( Jambroszyk, M; Potschka, H; Tipold, A, 2011) |
| "To report on a patient with epilepsy who developed leukopenia and thrombocytopenia during phenobarbital/lamotrigine treatment." | 7.76 | Phenobarbital/Lamotrigine coadministration-induced blood dyscrasia in a patient with epilepsy. ( Calabrò, G; De Sarro, G; Gallelli, L; Siniscalchi, A; Tolotta, GA, 2010) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| ", fasting concentrations) in dogs with epilepsy that had been treated long term (> or = 3 months) with phenobarbital or with phenobarbital and potassium bromide with concentrations in healthy control dogs." | 7.74 | Serum triglyceride concentration in dogs with epilepsy treated with phenobarbital or with phenobarbital and bromide. ( Govendir, M; Ilkin, WJ; Kluger, EK; Malik, R; Snow, D; Sullivan, DR, 2008) |
| "To assess pharmacokinetics, efficacy, and tolerability of oral levetiracetam administered as an adjunct to phenobarbital treatment in cats with poorly controlled suspected idiopathic epilepsy." | 7.74 | Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy. ( Bailey, KS; Barone, G; Boothe, DM; Dewey, CW; Kortz, GD, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 7.73 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "To evaluate the efficacy of phenobarbital in treatment of patients with convulsive forms of epilepsy in rural areas and to develop a suitable relevant model for rural China." | 7.73 | [Evaluation of the efficacy of phenobarbital in treatment of epilepsy in rural areas: study of 2455 patients in rural China]. ( Dai, XY; Hong, Z; Ma, GY; Wang, TP; Wang, WZ; Wu, JZ; Yang, B; Yuan, CL; Zhao, DH, 2006) |
| "A mechanism for the alleviation of the malfunction of a mutated (gamma2(K289M)) epilepsy-linked gamma-aminobutyric acid (GABA) neurotransmitter receptor by phenobarbital is presented." | 7.73 | On the mechanism of alleviation by phenobarbital of the malfunction of an epilepsy-linked GABA(A) receptor. ( Hess, GP; Krivoshein, AV, 2006) |
| "Questionnaires were mailed to owners of 29 dogs under management for suspected or diagnosed idiopathic epilepsy through the clinics of the Small Animal Hospital of the University of Glasgow Veterinary School, using either phenobarbitone or potassium bromide alone or in combination." | 7.73 | Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. ( Anderson, TJ; Chang, Y; Mellor, DJ, 2006) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 7.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 7.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre." | 7.70 | Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999) |
| "We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months." | 7.70 | Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999) |
| "Bromide toxicosis was diagnosed in an 8-year-old Labrador Retriever that had been treated for epilepsy with potassium bromide, at a dosage of 29 mg/kg of body weight/d." | 7.69 | Bromide toxicosis secondary to renal insufficiency in an epileptic dog. ( Linn, K; Nichols, ES; Trepanier, LA, 1996) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 7.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)." | 7.68 | Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992) |
| "The efficacy of phenobarbital and primidone against canine epilepsy was compared in a controlled study." | 7.67 | Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison. ( Frey, HH; Löscher, W; Schwartz-Porsche, D, 1985) |
| "Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered." | 7.66 | Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports. ( Arena, R; Bindi, A; Bonuccelli, U; De Scisciolo, G; Marcacci, G; Rossi, L, 1983) |
| "Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients of both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA)." | 7.66 | PB:PRM ratio in patients with epilepsy treated with primidone. ( Altamura, AC; Bianchi, M; Canger, R; Cornaggia, CM; Polana, P; Pruneri, C, 1983) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 7.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| "IgA, IgG and IgM concentrations were determined in sera and nasal washings from 20 patients with epilepsy on single-drug treatment with carbamazepine, in 20 patients on single-drug treatment with phenobarbital and in 26 healthy subjects." | 7.66 | Respiratory disease in patients with epilepsy on single-drug therapy with carbamazepine or phenobarbital. ( Aarli, JA; Gilhus, NE; Strandjord, RE, 1982) |
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 7.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide." | 7.65 | Acetazolamide-accelerated anticonvulsant osteomalacia. ( Mallette, LE, 1977) |
| "Five phenobarbital treated dogs were classified as true responders (≥50% reduction in seizures/month) whereas none of the levetiracetam treated dogs fulfilled this criterion." | 6.82 | A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy. ( Berendt, M; Fredsø, N; Møller, A; Sabers, A; Toft, N, 2016) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 6.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "In phenobarbital-treated dogs, significantly increased levels of alkaline phosphatase, gamma-glutamyl-transferase and other liver enzymes occurred, while no such effect was observed in the imepitoin group." | 6.80 | Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs. ( de Vries, F; Keefe, TJ; Löscher, W; Rundfeldt, C; Tipold, A, 2015) |
| " The median elimination half-life (t1/2) in patients receiving concomitant valproate (VPA) was 43." | 6.68 | Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. ( Boreus, L; Eriksson, AS; Hoppu, K; Nergårdh, A, 1996) |
| "Some excess risk of liver cancer was also found in cohort studies of patients hospitalized for epilepsy in Sweden and Taiwan, in the absence, however, of association with any specific drugs." | 6.50 | A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer. ( La Vecchia, C; Negri, E, 2014) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines." | 6.40 | Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. ( Chen, C; Cox, E; Fiedler-Kelly, J; Grasela, TH; Risner, ME; Womble, GP, 1999) |
| "The case of a two-year-old girl with generalized histiocytosis, probably induced by phenobarbital, is reported." | 6.38 | A case of hypersensitivity syndrome resembling Langerhans cell histiocytosis during phenobarbital prophylaxis for convulsion. ( Kawamura, N; Mino, M; Miyake, M; Motoyama, T; Nagata, T; Oguni, T; Yamasiro, K; Yoden, A; Yoshikawa, K, 1992) |
| "Valproic acid has become a regular component of antiepileptic therapy." | 6.36 | [Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978) |
| "High neonatal seizure burden is associated with worsened neurodevelopmental outcomes." | 5.72 | Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. ( Knox, A; Limjoco, J; Rajamanickam, V; Verwoerd, C, 2022) |
| "Lacosamide is a novel anticonvulsant that acts by enhancing sodium channel slow inactivation." | 5.56 | Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. ( Araki, Y; Fukushima, Y; Imai, K; Kagawa, Y; Takahashi, Y; Terada, K; Yamamoto, Y, 2020) |
| "Treatment with phenobarbital and potassium bromide completely terminated the seizures within 10days." | 5.43 | Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide. ( Itakura, A; Maegaki, Y; Nishimura, Y; Ohno, K; Okazaki, T; Saito, Y; Sejima, H; Yamamoto, T, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Drug-resistant epilepsy is believed to be multifactorial involving both genetic and non-genetic factors." | 5.42 | Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy. ( Chinvarun, Y; Keangpraphun, T; Kijsanayotin, P; Towanabut, S, 2015) |
| "Bumetanide, an inhibitor of the sodium-potassium-chloride cotransporter-1, has been suggested as an adjunct to phenobarbital for treating neonatal seizures." | 5.41 | Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies. ( Athikarisamy, S; Farhat, A; Ghosh, S; Nagarajan, L; Rakshasbhuvankar, A; Rao, S, 2023) |
| " Phenobarbital versus levetiracetam as first-line ASM in EEG-confirmed neonatal seizures (one trial) Phenobarbital is probably more effective than levetiracetam in achieving seizure control after first loading dose (RR 2." | 5.41 | Anti-seizure medications for neonates with seizures. ( Abiramalatha, T; Brigo, F; Hartmann, H; Pressler, R; Ramaswamy, VV; Thanigainathan, S, 2023) |
| " Available data suggests that phenobarbital is as effective as other first-line drugs for treating tonic-clonic seizures, but side effect reports differ widely between high and low-income settings." | 5.40 | Medication side effects among people with epilepsy taking phenobarbital in Zambia. ( Birbeck, GL; Bui, E; Elafros, MA, 2014) |
| "Phenobarbital treatment resulted in eradication of seizures (17/20 [85%]) significantly more often than did bromide (12/23 [52%]); phenobarbital treatment also resulted in a greater percentage decrease in seizure duration (88 ± 34%), compared with bromide (49 ± 75%)." | 5.38 | Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs. ( Boothe, DM; Carpenter, DM; Dewey, C, 2012) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 5.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "To determine whether there are therapeutically relevant changes in serum phenobarbital concentrations throughout a daily dosing interval in epileptic dogs receiving phenobarbital for > or = 3 weeks." | 5.31 | Effect of timing of blood collection on serum phenobarbital concentrations in dogs with epilepsy. ( Levitski, RE; Trepanier, LA, 2000) |
| " PB was also the most toxic drug, followed by CBZ and by PHT." | 5.30 | Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat. ( Alós, M; Barcia, JA; Belda, V; Rubio, P; Serralta, A, 1999) |
| "Phenobarbital monotherapy was given to 20 patients with idiopathic generalized epilepsy beginning in childhood but persisting into adulthood." | 5.30 | Phenobarbital still has a role in epilepsy treatment. ( Lerman, P; Lerman-Sagie, T, 1999) |
| " This study compares the pharmacokinetics of CBZ-CO against CBZ-CR in patients with epilepsies chronically treated with CBZ in monotherapy or CBZ-PB in bitherapy, the effect of PB on CBZ-CO and CBZ-CR pharmacokinetic parameters, and the effect of the two formulations of CBZ on PB pharmacokinetic parameters." | 5.29 | Steady state pharmacokinetics of carbamazepine-phenobarbital interaction in patients with epilepsy. ( Barra, Y; Bonneton, J; Genton, P; Iliadis, A; Mesdjian, E; Sennoune, S, 1996) |
| " Serum concentrations differed even with the same dosage among individual dogs." | 5.28 | [Effectiveness of bromide in therapy resistant epilepsy of dogs]. ( Jürgens, U; Schwartz-Porsche, D, 1991) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 5.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| " Fluctuations in the blood phenobarbital content from one administration to another is important for selecting its optimal dosage and the interval between intakes." | 5.27 | [Concentration of phenobarbital in biological fluids during the treatment of epilepsy patients]. ( Antadze, ZI; Okudzhava, VM; Vetrogon, FG, 1984) |
| "Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups." | 5.27 | Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. ( Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH, 1983) |
| " Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration." | 5.27 | Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984) |
| "Carbamazepine was given to 152 patients who were receiving multiple drug therapy for uncontrolled seizures." | 5.26 | Role of carbamazepine in reducing polypharmacy in epilepsy. ( Maheshwari, MC; Padmini, R, 1981) |
| "They conclude that epilepsy has a presentation rate of 9,6% in patients with previous febrile seizures, having the highest risk when they show previous familial seizures, neonatal pathology and altered EEG after the first febrile convulsion." | 5.26 | [Epilepsy after febrile seizures. Predisposing factors and role of phenobarbital in its prophylaxis (author's transl)]. ( Díez, JM; Palencia Luances, R; Sánchez-Villares, S; Tresierra, F, 1981) |
| "Phenobarbital was the major metabolite detected, and it reached peak levels in 6 to 12 hours." | 5.26 | Metabolism of dimethoxymethyl phenobarbital (eterobarb) in patients with epilepsy. ( Cho, AK; Gal, J; Goldberg, MA; Jenden, DJ, 1979) |
| "Of 290 children with an initial febrile convulsion, 216 met Livingston's criteria for a "simple" febrile convulsion and 74 for "epilepsy triggered by fever." | 5.26 | Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever". ( Wolf, SM, 1977) |
| "To investigate the current status of epilepsy treatment and the efficacy and adverse effects of phenobarbital therapy in rural areas of Northern China." | 5.24 | Current status of epilepsy treatment and efficacy of standard phenobarbital therapy in rural areas of Northern China. ( Lin, W; Luo, N; Wang, Z; Yu, J, 2017) |
| "Imepitoin was tested as a combination treatment with phenobarbital in an open-label mono-centre cohort study in dogs with drug-resistant epilepsy." | 5.24 | Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy. ( Keefe, T; Kostic, D; Löscher, W; Neßler, J; Rundfeldt, C; Tipold, A, 2017) |
| "This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
| "To evaluate the efficacy of Levetiracetam in the management of neonatal seizures." | 5.22 | Efficacy of Levetiracetam in neonatal seizures: a systematic review. ( Hussain, AM; Sharma, D; Sharma, SS, 2022) |
| "To study the impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate (TPM) and phenobarbital (PB)." | 5.22 | Comparison of impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate and phenobarbital. ( Deng, XQ; Huang, XX; Wang, MG; Wang, YY; Yao, D; Zhang, T, 2016) |
| "To assess tolerability and short-term efficacy of oral administration of pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with poorly controlled suspected idiopathic epilepsy." | 5.14 | Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy. ( Badgley, BL; Cerda-Gonzalez, S; Cooper, JJ; Dewey, CW; Ducoté, JM; Lavely, JA; Levine, JM; Packer, RA; Silver, GM, 2009) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "This review does not provide sufficient evidence to support levetiracetam, phenobarbital or lamotrigine for the treatment of epilepsy in people with Alzheimer's disease." | 5.12 | Treatment of epilepsy for people with Alzheimer's disease. ( Liu, J; Wang, LN, 2021) |
| "Patients with convulsive epilepsy were identified at primary care level and provided with phenobarbital monotherapy." | 5.12 | Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China. ( Bell, GS; Dai, XY; de Boer, HM; Hong, Z; Ma, GY; Prilipko, L; Sander, JW; Wang, TP; Wang, WZ; Wu, JZ; Yang, B; Yuan, CL, 2006) |
| "We conducted a study to assess the effect of phenobarbital, carbamazepine, and valproate on serum lipid profiles and lipoprotein (a) in 64 children with epilepsy (aged between 1 and 15 years) admitted to the child neurology outpatient clinic between July 2000 and July 2002." | 5.12 | Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes. ( Aslan, A; Demir, E; Orem, A; Orhan, F; Sonmez, FM; Topbas, M; Yildirmis, S, 2006) |
| "To compare the behavioural side effects associated with two commonly used antiepilepsy drugs-phenobarbital and carbamazepine-in children in Bangladesh." | 5.12 | Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial. ( Banu, SH; Ferdousi, S; Jahan, M; Khan, NZ; Koli, UK; Neville, B, 2007) |
| "The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy." | 5.10 | Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002) |
| "To determine whether biological maturation influences the kinetics of carbamazepine-serum protein binding, the carbamazepine free fraction (%) was investigated in the serum of 66 patients, ranging from 4 to 83 years, with epilepsy or trigeminal neuralgia, treated with carbamazepine alone or carbamazepine in combination with phenytoin, phenobarbital, and/or valproic acid, over a relatively long period." | 5.09 | Age-related alteration of carbamazepine-serum protein binding in man. ( Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A, 1999) |
| "One-hundred eighty patients with partial or idiopathic generalized nonabsence epilepsy, aged 6 to 65 years, requiring initiation of treatment with carbamazepine (CBZ), valproate (VPA), phenytoin (PHT), phenobarbital (PB), or primidone (PRM) were randomly allocated to two groups according to an open, prospective parallel-group design." | 5.09 | A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy. ( Bartoli, A; Cian, P; Fattore, C; Gatti, G; Jannuzzi, G; Monaco, F; Perucca, E, 2000) |
| "We determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TGs) in 125 healthy children and in 119 children with epilepsy who had been receiving carbamazepine (58 children), phenobarbital (22 children), or valproic acid (39 children) for 7 months to 10." | 5.08 | Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy. ( Bravo, M; Castro-Gago, M; Del Río, MC; Eirís, JM; Lojo, S; Novo, I; Pavón, P, 1995) |
| "Using a randomized parallel group study design, we compared the cognit ive effects of carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) in children with epilepsy." | 5.08 | Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study. ( Chen, YJ; Kang, WM; So, WC, 1996) |
| "To determine the efficacy of pyridoxine in treating seizures, 90 infants and children with recurrent convulsions primarily due to acute infectious diseases were enrolled in the present study." | 5.08 | Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. ( Bai, AN; Cao, YM; Chui, W; Gao, DY; Ge, ZL; Jiao, FY; Li, HR; Lieu, NS; Liu, SB; Liu, ZY; Takuma, Y; Wu, S; Zhang, XK, 1997) |
| "We investigated the neuropsychological effects of carbamazepine, phenobarbital, and phenytoin in 15 partial complex epilepsy patients treated with each drug for 3 months, using a randomized double-blind, triple crossover design." | 5.06 | Comparative cognitive effects of anticonvulsants. ( Gallagher, BB; Huh, K; King, DW; Loring, DW; Meador, KJ, 1990) |
| "Progabide, an experimental GABA-ergic antiepileptic drug, was given in a placebo-controlled double-blind cross-over trial to 19 adult patients with chronic partial epilepsy refractory to previous high-dose antiepileptic drug therapy." | 5.06 | Progabide for refractory partial epilepsy: a controlled add-on trial. ( Schmidt, D; Utech, K, 1986) |
| " The study included a total of 183 pediatric epilepsy patients, aged 15 months-16 years, comprising 114 patients treated with valproic acid, 69 patients treated with phenobarbital, and 151 age-matched healthy volunteers as the control group." | 5.05 | The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital. ( Güngör, O; Özkaya, AK; Temiz, F, 2020) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 5.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| "A group of 27 patients with various types of epilepsy were selected for a 6-month double-blind crossover study to compare the anticonvulsant effect and toxicity of eterobarb and phenobarbital." | 5.04 | Eterobarb therapy in epilepsy. ( Hanahan, E; Mattson, RH; Williamson, PD, 1976) |
| "5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness." | 4.89 | A child exposed to primidone not prescribed for her. ( 't Jong, GW; Colantonio, D; Friedman, JN; Koren, G; Merlocco, A; Simpson, J; Tanoshima, R, 2013) |
| "This article reviews the current position of phenobarbital using articles published since 2000 and speculates on its likely future contribution to epilepsy care." | 4.88 | Current position of phenobarbital in epilepsy and its future. ( Brodie, MJ; Kwan, P, 2012) |
| "Long-term use of phenytoin (PHT) causes gingival hyperplasia; however, little is known about the oral side effects of other antiepileptic drugs (AEDs)." | 4.87 | The effects of antiepileptic drugs on oral health. ( Aragon, CE; Burneo, JG; Cornacchio, AL, 2011) |
| " As the result of the detailed analysis of the literature the author recommends lamotrigine, carbamazepine and oxcarbazepine as first choice antiepileptic drug for epileptic patients suffering from depressive disorder, too." | 4.84 | [Effects of antiepileptic drugs on mood of people with epilepsy]. ( Rajna, P, 2007) |
| " Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy." | 4.81 | [Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001) |
| "The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone." | 4.80 | Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998) |
| "Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM." | 4.31 | Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study. ( Bättig, L; Cserpan, D; Dünner, C; Hagmann, C; Pisani, F; Ramantani, G; Rüegger, A; Schmitt, B, 2023) |
| "To investigate caregivers' assessments of outcome in dogs with idiopathic epilepsy (IE) administered levetiracetam (LEV), zonisamide (ZNS), or phenobarbital (PB) monotherapy." | 4.31 | Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy. ( Gristina, BR; Muñana, KR; Nettifee, JA; Waldron, RJ, 2023) |
| "Phenobarbital (PB) q12h is the most common treatment recommendation for cats with recurrent epileptic seizures." | 4.31 | Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy. ( De Decker, S; Mojarradi, A; Van Meervenne, S, 2023) |
| "Ganaxolone provided better seizure control than phenobarbital in this perinatal asphyxia model and was neuroprotective for the newborn brain, affording a new therapeutic opportunity for treatment of neonatal seizures." | 4.12 | Ganaxolone versus Phenobarbital for Neonatal Seizure Management. ( Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T, 2022) |
| "Phenobarbital (PB) is the most common antiseizure drug (ASD) used for the management of feline epilepsy." | 4.12 | Evaluation of the effect of phenobarbital administration on the biochemistry profile, with a focus on serum liver values, in epileptic cats. ( Bhatti, SF; Broeckx, BJ; Charalambous, M; Cornelis, I; Eisl-Glantschnigg, U; Hermans, M; Neßler, J; Paepe, D; Pakozdy, A; Serrano, G; Van Ham, L; Van Meervenne, SA, 2022) |
| "The aim of this study was to explore the compliance of epilepsy patients in the Phenobarbital Epilepsy Management Project in a rural area of China and its influencing factors, so as to provide the basis for further strategies." | 4.02 | Researching on the compliance of epilepsy patients of the Phenobarbital Epilepsy Management Project in a rural area of China: A retrospective study. ( Feng, XL; Luo, BA; Qin, LL, 2021) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| "Kaila, Löscher, and colleagues report that phenobarbital (PHB) and midazolam (MDZ) attenuate neonatal seizures following birth asphyxia, but the former only when applied before asphyxia and the latter before or after the triggering insult." | 4.02 | Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details. ( Ben-Ari, Y; Delpire, E, 2021) |
| "This study aims to compare the neurocognitive outcome in term infants who were treated using phenobarbital (PB) and levetiracetam (LEV) monotherapy for neonatal clinical seizures." | 3.96 | Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures. ( Akbay, S; Akkaya Inal, M; Arican, P; Cavusoglu, D; Gencpinar, P; Mete Atasever, N; Olgac Dundar, N; Tekgul, H, 2020) |
| "Patients who were provided Phenobarbital as a treatment and followed-up monthly were enrolled from the Convulsive Epilepsy Control and Management Program in West China." | 3.96 | Long-term seizure, comorbidity and socioeconomic outcomes of patients with convulsive epilepsy in rural West China. ( Chen, D; Deng, Y; He, J; He, YJ; Liu, L; Zhou, D; Zhu, LN, 2020) |
| "Phenobarbital and sodium valproate are broad spectrum and inexpensive antiepileptic drugs that are used to treat convulsive epilepsy." | 3.91 | Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. ( Li, J; Li, N; Lin, W; Yang, D; Zhao, D, 2019) |
| "This article presents an additional case of concomitant topiramate and phenobarbital administration that resulted in 8 hospital admissions for hypothermia that resolved after discontinuation of phenobarbital." | 3.91 | Recurrent Admissions for Hypothermia From Concomitant Topiramate and Phenobarbital: A Case Report. ( Mutch, AM, 2019) |
| " She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital." | 3.91 | Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report. ( Hatanaka, M; Ikeda, R; Matsumoto, N; Oda, Y; Sonoda, J; Tazaki, T; Yoshikawa, N, 2019) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 3.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| "This study evaluated the relationship between blood concentration of phenobarbital (PB) and its efficacy as well as adverse events in people with epilepsy in rural China." | 3.91 | Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China. ( Ding, D; Hong, Z; Sun, W; Wang, J; Wang, T; Zhang, Q, 2019) |
| " As first-line drug phenobarbital was the most common choice, it was used in 79% of cases of acute symptomatic seizures, in 63% of structural epilepsy, in 42% of genetic epilepsies." | 3.91 | Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists. ( Capovilla, G; Consonni, D; De Liso, P; Di Capua, M; Dilena, R; Falsaperla, R; Pisani, F; Pruna, D; Suppiej, A; Vitaliti, G, 2019) |
| "The aim of this study was to evaluate changes in epileptic seizures (ES) frequency and semiology in antiepileptic-medication (AEM)-naïve dogs with idiopathic epilepsy (DIE) after initiation of imepitoin (IMP) or phenobarbital (PB) monotherapy." | 3.91 | Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy. ( Barnett, CR; De Risio, L; Stabile, F; van Dijk, J, 2019) |
| "Neonatal seizures are treated with phenobarbital and prolonged treatment does not prevent postneonatal epilepsy." | 3.88 | Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures. ( Beatty, CW; Gust, J; Hamiwka, L; Natarajan, N, 2018) |
| "To compare the effectiveness of levetiracetam vs phenobarbital for nonsyndromic infantile epilepsy." | 3.88 | Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. ( Berg, AT; Chu, CJ; Coryell, J; Gaillard, WD; Grinspan, ZM; Keator, C; Knupp, KG; Kossoff, EH; Loddenkemper, T; Millichap, J; Mytinger, JR; Novotny, EJ; Ryan, N; Shellhaas, RA; Sullivan, JE; Valencia, I; Wirrell, EC; Wusthoff, C, 2018) |
| " Clinical trials have shown that mTOR inhibitors such as everolimus reduce seizures in tuberous sclerosis complex patients with intractable epilepsy." | 3.88 | The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy. ( Beaufils, F; Brandt, C; Fabbro, D; Hillmann, P; Löscher, W; Melone, A; Noack, A; Öhler, LA; Rageot, D; Römermann, K; Sele, AM; Wymann, MP, 2018) |
| "Based on the potential role of Na-K-Cl cotransporters (NKCCs) in epileptic seizures, the loop diuretic bumetanide, which blocks the NKCC1 isoforms NKCC1 and NKCC2, has been tested as an adjunct with phenobarbital to suppress seizures." | 3.88 | Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy. ( Brandt, C; Feit, PW; Hampel, P; Kaila, K; Kalesse, M; Kipper, A; Löscher, W; Lykke, K; MacAulay, N; Paavilainen, P; Puskarjov, M; Römermann, K; Seja, P; Spoljaric, I; Toft-Bertelsen, TL; Töllner, K, 2018) |
| "We used the database from the Convulsive Epilepsy Control and Management Program in West China, which routinely provides phenobarbital (PB) as a treatment for convulsive epilepsy." | 3.85 | Terminal seizure frequency and its relation to SUDEP. ( Chen, D; Chen, T; Deng, Y; He, J; He, YJ; Liu, L; Si, Y; Zhou, D, 2017) |
| " The dog was receiving levetiracetam and phenobarbital for epilepsy, and serum concentrations of both were within standard therapeutic ranges." | 3.85 | Suspected Phenobarbital-Induced Pseudolymphoma in a Dog. ( Lampe, R; Manens, J; Sharp, N, 2017) |
| "Phenobarbital or potassium bromide (KBr) add-on treatment decreases the average monthly seizure frequency in dogs with idiopathic epilepsy resistant to a maximum dose of imepitoin." | 3.85 | Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency. ( Bhatti, SFM; Broeckx, BJG; Martlé, V; Royaux, E; Stee, K; Van Ham, L, 2017) |
| "To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis." | 3.83 | Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016) |
| "Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children." | 3.83 | The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children." | 3.83 | Association of HLA genotypes with phenobarbital hypersensitivity in children. ( Benjaponpitak, S; Inunchot, W; Kamchaisatian, W; Likkasittipan, P; Mahasirimongkol, S; Manuyakorn, W; Visudtibhan, A; Wattanapokayakit, S; Wichukchinda, N, 2016) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| "To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)." | 3.81 | Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 3.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "We report a stillborn, GA/LMP = 37 weeks, delivered by an epileptic woman, who received in the first four months of pregnancy phenobarbital (PH) 0." | 3.79 | Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy. ( Brailoiu, CG; Cernea, N; Tica, AA; Tica, OS; Tica, VI, 2013) |
| "To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [(11)C]quinidine and [(11)C]laniquidar." | 3.79 | [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness. ( de Lange, EC; Eriksson, J; Koepp, M; Labots, M; Lammertsma, AA; Potschka, H; Rongen, M; Russmann, V; Schuit, R; Seeger, N; Syvänen, S; van Kooij, R; Verbeek, J; Voskuyl, RA; Windhorst, AD; Zellinger, C, 2013) |
| "-6-180T>G) associated with resistance to phenobarbital therapy has been found in the canine MDR1/ABCB1 gene in Border Collies with idiopathic epilepsy." | 3.79 | High frequency of a single nucleotide substitution (c.-6-180T>G) of the canine MDR1/ABCB1 gene associated with phenobarbital-resistant idiopathic epilepsy in Border Collie dogs. ( Chang, HS; Kohyama, M; Kushida, K; Mizukami, K; Rahman, MM; Uddin, MM; Yabuki, A; Yamato, O, 2013) |
| "To evaluate the long-term outcome of phenobarbital treatment for convulsive epilepsy in rural China, and to explore factors associated with overall seizure outcomes." | 3.79 | Long-term outcome of phenobarbital treatment for epilepsy in rural China: a prospective cohort study. ( Dai, X; de Boer, HM; Ding, D; Hong, Z; Kwan, P; Li, S; Ma, G; Sander, JW; Wang, T; Wang, W; Wu, J; Yang, B; Yang, H; Yuan, C, 2013) |
| " We conducted a pilot study to assess the feasibility, efficacy and side-effects of VPA in the treatment of convulsive epilepsy in primary care settings in rural China as an alternative to phenobarbital." | 3.78 | Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care. ( Li, S; Ru, X; Sander, JW; Wang, W; Wu, J; Zheng, J; Zhu, S, 2012) |
| "Phenobarbital is an effective treatment for epilepsy but concerns remain over its potential neurocognitive toxicity." | 3.78 | Cognitive and mood effects of phenobarbital treatment in people with epilepsy in rural China: a prospective study. ( Bell, GS; de Boer, HM; Ding, D; Hong, Z; Kwan, P; Li, S; Lin, W; Sander, JW; Sun, J; Thompson, PJ; Wang, W; Wu, J; Wu, Q; Yu, P; Zhang, Q; Zhao, Q; Zhou, D, 2012) |
| "We investigated the effectiveness of intravenous injection of phenobarbital (PB) in patients referred to Himeji Red Cross Hospital, Hyogo, Japan, with benign convulsions with mild gastroenteritis (CwG) between November 2009 and June 2011." | 3.78 | [Intravenous injection of phenobarbital for benign convulsions with mild gastroenteritis]. ( Ban, H; Takami, Y, 2012) |
| "An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)." | 3.78 | Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012) |
| "The failure of the maximum tolerated dosage to improve seizure control in dogs with phenobarbital-resistant epilepsy argues against the suitability of verapamil add-on treatment to overcome pharmacoresistance." | 3.77 | Add-on treatment with verapamil in pharmacoresistant canine epilepsy. ( Jambroszyk, M; Potschka, H; Tipold, A, 2011) |
| "The aim of the present study was to build population pharmacokinetic models for the clearance of carbamazepine (CBZ) in two separate populations of Serbian patients with epilepsy, children and adults." | 3.77 | Factors influencing carbamazepine pharmacokinetics in children and adults: population pharmacokinetic analysis. ( Jankovic, SM; Milovanovic, JR, 2011) |
| "To report on a patient with epilepsy who developed leukopenia and thrombocytopenia during phenobarbital/lamotrigine treatment." | 3.76 | Phenobarbital/Lamotrigine coadministration-induced blood dyscrasia in a patient with epilepsy. ( Calabrò, G; De Sarro, G; Gallelli, L; Siniscalchi, A; Tolotta, GA, 2010) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| " Hyperhomocysteinemia was defined as fasting total Hcy above 12 micromol/L and/or post-methionine load concentrations above 38 micromol/L." | 3.74 | Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. ( Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE, 2008) |
| ", fasting concentrations) in dogs with epilepsy that had been treated long term (> or = 3 months) with phenobarbital or with phenobarbital and potassium bromide with concentrations in healthy control dogs." | 3.74 | Serum triglyceride concentration in dogs with epilepsy treated with phenobarbital or with phenobarbital and bromide. ( Govendir, M; Ilkin, WJ; Kluger, EK; Malik, R; Snow, D; Sullivan, DR, 2008) |
| "Twenty-two dogs with idiopathic epilepsy which were pharmacoresistant to phenobarbitone and bromide were treated with levetiracetam as an add-on medication." | 3.74 | The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs. ( Chandler, KE; Luján Feliu-Pascual, A; Matiasek, LA; Platt, SR; Volk, HA, 2008) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| " We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease." | 3.74 | Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome. ( Fukuhara, M; Kano, Y; Sakuma, K; Shiohara, T, 2008) |
| "To assess pharmacokinetics, efficacy, and tolerability of oral levetiracetam administered as an adjunct to phenobarbital treatment in cats with poorly controlled suspected idiopathic epilepsy." | 3.74 | Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy. ( Bailey, KS; Barone, G; Boothe, DM; Dewey, CW; Kortz, GD, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "To assess the influence of aging on the pharmacokinetics of phenobarbital (PB) at steady state in patients receiving long-term therapy." | 3.73 | Phenobarbital pharmacokinetics in old age: a case-matched evaluation based on therapeutic drug monitoring data. ( Battino, D; Croci, D; Mamoli, D; Messina, S; Perucca, E; Ratti, S, 2005) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| "To assess whether there is a change in seizure activity in dogs with refractory epilepsy that are receiving appropriate doses of phenobarbitone and/or potassium bromide, when gabapentin is added to the therapeutic regimen." | 3.73 | Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. ( Govendir, M; Malik, R; Perkins, M, 2005) |
| "To evaluate the efficacy of phenobarbital in treatment of patients with convulsive forms of epilepsy in rural areas and to develop a suitable relevant model for rural China." | 3.73 | [Evaluation of the efficacy of phenobarbital in treatment of epilepsy in rural areas: study of 2455 patients in rural China]. ( Dai, XY; Hong, Z; Ma, GY; Wang, TP; Wang, WZ; Wu, JZ; Yang, B; Yuan, CL; Zhao, DH, 2006) |
| "A mechanism for the alleviation of the malfunction of a mutated (gamma2(K289M)) epilepsy-linked gamma-aminobutyric acid (GABA) neurotransmitter receptor by phenobarbital is presented." | 3.73 | On the mechanism of alleviation by phenobarbital of the malfunction of an epilepsy-linked GABA(A) receptor. ( Hess, GP; Krivoshein, AV, 2006) |
| "Questionnaires were mailed to owners of 29 dogs under management for suspected or diagnosed idiopathic epilepsy through the clinics of the Small Animal Hospital of the University of Glasgow Veterinary School, using either phenobarbitone or potassium bromide alone or in combination." | 3.73 | Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide. ( Anderson, TJ; Chang, Y; Mellor, DJ, 2006) |
| "The database of a large TDM service was used to identify retrospectively steady-state serum CBZ concentrations in 157 elderly patients with epilepsy (65 years and older) treated with CBZ alone or in combination with phenobarbital (PB)." | 3.72 | Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data. ( Battino, D; Croci, D; Mamoli, D; Messina, S; Perucca, E; Rossini, A, 2003) |
| "Dizocilpine inhibits the seizure of the amygdala kindling and improve the antiepileptic activity of phenobarbital, valproate and nicardipine, indicating that these combination may provide a new approach for treating epilepsy." | 3.72 | Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats. ( Gao, GM; Yang, ZH; Yue, W; Zhao, YJ; Zhong, WZ, 2004) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 3.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "To determine whether exposure during pregnancy to anticonvulsant drugs as monotherapy, and phenobarbital in particular, is associated with an increased risk of major malformations in comparison with unexposed controls." | 3.72 | The AED (antiepileptic drug) pregnancy registry: a 6-year experience. ( Holmes, LB; Lieberman, E; Wyszynski, DF, 2004) |
| "The nootropic drug piracetam was investigated in various experimental models of epilepsy." | 3.72 | Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| " After adjustment for prior fracture, use (ever) of corticosteroids, comorbidity, social variables, and diagnosis of epilepsy, carbamazepine [CBZ; odds ratio (OR), 1." | 3.72 | Fracture risk associated with use of antiepileptic drugs. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2004) |
| "Low doses of phenobarbital were very effective against epilepsy." | 3.71 | Treatment with phenobarbital and monitoring of epileptic patients in rural Mali. ( Desplats, D; Doumbo, O; Farnarier, G; Nimaga, K, 2002) |
| "To document the population pharmacokinetics of carbamazepine in patients with epilepsy living in Singapore, the majority of whom are of Chinese origin and others of minority races." | 3.71 | Population pharmacokinetics of carbamazepine in Singapore epileptic patients. ( Chan, E; Hue, SS; Lee, HS, 2001) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| "The prescription pattern reported here is in accordance with the general guidelines for the treatment of epilepsy in Denmark, except for a surprisingly extensive use of phenobarbital." | 3.71 | Antiepileptic drug utilization: a Danish prescription database analysis. ( Friis, ML; Gaist, D; Hallas, J; Rochat, P, 2001) |
| "The effect of pretreatment with either tetanus toxin (in ventral hippocampus) or kainic acid (into dorsal hippocampus, with or without suppression of seizures by phenobarbital) on the subsequent development of epilepsy in rats injected with tetanus toxin (into ventral hippocampus) has been studied." | 3.71 | Do fits really beget fits? The effect of previous epileptic activity on the subsequent induction of the tetanus toxin model of limbic epilepsy in the rat. ( Mellanby, J; Milward, AJ, 2001) |
| "To study adverse cutaneous reactions to phenobarbital in children with epilepsy." | 3.71 | Adverse cutaneous reactions to phenobarbital in epileptic children. ( Chiemchanya, S; Soongprasit, M; Visudhiphan, P; Visudtibhan, A, 2001) |
| "This work describes a novel epilepsy model, combining pentylenetetrazole (PTZ) kindling with the senescence-accelerated mouse P8 (SAMP8) a model for aging." | 3.71 | The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism. ( Bidar, A; Kondziella, D; Sletvold, O; Sonnewald, U; Urfjell, B, 2002) |
| "The last premortem serum concentrations of phenobarbital (PB), phenytoin (PHT), carbamazepine (CBZ) and its CBZ-10,11-epoxide metabolite (CE) were compared with the corresponding postmortem serum concentrations in 16 adult patients of an epilepsy centre." | 3.70 | Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy. ( Jürgens, U; May, T; Rambeck, B; Schnabel, R, 1999) |
| "A study was undertaken to evaluate owners' perception of the effect that epilepsy and long-term phenobarbital therapy had on the quality of pet and owner lifestyle." | 3.70 | Owner perception of the care of long-term phenobarbital-treated epileptic dogs. ( Lord, LK; Podell, M, 1999) |
| "We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months." | 3.70 | Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999) |
| "Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs." | 3.70 | Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. ( Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE, 2000) |
| "To determine what effects long-term phenobarbital administration to dogs with epilepsy would have on serum biochemical factors and adrenocortical function." | 3.69 | Effects of phenobarbital administration on results of serum biochemical analyses and adrenocortical function tests in epileptic dogs. ( Chauvet, AE; Feldman, EC; Kass, PH, 1995) |
| "Bromide toxicosis was diagnosed in an 8-year-old Labrador Retriever that had been treated for epilepsy with potassium bromide, at a dosage of 29 mg/kg of body weight/d." | 3.69 | Bromide toxicosis secondary to renal insufficiency in an epileptic dog. ( Linn, K; Nichols, ES; Trepanier, LA, 1996) |
| "Bromide treatment was successful in controlling seizures in an 11-year-old Dachshund with epilepsy and presumptive phenobarbital-associated hepatopathy." | 3.69 | High dietary chloride content associated with loss of therapeutic serum bromide concentrations in an epileptic dog. ( Center, SA; Garland, S; Shaw, N; Trepanier, LA, 1996) |
| "To evaluate the population pharmacokinetics of valproic acid in children, 97 steady-state serum valproate concentration measurements were gathered during normal, routine, outpatient care of 52 children with epilepsy (1." | 3.69 | A model for estimating individualized valproate clearance values in children. ( Botha, JH; Gray, AL; Miller, R, 1995) |
| "Neurocognitive performances were evaluated in 9 children with different types of epilepsy prior to and at least 6 months after discontinuation of phenobarbital." | 3.69 | Discontinuation of phenobarbital in children: effects on neurocognitive behavior. ( Devoti, M; Riva, D, 1996) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 3.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| "Nonlinear mixed effects modeling (NONMEM) was used to estimate the effects of drug-drug interaction on valproic acid relative clearance values using 792 serum levels gathered from 400 pediatric and adult patients with epilepsy (age range, 0." | 3.69 | Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1997) |
| "A multiparametric investigation of daytime sleepiness was carried out in 10 patients with a generalized epilepsy treated by phenobarbital, 10 with a cryptogenic partial epilepsy treated by carbamazepine and 10 healthy controls." | 3.68 | Daytime sleepiness in epileptic patients on long-term monotherapy: MSLT, clinical and psychometric assessment. ( Galimberti, CA; Manni, R; Morini, R; Perucca, E; Ratti, MT; Tartara, A, 1993) |
| "We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)." | 3.68 | Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992) |
| "In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid." | 3.68 | Plasma uric acid in patients receiving anticonvulsant monotherapy. ( Heller, AJ; Johnson, AL; Marshall, WJ; Reynolds, EH; Ring, HA, 1991) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three." | 3.68 | Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy. ( Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA, 1990) |
| "Chromosome studies were carried out on the peripheral blood of 26 epilepsy patients treated with phenobarbital and/or diphenylhydantoin, on ten healthy controls and on eight untreated epileptic controls." | 3.67 | Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin. ( Ambani, LM; Kulkarni, PS; Mondkar, VP; Sonawalla, AB, 1984) |
| "The potential of phenobarbital to interact with DNA has been studied using the sister chromatid exchange (SCE) assay in peripheral lymphocytes of nine adult male patients with epilepsy and of their matched controls." | 3.67 | Genotoxicity evaluation in patients on phenobarbital monotherapy by sister chromatid exchange. ( Pederson, M; Schaumann, BA; Winge, VB, 1989) |
| " The administration of daily phenobarbital did not reduce the frequency of epilepsy, in spite of a significant reduction in the incidence of recurrent febrile seizures." | 3.67 | Epilepsy and mental retardation following febrile seizures in childhood. ( Forsythe, A; Wolf, SM, 1989) |
| "The purpose of the follow-up study was to determine whether modern therapy with ethosuximide and/or valproate with/without phenobarbitone and its derivatives improves the longterm prognosis of absence epilepsy as compared to formerly used treatments." | 3.67 | Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset. ( Baier, WK; Dieterich, E; Doose, H; Fichsel, H; Tuxhorn, I, 1985) |
| "Steady-state serum concentrations of phenytoin and phenobarbital were obtained in 70 epileptic patients in Taiwan and evaluated with respect to age, sex, and body weight." | 3.67 | Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan. ( Lai, ML, 1985) |
| "The efficacy of phenobarbital and primidone against canine epilepsy was compared in a controlled study." | 3.67 | Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison. ( Frey, HH; Löscher, W; Schwartz-Porsche, D, 1985) |
| "A total of 20 children with various types of epilepsy were treated with valproate, 11 with monotherapy and 9 with valproate in combination with phenobarbitone, phenytoin, or carbamazepine." | 3.66 | Plasma concentrations of valproate during maintenance therapy in epileptic children. ( Boréus, LO; Lundberg, B; Nergårdh, A, 1982) |
| "The penetration of phenobarbital (PB) into cerebral tissue was determined in cats rendered epileptic by parenteral penicillin and in cats with focal penicillin-induced epilepsy." | 3.66 | The penetration of phenobarbital in generalized and focal penicillin-induced epileptic brain of the cat. ( Frassetto, M; Monaco, F; Mutani, R; Piredda, S; Russo, A; Sechi, GP; Zoroddu, GF, 1983) |
| "Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered." | 3.66 | Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports. ( Arena, R; Bindi, A; Bonuccelli, U; De Scisciolo, G; Marcacci, G; Rossi, L, 1983) |
| "Phenobarbitone (PB) and primidone (PRM) plasma concentrations were measured in 88 patients of both sexes with different types of epilepsy and treated with PRM, alone or in association with carbamazepine (CBZ), phenytoin (PHT), ethosuximide (ESM) or valproic acid (VPA)." | 3.66 | PB:PRM ratio in patients with epilepsy treated with primidone. ( Altamura, AC; Bianchi, M; Canger, R; Cornaggia, CM; Polana, P; Pruneri, C, 1983) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Clinical and experimental studies were performed on the mechanisms of metabolic acidosis observed in the children with epilepsy who had long been treated with anticonvulsants such as phenobarbital (PB) or diphenylhydantoin (DPH)." | 3.66 | [Studies on the mechanism of metabolic acidosis observed in the children treated with anticonvulsants]. ( Nagai, B, 1982) |
| "Cataracts developed in two young adults who were receiving prolonged antiepileptic treatment with phenobarbital sodium and phenytoin sodium." | 3.66 | Presenile cataracts in phenytoin-treated epileptic patients. ( Bar, S; Feller, N; Savir, H, 1983) |
| " In severely jaundiced patients (serum bilirubin concentrations greater than 140 mumol/l) a markedly decreased or absent uptake of 99mTc-EHIDA was observed." | 3.66 | The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans. ( Coenegracht, JM; Oei, TL; van Breda Vriesman, PJ, 1983) |
| "Fifteen dogs with idiopathic epilepsy were included in a 9-month clinical trial to determine the therapeutic serum concentrations of primidone and its active metabolites, phenobarbital and phenylethylmalonamide." | 3.66 | Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs. ( Cunningham, JG; Haidukewych, D; Jensen, HA, 1983) |
| "IgA, IgG and IgM concentrations were determined in sera and nasal washings from 20 patients with epilepsy on single-drug treatment with carbamazepine, in 20 patients on single-drug treatment with phenobarbital and in 26 healthy subjects." | 3.66 | Respiratory disease in patients with epilepsy on single-drug therapy with carbamazepine or phenobarbital. ( Aarli, JA; Gilhus, NE; Strandjord, RE, 1982) |
| "Two epileptic children treated with phenobarbital and suffering from tinea capitis, not responding to a long lasting treatment with Griseofulvin, healed only after phenobarbital has been discontinued." | 3.66 | [Treatment of tinea microsporum. Metabolic interference between phenobarbital and griseofulvin]. ( Beurey, J; Vignaud, JM; Weber, M, 1982) |
| " Those seizures had been wrongly attributed to a primary epilepsy of a neurologic origin and a treatment with Phenobarbital had been instituted." | 3.66 | [Amicrobic pustulosis hypoparathyroidism epilepsy: treatment by 25-hydroxycholecalciferol]. ( Barthelme, D; Beurey, J; Chaulieu, Y; Vignaud, JM; Weber, M, 1980) |
| "A pharmacokinetic study of phenobarbital labeled with stable (nonradioactive) isotopes [1,3-15N, 2-13C] was conducted in patients undergoing chronic drug treatment for epilepsy." | 3.66 | Stable isotope methodology and gas chromatography mass spectrometry in a pharmacokinetic study of phenobarbital. ( Kapetanović, IM; Kupferberg, HJ, 1980) |
| "Phenobarbital and carbamazepine concentrations were determined by the EMIT technique in tears, saliva, cerebrospinal fluid (CSF), and plasma of patients with epilepsy." | 3.66 | Tears as the best practical indicator of the unbound fraction of an anticonvulsant drug. ( Mastropaolo, C; Monaco, F; Mutani, R; Tondi, M, 1979) |
| "Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities." | 3.66 | Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978) |
| "A new anti-epileptic agent (barbexaclone) was tried in 48 patients suffering from epilepsy and presenting a total of 67 types of crises." | 3.65 | [Clinical trial with a new anti-epileptic: barbexaclone]. ( Bragatti, JH; Caleffi, GH; Prenna, FJ, 1977) |
| ", raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself." | 3.65 | Anticonvulsants and parental epilepsy in the development of birth defects. ( Hartz, SC; Heinonen, OP; Mitchell, AA; Monson, RR; Rosenberg, L; Shapiro, S; Siskind, V; Slone, D, 1976) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Plasma anticonvulsant levels were followed during pregnancy in 11 epileptic women taking phenytoin and/or phenobarbital or a drug metabolized in the body to phenobarbital." | 3.65 | Plasma anticonvulsant concentrations during pregnancy. ( Eadie, MJ; Edwards, VE; Lander, CM; Tyrer, JH, 1977) |
| "Cerebrospinal fluid (CSF) concentrations of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and probenecid were examined in 14 children with epilepsy (ages 6 months to 17 years) and 17 controls (ages 14 months to 16 years)." | 3.65 | Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy. ( Bowers, MB; Cohen, DJ; Shaywitz, BA, 1975) |
| "The influence of clonazepam on steady-state serum levels of diphenylhydantoin, phenobarbital and carbamazepine was studied in 22 patients with epilepsy receiving one or two of these drugs." | 3.65 | Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine. ( Johannessen, SI; Munthe-Kaas, AW; Strandjord, RE, 1977) |
| "Severe osteomalacia was present in two epileptic patients who were under long-term treatment with congeners of phenytoin, phenobarbital, and acetazolamide." | 3.65 | Acetazolamide-accelerated anticonvulsant osteomalacia. ( Mallette, LE, 1977) |
| "The influence of phenobarbital on bile composition was studied in 13 patients with epilepsy, treated with the drug in doses ranging from 0." | 3.65 | Influence of phenobarbital on bile composition in epileptic patients. ( Capron, JP; Dairou, R; Dumont, M; Erlinger, S, 1975) |
| "Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy." | 3.65 | Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974) |
| " Phenobarbital is usually given as well to prevent grand mal seizures." | 3.64 | Treatment of epilepsy. ( BAILEY, AA, 1963) |
| "Neonatal seizures are one of the most challenging problems for experts across the globe." | 3.11 | Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial. ( Deshmukh, L; Joshi, A; Londhe, A; Susnerwala, S, 2022) |
| "The long-term administration of phenobarbitone in neonates may be associated with adverse neurological outcome." | 3.01 | Effect of early withdrawal of phenobarbitone on the recurrence of neonatal seizures: An open-label randomized controlled trial. ( Angurana, SK; Jindal, A; Kumar, P; Sundaram, V; Suthar, R, 2021) |
| "Oral phenobarbital (PO-PB) was administered for weeks 1-14 (median starting dosage of 3." | 2.90 | Prospective crossover clinical trial comparing transdermal with oral phenobarbital administration in epileptic cats. ( Barnes Heller, HL; Mei, C; Robertson, M; Trepanier, LA, 2019) |
| "The aims of the study were to develop a population pharmacokinetic model of orally administered brivaracetam in paediatric patients and to provide dosing suggestions." | 2.84 | Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years. ( Schoemaker, R; Stockis, A; Wade, JR, 2017) |
| "Carbamazepine and phenytoin were the drugs most strongly associated with decreases in T4 and T3 levels while topiramate had the greatest elevating effect on TSH." | 2.82 | Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. ( Cai, M; Guo, X; Han, Y; Lin, W; Yang, J; Zhong, R, 2022) |
| "Seizures are the main neurological emergency during the neonatal period and are mostly acute and focal." | 2.82 | Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options. ( Bedetti, L; Berardi, A; Casa Muttini, ED; Cavalleri, F; Ferrari, F; Guidotti, I; Lugli, L; Ori, L; Pugliese, M; Roversi, MF; Stefanelli, F, 2022) |
| "Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy." | 2.82 | Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022) |
| "Five phenobarbital treated dogs were classified as true responders (≥50% reduction in seizures/month) whereas none of the levetiracetam treated dogs fulfilled this criterion." | 2.82 | A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy. ( Berendt, M; Fredsø, N; Møller, A; Sabers, A; Toft, N, 2016) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 2.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "In phenobarbital-treated dogs, significantly increased levels of alkaline phosphatase, gamma-glutamyl-transferase and other liver enzymes occurred, while no such effect was observed in the imepitoin group." | 2.80 | Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs. ( de Vries, F; Keefe, TJ; Löscher, W; Rundfeldt, C; Tipold, A, 2015) |
| "The demographic, seizure details and outcome measures were recorded." | 2.79 | The effect of phenobarbitone on cognition in adult patients with new onset epilepsy: a multi-centric prospective study from India. ( Dutta, A; Jayalakhsmi, S; Mukaddam, Q; Naik, M; Rao, SL; Ravat, S; Satischandra, P; Senapathy, A; Shah, U; Shunmukhi, MS; Sinha, S; Subbakrishna, DK, 2014) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| "Odds for epilepsy were higher among people who had positive family history (O." | 2.69 | A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. ( Chopra, JS; Kaur, P; Sawhney, IM; Singh, A; Suri, G, 1999) |
| " The median elimination half-life (t1/2) in patients receiving concomitant valproate (VPA) was 43." | 2.68 | Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. ( Boreus, L; Eriksson, AS; Hoppu, K; Nergårdh, A, 1996) |
| " When PB in the dosage of 30-60 mg/d was used in combination with PHT the above mentioned changes were not observed." | 2.68 | Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs. ( Gupta, HL; Mukhopadhyay, S; Panjwani, U; sel Vamurthy, W; Singh, SH; Thakur, L, 1996) |
| "Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use." | 2.68 | Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996) |
| "Mephobarbital was reported by parents to cause less severe problems than phenobarbital in subjects who had taken both barbiturate anticonvulsants." | 2.68 | Barbiturate anticonvulsants: a neuropsychological and quantitative electroencephalographic study. ( An, A; Black, FW; Borges, A; Nelson, A; Rice, J; Willis, J, 1997) |
| " Thus PB-N-G formation contributed significantly to the elimination of PB during long-term administration of the drug, and there was reason to suspect that some of the PB-N-G formed may have already been degraded to untraced products before excretion from the body." | 2.67 | Urinary excretion of phenobarbitone and its metabolites in chronically treated patients. ( Bernus, I; Dickinson, RG; Eadie, MJ; Hooper, WD, 1994) |
| "Both carbamazepine and phenytoin were associated with significantly lower incidences of intolerable side effects than were primidone or phenobarbital." | 2.66 | Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone. ( Collins, JF; Craft, B; Cramer, JA; Mattson, RH; Novelly, RA; Smith, DB, 1987) |
| "Decreased libido and impotence were more common in patients given primidone." | 2.66 | Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. ( Browne, TR; Collins, JF; Cramer, JA; Delgado-Escueta, AV; Mattson, RH; McCutchen, CB; McNamara, JO; Smith, DB; Treiman, DM; Williamson, PD, 1985) |
| " Absolute bioavailability of IM PB was 101 +/- 11%." | 2.65 | Kinetics of phenobarbital in normal subjects and epileptic patients. ( Comfort, CP; Friel, PN; Kaluzny, SP; Levy, RH; Wilensky, AJ, 1982) |
| "Ambulant patients with recently diagnosed generalised or psychomotor seizure disorders or both were randomly assigned to two dosage regimens of phenytoin." | 2.64 | Phenytoin dosage in ambulant epileptic patients. ( Alberts, M; Terrence, C, 1978) |
| " The data indicate that the dosage regimen described is suitable for patients on oral phenytoin who have to be transferred to im drug for short periods." | 2.64 | Oral and intramuscular phenytoin. ( Ramsay, RE; Wilder, BJ, 1976) |
| "Any type of seizure can be observed in Alzheimer's disease (AD)." | 2.58 | Treatment of epilepsy for people with Alzheimer's disease. ( Liu, J; Wang, LN; Wang, YP; Wu, LY, 2018) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| " The content includes dose-related adverse effects, idiosyncratic reactions, behavioural and psychiatric comorbidities, chronic problems, enzyme induction and teratogenesis." | 2.55 | Tolerability and Safety of Commonly Used Antiepileptic Drugs in Adolescents and Adults: A Clinician's Overview. ( Brodie, MJ, 2017) |
| "Any type of seizure can be observed in Alzheimer's disease (AD)." | 2.53 | Treatment of epilepsy for people with Alzheimer's disease. ( Liu, J; Wang, LN; Wang, YP; Wu, LY, 2016) |
| "Some excess risk of liver cancer was also found in cohort studies of patients hospitalized for epilepsy in Sweden and Taiwan, in the absence, however, of association with any specific drugs." | 2.50 | A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer. ( La Vecchia, C; Negri, E, 2014) |
| "Current therapeutic options to treat neonatal seizures (i." | 2.49 | Treatment of neonatal seizures. ( de Vries, LS; Hellström-Westas, L; van Rooij, LG, 2013) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Phenobarbital has been in use for a century." | 2.49 | Phenobarbitone in modern India. ( Gursahani, R, 2013) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Idiopathic epilepsy is the most common brain disease in dogs and also occurs in cats." | 2.46 | Idiopathic epilepsy in dogs and cats. ( Thomas, WB, 2010) |
| " Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients." | 2.44 | Therapeutic monitoring of antiepileptic drugs for epilepsy. ( Dahl, ML; Kimland, E; Tomson, T, 2007) |
| "Epilepsy is a major public health problem in developing countries." | 2.44 | [Management of epilepsy in developing countries]. ( Ngoungou, EB; Preux, PM; Quet, F; Tran, DS, 2007) |
| "Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome." | 2.43 | Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005) |
| "The prevalence of epilepsy is high in many areas of Africa." | 2.43 | Epilepsy and mortality in Africa: a review of the literature. ( Diop, AG; Hauser, WA; Hesdorffer, DC; Logroscino, G, 2005) |
| "If primidone treatment is discontinued too quickly, withdrawal seizures may appear, some of which may be severe." | 2.42 | [Antiepileptic primidone shortly to be withdrawn from sale: change medication now]. ( Carpay, JA; de Haan, GJ; van Donselaar, CA, 2003) |
| "Febrile seizures are most common seizures in childhood (2-4%)." | 2.42 | [Febrile seizures--an update]. ( Püst, B, 2004) |
| " However, on rare occasions, they can progress to more severe cutaneous disorders, including Stevens-Johnson syndrome and toxic epidermal necrolysis." | 2.41 | Therapeutic safety monitoring: what to look for and when to look for it. ( Harden, CL, 2000) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Idiopathic epilepsy is one of the most common and treatable neurologic diseases of small animals." | 2.40 | Idiopathic epilepsy. ( Knowles, K, 1998) |
| "Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment." | 2.40 | Antiepileptic drug therapy. ( Podell, M, 1998) |
| "Plasma concentrations of lamotrigine, an antiepileptic drug obtained in three adult controlled clinical trials conducted in the United States were pooled and analyzed using NONMEM, a population pharmacokinetic computer program, to facilitate development of dosing guidelines." | 2.40 | Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. ( Chen, C; Cox, E; Fiedler-Kelly, J; Grasela, TH; Risner, ME; Womble, GP, 1999) |
| " Because dosing is often modest, cost should rarely be the overriding factor in choosing a drug for a patient with newly diagnosed epilepsy in the developed world." | 2.40 | Monostars: an aid to choosing an antiepileptic drug as monotherapy. ( Brodie, MJ, 1999) |
| "Epilepsy is one of the most common neurological disorders." | 2.39 | Newer antiepileptic drugs. Towards an improved risk-benefit ratio. ( Patsalos, PN; Sander, JW, 1994) |
| "With the introduction of three new anti-epileptic drugs (AEDs) in the UK during the past 4 years as adjunctive add-on therapy, the possibility of AED pharmacokinetic interactions has become a relevant consideration." | 2.39 | Phenobarbitone to gabapentin: a guide to 82 years of anti-epileptic drug pharmacokinetic interactions. ( Patsalos, PN, 1994) |
| "Once epilepsy is diagnosed, long-term treatment with AEDs is recommended, beginning with monotherapy." | 2.39 | Standard approach to antiepileptic drug treatment in the United States. ( Pellock, JM, 1994) |
| " Particular attention has been paid to the role of age in determining the variability of pharmacokinetic parameters, but the effect of other factors, such as different formulations and routes of administration, concomitant treatments, gender and pathological conditions other than epilepsy, have also been considered." | 2.39 | Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide. ( Avanzini, G; Battino, D; Estienne, M, 1995) |
| " Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures." | 2.39 | Adverse effects of established and new antiepileptic drugs: an attempted comparison. ( Gram, L; Rogvi-Hansen, B, 1995) |
| " A drug concentration, however, can only be regarded as a guide around which to alter the dosage according to the patient's clinical condition." | 2.39 | Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring. ( Yukawa, E, 1996) |
| "The case of a two-year-old girl with generalized histiocytosis, probably induced by phenobarbital, is reported." | 2.38 | A case of hypersensitivity syndrome resembling Langerhans cell histiocytosis during phenobarbital prophylaxis for convulsion. ( Kawamura, N; Mino, M; Miyake, M; Motoyama, T; Nagata, T; Oguni, T; Yamasiro, K; Yoden, A; Yoshikawa, K, 1992) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| " However, their chronic use may be associated with serious sedative-hypnotic effects that interfere with cognitive function and behavior." | 2.37 | Use of barbiturates and benzodiazepines in treatment of epilepsy. ( Vining, EP, 1986) |
| "Febrile seizures are a common occurrence in early childhood and most children who experience them do well." | 2.36 | The natural history of febrile seizures. ( Hirtz, DG; Nelson, KB, 1983) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Valproic acid has become a regular component of antiepileptic therapy." | 2.36 | [Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978) |
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "97%), switching to or adjusting carbamazepine dosage (27." | 1.91 | The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study. ( Aricò, M; Di Noia, SP; Kalolo, A; Mabusi, MS; Mastrangelo, M; Pisani, F, 2023) |
| "Phenobarbital was the primary initial antiseizure medication for both groups (90%), and both groups had similarly high rates of incomplete response to initial antiseizure medication administration (66% vs 68%, P = ." | 1.72 | Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study. ( Abend, NS; Bonifacio, S; Chang, T; Chu, C; Cilio, MR; Glass, HC; Lemmon, ME; Massey, SL; McCulloch, CE; Shellhaas, RA; Soul, JS; Thomas, C; Wusthoff, CJ; Xiao, R, 2022) |
| "High neonatal seizure burden is associated with worsened neurodevelopmental outcomes." | 1.72 | Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures. ( Knox, A; Limjoco, J; Rajamanickam, V; Verwoerd, C, 2022) |
| "Sixty-seven dogs (13." | 1.72 | Approach to initial management of canine generalised epileptic seizures in primary-care veterinary practices in the United Kingdom. ( Garosi, L; Green, M; Lowrie, M; McConnell, K; Singleton, D, 2022) |
| "Planned pregnancy was the only independent factor significantly associated with decreased risk of adverse pregnancy outcomes (OR, 0." | 1.72 | Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China. ( Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J, 2022) |
| "Male accounted for 51." | 1.72 | Electroencephalographic Findings, Antiepileptic Drugs and Risk Factors of 433 Individuals Referred to a Tertiary Care Hospital in Ethiopia. ( Amare, A; Ayele, BA; Belay, HD; Gebrewold, MA; Gelan, YD; Gugssa, SA; Hagos, T; Kifelew, S; Mengesha, AT; Moges, A; Negash, HA; Oda, DM; Tsehayneh, F; Yifru, YM; Zewde, YZ, 2022) |
| "Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs." | 1.72 | Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022) |
| "The study objective was to investigate the prevalence and clinical characteristics of phenobarbitone-associated adverse effects in epileptic cats." | 1.62 | Prevalence and clinical characteristics of phenobarbitone-associated adverse effects in epileptic cats. ( Corsini, G; De Risio, L; Gutierrez-Quintana, R; Marsh, O; Van Dijk, J, 2021) |
| "Epilepsy was induced by pilocarpine, which was shown to produce long-lasting increases in NKCC1 in the hippocampus, whereas MEST did not alter NKCC1 mRNA in this region." | 1.62 | Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice. ( Gailus, B; Gericke, B; Hampel, P; Johne, M; Kaczmarek, E; Löscher, W; Römermann, K, 2021) |
| "Phenobarbital was available in only 26 (14." | 1.62 | Using community health workers as an alternative approach for epidemiological research on epilepsy in six health districts in Mali. ( Coulibaly, SY; Coulibaly, YI; Daou, M; Diallo, H; Dolo, H; Doumbia, S; Konipo, FDN; Maiga, YM; Sangare, M, 2021) |
| "Phenobarbital was used as a first line antiepileptic drug (AED)." | 1.62 | Benign juvenile idiopathic epilepsy in captive Iberian lynx (Lynx pardinus) in the ex situ conservation program (2005-2019). ( Asensio, V; El Bouyafrouri, Y; Fernández, J; Godoy, JA; Lorenzo, V; Mínguez, JJ; Perez-Aspa, MJ; Rivas, A; Serra, R, 2021) |
| " Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range." | 1.62 | Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021) |
| "Nodding syndrome is a highly debilitating, generalized seizure disorder, affecting children in subregions of sub-Saharan Africa." | 1.56 | Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo. ( Colebunders, R; Delahaye, L; Hotterbeekx, A; Idro, R; Mandro, M; Ogwang, R; Stove, CP; Velghe, S, 2020) |
| "Phenobarbital has been the most frequently prescribed drugs and thirteen percent of patients were in the escalation phase of treatment." | 1.56 | The treatment outcomes of epilepsy and its root causes in children attending at the University of Gondar teaching hospital: A retrospective cohort study, 2018. ( Ayalew, AF; Beyene, A; Birhan, T; Mulat, G; Simachew Kassa, A, 2020) |
| "Lacosamide is a novel anticonvulsant that acts by enhancing sodium channel slow inactivation." | 1.56 | Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range. ( Araki, Y; Fukushima, Y; Imai, K; Kagawa, Y; Takahashi, Y; Terada, K; Yamamoto, Y, 2020) |
| "Status epilepticus is defined as a state of unrelenting seizure activity." | 1.51 | Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus. ( Akerman, CJ; Burman, RJ; Calin, A; Codadu, NK; Katz, AA; Lee, JH; Newey, SE; Parrish, RR; Raimondo, JV; Selfe, JS; Trevelyan, AJ; van den Berg, M; Wilmshurst, JM; Wright, R, 2019) |
| "Phenobarbital was the antiepileptic drug most commonly prescribed in 76." | 1.51 | Clinical presentation of epilepsy in six villages in an onchocerciasis endemic area in Mahenge, Tanzania. ( Bhwana, D; Colebunders, R; Dekker, MC; Kakorozya, A; Makunde, WH; Matuja, W; Mmbando, BP; Mnacho, M; Weckhuysen, S, 2019) |
| "Determination of phenobarbital (PB) dosing during continuous haemodiafiltration (CHDF) requires evaluation of both the patient's own clearance and CHDF clearance." | 1.51 | Successful treatment of seizure disorder by evaluating phenobarbital clearance in a paediatric patient undergoing continuous haemodiafiltration. ( Ishii, I; Suzuki, T; Takatsuka, H; Yamazaki, S, 2019) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "Anamnestic data included a generalised seizure disorder and phenobarbital treatment started one month before presentation." | 1.48 | Pseudolymphoma in a cat on phenobarbital treatment. ( Lieser, J; Schwedes, CS, 2018) |
| "Epilepsy is a serious neurological disease affecting about 1% of people worldwide (65 million)." | 1.48 | Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model. ( Kondrat-Wróbel, MW; Łuszczki, JJ, 2018) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| "Psychiatric disorders are more common in patients with epilepsy than in the general population." | 1.48 | Psychiatric comedication in patients with epilepsy. ( Bosak, M; Cyranka, K; Dudek, D; Kowalik, M; Mołek, P; Słowik, A, 2018) |
| " A population pharmacokinetic approach and nonlinear mixed effects modeling were used to analyze the data." | 1.48 | Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide. ( Muñana, KR; Nettifee, JA; Otamendi, AJ; Papich, MG, 2018) |
| " Additionally, in this case the interaction was managed with concentration-guided dosing of apixaban, suggesting this approach may represent a feasible strategy for managing patients requiring treatment with direct-acting oral anticoagulants and enzyme-inducing antiepileptic drugs." | 1.48 | Managing Direct Oral Anticoagulants in Patients With Antiepileptic Medication. ( Dagan, G; Hochberg-Klein, S; Kalish, Y; Muszkat, M; Perlman, A, 2018) |
| "Perinatal arterial stroke is the most frequent form of cerebral infarction in children." | 1.46 | Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. ( Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G, 2017) |
| "Treatment with phenobarbital and potassium bromide completely terminated the seizures within 10days." | 1.43 | Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide. ( Itakura, A; Maegaki, Y; Nishimura, Y; Ohno, K; Okazaki, T; Saito, Y; Sejima, H; Yamamoto, T, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "The aim of this study was to compare ataxia levels in dogs with IE treated chronically with phenobarbitone or imepitoin, the two currently available first-line AED treatments." | 1.43 | Comparing the effects of first-line antiepileptic drugs on the gait of dogs with idiopathic epilepsy. ( Packer, RM; Suiter, EJ; Volk, HA, 2016) |
| " The dosage of PB was ranked first followed by that of CBZ and finally by the VPA." | 1.43 | [Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience]. ( Badrane, N; Bencheikh, RS; Moussa, LA; Ouammi, L; Serragui, S; Tanani, DS; Zalagh, F, 2016) |
| "The present study aimed to establish population pharmacokinetic model for phenobarbital (PB), examining and quantifying the magnitude of PB interactions with other antiepileptic drugs concomitantly used and to demonstrate its use for individualization of PB dosing regimen in adult epileptic patients." | 1.42 | Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients. ( Golubović, B; Jovanović, M; Kovačević, SV; Martinović, Ž; Miljković, B; Prostran, M; Vučićević, K, 2015) |
| "Drug-resistant epilepsy is believed to be multifactorial involving both genetic and non-genetic factors." | 1.42 | Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy. ( Chinvarun, Y; Keangpraphun, T; Kijsanayotin, P; Towanabut, S, 2015) |
| "Inflammatory conditions and specifically acute pancreatitis are of major concern in these animals." | 1.42 | Canine Pancreas-Specific Lipase and C-reactive Protein in Dogs Treated With Anticonvulsants (Phenobarbital and Potassium Bromide). ( Albarracín, V; Meléndez-Lazo, A; Pastor, J; Rodón, J; Teles, M, 2015) |
| " This type of protocol can be used to further evaluate AEDs and test effects of chronic administration of AEDs." | 1.40 | Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats. ( Inoue, M; Kaneko, Y; Naito, H; Noda, A; Yamamoto, A, 2014) |
| " Available data suggests that phenobarbital is as effective as other first-line drugs for treating tonic-clonic seizures, but side effect reports differ widely between high and low-income settings." | 1.40 | Medication side effects among people with epilepsy taking phenobarbital in Zambia. ( Birbeck, GL; Bui, E; Elafros, MA, 2014) |
| "Hyperammonemia was defined as a plasma ammonia level exceeding 100 μg/dl with reference to the standard range and previous reports." | 1.39 | Risk factors for hyperammonemia in pediatric patients with epilepsy. ( Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R, 2013) |
| "A device capable of detecting seizures and alerting caregivers would be a major advance for epilepsy management, and could be used to guide early intervention and prevent seizure-related injuries." | 1.39 | Feasibility study of a caregiver seizure alert system in canine epilepsy. ( Cloyd, JC; Coles, LD; Higgins, J; Leyde, K; Litt, B; Mavoori, J; Michael, B; Patterson, EE; Sheffield, WD; Vite, C; Worrell, GA, 2013) |
| "Barbexaclone is a salt compound of phenobarbital and propylhexedrine (a drug with indirect sympathomimetic properties)." | 1.39 | End of the barbexaclone era: an experience of treatment withdrawal. ( Bolukbasi, F; Bulus, E; Delil, S; Karaagac, N; Senturk, A; Yeni, N, 2013) |
| "Phenobarbital was assayed using the ONLINE TDM Roche/Hitachi automated clinical chemistry analyzer." | 1.38 | Urine phenobarbital drug screening: potential use for compliance assessment in neonates. ( Chen, S; Guillet, R; Kwon, JM; McDermott, MP, 2012) |
| "Phenobarbital treatment resulted in eradication of seizures (17/20 [85%]) significantly more often than did bromide (12/23 [52%]); phenobarbital treatment also resulted in a greater percentage decrease in seizure duration (88 ± 34%), compared with bromide (49 ± 75%)." | 1.38 | Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs. ( Boothe, DM; Carpenter, DM; Dewey, C, 2012) |
| " Moreover, a VPA dose-response curve was performed on PBMC obtained from healthy controls, demonstrating an increase of acetyl-histone H3 content." | 1.38 | Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients. ( Conti, E; Difrancesco, JC; Ferrarese, C; Galimberti, G; Riva, C; Rodriguez-Menendez, V; Ruffmann, C; Tremolizzo, L, 2012) |
| "Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912." | 1.38 | How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012) |
| "Stroke is the major cause of acquired epilepsy in the adult population." | 1.37 | An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. ( Delorenzo, RJ; Deshpande, LS; Ziobro, JM, 2011) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 1.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Phenobarbital levels were higher in symptomatic infants than asymptomatic infants, although the difference was not statistically significant." | 1.37 | Infants born to mothers under phenobarbital treatment: correlation between serum levels and clinical features of neonates. ( Antichi, E; Cardiello, V; Carducci, C; Catenazzi, P; D'Antuono, A; Piras, A; Pozzoli, G; Romagnoli, C; Scorrano, A; Zuppa, AA, 2011) |
| "Epilepsy was confirmed in 58 cases." | 1.37 | [Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011) |
| " To demonstrate a case of a 15 year old girl suffering from refractory epilepsy with underlying focal cortical dysplasia (FCD), whose seizure deterioration was most probably associated with drug-drug interactions between prescribed common antiepileptic drugs, namely valproic acid, phenobarbital or the prodrug primidon and carbamazepine." | 1.37 | Antiepleptic drug interactions: a clinical case demonstration. ( Klapková, E; Komárek, V; Tesfaye, H; Tesfayeová, A, 2011) |
| " Nine patients received 20 mg/kg; the maximum total dosage administered was 80 mg/kg with a concentration of 283 micromol/L." | 1.36 | Rescue therapy with high-dose oral phenobarbitone loading for refractory status epilepticus. ( Ackermann, S; Blockman, M; Karlsson, MO; van der Walt, JS; Wilmshurst, JM, 2010) |
| "The aim of the present study was to build population pharmacokinetic models for the clearance of valproate (VPA) in 2 separate populations of Serbian patients with epilepsy, children and adults." | 1.36 | Factors influencing valproate pharmacokinetics in children and adults. ( Jankovic, S; Jankovic, SM; Milovanovic, JR, 2010) |
| " Outcome did not depend on duration of barbiturate therapy, dosage or serum concentration, co-medication, reduction rate, degree of intellectual disability, or epilepsy syndrome." | 1.35 | Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability. ( Bocchicchio, M; Hauser, I; Horstmann, V; Huber, B; Jokeit, G; May, T; Meinert, T; Robertson, E; Schorlemmer, H; Schulz, L; Seidel, M; Wagner, W, 2009) |
| "Epilepsy is the most common neurological disorder in both dogs and humans." | 1.35 | Positive impact of omega-3 fatty acid supplementation in a dog with drug-resistant epilepsy: a case study. ( Arida, RM; Cavalheiro, EA; Cysneiros, RM; Ribeiro, MO; Scorza, CA; Scorza, FA; Terra, VC, 2009) |
| " Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel and non-parallel dose-response effects was used to characterize the consequent anticonvulsant interactions between the various drug combinations." | 1.35 | Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. ( Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E, 2009) |
| " The pharmacokinetics of the 260 PB concentrations at a steady-state obtained from 79 patients was described with a one-compartment open pharmacokinetic model with first-order elimination." | 1.34 | Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. ( Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N, 2007) |
| " Carbamazepine (CBZ) and phenobarbital (PHB) during pregnancy should be used at the lowest dosage compatible with maternal disease." | 1.34 | Unilateral multicystic dysplastic kidney in infants exposed to antiepileptic drugs during pregnancy. ( Carta, M; Cimador, M; Corsello, G; De Grazia, E; Di Pace, MR; Giuffrè, M; Sergio, M, 2007) |
| "In phenobarbital-treated patients, serum levels in 73% of the patients were in therapeutic range of 10-40 microg/ml, and about 44% of phenytoin-treated patients had serum levels in therapeutic range of 10-20 microg/ml." | 1.34 | Evaluation of therapeutic drug level monitoring of phenobarbital, phenytoin and carbamazepine in Iranian epileptic patients. ( Babaei, A; Eslamai, MH, 2007) |
| "Treatment with phenobarbital or phenytoin caused a reduction in seizure frequency, but did not improve EEG background or prevent death." | 1.34 | The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. ( Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH, 2007) |
| "Phenobarbital was defined as being of correct quality if the active substance average content corresponded to +/-15% of the indicated amount." | 1.34 | Availability and costs of antiepileptic drugs and quality of phenobarbital in Vientiane municipality, Lao PDR. ( Angerth, T; Gaulier, JM; Ly, S; Mac, TL; Odermatt, P; Phongsamouth, V; Preux, PM; Ratsimbazafy, V; Simmala, C; Strobel, M, 2007) |
| "In this comparative, cross-sectional study, we evaluated 55 patients with epilepsy on chronic use of antiepileptic drugs (AED); [(38 females and 17 males, 35 +/- 6 years (25 to 47)] and compared to 24 healthy subjects (17 females/7 males)." | 1.34 | Bone density and bone turnover markers in patients with epilepsy on chronic antiepileptic drug therapy. ( Bilezikian, JP; Boguszewski, CL; Borba, VZ; Kulak, CA; Paola, Ld; Seibel, MJ; Silvado, CE, 2007) |
| "Epilepsy is a major public-health problem in Africa." | 1.33 | Quality of phenobarbital solid-dosage forms in the urban community of Nouakchott (Mauritania). ( Gaulier, JM; Laroche, ML; Merle, L; Preux, PM; Traore, H; Viana, M, 2005) |
| "Clinical pharmacologists, neurologists, internists, and all health care givers must consider the efficacy, safety, and side effect profile of a given antiepileptic drug (AED) when determining which drug is best for a given patient." | 1.32 | Clinical pharmacology of topiramate versus lamotrigine versus phenobarbital: comparison of efficacy and side effects using odds ratios. ( Claycamp, HG; Lathers, CM; Schraeder, PL, 2003) |
| "The average annual cost of outpatient treatment of epilepsy was found to be 47 US dollars per patient." | 1.32 | Cost of epilepsy in patients attending a secondary-level hospital in India. ( Kapoor, SK; Krishnan, A; Sahariah, SU, 2004) |
| "Quinolinic acid (QA) has been used as a model for experimental overstimulation of the glutamatergic system." | 1.32 | Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004) |
| "In phenobarbital-treated dogs with high serum total AP activity in the cross-sectional study, the increase was due predominantly to increased activities of the corticosteroid-induced (C-AP) and liver (L-AP) isoenzymes." | 1.32 | Serum alkaline phosphatase isoenzyme profiles in phenobarbital-treated epileptic dogs. ( Cribb, AE; Gaskill, CL; Hoffmann, WE, 2004) |
| "The purpose of this study was to investigate the relationship of changes in the enzyme-inducing anticonvulsant daily dosage (drug score) to variations in urinary D-glucaric acid excretion and gamma-glutamyltransferase and beta-glucuronidase serum activities." | 1.31 | Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment. ( Fernández, MP; Hermida, J; Tutor, JC, 2002) |
| " The objectives were: education for the patient, family, and village leaders in orders to achieve good compliance, uninterrupted supply of generic phenobarbitol, follow-up visits once a month for one year then every two months if good compliance with a country physician with delivery of phenobarbitol in sufficient quantity to reach the next visit, verification of correct drug dosage and use, supervision of treatment effect." | 1.31 | [Treatment of epilepsy in rural areas in Mali]. ( Desplats, D; Doumbo, O; Farnarier, G; Nimaga, K, 2002) |
| "To establish a dosing regimen for potassium bromide and evaluate use of bromide to treat spontaneous seizures in cats." | 1.31 | Disposition and clinical use of bromide in cats. ( Boothe, DM; Couch, P; George, KL, 2002) |
| "Five patients had had several febrile seizures prior to the onset of prefebrile seizures." | 1.31 | [Apparently unprovoked seizures precipitated by prefebrile condition]. ( Hattori, H; Kato, T; Minamiura, Y; Murakami, M; Nakajima, T, 2000) |
| " In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months." | 1.31 | Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000) |
| "Carnitine is an nonproteic nitrogenated compound acid present in all mammalian tissue and its principal activity is the long-chain fatty acid transport across the mitochondrial membrane for beta-oxidation." | 1.31 | [Antiepileptic drugs and carnitine]. ( Artuch, R; Campistol, J; Chávez, B; Vilaseca, MA, 2000) |
| "To determine whether there are therapeutically relevant changes in serum phenobarbital concentrations throughout a daily dosing interval in epileptic dogs receiving phenobarbital for > or = 3 weeks." | 1.31 | Effect of timing of blood collection on serum phenobarbital concentrations in dogs with epilepsy. ( Levitski, RE; Trepanier, LA, 2000) |
| " To avoid complex pharmacokinetic interactions among multiple antiepileptic drugs, the data on serum concentrations in the current study were collected from patients who were co-administered only one additional antiepileptic drug (phenobarbital-carbamazepine, phenobarbital-valproic acid, or carbamazepine-valproic acid) or who received monotherapy." | 1.31 | Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios. ( Aoyama, T; Higuchi, S; Hokazono, T; Ohdo, S; Satou, M; Yukawa, E, 2000) |
| "Epilepsy is the most common serious neurological disorder and is one of the world's most prevalent noncommunicable diseases." | 1.31 | The treatment of epilepsy in developing countries: where do we go from here? ( Lhatoo, SD; Sander, JW; Scott, RA, 2001) |
| "Stroke is the major cause of acquired epilepsy." | 1.31 | Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy". ( DeLorenzo, RJ; Sombati, S; Sun, DA, 2001) |
| "Prodromal phase and aura were present in the majority of the dogs with generalised seizures." | 1.30 | Clinical, epidemiological and treatment results of idiopathic epilepsy in 54 labrador retrievers: a long-term study. ( Faissler, D; Heynold, Y; Jaggy, A; Steffen, F, 1997) |
| "Invasive or complex treatments for epilepsy with partial and generalized tonic-clonic seizures should not be used until at least two AEDs have failed to control seizures." | 1.30 | If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug? ( Camfield, CS; Camfield, PR; Dooley, JM; Gordon, K, 1997) |
| "Epilepsy is a relatively common problem in children, adults and the elderly." | 1.30 | Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998) |
| " Patients received phenobarbitone as monotherapy or in combination with either of the antiepileptic drugs carbamazepine or valproic acid." | 1.30 | Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1998) |
| " Similarly, there was a reduction in maximal plasma concentration, bioavailability (F), mean residence time, and time to target and peak concentrations in the postphenobarbital p." | 1.30 | Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog. ( Podell, M; Sams, RA; Wagner, SO, 1998) |
| " When phenobarbital is used in combination with bromide, a reasonable therapeutic range for serum phenobarbital concentrations is 9 to 36 micrograms/ml, although in some dogs treated with bromide, phenobarbital can eventually be discontinued." | 1.30 | Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996). ( Carrillo, J; Schwark, WS; Trepanier, LA; Van Schoick, A, 1998) |
| " PB was also the most toxic drug, followed by CBZ and by PHT." | 1.30 | Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat. ( Alós, M; Barcia, JA; Belda, V; Rubio, P; Serralta, A, 1999) |
| "This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat." | 1.30 | Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. ( D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR, 1999) |
| "Simple febrile seizures that occur in children ages 6 months to 5 years are common events with few adverse outcomes." | 1.30 | Technical report: treatment of the child with simple febrile seizures. ( Baumann, RJ, 1999) |
| "In 1993, 27% of patients were being treated for epilepsy and in 1995/6, 30." | 1.30 | The management of epilepsy in a hospital for people with a learning disability. ( Carvill, S; Cassidy, G; Clarke, D, 1999) |
| "Bromide treatment was not associated with any significant change in these serum thyroid hormone concentrations." | 1.30 | Serum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin concentrations in epileptic dogs treated with anticonvulsants. ( Kantrowitz, LB; Melián, C; Nichols, R; Peterson, ME; Trepanier, LA, 1999) |
| " Valproate, when the proper therapeutic dosage was belatedly realized, was seen as a superior treatment for generalized and partial epilepsies." | 1.30 | Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. ( Loiseau, PJ, 1999) |
| "Phenobarbital monotherapy was given to 20 patients with idiopathic generalized epilepsy beginning in childhood but persisting into adulthood." | 1.30 | Phenobarbital still has a role in epilepsy treatment. ( Lerman, P; Lerman-Sagie, T, 1999) |
| "We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy, developed Dupuytren's and Ledderhose's diseases." | 1.30 | [Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report]. ( Coral, P; Correa Neto, Y; Nóvak, EM; Teive, HA; Werneck, LC; Zanatta, A, 1999) |
| " Individual optimal drug dosage can be calculated for each patient at little cost to the pet owner." | 1.30 | Drug choice and therapeutic drug monitoring in the management of canine primary epilepsy. ( Taylor, JH; Vaughan-Scott, T, 1999) |
| "The medication regimens used to treat epilepsy are further complicated by the fact that most seizure medications are metabolized in the liver and have the potential for serious pharmacokinetic drug-drug interactions with many other medications." | 1.29 | Practical considerations in anticonvulsant therapy--Part 2. ( Cloyd, J; Garnett, WR; Holmes, GL; Meyer, MC; Schiffer, JR, 1995) |
| "Phenobarbital analysis was performed in vertex hair of patients by gas chromatography mass spectrometry (GC/MS)." | 1.29 | Phenobarbital in hair and drug monitoring. ( Bouige, D; Goullé, JP; Jouen, F; Layet, A; Noyon, J; Pignier, Y; Rapoport, NF; Vaschalde, Y, 1995) |
| "Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures." | 1.29 | Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. ( Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS, 1996) |
| "Treatment with carbamazepine raised serum total cholesterol levels, C-HDL, phospholipid and A-I apoprotein in all groups, low density lipoproteins in females and B apoprotein males." | 1.29 | [The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population]. ( Braga Hernández, S; Crespo Hernández, M; de Juan Frigola, J, 1996) |
| " Routine clinical pharmacokinetic data (N = 1,010) collected from 466 patients receiving carbamazepine were analyzed according to a simple steady-state pharmacokinetic model with the use of NONMEM, a computer program designed for population pharmacokinetic analysis that allows pooling of data." | 1.29 | Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data. ( Aoyama, T; Yukawa, E, 1996) |
| " This study compares the pharmacokinetics of CBZ-CO against CBZ-CR in patients with epilepsies chronically treated with CBZ in monotherapy or CBZ-PB in bitherapy, the effect of PB on CBZ-CO and CBZ-CR pharmacokinetic parameters, and the effect of the two formulations of CBZ on PB pharmacokinetic parameters." | 1.29 | Steady state pharmacokinetics of carbamazepine-phenobarbital interaction in patients with epilepsy. ( Barra, Y; Bonneton, J; Genton, P; Iliadis, A; Mesdjian, E; Sennoune, S, 1996) |
| "The duration of the vegetative state was 12 days, 15 days or about 4 months until death and was associated with corresponding stages of generalized ischemic brain damage." | 1.29 | Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death. ( Jürgens, U; Lahl, R; May, T; Rambeck, B; Schnabel, R, 1996) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| "Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable." | 1.28 | Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992) |
| " Regular 2 weekly follow up for a minimum period of 2 months was done, after altering the drug dosage and bringing plasma level(s) within therapeutic range." | 1.28 | "An analysis of epileptic patients nonresponsive to drugs". ( Joshi, MV; Karande, SC; Kshirsagar, NA; Shah, PU, 1992) |
| " There was no calcitonin correlation with the anticonvulsant dosage or with the total doses ingested." | 1.28 | Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin. ( Arias, JA; Cabranes, JA; Rico, H; Varela de Seijas, E, 1992) |
| "The incidence of Dupuytren's disease amongst the residents of two epileptic centres was found to be 12." | 1.28 | Dupuytren's and epilepsy revisited. ( Allen, J; Arafa, M; Noble, J; Royle, SG; Trail, IA, 1992) |
| "Loreclezole was also shown to inhibit 'low Ca2+' and 'low Mg2+' epileptogenesis at similar concentrations to those active on inhibition." | 1.28 | In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus. ( Ashton, D; Willems, R, 1992) |
| " Prevalence of adverse effects was 12% and 4% in these two groups, respectively." | 1.28 | [Evaluation of the prevalence of side effects of phenobarbital in patients in the Champagne-Ardenne region]. ( Delasnerie-Lauprêtre, N; Turpin, JC, 1991) |
| " Serum concentrations differed even with the same dosage among individual dogs." | 1.28 | [Effectiveness of bromide in therapy resistant epilepsy of dogs]. ( Jürgens, U; Schwartz-Porsche, D, 1991) |
| "007) and a significantly shorter plasma half-life (mean values +/- SD = 4." | 1.28 | Effect of phenobarbital on the pharmacokinetics of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine. ( Fazio, A; Martines, C; Pisani, F; Spina, E; Tomson, T; Trio, R, 1991) |
| "The grave course of epilepsy is associated with a decrease of the LCBF on the side of the focus." | 1.28 | [Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy]. ( Shestakov, VV; Shutov, AA, 1990) |
| "1% seizure control rate), with adverse effects of sedation and intellectual depression." | 1.28 | Plasma level distribution, effect and toxicity of antiepileptic drugs among Ethiopian epileptics. ( Abebe, Y; Bekele, G; T'Haimanot, R, 1990) |
| "When phenytoin was given with carbamazepine percentage (mean +/- SEM) protein binding was 87." | 1.28 | Serum protein binding of antiepileptic drugs in Sri Lankans. ( Joice, PD; Karunanayake, EH; Meijer, JW; Meinardi, H; Peiris, JB, 1990) |
| " On investigating the dose response curve for tumour promotion one finds that hepatocellular carcinomas only appear at a high dosage of phenobarbital and it seems likely that the human exposure to inducers in food, and in therapy with anticonvulsants, is in the dosage range well below that which causes promotion of liver cancer." | 1.28 | Nutrition and enzyme inducers in liver tumor promotion in human and rat. ( Driver, H; McDanell, R; McLean, EM, 1990) |
| "There was a greater risk of recurrence among girls." | 1.28 | [Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989) |
| " These results support the increased use of dosing aids for PHT that may help clinicians more accurately choose PHT doses and estimate time to steady state." | 1.28 | Dosing accuracy of antiepileptic drug regimens as determined by serum concentrations in outpatient epilepsy clinic patients. ( Privitera, MD, 1989) |
| "The excess numbers of brain cancer were concentrated within 10 years of hospitalization (RR = 20." | 1.28 | Cancer among epileptic patients exposed to anticonvulsant drugs. ( Boice, JD; Fraumeni, JF; Jensen, JP; Olsen, JH, 1989) |
| "The syndrome is characterized by a clinical ictal triad of nocturnal seizures, tonic deviation of the eyes, and vomiting." | 1.28 | Benign nocturnal childhood occipital epilepsy: a new syndrome with nocturnal seizures, tonic deviation of the eyes, and vomiting. ( Panayiotopoulos, CP, 1989) |
| " We found a noticeable relationship between conduction velocity slowing and daily dosage for CBZ only." | 1.27 | Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study. ( Faedda, MT; Geraldini, C; Sideri, G, 1984) |
| " Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable." | 1.27 | Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983) |
| "Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety." | 1.27 | Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent." | 1.27 | Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy. ( Iivanainen, M; Savolainen, H, 1983) |
| " Significant positive correlations were found between the dosage of CBZ, DPH, PMD and PB and both indices of enzyme induction." | 1.27 | A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. ( Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF, 1984) |
| " Fluctuations in the blood phenobarbital content from one administration to another is important for selecting its optimal dosage and the interval between intakes." | 1.27 | [Concentration of phenobarbital in biological fluids during the treatment of epilepsy patients]. ( Antadze, ZI; Okudzhava, VM; Vetrogon, FG, 1984) |
| " Serum concentrations of phenobarbital were measured in all dogs before and after primidone therapy was initiated, to ensure that the primidone dosage achieved comparable or higher values when derived from primidone." | 1.27 | Efficacy of primidone in dogs with seizures unresponsive to phenobarbital. ( Farnbach, GC, 1984) |
| " Fifty-one percent of the 53 patients receiving phenytoin were completely controlled at either below or above the 10 to 20 micrograms/ml range, suggesting that individual dosage adjustment is preferably based on clinical judgment rather than numerical limits of published therapeutic ranges." | 1.27 | Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type. ( Haenel, F; Schmidt, D, 1984) |
| "Oxazepam was more than 93% bound to serum proteins, but the extent of binding was not significantly different between the two groups." | 1.27 | Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone. ( Hawksworth, GM; Khir, AS; Petrie, JC; Scott, AK; Steele, WH, 1983) |
| "Most patients have quiescent seizure disorders and can manage well on monotherapy." | 1.27 | Reduction of polypharmacy for epilepsy in an institution for the retarded. ( Bennett, HS; Dunlop, T; Ziring, P, 1983) |
| " Serum carbamazepine levels were measured before, during, and, in most cases, after the toxic episodes." | 1.27 | Carbamazepine--erythromycin interaction leading to carbamazepine toxicity in four epileptic children. ( Cate, JC; Hedrick, R; Lamb, WA; Morin, R; Williams, F, 1983) |
| "The critical vomiting is always sudden, projectile, and lasts a short period." | 1.27 | [Vomiting: symptom of an epileptic seizure]. ( Aguglia, U; De Carvalho, GV; Farnarier, G; Tinuper, P, 1983) |
| "Percentage of recurrences in phenobarbital treated cases (4 +/- 0,6 mg/Kg/d) was 18,67%, versus 55,89% in untreated children (p less than 0." | 1.27 | [Efficacy and failure of phenobarbital in the prevention of febrile convulsions. Importance of familial antecedents]. ( Blanco, A; Cilleruelo, ML; Palencia, R; Tresierra, F, 1983) |
| " Further, for dogs given phenobarbital, there was a sixfold variation between dosage and achieved serum concentration, whereas dogs given primidone manifested even greater variability between dosage and serum concentration." | 1.27 | Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy. ( Farnbach, GC, 1984) |
| "In a study with 113 Asian children in which phenobarbitone was used as the sole antiepileptic drug in 75 children, including Chinese, Malays, and Indians, the mean phenobarbitone dosage required to produce a plasma level of 15 micrograms/ml was 5." | 1.27 | Variability of plasma phenobarbitone concentration in Asian children in Singapore. ( Lee, HS, 1984) |
| " After the first week of life, drug eliminating mechanisms mature and drug dosage requirements often increase dramatically." | 1.27 | Antiepileptic drug utilization in pediatric patients. ( Dodson, WE, 1984) |
| "Carbamazepine was the most effective to block SEA at concentrations of 1-15 microM." | 1.27 | Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. ( Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y, 1985) |
| "Phenytoin was associated with the most frequent and highest enzyme elevations in both adult and pediatric patients." | 1.27 | Serum 5'-nucleotidase in patients receiving anti-epileptic drugs. ( Fortman, CS; Witte, DL, 1985) |
| "Carbamazepine, in contrast, has rather a stimulatory action." | 1.27 | [Modification of psychophysical performance of the human by anticonvulsants]. ( Meyer, FP; Walther, H, 1987) |
| "In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted." | 1.27 | [Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987) |
| "A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported." | 1.27 | Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity. ( Carde, P; Droz, JP; Flamant, F; Friedman, S; Ghosn, M; Hayat, M; Leclerq, B, 1988) |
| "Seizures were classified as subtle, multifocal clonic, generalized tonic, focal clonic, and myoclonic." | 1.27 | Seizures in the neonatal intensive care unit of the 1980s. Types, Etiologies, Timing. ( Calciolari, G; Perlman, JM; Volpe, JJ, 1988) |
| " Thus, frequent phenytoin serum concentration determinations or a change in phenytoin dosing rate are probably not necessary after adding phenobarbital." | 1.27 | Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics. ( Browne, TR; Evans, BA; Evans, J; Greenblatt, DJ; Mikati, MA; Szabo, GK, 1988) |
| "Behavior problems, such as withdrawal symptoms, were observed in neonates who eliminated PMD with short half-lives, while other infants with longer PMD half-lives or slower elimination because of nursing showed no such symptoms." | 1.27 | Primidone and phenobarbital during lactation period in epileptic women: total and free drug serum levels in the nursed infants and their effects on neonatal behavior. ( Helge, H; Koch, S; Kuhnz, W; Nau, H, 1988) |
| " The most common of these causes include malpractice of the dosage build-up in the absence of the clinical effect, polytherapy--not infrequently with drugs of the same chemical group, and insufficient attention to the potentiating drug interaction." | 1.27 | [Phenomenon of "paradoxical poisoning" during antiepileptic therapy]. ( Geladze, TSh, 1986) |
| " Data were excluded for patients who required dosage adjustments because of toxicity or seizures." | 1.27 | Effect of influenza vaccine on serum anticonvulsant concentrations. ( Fidone, GS; Jann, MW, 1986) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Fifty-nine patients with chronic generalized tonic-clonic or partial seizures refractory to the maximally tolerated daily dosage of single-drug therapy with carbamazepine, phenytoin, phenobarbital, or primidone subsequently received single-drug therapy with another one of these primary anticonvulsant drugs." | 1.27 | Alternative single anticonvulsant drug therapy for refractory epilepsy. ( Richter, K; Schmidt, D, 1986) |
| "Phenobarbital pretreatment depressed heart rate, blood pressure and postganglionic cardiac sympathetic neural discharge." | 1.27 | Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat. ( Carnel, SB; Lathers, CM; Schraeder, PL, 1985) |
| "A Consensus Development Conference on Febrile Seizures was held at the National Institutes of Health in USA in May 1980." | 1.26 | ["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis]. ( Helwig, H; Staudt, F, 1982) |
| "A high proportion of toxic and carcinogenic effects of chemicals develop through the pathway of lethal synthesis." | 1.26 | The influence of nutrition and inducers on mechanisms of toxicity in humans and animals. ( McLean, AE; Tame, D; Witts, DJ, 1980) |
| "The prevalence of treated epilepsy in Wellington is 4." | 1.26 | Prescribing patterns for epilepsy. ( Johnson, RH; Lambie, DG; Stanaway, L, 1981) |
| " The drug was absorbed and excreted rapidly; the mean half-life was 9." | 1.26 | Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures. ( Dreifuss, FE; Kupferberg, HJ; Penry, JK; Redenbaugh, JE; Sato, S, 1980) |
| "0% at discharge) versus polytherapy; degree of correspondence between recommended and observed dosage regimens (undertreatment being a more common problem than excessive dosing); and reporting of side effects." | 1.26 | Quality of care of epilepsy in Italy: multi-hospital survey of diagnosis and treatment of 1104 epileptic patients. ( Beghi, E; Sasanelli, F; Spagnoli, A; Tognoni, G, 1982) |
| "Carbamazepine was given to 152 patients who were receiving multiple drug therapy for uncontrolled seizures." | 1.26 | Role of carbamazepine in reducing polypharmacy in epilepsy. ( Maheshwari, MC; Padmini, R, 1981) |
| "They conclude that epilepsy has a presentation rate of 9,6% in patients with previous febrile seizures, having the highest risk when they show previous familial seizures, neonatal pathology and altered EEG after the first febrile convulsion." | 1.26 | [Epilepsy after febrile seizures. Predisposing factors and role of phenobarbital in its prophylaxis (author's transl)]. ( Díez, JM; Palencia Luances, R; Sánchez-Villares, S; Tresierra, F, 1981) |
| "Febrile convulsions occur in 3." | 1.26 | Febrile convulsions. ( Curry, HB, 1980) |
| " The authors draw attention to the fact that there was a concomitant improvement in the behaviour of some patients and a diminution of maintainence dosage in relation to a previously published trial." | 1.26 | [Re-evaluation of barbexaclone in 20 epileptic patients]. ( de Lima, JM; Fernandes, I; Oliveira, C, 1978) |
| "Phenytoin dosage was increased to study the effect on the frequency of seizures and the serum concentrations of phenytoin and phenobarbitone." | 1.26 | Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy. ( Johnson, RH; Lambie, DG; Nanda, RN; Shakir, RA, 1976) |
| "The phenytoin plasma levels were measured in 45 epileptic patients whose only treatment was phenytoin." | 1.26 | In vivo interaction of anticonvulsant drugs. The mathematical correlation of plasma levels of anticonvulsant drugs in epileptic patients. ( Abarbanel, J; Eylath, U; Herishanu, Y; Rosenberg, P, 1978) |
| "Carbamazepine has recently been introduced for the treatment of generalized tonic-clonic and partial seizures." | 1.26 | Recent advances in drug therapy for epilepsy. ( Bruni, J, 1979) |
| "Phenobarbital is know to be a stimulator of the drug metabolizing enzyme system in the liver." | 1.26 | [The effect of primidone treatment of thyroid hormones in epileptic children and adolescents (author's transl)]. ( Fichsel, H; Knöpfle, G, 1977) |
| "Phenobarbital was the major metabolite detected, and it reached peak levels in 6 to 12 hours." | 1.26 | Metabolism of dimethoxymethyl phenobarbital (eterobarb) in patients with epilepsy. ( Cho, AK; Gal, J; Goldberg, MA; Jenden, DJ, 1979) |
| " The plasma level/dosage ratio has been found to have a highly significant correlation with the age of the patient both for dosage in mg/kg and in mg/m2." | 1.26 | Correlation between age and plasma level/dosage ratio for phenobarbital in infants and children. ( Nino, LM; Principi, N; Rossi, LN, 1979) |
| " The majority of the patients receiving Comital-L tablets showed low serum levels of phenytoin and high serum levels of phenobarbital, while patients treated with the usual daily dosage of Hydantol-F tablets showed adequate therapeutic serum levels of both phenytoin and phenobarbital." | 1.26 | Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F. ( Hattori, M; Kazamatsuri, H, 1979) |
| "The effect of dosage schedules on plasma drug levels was evaluated in two groups of ambulant epileptic patients, whose treatment with diphenylhydantoin (DPH) or phenobarbital (PB) had been simplified by reducing the daily frequency of the dosage regimens." | 1.26 | Effectiveness of simplified dosage schedules on the management of ambulant epileptic patients. ( Galli, A; Zaccara, G, 1979) |
| "The risk of another febrile convulsion is approximately 30%." | 1.26 | Continuous phenobarbital treatment after a 'simple febril convulsion'. ( Pollack, MA, 1978) |
| " Mean saliva phenytoin concentrations did not differ significantly between the two treatment settings and were low largely because of the low mean dosage prescribed." | 1.26 | Compliance with anticonvulsant therapy in a hospital clinic and in the community. ( Dollery, CT; Mucklow, JC, 1978) |
| " Monitoring plasma concentrations may lead to adaptations of the choice of the drug and of the dosage regimen." | 1.26 | Kinetics of drug interactions in the treatment of epilepsy. ( Guelen, P; Knop, H; Schobten, F; van der Kleijn, E; Vree, T; Westenberg, H, 1978) |
| "The present study investigated order and temporal spacing interactions of phenytoin and phenobarbital in terms of plasma levels during multiple dosing in monkeys." | 1.26 | Interactions of phenytoin and phenobarbital in terms of order and temporal spacing of administration in monkeys. ( Farquhar, JS; Levy, RH; Lockard, JS; Uhlir, V, 1976) |
| "Of 290 children with an initial febrile convulsion, 216 met Livingston's criteria for a "simple" febrile convulsion and 74 for "epilepsy triggered by fever." | 1.26 | Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever". ( Wolf, SM, 1977) |
| " 4 In individual patients, within the limits of dosage studied, the relation between plasma phenobarbitone level and drug dose was not rectilinear if phenobarbitone itself was taken, but was rectilinear if methylphenobarbitone was taken." | 1.26 | Factors influencing plasma phenobarbitone levels in epileptic patients. ( Eadie, MJ; Hooper, WD; Lander, CM; Tyrer, JH, 1977) |
| " The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone." | 1.26 | Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. ( Critchley, EM; Hayward, HW; Owen, VM; Vakil, SD, 1976) |
| " Subtherapeutic levels appear to be due to inadequate dosage adjustment." | 1.26 | The necessity of drug level monitoring in anticonvulsant drug therapy. ( Bailey, DG; Davis, HL; Johnson, GE; Wilson, TW, 1976) |
| " The relation changed with age, the dosage requirement (on a day weight basis) tending to fall as patients grew older." | 1.26 | The effects of phenobarbitone dose on plasma phenobarbitone levels in epileptic patients. ( Eadie, MJ; Hooper, WD; Lander, CM; Tyrer, JH, 1976) |
| "Positive serum tests for infectious mononucleosis (IM) unaccompanied by the clinical syndrome or blood changes characteristic of the disease were detected in 39/177 (22%) mentally subnormal patients investigated with three different commercially available IM slide tests." | 1.25 | False positive infectious mononucleosis serology in epilepsy. ( Davidson, RJ; Edmond, E; Hamilton, PJ, 1975) |
| " (3) Use of well-standardized, yet simplified, mental performance tests in combination with changes in the dosage of medication can help in reaching a compromise between acceptable seizure control and avoidance of excessive slowing of mental activity." | 1.25 | Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy. ( Dekaban, AS; Lehman, EJ, 1975) |
| "Recurrent acute respiratory failure in an epileptic subject is described." | 1.25 | Respiratory failure as a seizure phenomenon. A case report. ( Malatinský, J; Procházka, M; Sámel, M, 1975) |
| "Phenobarbital: --Is a "safe" anticonvulsant: steady serum level during 24 hours periods in chronic treatment and rather stable relationship between ingested dose and serum level." | 1.25 | [Serum phenobarbital levels in epileptics]. ( Brachet, A; Henry, P; Loiseau, P, 1975) |
| " Hypocalcaemia was related to high dosage of anticonvulsant drugs, to multiple drug therapy, and to the use of individual anticonvulsant drugs in the following order, with decreasing order of importance: pheneturide, primidone, phenytoin, phenobarbitone." | 1.25 | Disturbance of calcium metabolism by anticonvulsant drugs. ( Richens, A; Rowe, DJ, 1970) |
| "Although sneezing is a particularly common symptom, there are surprisingly few references to this subject in the medical literature." | 1.24 | PAROXYSMAL SNEEZING. ( KOFMAN, O, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 922 (60.54) | 18.7374 |
| 1990's | 213 (13.99) | 18.2507 |
| 2000's | 165 (10.83) | 29.6817 |
| 2010's | 160 (10.51) | 24.3611 |
| 2020's | 63 (4.14) | 2.80 |
| Authors | Studies |
|---|---|
| Conley, JD | 1 |
| Kohn, H | 1 |
| Flaherty, PT | 1 |
| Greenwood, TD | 1 |
| Manheim, AL | 1 |
| Wolfe, JF | 1 |
| Alam, O | 1 |
| Mullick, P | 1 |
| Verma, SP | 1 |
| Gilani, SJ | 1 |
| Khan, SA | 1 |
| Siddiqui, N | 1 |
| Ahsan, W | 1 |
| Dawidowski, M | 2 |
| Herold, F | 1 |
| Chodkowski, A | 1 |
| Kleps, J | 1 |
| Szulczyk, P | 1 |
| Wilczek, M | 1 |
| Chońska, J | 1 |
| Mika, W | 1 |
| Turło, J | 1 |
| Kumari, S | 1 |
| Mishra, CB | 1 |
| Tiwari, M | 1 |
| Feng, XL | 1 |
| Luo, BA | 1 |
| Qin, LL | 1 |
| Massey, SL | 1 |
| Glass, HC | 1 |
| Shellhaas, RA | 3 |
| Bonifacio, S | 1 |
| Chang, T | 1 |
| Chu, C | 1 |
| Cilio, MR | 1 |
| Lemmon, ME | 1 |
| McCulloch, CE | 1 |
| Soul, JS | 1 |
| Thomas, C | 1 |
| Wusthoff, CJ | 1 |
| Xiao, R | 2 |
| Abend, NS | 1 |
| Verwoerd, C | 1 |
| Limjoco, J | 1 |
| Rajamanickam, V | 1 |
| Knox, A | 1 |
| Shawahna, R | 1 |
| Zaid, L | 1 |
| Han, Y | 1 |
| Yang, J | 2 |
| Zhong, R | 1 |
| Guo, X | 1 |
| Cai, M | 1 |
| Lin, W | 5 |
| Susnerwala, S | 1 |
| Joshi, A | 1 |
| Deshmukh, L | 1 |
| Londhe, A | 1 |
| Thomas, SV | 3 |
| Jeemon, P | 1 |
| Jose, M | 1 |
| Amrithum, LM | 1 |
| Bhaskar, D | 1 |
| Nair, MKC | 1 |
| George, B | 1 |
| Guidotti, I | 1 |
| Lugli, L | 1 |
| Ori, L | 1 |
| Roversi, MF | 1 |
| Casa Muttini, ED | 1 |
| Bedetti, L | 1 |
| Pugliese, M | 1 |
| Cavalleri, F | 1 |
| Stefanelli, F | 1 |
| Ferrari, F | 1 |
| Berardi, A | 1 |
| Green, M | 1 |
| Lowrie, M | 1 |
| Singleton, D | 1 |
| Garosi, L | 1 |
| McConnell, K | 1 |
| Miller, SL | 1 |
| Bennet, L | 1 |
| Sutherland, AE | 1 |
| Pham, Y | 1 |
| McDonald, C | 1 |
| Castillo-Melendez, M | 1 |
| Allison, BJ | 1 |
| Mihelakis, J | 1 |
| Nitsos, I | 1 |
| Boyd, BJ | 1 |
| Hirst, JJ | 1 |
| Walker, DW | 1 |
| Hunt, RW | 1 |
| Jenkin, G | 1 |
| Wong, F | 1 |
| Malhotra, A | 1 |
| Fahey, MC | 1 |
| Yawno, T | 1 |
| Shi, X | 1 |
| Wang, Y | 1 |
| Zhang, Y | 3 |
| Song, C | 1 |
| Jiang, Y | 1 |
| Zhao, J | 1 |
| Xia, L | 1 |
| Ma, L | 1 |
| Jiang, W | 1 |
| Tomson, T | 7 |
| Battino, D | 8 |
| Bromley, R | 1 |
| Kochen, S | 1 |
| Meador, KJ | 2 |
| Pennell, PB | 1 |
| Martin, M | 1 |
| Karenberg, A | 1 |
| Fangerau, H | 1 |
| Soto-Insuga, V | 1 |
| González-Alguacil, E | 1 |
| García-Peñas, JJ | 1 |
| Borowicz-Reutt, K | 2 |
| Banach, M | 3 |
| Ayele, BA | 1 |
| Belay, HD | 1 |
| Oda, DM | 1 |
| Gelan, YD | 1 |
| Negash, HA | 1 |
| Kifelew, S | 1 |
| Gebrewold, MA | 2 |
| Hagos, T | 1 |
| Zewde, YZ | 1 |
| Yifru, YM | 2 |
| Tsehayneh, F | 1 |
| Amare, A | 1 |
| Moges, A | 1 |
| Gugssa, SA | 1 |
| Mengesha, AT | 1 |
| Omefe, PN | 1 |
| N Adeboye, MA | 1 |
| Biliaminu, SA | 1 |
| Ojuawo, A | 1 |
| Bättig, L | 3 |
| Dünner, C | 3 |
| Cserpan, D | 3 |
| Rüegger, A | 3 |
| Hagmann, C | 3 |
| Schmitt, B | 3 |
| Pisani, F | 10 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Investigation of Levetiracetam in Alzheimer's Disease (ILiAD): a Proof of Concept Study[NCT03489044] | Phase 2 | 30 participants (Anticipated) | Interventional | 2018-10-28 | Active, not recruiting | ||
| Phase 2a Levetiracetam Trial for AD-Associated Network Hyperexcitability[NCT02002819] | Phase 2 | 34 participants (Actual) | Interventional | 2014-10-16 | Completed | ||
| Big Data Construction and Biological Etiological Epidemiology Study of Children Epilepsy in China[NCT02969213] | 10,000 participants (Anticipated) | Observational | 2016-11-30 | Not yet recruiting | |||
| Phase 1 Study for Measuring the Effect of Antiepileptic Drugs on Mitochondrial Activity[NCT01218321] | 60 participants (Actual) | Observational | 2011-01-31 | Completed | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| [NCT00381537] | 92 participants | Interventional | Completed | ||||
| A Prospective Study on Long-term Outcome and Potential Usefulness fo an Intervention Aimed at Reducing Adverse Effects in Patients With Refractory Epilepsy[NCT03939507] | 1,000 participants (Actual) | Interventional | 2006-11-06 | Completed | |||
| An MRI Ancillary Study of a Malaria Fever Randomized Controlled Trial (RCT)[NCT05746819] | 256 participants (Anticipated) | Observational | 2021-01-02 | Enrolling by invitation | |||
| The Diagnosis and Management of Patients With Epilepsy: Nationwide, Multicenter Study of Recordings for the Diagnosis and Management of Patients With Epilepsy and Treatment With Levetiracetam in Daily Clinical Practice in Greece[NCT02356731] | 450 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| An Open Prospective Randomised Long-Term Effectiveness Study, Comparing Best Medical Practice With or Without Adjunctive VNS Therapy in Patients 16 Years and Older With Pharmaco-resistant Partial Epilepsy[NCT00522418] | Phase 4 | 122 participants (Actual) | Interventional | 2006-02-28 | Terminated (stopped due to Insufficient enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) - The ADAS-cog rating instrument (Rosen et al. 1984) will be used to evaluate the global cognitive functioning. The ADAS-cog is a 70-point scale that includes an assessment of verbal memory, language, orientation, reasoning, and praxis.The score is derived from adding point values from each of its subsections. The higher your score on the ADAS-cog, the better you do. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam (Epileptiform Activity) | -1.0 |
| Placebo (Epileptiform Activity) | 1.5 |
Blood samples intended for Quest Diagnostics LEV and prolactin serum levels (one 6 mL tube) will be processed in the following manner, as outlined in the Quest Diagnostics lab manual. The whole blood will be allowed to clot for 60 minutes and centrifuged at 2200 - 2500 revolutions per minute (RPM) for at least 15 minutes. The resulting serum will be split into 2 cryovials which will be stored at -20°C and immediately shipped for external assessment of LEV and prolactin levels. Prolactin will be assessed via immunoassay. The concentration of LEV in serum will be measured using validated liquid chromatography/tandem mass spectrometry (LC/MS-MS) methods. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | ng/mL (Mean) |
|---|---|
| Levetiracetam | 0.1 |
| Placebo | 0.2 |
Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-cog) - The ADAS-cog rating instrument (Rosen et al. 1984) will be used to evaluate the global cognitive functioning. The ADAS-cog is a 70-point scale that includes an assessment of verbal memory, language, orientation, reasoning, and praxis.The score is derived from adding point values from each of its subsections. The higher your score on the ADAS-cog, the better you do. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.2 |
| Placebo | 0.8 |
Alzheimer's Disease Cooperative Study Activities of Daily Living Scale (ADCS-ADL) - The ADCS-ADL rating instrument (Galasko et al. 1997) will be used to evaluate functional capacity. The ADCS-ADL is a caregiver rated questionnaire. Scores on the 24-item ADCS-ADL range from 0 to 78. A higher score indicates less severity while a lower score indicates greater severity. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.4 |
| Placebo | 0.3 |
ADCS-Clinical Global Impression of Change (ADCS-CGIC) - The ADCS-CGIC is a seven-point scale that gives a global rating of change from baseline (Schneider et al. 1997). The baseline and follow up assessments are based on interviews with the subject and the informant. The ADCS-CGIC is a clinician-rated measure of: global severity at baseline scored from 1 (normal, not at all ill) to 7 (among the most extremely ill patients); and global change at follow-up scored from 1 (marked improvement) to 7 (marked worsening), where 4 indicates no change. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 4.0 |
| Placebo | 4.0 |
Neuropsychiatric Inventory (NPI) - The NPI (Cummings et al. 1994) will be used to evaluate the severity of behavioral symptoms. The severity scale has scores ranging from 1 to 3 points (1=mild; 2=moderate; and 3=severe) and the scale for assessing caregiver distress has scores ranging from 0 to 5 points (0=no distress; 1=minimal distress; 2=mild distress; 3=moderate distress; 4=severe distress; and 5=extreme distress). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.8 |
| Placebo | 0.2 |
A 20-minute computer-based virtual navigation test will be used to assess how well a subject can navigate a virtual community to reach a goal destination. The subjects will then be measured on their ability to accurately navigate the virtual community after a period of a few hours. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | correct turns (Mean) |
|---|---|
| No Epileptiform Activity | -6.0 |
| Epileptic Activity | 17.4 |
"Epileptiform activity will be measured using a 1-hr resting magnetoencephalogram/electroencephalogram (M/EEG). M/EEG can detect abnormal epileptiform findings called spikes. The M/EEG will be read by an epileptologist with specialized training to assess whether there are any spikes. If spikes are observed during the M/EEG they will be counted to determine their frequency (e.g., 5 spikes per 1 hour recording). The frequency of spikes will then be compared to baseline values from before beginning the study treatment, using statistical tests to determine if the frequency changed with treatment." (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | Epileptiform events (Mean) |
|---|---|
| Levetiracetam | -0.1 |
| Placebo | -0.2 |
Changes in executive function were measured using the NIH EXAMINER, a 1-hour computer-based battery of various executive function tasks. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. The Examiner assessment consists of the following scales: antisaccade , set shifting , flanker task, dot counting, spatial 1-back, category fluency, and letter fluency. Scores for this task have an indefinite range. Higher scores however do indicate better performance. Scores for this scale were generated using item response theory. For this study, scores with SEs greater than 0.55 were classified as unreliable and excluded from analysis. Composite scores from 2 participants were excluded on this basis.The EXAMINER ranges for the participants in the study were -2.59 to 1.33. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | -0.06 |
| Placebo | -0.14 |
Stroop Test - The Stroop Test (Stroop 1935) will be used to assess executive functions including selective attention, cognitive flexibility and processing speed. Subtasks include Stroop color naming and Stroop interference naming, and each subtask is restricted to 1 minute. The minimum score is 0 and the maximum score is 126. The higher the score the better a participant does. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 1.5 |
| Placebo | -1.4 |
Clinical Dementia Rating Sum of Boxes (CDR-SOB) - The CDR will be used as a global measure of dementia severity (Morris 1993). The CDR consists of questions addressed to the caregiver/informant. The lowest score one can receive is a 0 and the highest is a 3. Score is measured by getting the mean of the individual scores in each category. Lower scores equate to less dementia severity. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.1 |
| Placebo | 0.1 |
Changes in executive function will be measured using the NIH EXAMINER, a 1-hour computer-based battery of various executive function tasks. The subject's performance after the study treatment will be compared with results from a baseline assessment done before the study treatment, using statistical tests to assess whether there was any significant change. The Examiner assessment consists of the following scales: NIH EXAMINER - antisaccade , NIH EXAMINER - set shifting , NIH EXAMINER - flanker task, NIH EXAMINER - dot counting, NIH EXAMINER - spatial 1-back, NIH EXAMINER - category fluency, and NIH EXAMINER - letter fluency. Scores for this task have an indefinite range. Higher scores however do indicate better performance. Scores for this scale were generated using item response theory (Kramer et al. J Int Neuropsychol Soc. 2014;20(1):11-19. doi:10.1017/S1355617713001094). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| No Epileptiform Activity | -0.01 |
| Epileptiform Activity | 0.22 |
The One Day Fluctuation Assessment Scale will be used to quantitate fluctuations of dementia symptoms (Walker et al. 2000). The One Day Fluctuation Assessment Scale has a score range of 0-21 points,with higher scores indicatingmore fluctuations. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.3 |
| Placebo | -0.4 |
Two standardized methods will be used to quantitate fluctuations of dementia symptoms: The Clinician Assessment of Fluctuation and the One Day Fluctuation Assessment Scale (Walker et al. 2000). : The Clinician Assessment of Fluctuation (score range,0-12 points, with higher scores indicating more fluctuations),26 the One Day Fluctuation Assessment Scale (score range,0-21 points, with higher scores indicatingmore fluctuations). (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam | 0.9 |
| Placebo | 0.1 |
Stroop Test - The Stroop Test (Stroop 1935) will be used to assess executive functions including selective attention, cognitive flexibility and processing speed. Subtasks include Stroop color naming and Stroop interference naming, and each subtask is restricted to 1 minute. The minimum score is 0 and the maximum score is 126. The higher the score the better a participant does. The mean below represents the average change in score between the timepoints for all participants. (NCT02002819)
Timeframe: Difference between weeks 0-4 (Baseline) and weeks 8-12 (Treatment)
| Intervention | score on a scale (Mean) |
|---|---|
| Levetiracetam (Epileptiform Activity) | 4.7 |
| Placebo (Epileptiform Activity) | -2.6 |
Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Mean change from baseline AEP Score at 12 months
| Intervention | Units on a scale (Mean) |
|---|---|
| VNS Therapy | -6.0 |
| Best Medical Practice | -3.2 |
The Center for Epidemiologic Studies Depression Scale (CES-D) includes 20 items comprising six scales reflecting major dimensions of depression: depressed mood, feelings of guilt and worthlessness, feelings of helplessness and hopelessness, psychomotor retardation, loss of appetite, and sleep disturbance. Possible range of scores is 0 to 60, higher scores indicate more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline CES-D Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -2.2 |
| Best Medical Practice | 0.5 |
The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a 6-item questionnaire validated to screen for depression in people with epilepsy. Scores range from 6 to 24, with higher scores indicating more depressive symptoms. (NCT00522418)
Timeframe: Mean change from baseline NDDI-E Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -1.0 |
| Best Medical Practice | -0.2 |
Change from baseline in number of AED medications by visit (NCT00522418)
Timeframe: Change from baseline in number of AEDs at 12 months
| Intervention | Number of AEDs Taken (Median) |
|---|---|
| VNS Therapy | 0 |
| Best Medical Practice | 0 |
The Clinical Global Impression scale (CGI-I) is a 7 point scale that requires the clinician to assess how much the patient's illness has improved or worsened relative to a baseline state at the beginning of the intervention Scores range from 1-7: 1, very much improved; 2, much improved; 3, minimally improved; 4, no change; 5, minimally worse; 6, much worse; or 7, very much worse. (NCT00522418)
Timeframe: Mean change from baseline CGI-I Score at 12 months
| Intervention | Units on a Scale (Mean) |
|---|---|
| VNS Therapy | -0.8 |
| Best Medical Practice | -0.3 |
Percent change in total seizuires per week from baseline at 12 months (NCT00522418)
Timeframe: Mean percent change from baseline in seizure frequency at 12 months
| Intervention | Percent Change (Mean) |
|---|---|
| VNS Therapy | -19.1 |
| Best Medical Practice | -1.0 |
QOLIE-89 contains 17 multi-item measures of overall quality of life, emotional well-being, role limitations due to emotional problems, social support, social isolation, energy/fatigue, worry about seizure, medication effects, health discouragement, work/driving/social function, attention/concentration, language, memory, physical function, pain, role limitations due to physical problems, and health perceptions. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. (NCT00522418)
Timeframe: Mean change from baseline QOLIE-89 Overall Score at 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| VNS Therapy | 5.5 |
| Best Medical Practice | 1.2 |
Response Rate is defined as the percent of participants who are responders. A Responder is defined as participants with a reduction of at least 50% or 75% in seizure frequency from baseline to the seizure count evaluation period. (NCT00522418)
Timeframe: Number of Responders at 12 Months
| Intervention | participants (Number) |
|---|---|
| VNS Therapy | 10 |
| Best Medical Practice | 7 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | units on a scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score < 40 | 3.3 | 0.5 |
QOLIE-89 contains 17 multi-item measures of overall quality of life. Range of values 0-100. Higher scores reflect better quality of life; lower ones, worse quality of life. Adverse Events Profile (AEP) is a 19-item scale used as a systematic measure of adverse effects from antiepileptic drugs (AEDs). Scores range from 19-76; higher scores indicate high prevelance and severity of adverse events. (NCT00522418)
Timeframe: Change from baseline up to 12 months
| Intervention | Units on a Scale (Least Squares Mean) | |
|---|---|---|
| VNS Therapy | Best Medical Practice | |
| Baseline Adverse Event Profile Score >= 40 | 3.3 | 0.7 |
135 reviews available for phenobarbital and Epilepsy
| Article | Year |
|---|---|
Concentrations of antiseizure medications in breast milk of lactating women with epilepsy: A systematic review with qualitative synthesis.
Topics: Anticonvulsants; Breast Feeding; Epilepsy; Ethosuximide; Female; Humans; Infant; Lactation; Milk, Hu | 2022 |
Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis; | 2022 |
Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Disease | 2022 |
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Eve | 2022 |
[Late forced emigration without perspectives: Alfred Hauptmann and Adolf Wallenberg].
Topics: Aged; Emigration and Immigration; Epilepsy; Germany; History, 20th Century; Humans; Male; Middle Age | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac | 2022 |
Effects of bumetanide on neonatal seizures: A systematic review of animal and human studies.
Topics: Aminoglycosides; Animals; Anticonvulsants; Bumetanide; Epilepsy; Hearing Loss; Humans; Infant; Infan | 2023 |
Anti-seizure medications for neonates with seizures.
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Infant; Infant, Newborn; Levetiracetam; Phenobarbital; P | 2023 |
Phenobarbital rheumatism-A fresh look at an old malady: Case report and systematic review of literature.
Topics: Adult; Anticonvulsants; Antirheumatic Agents; Arthritis, Rheumatoid; Carbamazepine; Complex Regional | 2020 |
Efficacy of Levetiracetam in neonatal seizures: a systematic review.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Pira | 2022 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Treatment of epilepsy for people with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cognition; Depression; Epilepsy; Female | 2021 |
Treatment of epilepsy for people with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cognition; Depression; Epilepsy; Female | 2021 |
Treatment of epilepsy for people with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cognition; Depression; Epilepsy; Female | 2021 |
Treatment of epilepsy for people with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cognition; Depression; Epilepsy; Female | 2021 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Feline Epilepsy.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Epilepsy; Levetiracetam; Phenobarbital; Piracetam; Pro | 2018 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Interventional programs to improve therapeutic management of people with epilepsy in low- and middle-income countries.
Topics: Africa; Anticonvulsants; Asia; Developing Countries; Epilepsy; Health Services Accessibility; Humans | 2018 |
The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyroidism; Inci | 2020 |
Treatment of epilepsy for people with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cognition; Depression; Epilepsy; Female | 2018 |
Treatment of neonatal seizures.
Topics: Animals; Anticonvulsants; Brain; Child Development; Drug Resistance; Epilepsy; Humans; Infant, Newbo | 2013 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer.
Topics: Anticonvulsants; Epidemiologic Studies; Epilepsy; Humans; Liver Neoplasms; Molecular Epidemiology; P | 2014 |
A child exposed to primidone not prescribed for her.
Topics: Animals; Anticonvulsants; Child; Epilepsy; Female; Gastrointestinal Diseases; Humans; Phenobarbital; | 2013 |
WITHDRAWN: Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2014 |
Phenobarbitone in modern India.
Topics: Anticonvulsants; Epilepsy; Health Services; India; Phenobarbital | 2013 |
GABAergic Synchronization in Epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Cortical Synchronization; Disease Models, Animal; Epile | 2016 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
Treatment of epilepsy for people with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticonvulsants; Cognition; Depression; Epilepsy; Female | 2016 |
Tolerability and Safety of Commonly Used Antiepileptic Drugs in Adolescents and Adults: A Clinician's Overview.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Humans; Phenobarbita | 2017 |
Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2009 |
Idiopathic epilepsy in dogs and cats.
Topics: Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Dog Diseases; Dogs; Dose-Response Relationsh | 2010 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
The effects of antiepileptic drugs on oral health.
Topics: Alveolar Bone Loss; Anticonvulsants; Carbamazepine; Epilepsy; Gingival Hyperplasia; Humans; Oral Hea | 2011 |
[Epilepsy in Lao Popular Democratic Republic: difficult procurement of a first-line antiepileptic contributes to widening the treatment gap].
Topics: Adult; Anticonvulsants; Child; Developing Countries; Epilepsy; Health Services Accessibility; Humans | 2012 |
Current position of phenobarbital in epilepsy and its future.
Topics: Anticonvulsants; China; Epilepsy; Forecasting; Humans; Phenobarbital; Randomized Controlled Trials a | 2012 |
ANTICONVULSANT DRUGS.
Topics: Acetazolamide; Acetylcholine; Amides; Aminobutyrates; Anticonvulsants; Brain; Chemistry, Pharmaceuti | 1963 |
[Antiepileptic primidone shortly to be withdrawn from sale: change medication now].
Topics: Anticonvulsants; Drug and Narcotic Control; Epilepsy; Humans; Phenobarbital; Primidone; Substance Wi | 2003 |
Phenobarbital for the treatment of epilepsy in the 21st century: a critical review.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cost-Benefit Analysis; Developing Countries; Drug Costs; E | 2004 |
[Febrile seizures--an update].
Topics: Administration, Oral; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants | 2004 |
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats | 2005 |
Epilepsy and mortality in Africa: a review of the literature.
Topics: Africa; Anticonvulsants; Cause of Death; Child; Developing Countries; Epilepsy; Humans; Malaria; Mal | 2005 |
Therapeutic monitoring of antiepileptic drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin; Primido | 2007 |
[Effects of antiepileptic drugs on mood of people with epilepsy].
Topics: Affect; Anticonvulsants; Antidepressive Agents; Carbamazepine; Depressive Disorder; Epilepsy; Fructo | 2007 |
The treatment of the first seizure: the benefits.
Topics: Actuarial Analysis; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Prognosis; Rand | 2008 |
[Management of epilepsy in developing countries].
Topics: Anticonvulsants; Developing Countries; Epilepsy; Health Workforce; Healthcare Disparities; Humans; M | 2007 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
[Advance and clinic of antiepileptic drugs (author's transl)].
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Epilepsy; Humans; Ion Channels; Mic | 1981 |
The natural history of febrile seizures.
Topics: Animals; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant | 1983 |
Diagnosis and treatment of epilepsy.
Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; E | 1983 |
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr | 1983 |
Final adult height of patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Body Height; Epilepsies, Partial; Epilepsy; Epilepsy, Tonic-Clonic; | 1983 |
Pharmacological principles in the long-term treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long | 1981 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas | 1982 |
The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.
Topics: Acetaminophen; Alcoholism; Animals; Antipyrine; Aryl Hydrocarbon Hydroxylases; Electron Transport; E | 1980 |
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Antiepileptic drugs and mechanisms of epileptogenesis. A review.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Epilepsy; Phenobarbital; Phenytoin; Receptors, GABA | 1995 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
Newer antiepileptic drugs. Towards an improved risk-benefit ratio.
Topics: Acetamides; Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Dioxolane | 1994 |
Phenobarbitone to gabapentin: a guide to 82 years of anti-epileptic drug pharmacokinetic interactions.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; Gabapen | 1994 |
Standard approach to antiepileptic drug treatment in the United States.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Drug Administration Schedule; Drug Th | 1994 |
Standard approach to antiepileptic drug treatment in the United Kingdom.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Drug Monitor | 1994 |
Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedu | 1994 |
Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Infant; Infant | 1995 |
Parenteral antiepileptic/anticonvulsant drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin | 1996 |
Adverse effects of established and new antiepileptic drugs: an attempted comparison.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; gamma-Aminobutyric Acid; Gastrointestinal Disease | 1995 |
Seizures in dogs.
Topics: Animals; Anticonvulsants; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Phenobarb | 1996 |
Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin | 1996 |
[Idiopathic epilepsy in the dog].
Topics: Animals; Anticonvulsants; Breeding; Dog Diseases; Dogs; Electroencephalography; Epilepsy; Phenobarbi | 1996 |
Idiopathic epilepsy.
Topics: Age Factors; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Diagnosis, Differential; Dog Di | 1998 |
Antiepileptic drug therapy.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid | 1998 |
Antiepileptic drug hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D | 1998 |
Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials, Phase II as Topic; Clinical Tria | 1999 |
[Central apnea in newborns].
Topics: Acetazolamide; Anticonvulsants; Apnea; Arnold-Chiari Malformation; Diagnosis, Differential; DiGeorge | 1999 |
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration S | 1999 |
Therapeutic safety monitoring: what to look for and when to look for it.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epil | 2000 |
[Febrile convulsions, Treatment and prognosis].
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 2001 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Update on therapy of canine epilepsy.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Monit | 1999 |
[Pharmacotherapy of epilepsy. II].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin | 1978 |
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te | 1978 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
The medical treatment of epilepsy: initiation of drug therapy.
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Pre | 1979 |
Behavioural effects of anti-epileptic drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Confusion; Disorders of Excess | 1975 |
[Treatment of epileptics with the aid of antiepileptic drug blood level determinations (author's transl)].
Topics: Anticonvulsants; Biological Availability; Dose-Response Relationship, Drug; Drug Interactions; Epile | 1977 |
[Epilepsies of infancy and early childhood (author's transl)].
Topics: Clonazepam; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Dise | 1978 |
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)].
Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Ph | 1978 |
Febrile seizures: the treatment controversy.
Topics: Child; Epilepsy; Humans; Nervous System Diseases; Phenobarbital; Phenytoin; Recurrence; Seizures; Se | 1979 |
Febrile convulsions: diagnosis, treatment, and prognosis.
Topics: Child; Epilepsy; Humans; Infant; Intellectual Disability; Intelligence; Meningitis; Phenobarbital; P | 1979 |
The medical treatment of epilepsy: maintenance of drug therapy.
Topics: Adolescent; Adult; Anticonvulsants; Biological Availability; Bromides; Carbamazepine; Child; Dextroa | 1979 |
The effect of anti-convulsant drugs on cognitive abilities.
Topics: Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; | 1979 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Management of seizure disorders: selected aspects. Part I.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography, | 1976 |
A case of hypersensitivity syndrome resembling Langerhans cell histiocytosis during phenobarbital prophylaxis for convulsion.
Topics: Child, Preschool; Diagnosis, Differential; Drug Eruptions; Eosinophils; Epilepsy; Female; Histiocyte | 1992 |
Liver tumour promotion by phenobarbital: comparison of rat and human studies.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Epilepsy; Humans; Liver Neoplasms; Liver Neoplasms, | 1992 |
[The effect of monotherapy on concentration of selected blood serum hormones and upon cognitive function of children with epilepsy].
Topics: Adolescent; Carbamazepine; Child; Cognition; Epilepsy; Female; Follow-Up Studies; Humans; Male; Phen | 1992 |
[Review: development of the spontaneously epileptic rat].
Topics: Animals; Crosses, Genetic; Disease Models, Animal; Epilepsy; Female; Male; Phenobarbital; Rats; Rats | 1992 |
Eterobarb.
Topics: Animals; Anticonvulsants; Drug Interactions; Drugs, Investigational; Electroencephalography; Epileps | 1991 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; | 1990 |
Efficacy and adverse effects of antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 1989 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; E | 1986 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru | 1987 |
Mechanisms of anticonvulsant drug action. I. Drugs primarily used for generalized tonic-clonic and partial epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Kinetics; Phenobarbital; Phen | 1987 |
Febrile seizures.
Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female | 1987 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Ph | 1987 |
Anticonvulsant drugs and cognitive function: a review of the literature.
Topics: Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; Phenobarbital; Phe | 1987 |
[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Child; Child, Preschool; Drug The | 1987 |
Use of barbiturates and benzodiazepines in treatment of epilepsy.
Topics: Adult; Barbiturates; Benzodiazepines; Child; Clonazepam; Clorazepate Dipotassium; Diazepam; Epilepsy | 1986 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
Anticonvulsants, folic acid, and epilepsy.
Topics: Anemia, Macrocytic; Animals; Anticonvulsants; Blood-Brain Barrier; Chemical Phenomena; Chemistry; Ep | 1973 |
Usefulness of blood levels of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, G | 1974 |
Diagnosis and treatment of epilepsy: overview and general principles.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; | 1974 |
[Epilepsy in children].
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Fever; Humans; Infant; | 1974 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Effects of tetanization on transmitter dynamics.
Topics: Acetazolamide; Acetylcholine; Action Potentials; Animals; Biological Transport; Carbon Dioxide; Cell | 1969 |
[Calcium metabolism disorders in antiepileptic therapy].
Topics: Animals; Anticonvulsants; Bone Diseases; Calcium; Calcium Metabolism Disorders; Cholecalciferol; Enz | 1973 |
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che | 1973 |
Toxic effects of anticonvulsants: general principles.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig | 1974 |
Disordered calcium metabolism during anticonvulsant treatment.
Topics: Adolescent; Animals; Anticonvulsants; Biliary Tract; Bone Diseases; Calcium; Child; Cholecalciferol; | 1973 |
The management of children with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Ethosuxim | 1970 |
Epilepsy.
Topics: Animals; Brain; Carbamazepine; Diet Therapy; Epilepsy; Humans; Phenobarbital; Phenytoin | 1972 |
Recent progress in epilepsy. Diagnostic procedures and treatment.
Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Epilepsy in the adolescent.
Topics: Acetazolamide; Adolescent; Age Factors; Alcoholic Intoxication; Amphetamine; Anticonvulsants; Attitu | 1974 |
The treatment of status epilepticus.
Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases; | 1974 |
The use of blood levels of antiepileptic drugs in clinical practice.
Topics: Administration, Oral; Adult; Anticonvulsants; Biopharmaceutics; Carbamazepine; Child; Drug Tolerance | 1974 |
Osteomalacia and anticonvulsant drugs.
Topics: Alkaline Phosphatase; Anticonvulsants; Calcium; Epilepsy; Folic Acid; Humans; Liver; Osteomalacia; P | 1971 |
[General review of the present therapy of epilepsy].
Topics: Anticonvulsants; Barbiturates; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hydantoins; Phenobarbit | 1971 |
[Drug therapy of epilepsy].
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Phenytoin; Trimethadione; Urea | 1967 |
108 trials available for phenobarbital and Epilepsy
| Article | Year |
|---|---|
Levetiracetam or Phenobarbitone as a First-Line Anticonvulsant in Asphyxiated Term Newborns? An Open-Label, Single-Center, Randomized, Controlled, Pragmatic Trial.
Topics: Adult; Anticonvulsants; Child; Epilepsy; Humans; Infant; Infant, Newborn; Infant, Newborn, Diseases; | 2022 |
Comparison between Phenobarbitone and Levetiracetam as the initial anticonvulsant in preterm neonatal seizures - a pilot randomized control trial in developing country setup.
Topics: Anticonvulsants; Developing Countries; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; | 2023 |
Effect of early withdrawal of phenobarbitone on the recurrence of neonatal seizures: An open-label randomized controlled trial.
Topics: Anticonvulsants; Child; Epilepsy; Humans; India; Infant, Newborn; Phenobarbital; Seizures | 2021 |
Prospective crossover clinical trial comparing transdermal with oral phenobarbital administration in epileptic cats.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Anticonvulsants; Cat Diseases; Cats; Cross | 2019 |
The effect of phenobarbitone on cognition in adult patients with new onset epilepsy: a multi-centric prospective study from India.
Topics: Adult; Anticonvulsants; Cognition; Epilepsy; Female; Humans; India; Male; Neuropsychological Tests; | 2014 |
Clinical efficacy and safety of imepitoin in comparison with phenobarbital for the control of idiopathic epilepsy in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Epilepsy; Imidazoles | 2015 |
A randomised trial of a medium-chain TAG diet as treatment for dogs with idiopathic epilepsy.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Blood Glucose; Bromides; Cross-Over Studies; Diet, | 2015 |
A single-blinded phenobarbital-controlled trial of levetiracetam as mono-therapy in dogs with newly diagnosed epilepsy.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Levetiracetam; Male; Phenobarbital; | 2016 |
Comparison of impact on seizure frequency and epileptiform discharges of children with epilepsy from topiramate and phenobarbital.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Fructose; Humans; Male; Phenobarbital; T | 2016 |
The effect of imepitoin, a recently developed antiepileptic drug, on thyroid parameters and fat metabolism in healthy Beagle dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Imidazoles; Lipid Metabolism; Longit | 2016 |
Current status of epilepsy treatment and efficacy of standard phenobarbital therapy in rural areas of Northern China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; China; Dizzine | 2017 |
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male | 2016 |
Clinical evaluation of a combination therapy of imepitoin with phenobarbital in dogs with refractory idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Cohort Studies; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug | 2017 |
Phenobarbital or potassium bromide as an add-on antiepileptic drug for the management of canine idiopathic epilepsy refractory to imepitoin.
Topics: Animals; Anticonvulsants; Belgium; Bromides; Dog Diseases; Dogs; Epilepsy; Imidazoles; Phenobarbital | 2017 |
Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.
Topics: Administration, Oral; Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Prescho | 2017 |
Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Female; | 2009 |
Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Anticonvulsants; Case-Control Stud | 2010 |
Children on phenobarbital monotherapy requires more sedatives during MRI.
Topics: Anesthetics, Dissociative; Anticonvulsants; Child; Child, Preschool; Conscious Sedation; Double-Blin | 2011 |
Microdialysis sampling of carbamazepine, phenytoin and phenobarbital in subcutaneous extracellular fluid and subdural cerebrospinal fluid in humans: an in vitro and in vivo study of adsorption to the sampling device.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Extracellular Space; Female; Humans; Male; Microdia | 2002 |
The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Female; Ha | 1993 |
Phenytoin and phenobarbital stable isotope studies in neonates.
Topics: Anticonvulsants; Carbon Isotopes; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Infant; In | 2003 |
Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study.
Topics: Anticonvulsants; Clonazepam; Drug Resistance; Electroencephalography; Epilepsy; Female; Humans; Infa | 2004 |
Efficacy assessment of phenobarbital in epilepsy: a large community-based intervention trial in rural China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; China; Communi | 2006 |
Evolution of serum lipids and lipoprotein (a) levels in epileptic children treated with carbamazepine, valproic acid, and phenobarbital.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Diet; Epilepsy; Female; Humans; Lipids; Lipoprote | 2006 |
Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Apolipoproteins; Carbamazepine; Child; Child, Pre | 2006 |
Side effects of phenobarbital and carbamazepine in childhood epilepsy: randomised controlled trial.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Doubl | 2007 |
Primary care treatment of epilepsy with phenobarbital in rural China: cost-outcome analysis from the WHO/ILAE/IBE global campaign against epilepsy demonstration project.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Costs and Cost Analysis; Disease | 2008 |
Historical perspective on the choice of antiepileptic drugs for the treatment of seizures in adults.
Topics: Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; History, 20th Century; Hu | 1983 |
Controlled and comparative trials of valproate performed in Europe and Asia.
Topics: Adolescent; Adult; Asia; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Europe; Humans; P | 1984 |
Influence of therapeutic phenobarbital and phenytoin medication on the polygraphic sleep of patients with epilepsy.
Topics: Adolescent; Adult; Aged; Drug Interactions; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Mid | 1984 |
[Experience with the use of new Bulgarian psychotropic drugs].
Topics: Adolescent; Adult; Aminopyrine; Aminoquinolines; Child; Clinical Trials as Topic; Depression; Dipyro | 1982 |
Influence of dextropropoxyphene on steady state serum levels and protein binding of three anti-epileptic drugs in man.
Topics: Adolescent; Adult; Aged; Carbamazepine; Chromatography, Gas; Chromatography, High Pressure Liquid; C | 1980 |
Kinetics of phenobarbital in normal subjects and epileptic patients.
Topics: Administration, Oral; Adult; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Injec | 1982 |
A double-blind investigation of the relationship between seizure activity and the sleep EEG following EEG biofeedback training.
Topics: Adolescent; Adult; Biofeedback, Psychology; Child; Double-Blind Method; Electroencephalography; Epil | 1982 |
A multiparametric investigation of daytime sleepiness and psychomotor functions in epileptic patients treated with phenobarbital and sodium valproate: a comparative controlled study.
Topics: Adult; Affect; Analysis of Variance; Epilepsy; Humans; Male; Neuropsychological Tests; Phenobarbital | 1993 |
Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Cholesterol, | 1995 |
Inhibition of phenobarbitone N-glucosidation by valproate.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dose-Response Relationship, Dr | 1994 |
Urinary excretion of phenobarbitone and its metabolites in chronically treated patients.
Topics: Adult; Aged; Aged, 80 and over; Biotransformation; Chromatography, High Pressure Liquid; Epilepsy; F | 1994 |
Thiamine and folate treatment of chronic epileptic patients: a controlled study with the Wechsler IQ scale.
Topics: Adult; Brain; Double-Blind Method; Drug Therapy, Combination; Education; Electroencephalography; Epi | 1993 |
Pharmacokinetic interaction between valproic acid and phenobarbital.
Topics: Administration, Oral; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; | 1993 |
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Female; Fluorescence Polarization Immunoa | 1995 |
Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (Hb ASSG) in epileptic patients with long-term antiepileptic therapy.
Topics: Anticonvulsants; Antioxidants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fem | 1995 |
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 1996 |
Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study.
Topics: Adolescent; Anticonvulsants; Bender-Gestalt Test; Carbamazepine; Child; Cognition; Epilepsy; Event-R | 1996 |
Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle | 1996 |
Systematic testing of medical intractability for carbamazepine, phenytoin, and phenobarbital or primidone in monotherapy for patients considered for epilepsy surgery.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Protocols; Dose | 1996 |
Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cl | 1996 |
Effect of enzyme inducing anticonvulsants on ethosuximide pharmacokinetics in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Enzyme Induction; Epilepsy; Ethosuximide; | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Phenobarbital induces the 2-hydroxylation of desipramine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 | 1996 |
Brainstem auditory evoked potentials in epileptics on different anti-epileptic drugs.
Topics: Acoustic Stimulation; Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy | 1996 |
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D | 1996 |
Relationships between carbamazepine-diol, carbamazepine-epoxide, and carbamazepine total and free steady-state concentrations in epileptic patients: the influence of age, sex, and comedication.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug | 1996 |
Barbiturate anticonvulsants: a neuropsychological and quantitative electroencephalographic study.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Humans; Hypnotics and Sedative | 1997 |
Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children.
Topics: Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combinatio | 1997 |
Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital.
Topics: Adolescent; Animals; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; H | 1998 |
[Treatment for generalized seizures: the best of four methods].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Lorazepam; Phenobarbital; Phenytoin | 1999 |
Anti-epileptic drug intake adherence. The value of the blood drug level measurement and the clinical approach.
Topics: Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Drug Monitoring; Epilepsy; Female; Humans; | 1998 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Craniocerebral Trauma; Developmenta | 1999 |
Age-related alteration of carbamazepine-serum protein binding in man.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anticonvulsants; Child; Child, Preschool; Diethyl | 1999 |
A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dizziness; Drug Administration Sched | 2000 |
Epilepsy and antiepileptic drug therapy in juvenile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbidity; | 2000 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr | 2002 |
[Clinical trial with barbexaclone in epilepsies].
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Drug Combinations; Drug Evalua | 1977 |
One drug (phenytoin) in the treatment of epilepsy.
Topics: Adolescent; Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Epilepsy; Epilepsy, Absence; Ep | 1976 |
[Value of anticonvulsant level determination in the treatment of epilepsies].
Topics: Clinical Trials as Topic; Drug Administration Schedule; Epilepsy; Humans; Patient Dropouts; Phenobar | 1977 |
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica | 1977 |
Valproate sodium: a controlled clinical trial including monitoring of drug levels.
Topics: Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinat | 1977 |
[Double-blind study on the anti-convulsive effect of phenobarbital and valproate in the Lennox syndrome].
Topics: Benzodiazepines; Child; Child, Preschool; Double-Blind Method; Drug Synergism; Drug Therapy, Combina | 1978 |
Clonazepam: its efficacy in association with phenytoin and phenobarbital in mental patients with generalized major motor seizures.
Topics: Benzodiazepinones; Clinical Trials as Topic; Clonazepam; Double-Blind Method; Drug Therapy, Combinat | 1978 |
A comparison of phenobarbitone and primidone in the control of seizures in chronic epilepsy [proceedings].
Topics: Adult; Aged; Chronic Disease; Clinical Trials as Topic; Epilepsy; Humans; Middle Aged; Phenobarbital | 1979 |
Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Dimethadione; Dose-Response Relati | 1979 |
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
Topics: Adolescent; Adult; Ambulatory Care; Benzodiazepinones; Brain; Child; Clinical Trials as Topic; Clona | 1977 |
Phenytoin dosage in ambulant epileptic patients.
Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin | 1978 |
Oral and intramuscular phenytoin.
Topics: Administration, Oral; Adult; Clinical Trials as Topic; Drug Administration Schedule; Epilepsy; Epile | 1976 |
[Changes in serum concentrations of calcium and inorganic phosphates and alkaline phosphatase activity due to anti-ipileptic treatment].
Topics: Adolescent; Adult; Alkaline Phosphatase; Calcium; Clinical Trials as Topic; Epilepsy; Female; Humans | 1976 |
Serum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin D.
Topics: Adolescent; Alkaline Phosphatase; Bone and Bones; Calcium; Child; Child, Preschool; Collagen; Drug T | 1975 |
Eterobarb therapy in epilepsy.
Topics: Adolescent; Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Evaluation; Epil | 1976 |
Clinical evaluation of eterobarb, a new anticonvulsant drug.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluati | 1975 |
Controlled trial of sodium valproate in severe epilepsy.
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsy; Female; Humans; Male; | 1975 |
The efficacy of carbamazepine combinations in epilepsy.
Topics: Adult; Biological Availability; Carbamazepine; Clinical Trials as Topic; Drug Administration Schedul | 1975 |
A large-scale study of epilepsy in Ecuador: methodological aspects.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Developing Count | 1992 |
Comprehensive primary health care antiepileptic drug treatment programme in rural and semi-urban Kenya. ICBERG (International Community-based Epilepsy Research Group)
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; Humans; Kenya; M | 1991 |
Comparative cognitive effects of anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Neuro | 1990 |
Aspects of compliance: taking drugs and keeping clinic appointments.
Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Clinical Trials as To | 1988 |
A randomized, double-blind, crossover study of phenobarbital and mephobarbital.
Topics: Child; Child Behavior; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Female; Humans; Male | 1986 |
Results of a nationwide Veterans Administration Cooperative Study comparing the efficacy and toxicity of carbamazepine, phenobarbital, phenytoin, and primidone.
Topics: Adult; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsy; Humans; Phenobarbital | 1987 |
Progabide for refractory partial epilepsy: a controlled add-on trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Double-Blind Meth | 1986 |
Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epilepsies, P | 1985 |
Influence of folic acid on blood-phenytoin levels.
Topics: Adult; Anticonvulsants; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Male; Phenobarbital; Ph | 1971 |
Evaluation of albutoin as an antiepileptic drug.
Topics: Adolescent; Adult; Allyl Compounds; Analysis of Variance; Anticonvulsants; Appetite; Biopharmaceutic | 1974 |
"Anticonvulsant action" of vitamin D in epileptic patients? A controlled pilot study.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Child; Clinical Trials as Topic; | 1974 |
Carbamazepine for epilepsy. A controlled prospective evaluation.
Topics: Adult; Blood Cell Count; Bone Marrow Diseases; Carbamazepine; Clinical Trials as Topic; Electroencep | 1974 |
Relation of laboratory evaluation to clinical effectiveness of antiepileptic drugs.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzazepines; Clinical Trials | 1969 |
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
Drug--interaction between sulthiame (Ospolot (R)) and phenytoin in the treatment of epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Thiazines; Time Fa | 1969 |
Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Clinical Trials as Topic; Epilepsy; Ergocalci | 1972 |
Folate therapy in epilepsy. A controlled study.
Topics: Clinical Trials as Topic; Cognition; Epilepsy; Evaluation Studies as Topic; Folic Acid; Humans; Leuc | 1973 |
Cerebrospinal folate levels in epileptics and their response to folate therapy.
Topics: Anticonvulsants; Blood-Brain Barrier; Clinical Trials as Topic; Epilepsy; Folic Acid; Folic Acid Def | 1974 |
Renal insensitivity to frusemide caused by chronic anticonvulsant therapy.
Topics: Administration, Oral; Adult; Anticonvulsants; Clinical Trials as Topic; Diuresis; Drug Interactions; | 1974 |
Incidence of anticonvulsant osteomalacia and effect of vitamin D: controlled therapeutic trial.
Topics: Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Bone and Bones; Calcium; Creatinine; Epilepsy; F | 1973 |
Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug-induced subnormal serum folates.
Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Erythrocyte Count; Female; Folic Acid; H | 1970 |
A survey of 156 seizure patients in a general pediatric clinic.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, | 1966 |
The metabolic conversion of primidone (Mysoline) to phenobarbitone in patients under long-term treatment. An attempt to estimate the independent effect of primidone.
Topics: Adult; Behavior; Clinical Trials as Topic; Drug Synergism; Electroencephalography; Epilepsy; Epileps | 1967 |
Relative anticonvulsant potency of primidone; a double blind comparison.
Topics: Clinical Trials as Topic; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1966 |
The influence of phenobarbital on the half-life of diphenylhydantoin in man.
Topics: Adolescent; Adult; Aged; Carbon Isotopes; Enzyme Induction; Epilepsy; Humans; Metabolic Clearance Ra | 1969 |
1282 other studies available for phenobarbital and Epilepsy
| Article | Year |
|---|---|
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur | 1987 |
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA | 1996 |
Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Drug Synergism; Epilepsy; Liver; Mice; Nervo | 2010 |
Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 1: perhydropyrrole[1,2-a]pyrazines.
Topics: Animals; Anticonvulsants; Diketopiperazines; Electroshock; Epilepsy; Humans; Male; Mice; Models, Mol | 2011 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Researching on the compliance of epilepsy patients of the Phenobarbital Epilepsy Management Project in a rural area of China: A retrospective study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Humans; Infant | 2021 |
Characteristics of Neonates with Cardiopulmonary Disease Who Experience Seizures: A Multicenter Study.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Monitoring, Physiologic; | 2022 |
Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2022 |
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposur | 2022 |
Approach to initial management of canine generalised epileptic seizures in primary-care veterinary practices in the United Kingdom.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Phenobarbital; Seizures | 2022 |
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; H | 2022 |
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnanc | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Electroencephalographic Findings, Antiepileptic Drugs and Risk Factors of 433 Individuals Referred to a Tertiary Care Hospital in Ethiopia.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Craniocerebral Trauma; Electroencephalography; Epilepsy; Et | 2022 |
Serum folate levels in children with epilepsy seen in a tertiary health care facility in north central Nigeria.
Topics: Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Delivery of Health Care; Epilepsy; F | 2022 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetiracetam; Phenob | 2023 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
A real-life pilot study of the clinical application of pharmacogenomics testing on saliva in epilepsy.
Topics: Anticonvulsants; Clobazam; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C | 2023 |
Comparison of caregivers' assessments of clinical outcome in dogs with idiopathic epilepsy administered levetiracetam, zonisamide, or phenobarbital monotherapy.
Topics: Animals; Anticonvulsants; Caregivers; Dog Diseases; Dogs; Epilepsy; Humans; Levetiracetam; Phenobarb | 2023 |
Bumetanide potentiates the anti-seizure and disease-modifying effects of midazolam in a noninvasive rat model of term birth asphyxia.
Topics: Animals; Anticonvulsants; Asphyxia; Asphyxia Neonatorum; Bumetanide; Epilepsy; Humans; Infant, Newbo | 2023 |
Once-a-day oral treatment with phenobarbital in cats with presumptive idiopathic epilepsy.
Topics: Animals; Cat Diseases; Cats; Epilepsy; Phenobarbital; Prospective Studies; Quality of Life; Retrospe | 2023 |
The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Tanzania; V | 2023 |
Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Follow-Up Stud | 2019 |
Antiepileptic drug-induced psychosis associated with MTHFR C677T: a case report.
Topics: Adolescent; Anticonvulsants; Avitaminosis; Epilepsy; Humans; Male; Methylenetetrahydrofolate Reducta | 2019 |
Levetiracetam in Neonatal seizures.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Piracetam; Seizures | 2019 |
Reply to Grinspan et al.
Topics: Epilepsy; Humans; Levetiracetam; Phenobarbital | 2019 |
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippoca | 2020 |
Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Child, Preschool; Diazepam; Drug Resistance; Drug Resista | 2019 |
Clinical presentation of epilepsy in six villages in an onchocerciasis endemic area in Mahenge, Tanzania.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Neurologists; Onchocerciasis; Phenobarbital; | 2019 |
Phenobarbital-induced anticonvulsant hypersensitivity syndrome in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Drug Hypersensitivity; Epilepsy; Fever; Lymphadenopath | 2019 |
Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Democratic Republic of the Congo; Dri | 2020 |
Treatment of Neonatal Seizures: Levetiracetam vs Phenobarbitone.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2019 |
Treatment of Neonatal Seizures: Levetiracetam vs Phenobarbitone: Author's Reply.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2019 |
Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia.
Topics: Adolescent; Adult; Ambulatory Care Facilities; Anticonvulsants; Cross-Sectional Studies; Drug Intera | 2020 |
Levetiracetam is Still Not a First-line Treatment in Neonatal Seizures.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2020 |
Levetiracetam is Still Not a First-line Treatment in Neonatal Seizures: Author's Reply.
Topics: Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2020 |
The treatment outcomes of epilepsy and its root causes in children attending at the University of Gondar teaching hospital: A retrospective cohort study, 2018.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Hospitals, Teaching; Hospita | 2020 |
Influence of dose and antiepileptic comedication on brivaracetam serum concentrations in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dibenzazepines; Drug Interactions; D | 2020 |
A further contribution to the delineation of epileptic phenotype in PACS2-related syndrome.
Topics: Brain; Epilepsy; Female; Humans; Infant, Newborn; Levetiracetam; Magnetic Resonance Imaging; Mutatio | 2020 |
Prevalence and clinical characteristics of phenobarbitone-associated adverse effects in epileptic cats.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Epilepsy; Phenobarbital; Prevalence | 2021 |
Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsy | 2020 |
Comparison of the neurocognitive outcomes in term infants treated with levetiracetam and phenobarbital monotherapy for neonatal clinical seizures.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Infant; Infant, Newborn; Levetiracetam; Phenobarbital; Sei | 2020 |
Population pharmacokinetics of phenobarbital in Caucasian patients with epilepsy.
Topics: Anticonvulsants; Bayes Theorem; Epilepsy; Humans; Models, Biological; Phenobarbital; Retrospective S | 2020 |
Therapeutic Monitoring of Lacosamide in Japanese Patients With Epilepsy: Clinical Response, Tolerability, and Optimal Therapeutic Range.
Topics: Adult; Anticonvulsants; Asian People; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therap | 2020 |
Long-term seizure, comorbidity and socioeconomic outcomes of patients with convulsive epilepsy in rural West China.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; China; Comorbidity; Epilepsy; Female; H | 2020 |
Pharmacokinetics, tolerability, and clinical effectiveness of perampanel in Japanese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Drug T | 2020 |
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Effects of the NKCC1 inhibitors bumetanide, azosemide, and torasemide alone or in combination with phenobarbital on seizure threshold in epileptic and nonepileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Drug Therapy, Combination; Epilepsy; Female; Mice; Phenobarbit | 2021 |
Phenobarbital, midazolam, bumetanide, and neonatal seizures: The devil is in the details.
Topics: Animals; Anticonvulsants; Bumetanide; Epilepsy; Humans; Midazolam; Phenobarbital; Prohibitins; Seizu | 2021 |
Using community health workers as an alternative approach for epidemiological research on epilepsy in six health districts in Mali.
Topics: Community Health Workers; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Mali; Phenobarbit | 2021 |
Comparative efficacy of levetiracetam to phenobarbital in the treatment of neonatal seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Seizures | 2021 |
Benign juvenile idiopathic epilepsy in captive Iberian lynx (Lynx pardinus) in the ex situ conservation program (2005-2019).
Topics: Animals; Anticonvulsants; Conservation of Natural Resources; Epilepsy; Female; Inheritance Patterns; | 2021 |
Comparison of efficacy and safety of levetiracetam and phenobarbitone in neonatal seizure.
Topics: Anticonvulsants; Epilepsy; Humans; Infant, Newborn; Levetiracetam; Phenobarbital; Piracetam; Seizure | 2022 |
Efficacy of phenobarbital in treating elderly epilepsy patients in rural northeast China: A community-based intervention trial.
Topics: Aged; Anticonvulsants; Carbamazepine; China; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; H | 2021 |
Daytime and nocturnal activity in treated dogs with idiopathic epilepsy compared to matched unaffected controls.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Phenobarbital; Prospective Studies | 2021 |
pH-induced homogeneous liquid-liquid microextraction method based on new switchable deep eutectic solvent for the extraction of three antiepileptic drugs from breast milk.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Hydrogen-Ion Concentration; Lamotrigine; Liquid Phase Mic | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut | 2021 |
Evaluation of the effect of phenobarbital administration on the biochemistry profile, with a focus on serum liver values, in epileptic cats.
Topics: Alanine Transaminase; Animals; Anticonvulsants; Cat Diseases; Cats; Dog Diseases; Dogs; Epilepsy; Fe | 2022 |
Terminal seizure frequency and its relation to SUDEP.
Topics: Adult; Anticonvulsants; China; Death, Sudden; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mid | 2017 |
Evaluation of Patients With Febrile Seizure: Risk Factors, Reccurence, Treatment and Prognosis.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Fever; Humans; Infant; | 2020 |
Pseudolymphoma in a cat on phenobarbital treatment.
Topics: Animals; Cat Diseases; Cats; Epilepsy; Female; Lymphadenopathy; Phenobarbital; Pseudolymphoma | 2018 |
Suspected Phenobarbital-Induced Pseudolymphoma in a Dog.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Levetiracetam; Male; Phenobarbital; Piraceta | 2017 |
Preliminary study of the association between the elimination parameters of phenytoin and phenobarbital.
Topics: Adult; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Linear Models; Male; Middle Aged; | 2017 |
Recurrent Admissions for Hypothermia From Concomitant Topiramate and Phenobarbital: A Case Report.
Topics: Anticonvulsants; Drug Interactions; Epilepsy; Female; Hospitalization; Humans; Hypothermia; Middle A | 2019 |
Imepitoin withdrawal in dogs with idiopathic epilepsy well-controlled with imepitoin and phenobarbital and/or potassium bromide does not increase seizure frequency.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Female; | 2017 |
Provider Practices of Phenobarbital Discontinuation in Neonatal Seizures.
Topics: Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Infant, Newborn; Male; Phenobarbital; | 2018 |
Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy.
Topics: Anticonvulsants; Cohort Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant; Levetiracetam | 2018 |
Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epileps | 2018 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
Psychiatric comedication in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Interactions; Drug | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; E | 2018 |
Availability and sufficiency of phenobarbital, an essential medication, in Bhutan: a survey of global and neuropsychiatric relevance.
Topics: Adolescent; Aged; Anticonvulsants; Asia; Bhutan; Child; Child, Preschool; Epilepsy; Female; Humans; | 2018 |
The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Azabicyclo Compounds; Blood-Brain Barrier; Catalysis; Electroshock; Enzyme | 2018 |
Frequency of drug combinations between enzyme-inducing first-generation antiepileptic drugs and inducible drugs in patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Drug Interactions; Drug Therapy, C | 2018 |
Population pharmacokinetics of extended-release levetiracetam in epileptic dogs when administered alone, with phenobarbital or zonisamide.
Topics: Animals; Anticonvulsants; Delayed-Action Preparations; Dog Diseases; Dogs; Drug Interactions; Epilep | 2018 |
Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Bumetanide; Drug Evaluation, Preclinical; Drug Synerg | 2018 |
Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report.
Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; E | 2019 |
Managing Direct Oral Anticoagulants in Patients With Antiepileptic Medication.
Topics: Administration, Oral; Aged, 80 and over; Anticoagulants; Anticonvulsants; Atrial Fibrillation; Drug | 2018 |
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2019 |
Blood concentration, efficacy, and adverse events of phenobarbital: A prospective study in rural China.
Topics: Adult; Anticonvulsants; China; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pheno | 2019 |
Successful treatment of seizure disorder by evaluating phenobarbital clearance in a paediatric patient undergoing continuous haemodiafiltration.
Topics: Child; Epilepsy; Female; Hemodiafiltration; Humans; Phenobarbital; Renal Dialysis | 2019 |
Comparative Effectiveness of Phenobarbital versus Levetiracetam for Infantile Epilepsy.
Topics: Anticonvulsants; Child, Preschool; Comparative Effectiveness Research; Epilepsy; Humans; Infant; Lev | 2019 |
Influence of etiology on treatment choices for neonatal seizures: A survey among pediatric neurologists.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant, | 2019 |
Etiology of neonatal seizures and maintenance therapy use: a 10-year retrospective study at Toulouse Children's hospital.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cohort Studies; Databases, Factual; Dose-Response Relati | 2019 |
Two Patients With KCNT1-Related Epilepsy Responding to Phenobarbital and Potassium Bromide.
Topics: Anticonvulsants; Bromides; Child, Preschool; Drug Therapy, Combination; Electroencephalography; Epil | 2019 |
Epileptic seizure frequency and semiology in dogs with idiopathic epilepsy after initiation of imepitoin or phenobarbital monotherapy.
Topics: Animals; Anticonvulsants; Cohort Studies; Dog Diseases; Dogs; Epilepsy; Imidazoles; Phenobarbital; P | 2019 |
FGF12p.Gly112Ser variant as a cause of phenytoin/phenobarbital responsive epilepsy.
Topics: Alleles; Amino Acid Substitution; Anticonvulsants; Child, Preschool; Electroencephalography; Epileps | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
Risk factors for hyperammonemia in pediatric patients with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Rela | 2013 |
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
Osteomalacic myopathy: an uncommon side effect of antiepileptic drugs.
Topics: Anticonvulsants; Bone Density Conservation Agents; Carbamazepine; Cholecalciferol; Epilepsy; Humans; | 2013 |
Sirenomelia after phenobarbital and carbamazepine therapy in pregnancy.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Ectromelia; Epilepsy; Fatal Outcome; Female; Humans; Phe | 2013 |
[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Carbon Radioisotopes | 2013 |
Feasibility study of a caregiver seizure alert system in canine epilepsy.
Topics: Algorithms; Animals; Anticonvulsants; Caregivers; Chromatography, High Pressure Liquid; Clinical Ala | 2013 |
End of the barbexaclone era: an experience of treatment withdrawal.
Topics: Adult; Age of Onset; Anticonvulsants; Electroencephalography; Epilepsy; Female; Guidelines as Topic; | 2013 |
Switching between medications for the management of epilepsy in dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Phenobarbital | 2013 |
High frequency of a single nucleotide substitution (c.-6-180T>G) of the canine MDR1/ABCB1 gene associated with phenobarbital-resistant idiopathic epilepsy in Border Collie dogs.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dog Diseases; Dog | 2013 |
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Bumetanide; Convulsants; Disease Models, Animal | 2014 |
Phenobarbitone-induced haematological abnormalities in idiopathic epileptic dogs: prevalence, risk factors, clinical presentation and outcome.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Hematologic Diseases; Male; Phenobar | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh | 2014 |
Antiepileptic efficacy of lamotrigine in phenobarbital-resistant and -responsive epileptic rats: a pilot study.
Topics: Animals; Anticonvulsants; Electric Stimulation; Electroencephalography; Epilepsy; Female; Lamotrigin | 2014 |
[Epilepsy in the child and in the adult. Part 1. Epilepsy in the child].
Topics: Anticonvulsants; Benzodiazepines; Child; Electroencephalography; Epilepsy; Follow-Up Studies; Humans | 2014 |
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2014 |
Perinatal outcomes from the use of antiepileptic drugs during pregnancy: a case-control study.
Topics: Adult; Anticonvulsants; Apgar Score; Case-Control Studies; Congenital Abnormalities; Epilepsy; Femal | 2015 |
Monitoring side effects of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Dog Diseases; Epilepsy; Female; Hematologic Diseases; Male; Phenobarbital | 2014 |
Medication side effects among people with epilepsy taking phenobarbital in Zambia.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Nervous System Diseases; Phenoba | 2014 |
Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Femal | 2015 |
Electroencephalography recording analysis in monitoring of canine idiopathic epilepsy treated with phenobarbital. Pilot study.
Topics: Animals; Anticonvulsants; Dogs; Electroencephalography; Epilepsy; Monitoring, Physiologic; Phenobarb | 2014 |
Association of ABCB1 C3435T polymorphism with phenobarbital resistance in Thai patients with epilepsy.
Topics: Adult; Anticonvulsants; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cas | 2015 |
Undue regulatory control on phenobarbital--an important yet overlooked reason for the epilepsy treatment gap.
Topics: Anticonvulsants; Drug and Narcotic Control; Epilepsy; Humans; Phenobarbital; Treatment Outcome | 2015 |
Canine Pancreas-Specific Lipase and C-reactive Protein in Dogs Treated With Anticonvulsants (Phenobarbital and Potassium Bromide).
Topics: Animals; Anticonvulsants; Bromides; C-Reactive Protein; Dog Diseases; Dogs; Epilepsy; Female; Lipase | 2015 |
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Ch | 2015 |
Concentration of antiepileptic drugs in persons with epilepsy: a comparative study in serum and saliva.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Age | 2016 |
Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E | 2015 |
Successful treatment of migrating partial seizures in Wolf-Hirschhorn syndrome with bromide.
Topics: Anticonvulsants; Brain; Bromides; Chromosome Deletion; Chromosomes, Human, Pair 4; Comparative Genom | 2016 |
A hemophagocytosis syndrome attributed to phenobarbital.
Topics: Anemia; Anticonvulsants; Autoimmune Diseases; Diagnosis, Differential; Drug Hypersensitivity Syndrom | 2016 |
Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; M | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clon | 2016 |
Comparing the effects of first-line antiepileptic drugs on the gait of dogs with idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Ataxia; Case-Control Studies; Dog Diseases; Dogs; Epilepsy; Gait; Imidazol | 2016 |
Development, validation and clinical application of an online-SPE-LC-HRMS/MS for simultaneous quantification of phenobarbital, phenytoin, carbamazepine, and its active metabolite carbamazepine 10,11-epoxide.
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Monitoring; Epilep | 2016 |
Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Drug T | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Overview of accessibility and quality of antiepileptic drugs in Madagascar.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Epilepsy; Female; Health Services Acces | 2016 |
Association of HLA genotypes with phenobarbital hypersensitivity in children.
Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Hypersensitivity; | 2016 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
[Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Humans; | 2016 |
Continuous phenobarbital treatment leads to recurrent plantar fibromatosis.
Topics: Adult; Anticonvulsants; Drug Administration Schedule; Drug Therapy, Combination; Epilepsy; Female; F | 2008 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; | 2008 |
Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability.
Topics: Anticonvulsants; Barbiturates; Cognition; Drug Therapy, Combination; Epilepsy; Humans; Intellectual | 2009 |
Serum triglyceride concentration in dogs with epilepsy treated with phenobarbital or with phenobarbital and bromide.
Topics: Animals; Bromides; Case-Control Studies; Cross-Sectional Studies; Dog Diseases; Dogs; Epilepsy; Fast | 2008 |
Altered pharmacology and GABA-A receptor subunit expression in dorsal midline thalamic neurons in limbic epilepsy.
Topics: Animals; Epilepsy; GABA Agents; Glutamate Decarboxylase; In Vitro Techniques; Inhibitory Postsynapti | 2009 |
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Mal | 2008 |
The problem of epilepsy and its care in rural Ethiopia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Educational Status; Epilepsy; Ethiopia; Female; F | 2008 |
Drug treatment of epilepsy in the century of the ILAE: the first 50 years, 1909-1958.
Topics: Advertising; Anticonvulsants; Bromides; Epilepsy; Herbal Medicine; History, 18th Century; History, 1 | 2009 |
[Anticonvulsant hypersensitivity syndrome and lamotrigine-associated anticonvulsant hypersensitivity syndrome].
Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; | 2009 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
Positive impact of omega-3 fatty acid supplementation in a dog with drug-resistant epilepsy: a case study.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dietary Supplements; Dog Diseases; Dogs; Drug Resistance | 2009 |
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2009 |
Reversible coma associated with prolonged high-dose phenobarbital therapy in bilateral Sturge-Weber syndrome.
Topics: Anticonvulsants; Brain; Causality; Cerebrovascular Disorders; Coma; Consciousness; Contraindications | 2009 |
Hyperhomocysteinemia in epileptic patients on new antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Enzyme Induction; Epilepsy; Female; Folic Acid; F | 2010 |
Development of multi-electrode array screening for anticonvulsants in acute rat brain slices.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Evaluation | 2010 |
Pharmacogenetic association study of 30 genes with phenobarbital drug response in epileptic dogs.
Topics: Animals; Anticonvulsants; Case-Control Studies; Dog Diseases; Dogs; Drug Resistance; Epilepsy; Pharm | 2009 |
Veterinarians' preferences for anticonvulsant drugs for treating seizure disorders in dogs and cats.
Topics: Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cross-Sectional Studies; Dog Diseases; Dogs; | 2009 |
Variations in serum concentration of phenobarbitone in dogs receiving regular twice daily doses in relation to the times of administration.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Administration | 2009 |
Rescue therapy with high-dose oral phenobarbitone loading for refractory status epilepticus.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Enteral Nutrition; Epilepsy; | 2010 |
Severe cutaneous reactions caused by barbiturates in seven Iranian children.
Topics: Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans; Infant; | 2009 |
Combined effects of epileptic seizure and phenobarbital induced overexpression of P-glycoprotein in brain of chemically kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Behavior, Animal; B | 2010 |
The control of epilepsy: an interim report of 3-methyl-5,5-phenylethylhydantoin and phenobarbital therapy.
Topics: Epilepsy; Humans; Phenobarbital | 1947 |
Skin eruption due to phenobarbital among mentally defective epileptic patients.
Topics: Drug Hypersensitivity; Epilepsy; Exanthema; Humans; Hypersensitivity; Phenobarbital | 1946 |
The effect of antiepileptic drugs on mitochondrial activity: a pilot study.
Topics: Adenosine Triphosphate; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electro | 2010 |
[Phenobarbital].
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Humans; Phenobarbital; Prescription Drugs | 2010 |
Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Casse | 2010 |
Epilepsy research: occurrences of sudden death in dogs with epilepsy may be numbered.
Topics: Animals; Anticonvulsants; Biomedical Research; Death, Sudden; Dogs; Epilepsy; Male; Phenobarbital | 2010 |
Partial disinhibition is required for transition of stimulus-induced sharp wave-ripple complexes into recurrent epileptiform discharges in rat hippocampal slices.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electric | 2011 |
Factors influencing valproate pharmacokinetics in children and adults.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Pre | 2010 |
Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Ep | 2010 |
Phenobarbital/Lamotrigine coadministration-induced blood dyscrasia in a patient with epilepsy.
Topics: Adult; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamo | 2010 |
An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Survival; Epilepsy; Ethosuximide; Glutamic Acid; H | 2011 |
Treatment gap for people living with epilepsy in Madagascar.
Topics: Anticonvulsants; Barbiturates; Delivery of Health Care; Developing Countries; Diazepam; Drug Therapy | 2011 |
Add-on treatment with verapamil in pharmacoresistant canine epilepsy.
Topics: Age of Onset; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blo | 2011 |
Suicidal risk and suicide attempts in people treated with antiepileptic drugs for epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Comorbidity; Depressive Disorder; Electroencephalography; | 2011 |
Suspected phenobarbital-induced pseudolymphoma in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Epilepsy; Female; Levetiracetam; Phenobarbital; Pirace | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T | 2011 |
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epile | 2011 |
Hyperammonemic encephalopathy related to valproate, phenobarbital, and topiramate synergism.
Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Middl | 2011 |
Factors influencing carbamazepine pharmacokinetics in children and adults: population pharmacokinetic analysis.
Topics: Adult; Aging; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressure Liquid; Drug Inte | 2011 |
Infants born to mothers under phenobarbital treatment: correlation between serum levels and clinical features of neonates.
Topics: Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Hospitals, University; Humans; Infant, New | 2011 |
Long-term neurological outcome of term-born children treated with two or more anti-epileptic drugs during the neonatal period.
Topics: Anticonvulsants; Apgar Score; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Fol | 2012 |
Fast activity during EEG seizures in neonates.
Topics: Anticonvulsants; Brain; Child Development; Electroencephalography; Epilepsy; Female; Humans; Infant, | 2011 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, | 2011 |
Urine phenobarbital drug screening: potential use for compliance assessment in neonates.
Topics: Epilepsy; Humans; Infant, Newborn; Medication Adherence; Phenobarbital | 2012 |
Sturge-Weber syndrome with an unusual onset in the sixth decade: a case report.
Topics: Anticonvulsants; Calcinosis; Epilepsy; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Mal | 2012 |
Antiepleptic drug interactions: a clinical case demonstration.
Topics: Adolescent; Anticonvulsants; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epi | 2011 |
Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report.
Topics: Adenoma, Liver Cell; Adolescent; Anticonvulsants; Epilepsy; Female; Humans; Intracranial Arterioveno | 2012 |
Neurogenesis in a young dog with epileptic seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Autopsy; Case-Control Studies; Cell Differentiation; | 2012 |
Safety profile of phenobarbital: can meta-analyses tell us the truth?
Topics: Anticonvulsants; Epilepsy; Female; Humans; Male; Phenobarbital; Pregnancy | 2011 |
Comparison of phenobarbital with bromide as a first-choice antiepileptic drug for treatment of epilepsy in dogs.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Epilepsy; Female; Male; Phenobarbital; Time | 2012 |
Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients.
Topics: Acetylation; Adult; Anticonvulsants; Case-Control Studies; DNA Methylation; Dose-Response Relationsh | 2012 |
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dioxolanes; Dose-Response | 2012 |
Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; China; Epilepsy; Female; Follow- | 2012 |
Cognitive and mood effects of phenobarbital treatment in people with epilepsy in rural China: a prospective study.
Topics: Adult; Affect; Anticonvulsants; China; Cognition; Demography; Epilepsy; Female; Follow-Up Studies; H | 2012 |
Results of an action-research on epilepsy in rural Mali.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Disease-Free Survival; Epilepsy; Female | 2012 |
Long-term outcome of phenobarbital treatment for epilepsy in rural China: a prospective cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; China; Cohort | 2013 |
Special issue: Phenobarbital: the Centenary - 10th European Congress on Epileptology, London - October 1, 2012. Introduction.
Topics: Anticonvulsants; Epilepsy; History, 20th Century; History, 21st Century; Humans; Phenobarbital | 2012 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human | 2012 |
How phenobarbital revolutionized epilepsy therapy: the story of phenobarbital therapy in epilepsy in the last 100 years.
Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Drug Costs; Epilepsy; Europe; Germany; History, 19 | 2012 |
Leukemoid reaction secondary to hypersensitivity syndrome to phenobarbital: a case report.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Epilepsy; Female; Humans; Leukemoid Reaction; Phenoba | 2013 |
[Intravenous injection of phenobarbital for benign convulsions with mild gastroenteritis].
Topics: Child, Preschool; Epilepsy; Female; Gastroenteritis; Humans; Infant; Injections, Intravenous; Male; | 2012 |
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr | 2012 |
Phenobarbital: missing in action.
Topics: Anticonvulsants; Epilepsy; Global Health; Humans; Phenobarbital; World Health Organization | 2012 |
P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barri | 2002 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Relationship between changes in drug score, D-glucaric acid excretion, and gamma-glutamyltransferase and beta-glucuronidase serum activities during anticonvulsant treatment.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Enzyme Induction; Epilepsy; | 2002 |
Treatment with phenobarbital and monitoring of epileptic patients in rural Mali.
Topics: Adolescent; Adult; Aftercare; Aged; Anticonvulsants; Case Management; Child; Child, Preschool; Drug | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Epilepsy in children in Benin City, Nigeria.
Topics: Adolescent; Age Distribution; Anticonvulsants; Asphyxia Neonatorum; Child; Child, Preschool; Develop | 2002 |
[Treatment of epilepsy in rural areas in Mali].
Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Follow-Up Studies; Humans; Male; Mali; Middle Aged; | 2002 |
Placental transfer of phenobarbitone in epileptic women, and elimination in newborns.
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; | 1967 |
Disposition and clinical use of bromide in cats.
Topics: Administration, Oral; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Dose-Response Relation | 2002 |
Evaluation of therapeutic drug monitoring of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Rela | 2003 |
Clinical pharmacology of topiramate versus lamotrigine versus phenobarbital: comparison of efficacy and side effects using odds ratios.
Topics: Anticonvulsants; Costs and Cost Analysis; Dose-Response Relationship, Drug; Epilepsy; Fructose; Huma | 2003 |
Effects of valproic acid, carbamazepine, and phenobarbitone on the fatty acid composition of erythrocyte membranes in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocyte Membrane; | 2003 |
Serum carbamazepine concentrations in elderly patients: a case-matched pharmacokinetic evaluation based on therapeutic drug monitoring data.
Topics: Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 CYP | 2003 |
Liver-related biochemical changes in the serum of dogs being treated with phenobarbitone.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Chemical and Drug Induced Live | 2003 |
Famine-associated AED toxicity in rural Zambia.
Topics: Anticonvulsants; Developing Countries; Drug Therapy, Combination; Epilepsy; Follow-Up Studies; Human | 2003 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions.
Topics: Acetic Acid; Age Factors; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; G | 2003 |
[Experiences with comital and comital-L].
Topics: Barbiturates; Drug Combinations; Epilepsy; Hydantoins; Mephobarbital; Phenobarbital; Phenytoin | 1951 |
[Significance of the attack point of diphenylhydantoin, phenobarbital and the acylureas for our comprehension of the physiopathological mechanism of epilepsy].
Topics: Animals; Barbiturates; Behavior, Animal; Comprehension; Epilepsy; Humans; Hydantoins; Phenobarbital; | 1953 |
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..].
Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S | 1953 |
[Epilepsy therapy with the combination preparation centronal compositum].
Topics: Aminopyrine; Caffeine; Epilepsy; Humans; Hydantoins; Phenobarbital; Porphyrins | 1957 |
Megaloblastic anaemia occurring during treatment of epilepsy with phenytoin sodium, primidone and phenobarbitone.
Topics: Anemia; Anemia, Megaloblastic; Anticonvulsants; Epilepsy; Humans; Hydantoins; Phenobarbital; Phenyto | 1957 |
Objective comparison of primidone and phenobarbital in epileptics.
Topics: Epilepsy; Humans; Phenobarbital; Primidone | 1957 |
New method of phenobarbitone administration in the treatment of epilepsy.
Topics: Epilepsy; Humans; Phenobarbital | 1958 |
[Practical notes on the symptomatic treatment in essential epilepsy].
Topics: Epilepsy; Humans; Phenobarbital | 1958 |
Diphenylhydantoin and phenobarbital in serum in patients with epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Phenobarbital; Phenytoin | 1958 |
Clinical trial with trinuride.
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital | 1958 |
Effects of drugs on secondary epileptogenic lesions.
Topics: Chlorpromazine; Epilepsy; Humans; Hydantoins; Phenobarbital | 1961 |
[The medical therapy of temporal epilepsy].
Topics: Epilepsy; Humans; Phenobarbital | 1960 |
Effect of-anticonvulsant drugs on cortical and subcortical seizure discharges in cats.
Topics: Animals; Anticonvulsants; Cats; Epilepsy; Humans; Hydantoins; Phenobarbital; Seizures | 1960 |
Serum bromide and urine phenobarbital contents of epilepitc patients.
Topics: Bromides; Epilepsy; Humans; Phenobarbital | 1960 |
Aspects of the pharmacology of phenytoin (dilantin) and phenobarbital relevant to their dosage in the treatment of epilepsy.
Topics: Epilepsy; Humans; Hydantoins; Phenobarbital; Phenytoin | 1960 |
Megaloblastic anaemia during combined phensuximide and phenobarbitone therapy.
Topics: Anemia; Anemia, Megaloblastic; Anticonvulsants; Epilepsy; Phenobarbital; Succinimides | 1961 |
[Clinical experiences of trinuride on epilepsy].
Topics: Anticonvulsants; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Seizures | 1962 |
Differential effects of antiepileptics on hippocampal and pallidal afterdischarges in cats.
Topics: Animals; Anticonvulsants; Cats; Epilepsy; Globus Pallidus; Hippocampus; Phenobarbital; Phenytoin | 1962 |
[Now and then: development of drug treatment of epilepsy since A. Hauptmann].
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone; Pyrrolidinones | 1962 |
Treatment of epilepsy.
Topics: Acetazolamide; Anticonvulsants; Automatism; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clon | 1963 |
[Neurologic-psychiatric problems of extended 1st aid].
Topics: Cerebrovascular Disorders; Chlorpromazine; Epilepsy; First Aid; Humans; Mental Disorders; Meperidine | 1963 |
Phenobarbital. Its effect on learning in epileptic children.
Topics: Child; Epilepsy; Humans; Learning; Phenobarbital | 1962 |
ANTIEPILEPTIC DRUGS.
Topics: Acetazolamide; Amphetamine; Amphetamines; Anticonvulsants; Barbiturates; Bromides; Epilepsy; Ethosux | 1963 |
ANTI-EPILEPTIC DRUGS AND THE FOETUS.
Topics: Barbiturates; Epilepsy; Female; Fetal Diseases; Fetus; Phenobarbital; Phenytoin; Pregnancy; Pregnanc | 1963 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT THERAPY.
Topics: Amobarbital; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Barbiturates; Epilepsy; Fol | 1963 |
MEGALOBLASTIC ANEMIA ASSOCIATED WITH THE INGESTION OF PHENOBARBITAL AND PRIMIDONE. REPORT OF A CASE IN A SIX-YEAR-OLD CHILD.
Topics: Anemia, Aplastic; Anemia, Macrocytic; Anemia, Megaloblastic; Anti-Bacterial Agents; Barbiturates; Ca | 1963 |
EFFECT OF PSYCHOACTIVE DRUGS ON ESCAPE FROM AUDIOGENIC SEIZURES.
Topics: Behavior, Animal; Chlorpromazine; Epilepsy; Imipramine; Mice; Pentobarbital; Perphenazine; Pharmacol | 1963 |
CURABLE MEDICAL DISEASES. THE NERVOUS SYSTEM. V. THE MANAGEMENT OF EPILEPSY.
Topics: Anticonvulsants; Central Nervous System Depressants; Epilepsy; Humans; Hydantoins; Phenobarbital; Pr | 1963 |
THE INFANT WITH EPILEPSY.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific | 1963 |
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate; | 1963 |
DOSAGE OF PHENYTOIN AND PHENOBARBITAL IN CHILDREN.
Topics: Blood Chemical Analysis; Child; Epilepsy; Fever; Humans; Phenobarbital; Phenytoin; Seizures | 1963 |
[EPILEPSY IN INFANCY AND CHILDHOOD. REMARKS ON 360 PERSONAL CASES].
Topics: Adolescent; Adrenocorticotropic Hormone; Birth Injuries; Brain; Brain Damage, Chronic; Brain Disease | 1963 |
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.
Topics: Anemia; Anemia, Macrocytic; Anticonvulsants; Biological Assay; Blood Chemical Analysis; Enterococcus | 1964 |
[GENESIS, CLASSIFICATION AND THERAPY OF LOSS OF CONSCIOUSNESS].
Topics: Caffeine; Child; Classification; Electroencephalography; Epilepsy; Epilepsy, Absence; Humans; Oxyphe | 1963 |
CONVULSIONS.
Topics: Black People; Diagnosis, Differential; Epilepsy; Humans; Intellectual Disability; Phenobarbital; Phe | 1964 |
EPILEPSY AND LUPUS ERYTHEMATOSUS.
Topics: Acetazolamide; Amphetamine; Anticonvulsants; Child; Dexamethasone; Diagnosis; Epilepsy; Lupus Erythe | 1964 |
ACCUMULATION OF PHENOBARBITAL IN MAN.
Topics: Blood Chemical Analysis; Epilepsy; Humans; Male; Metabolism; Phenobarbital | 1963 |
MEDICAL TREATMENT OF EPILEPSIES IN CHILDHOOD. A LONG-TERM SURVEY OF 801 PATIENTS.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child; Electroenc | 1963 |
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK.
Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions, | 1964 |
PSYCHOMOTOR VARIANT TYPE OF SEIZURE DISCHARGE.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1963 |
CONVULSIVE EQUIVALENT SYNDROME OF CHILDHOOD.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Autonomic Nervous System Diseases; Child; Chlorpromazine | 1964 |
[THERAPY OF EPILEPSY].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Chlordiazepoxide; Epilepsy; Epilepsy, Temporal Lobe; H | 1964 |
[TREATMENT OF EPILEPSY IN ADULTS. A BRIEF SURVEY OF THE CLINICAL PROBLEMS].
Topics: Acetazolamide; Anticonvulsants; Blood Chemical Analysis; Chloral Hydrate; Data Collection; Electroen | 1964 |
CONVULSIONS IN INFANCY AND CHILDHOOD.
Topics: Anticonvulsants; Child; Electroencephalography; Encephalitis; Epilepsy; Epilepsy, Absence; Epilepsy, | 1963 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL. SERUM LEVELS IN CHILDREN.
Topics: Adolescent; Blood; Child; Drug Therapy; Epilepsy; Humans; Infant; Pharmacology; Phenobarbital; Pheny | 1964 |
[CONVULSIONS IN CHILDREN (3)].
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Bromides; Child; Electroence | 1964 |
SEIZURES INDUCED BY MOVEMENT: A FORM OF REFLEX EPILEPSY.
Topics: Adolescent; Athetosis; Cerebral Angiography; Diagnosis, Differential; Electroencephalography; Epilep | 1964 |
[OBSERVATION ON TWO CASES OF EPILEPSIA CURSIVA].
Topics: Adolescent; Atrophy; Barbiturates; Cerebral Cortex; Chlordiazepoxide; Dichlorphenamide; Electroencep | 1964 |
REPORT ON THE ANTI-EPILEPTIC ACTION OF TEGRETOL.
Topics: Acetazolamide; Adolescent; Anticonvulsants; Biomedical Research; Carbamazepine; Child; Chlordiazepox | 1964 |
ZARONTIN (ETHOSUXIMIDE) IN THE TREATMENT OF PETIT MAL AND RELATED DISORDERS.
Topics: Adolescent; Anticonvulsants; Biomedical Research; Child; Denmark; Drug Therapy; Epilepsy; Epilepsy, | 1964 |
[ANTI-EPILEPTIC ACTIVITY OF TRINURIDE].
Topics: Anticonvulsants; Epilepsy; Pharmacology; Phenobarbital; Phenytoin; Toxicology | 1964 |
EFFECTS OF ANTICONVULSIVE MEDICATION ON VESTIBULAR FUNCTION. AN ELECTRONYSTAGMOGRAPHIC STUDY.
Topics: Electronystagmography; Epilepsy; Humans; Nystagmus, Pathologic; Pharmacology; Phenobarbital; Phenyto | 1964 |
CYSTICERCUS CELLULOSAE. A CASE REPORT.
Topics: Animals; Brain Diseases; Calcification, Physiologic; Cysticercosis; Cysticercus; Epilepsy; Epilepsy, | 1964 |
[REHABILITATION OF THE EPILEPTIC. CLINICAL EXPERIENCE WITH A POTENTIALIZED ANTICONVULSANT].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin | 1964 |
[EFFECT AND INDICATION OF A NEW ANTIEPILEPTIC DRUG].
Topics: Anticonvulsants; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tempor | 1964 |
[THE PROSTRATION SYNDROME. SERIOUS DANGER OF DRUG THERAPY IN EPILEPSY].
Topics: Adolescent; Anticonvulsants; Chlorpromazine; Down Syndrome; Drug Therapy; Electroencephalography; Ep | 1964 |
[TREATMENT OF PATIENTS WITH EPILEPSY WITH FREQUENT PETIT MAL SEIZURES].
Topics: Anticonvulsants; Caffeine; Drug Therapy; Epilepsy; Epilepsy, Absence; Humans; Phenobarbital; Seizure | 1964 |
PAROXYSMAL SNEEZING.
Topics: Anticonvulsants; Child; Child Psychiatry; Epilepsy; Epilepsy, Temporal Lobe; Humans; Hydantoins; Met | 1964 |
EXPERIMENTAL SUBCORTICAL EPILEPTIFORM FOCUS.
Topics: Aluminum; Amygdala; Cats; Electroencephalography; Epilepsy; Hippocampus; Pharmacology; Phenobarbital | 1964 |
HINTS ON SEIZURE MANAGEMENT.
Topics: Anticonvulsants; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Hu | 1964 |
IATROGENIC MEGALOBLASTIC ANAEMIA WITH NEUROLOGICAL COMPLICATIONS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Brain Diseases; Cysticercosis; Drug Therapy; Epil | 1964 |
HAEMORRHAGE ASSOCIATED WITH THROMBOCYTOPENIA IN MEGALOBLASTIC ANAEMIA.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Blood Platelet Disorders; Drug Therapy; Epilepsy; | 1964 |
[3 CASES OF TELEVISION EPILEPSY].
Topics: Child; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Reflex; Humans; Phenobarbital; Phen | 1964 |
NOTE ON THE INTERACTIONS OF AMPHETAMINE WITH ANTICONVULSANT DRUGS.
Topics: Amphetamine; Amphetamines; Animals; Anticonvulsants; Electricity; Electroshock; Epilepsy; Epilepsy, | 1964 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
EPILEPSY AFTER RUPTURED INTRACRANIAL ANEURYSM.
Topics: Aneurysm, Ruptured; Anticonvulsants; Diagnosis; Epilepsy; Hematoma; Humans; Intracranial Aneurysm; P | 1965 |
[POSSIBILITIES OF COMBINED ANTICONVULSANT TREATMENT IN CHRONIC SEIZURES].
Topics: Adolescent; Anticonvulsants; Child; Drug Therapy; Epilepsy; Humans; Infant; Infant, Newborn; Phenoba | 1964 |
MEGALOBLASTIC ANEMIA AND NEUROLOGIC DISTURBANCES COMBINED WITH FOLIC ACID DEFICIENCY. OBSERVATIONS ON AN EPILEPTIC PATIENT TREATED WITH ANTICONVULSANTS.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Avitaminosis; Barbiturates; Brai | 1964 |
TREATMENT OF HEADACHES IN CHILDREN.
Topics: Adolescent; Child; Drug Therapy; Epilepsy; Headache; Humans; Methysergide; Migraine Disorders; Pheno | 1964 |
NOCTURNAL EPILEPSY AND HYPOGLYCAEMIA.
Topics: Anticonvulsants; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Therapy; Electroencephal | 1964 |
TEMPORAL LOBE EPILEPSY: A CLINICAL STUDY OF 47 CASES.
Topics: Adolescent; Biomedical Research; Birth Injuries; Depression; Depressive Disorder; Diagnosis, Differe | 1964 |
CHILD CARE IN GENERAL PRACTICE. CONVULSIONS IN INFANCY AND CHILDHOOD. II.
Topics: Acetazolamide; Anticonvulsants; Bromides; Child; Child Care; Chloral Hydrate; Diagnosis; Drug Therap | 1965 |
EPILEPSY DUE TO WATER IMMERSION: AN UNUSUAL CASE OF REFLEX SENSORY EPILEPSY.
Topics: Baths; Drug Therapy; Epilepsy; Epilepsy, Partial, Sensory; Humans; Infant; Phenobarbital; Reflex; Wa | 1965 |
[CONTRIBUTION TO THE STUDY OF THE EPILEPTIC DISEASE].
Topics: Acetylcholine; Antidepressive Agents; Biomedical Research; Drug Therapy; Epilepsy; Metabolism; Patho | 1964 |
[CLINICAL CONTRIBUTION TO TEMPORAL LOBE EPILEPSY].
Topics: Adolescent; Child; Drug Therapy; Electroencephalography; Epilepsy; Epilepsy, Temporal Lobe; Humans; | 1965 |
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti | 1965 |
SERUM PHENYTOIN DETERMINATIONS IN EPILEPTICS.
Topics: Anticonvulsants; Blood Chemical Analysis; Child; Drug Therapy; Electroencephalography; Epilepsy; Hum | 1964 |
[CLINICAL COMMUNICATION ON THE THERAPY OF EPILEPSY WITH MALIASIN].
Topics: Anticonvulsants; Drug Therapy; Epilepsy; Phenobarbital | 1965 |
SKIN PIGMENTATION, A RARE SIDE EFFECT OF CHLORPROMAZINE.
Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Diagnosis, Differential; Drug Therapy; Epilepsy; Eye | 1965 |
SEXUAL IMPOTENCE AND THE LIMBIC SYSTEM.
Topics: Astrocytoma; Brain Neoplasms; Diagnosis, Differential; Epilepsy; Epilepsy, Temporal Lobe; Erectile D | 1965 |
EFFECTS OF CORTICAL SPREADING DEPRESSION AND DRUGS UPON AUDIOGENIC SEIZURES IN RATS.
Topics: Brain; Cerebral Cortex; Cortical Spreading Depression; Electrophysiology; Epilepsy; Epilepsy, Reflex | 1965 |
MEGALOBLASTIC ANAEMIA ASSOCIATED WITH ANTICONVULSANT DRUGS: STUDIES ON A CASE WITH FOUR RELAPSES.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Drug Therapy; Electrophoresis; Epilepsy; | 1965 |
TRINURIDE IN THE TREATMENT OF MAJOR EPILEPSY.
Topics: Aggression; Anticonvulsants; Depression; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Phenobarbit | 1965 |
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu | 1965 |
[EXPERIENCES IN THE TREATMENT OF EPILEPSY IN ADULTS].
Topics: Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Hydantoins; Phenobarbital | 1964 |
THE PERIODICALLY RECURRING FOCAL DISCHARGE.
Topics: Animals; Cerebrovascular Disorders; Child; Drug Therapy; Electrocardiography; Electroencephalography | 1965 |
Blood serum and cerebrospinal fluid levels and renal clearance of phenemal in treated epileptics.
Topics: Barbiturates; Blood; Cerebrospinal Fluid; Epilepsy; Phenobarbital; Serum; Urinary Tract Physiologica | 1954 |
[Leukemia in an epileptic treated with gardenal and dihydan; recovery; fatal mysoline poisoning with fatty degeneration of the liver and acute epithelial nephritis].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Hydantoins; Leukemia; Leukocytosis; Liver Diseases; | 1955 |
Validated high performance liquid chromatographic method for simultaneous determination of phenytoin, phenobarbital and carbamazepine in human serum.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Indicators a | 2003 |
Comparative results in seizure control using phenobarbital, dilantin, and mesantoin.
Topics: Barbital; Epilepsy; Hydantoins; Mephenytoin; Phenobarbital; Phenytoin; Seizures | 1950 |
[Blood and spinal phenemal levels in epilepsy therapy].
Topics: Barbiturates; Epilepsy; Humans; Phenobarbital | 1952 |
Barbexaclone use in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Phen | 2004 |
Cost of epilepsy in patients attending a secondary-level hospital in India.
Topics: Anticonvulsants; Carbamazepine; Efficiency, Organizational; Epilepsy; Hospital Costs; Hospitalizatio | 2004 |
The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cholesterol; Cholesterol, HDL; Cholesterol, | 2004 |
Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats.
Topics: Amygdala; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Female; Kin | 2004 |
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2004 |
The AED (antiepileptic drug) pregnancy registry: a 6-year experience.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Maternal Exposure; Phenobarb | 2004 |
Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electro | 2004 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2004 |
Epilepsy in the United Kingdom: seizure frequency and severity, anti-epileptic drug utilization and impact on life in 1652 people with epilepsy.
Topics: Adult; Aged; Anticonvulsants; Drug Utilization; Epilepsy; Female; Humans; Male; Middle Aged; Phenoba | 2004 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination | 2004 |
[Carbamazepine or phenobarbitone monotherapy in epilepsy?].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Evidence-Based Medicine; Humans; Phenobarbital | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Assessment of the epilepsy treatment gap in two cities of south-east of Brazil.
Topics: Adult; Anticonvulsants; Brazil; Carbamazepine; Epilepsy; Health Services Accessibility; Health Servi | 2004 |
Fracture risk associated with use of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Denmark; Epilepsy; Female | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
Revisiting phenobarbital for epilepsy.
Topics: Anticonvulsants; Developed Countries; Developing Countries; Epilepsy; Humans; Phenobarbital | 2004 |
Serum alkaline phosphatase isoenzyme profiles in phenobarbital-treated epileptic dogs.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Cross-Sectional Studies; Dog Diseases; Dogs; Epileps | 2004 |
Isoforms of serum gamma-glutamyltransferase in epileptic patients treated with enzyme-inducing anticonvulsant drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; gamma-Glutamyltransferase; Humans; Isoenzym | 2004 |
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Chil | 2004 |
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine; | 2004 |
Phenobarbital: a drug for the 21st century?
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital | 2004 |
Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 2004 |
Gingival enlargement in children treated with antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Cross-Sectional Studies; Dental Plaque | 2004 |
Phenobarbital pharmacokinetics in old age: a case-matched evaluation based on therapeutic drug monitoring data.
Topics: Adult; Age Distribution; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anticonvulsants; B | 2005 |
Liver histopathology and liver and serum alanine aminotransferase and alkaline phosphatase activities in epileptic dogs receiving phenobarbital.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Chemical and Drug Induced Live | 2005 |
Determination of levetiracetam in human plasma with minimal sample pretreatment.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Epilepsy; Humans; | 2005 |
Phenobarbital for epilepsy: much is still to be learnt.
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital | 2005 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
Quality of phenobarbital solid-dosage forms in the urban community of Nouakchott (Mauritania).
Topics: Anticonvulsants; Chemistry, Pharmaceutical; Cross-Cultural Comparison; Cross-Sectional Studies; Drug | 2005 |
Fit for a fracture.
Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fract | 2005 |
Use of phenobarbitone for treating childhood epilepsy in resource-poor countries.
Topics: Anticonvulsants; Child; Developing Countries; Epilepsy; Health Policy; Health Resources; Humans; Phe | 2005 |
Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetamides; Anim | 2006 |
Treatment delay and the risk of prolonged status epilepticus.
Topics: Administration, Rectal; Anticonvulsants; Benzodiazepines; Child, Preschool; Clinical Protocols; Dise | 2005 |
Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent.
Topics: Amines; Animals; Anticonvulsants; Bromides; Chemotherapy, Adjuvant; Cyclohexanecarboxylic Acids; Dog | 2005 |
Neurocognitive effects of phenobarbital discontinuation in epileptic children.
Topics: Anticonvulsants; Child; Cognition; Epilepsy; Female; Humans; Intelligence; Male; Phenobarbital; Pros | 2006 |
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; | 2005 |
[Epileptic encephalopathy].
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Cognition Disorders; Electroencephalography; Epilep | 2006 |
[Rapid analysis of antiepileptic drugs in human plasma by micellar electrokinetic capillary chromatography].
Topics: Anticonvulsants; Buffers; Carbamazepine; Chromatography, Micellar Electrokinetic Capillary; Clonazep | 2006 |
[Evaluation of the efficacy of phenobarbital in treatment of epilepsy in rural areas: study of 2455 patients in rural China].
Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Fema | 2006 |
On the mechanism of alleviation by phenobarbital of the malfunction of an epilepsy-linked GABA(A) receptor.
Topics: Allosteric Regulation; Animals; Cells, Cultured; Drug Synergism; Epilepsy; gamma-Aminobutyric Acid; | 2006 |
Premature mortality in people with epilepsy in rural China: a prospective study.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Cause of Death; Child; Chi | 2006 |
Idiopathic epilepsy in dogs: owners' perspectives on management with phenobarbitone and/or potassium bromide.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Phenoba | 2006 |
Antiepileptic TDM pattern at a tertiary care hospital in India.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; India; Pharmacology, Clinical; Ph | 2006 |
Serum lipid profile in children receiving anti-epileptic drug monotherapy: is it atherogenic?
Topics: Adolescent; Anticonvulsants; Apolipoproteins; Atherosclerosis; Carbamazepine; Child; Cholesterol, HD | 2006 |
Psychological factors and use of antiepileptic drugs: pilot work using an objective measure of adherence.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Anxiety; Culture; Depression; Drug Monitoring; Drug Therap | 2007 |
The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children.
Topics: Anticonvulsants; Antioxidants; Bilirubin; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; | 2007 |
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CY | 2007 |
Unilateral multicystic dysplastic kidney in infants exposed to antiepileptic drugs during pregnancy.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Follow-Up Studies; Humans; Infant, Newborn; Matern | 2007 |
Evaluation of therapeutic drug level monitoring of phenobarbital, phenytoin and carbamazepine in Iranian epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile | 2007 |
The efficacy and tolerability of levetiracetam in pharmacoresistant epileptic dogs.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Thera | 2008 |
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 2007 |
Availability and costs of antiepileptic drugs and quality of phenobarbital in Vientiane municipality, Lao PDR.
Topics: Anticonvulsants; Costs and Cost Analysis; Developing Countries; Epilepsy; Female; Health Services Ac | 2007 |
Bone density and bone turnover markers in patients with epilepsy on chronic antiepileptic drug therapy.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone and Bones; Bone Density; Bone Density | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Increased P-glycoprotein expression and decreased phenobarbital distribution in the brain of pentylenetetrazole-kindled rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Brain; Brain Ch | 2007 |
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H | 2007 |
Fractures and handicap in an adult population: A clinical study.
Topics: Adult; Biomarkers; Calcium; Collagen Type I; Comorbidity; Disabled Persons; Epilepsy; Female; Fractu | 2007 |
Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome.
Topics: Acyclovir; Aged; Anticonvulsants; Antiviral Agents; Coma; Drug Hypersensitivity; Encephalitis; Epile | 2008 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose- | 2008 |
Response to Birbeck et al.
Topics: Acquired Immunodeficiency Syndrome; Africa South of the Sahara; Anti-Retroviral Agents; Anticonvulsa | 2008 |
Levetiracetam as an adjunct to phenobarbital treatment in cats with suspected idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Drug Therapy, Combination; Epilepsies, Partial; Epilep | 2008 |
[Study of oro-dental injuries during seizures in Senegalese children with epilepsy].
Topics: Accidental Falls; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Ma | 2007 |
Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Cel | 2008 |
Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cognition Disorders; Dis | 2008 |
Post-hemiplegic epilepsy in the elderly.
Topics: Aged; Epilepsy; Female; Hemiplegia; Humans; Intracranial Embolism and Thrombosis; Male; Middle Aged; | 1967 |
Epilepsy--facts and fancy.
Topics: Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin | 1967 |
Language-induced epilepsy.
Topics: Electroencephalography; Epilepsy; Ethosuximide; Humans; Male; Middle Aged; Movement Disorders; Penty | 1967 |
The influence of disulfiram and calcium carbimide on the serum diphenylhydantoin. Excretion of HPPH in the urine.
Topics: Acetazolamide; Adult; Aged; Alcoholism; Amitriptyline; Chlordiazepoxide; Chlorpromazine; Chromatogra | 1967 |
[The schooling of epileptic children. Longitudinal study of 32 children of the Centre de Toul-Ar-C'Hoat who successfully passed school examinations in 1965 and 1966].
Topics: Adolescent; Calcium; Education; Epilepsy; Humans; Phenobarbital; Vitamins | 1967 |
[EEG studies of cases with epileptic and intricate somatic manifestations].
Topics: Adult; Asthma; Atropa belladonna; Caffeine; Child; Drug Tolerance; Eczema; Electroencephalography; E | 1967 |
Serum creatine phosphokinase activity in epilepsy. Clinical and experimental studies.
Topics: Animals; Child; Creatine Kinase; Electroshock; Epilepsy; Female; Gallamine Triethiodide; Humans; Mal | 1967 |
Epilepsy induced by cardiac pacemaker.
Topics: Aged; Amobarbital; Digoxin; Epilepsy; Female; Humans; Nerve Crush; Pacemaker, Artificial; Phenobarbi | 1967 |
[Severe megaloblastic anemia due to anticonvulsants, sensitive to folic acid].
Topics: Adult; Anemia, Macrocytic; Epilepsy; Humans; Male; Phenobarbital; Primidone | 1967 |
Anticonvulsant therapy and its possible consequences on peripheral nervous system: a neurographic study.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neural Conduction; Peripheral Nerves; Peripheral N | 1984 |
Psychiatric implications of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dose-Response Relationship, Dr | 1980 |
[Effect of barbexaclone treatment on thyroid function in epileptic children and juveniles (author's transl)].
Topics: Adolescent; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenyt | 1980 |
Epileptic seizures induced by thyrotropin releasing hormone.
Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Thyrotropin-Releasing Hormone | 1981 |
Choice of anticonvulsants in epilepsy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1981 |
The influence of antiepileptic drugs on the electroencephalogram: a review of controlled clinical studies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Electroencephalography; Epil | 1982 |
[Rise in gamma-GT during anticonvulsive therapy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio | 1982 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1983 |
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorde | 1983 |
A rapid gas liquid chromatography method for simultaneous determination of various anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; Humans; Ph | 1980 |
Plasma concentrations of valproate during maintenance therapy in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, A | 1982 |
Interactions between primidone, carbamazepine, and nicotinamide.
Topics: Animals; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epile | 1982 |
Potentiation of the antiepileptic activity of phenobarbital by nicotinamide.
Topics: Animals; Anticonvulsants; Drug Synergism; Epilepsy; Female; Mice; Niacinamide; Phenobarbital | 1983 |
[Antiepileptic effects of synthetic pharmacologic agents and vitamin preparations used in combination].
Topics: Animals; Anticonvulsants; Crosses, Genetic; Diazepam; Drug Therapy, Combination; Epilepsy; Mice; Mic | 1984 |
Peripheral neuropathy in epileptic patients.
Topics: Epilepsy; H-Reflex; Humans; Neural Conduction; Peripheral Nervous System Diseases; Peroneal Nerve; P | 1981 |
[Sodium valproate: a hyperammonemic drug. Study in the epileptic and healthy volunteer].
Topics: Ammonia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; | 1983 |
The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Epilepsy; Humans; | 1983 |
Diurnal fluctuations in free and total plasma concentrations of valproic acid at steady state in epileptic patients.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1983 |
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbit | 1983 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar | 1983 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Statu | 1983 |
Sodium valproate associated with phenobarbital: effects on ammonia metabolism in humans.
Topics: Adult; Ammonia; Epilepsy; Female; Humans; Kidney; Liver; Male; Middle Aged; Phenobarbital; Valproic | 1983 |
Treatment of the nonconvulsive epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi | 1983 |
The penetration of phenobarbital in generalized and focal penicillin-induced epileptic brain of the cat.
Topics: Absorption; Animals; Brain; Cats; Epilepsies, Partial; Epilepsy; Penicillins; Phenobarbital | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Unnecessary polypharmacy in patients with frequent seizures.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Epi | 1984 |
Side effects of phenobarbital and phenytoin during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain; Dose-Response Relationship, Drug; Drug Tolerance; Endocrine Syst | 1983 |
Antiepileptic drugs and psychiatric disorders: mechanism involved in manifestation of psychic symptoms of high blood level of antiepileptics.
Topics: Adult; Anticonvulsants; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Male; Mental D | 1983 |
Potentiation of the anticonvulsant effects of antiepileptic drugs by "nootropics"; a potential new therapeutic approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Drug Synergis | 1984 |
Summing up of the success so far gained through choice of drugs or combinations of drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum | 1984 |
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; In | 1984 |
[Clinical and electroencephalographic features of the action of the psychic stimulant sydnocarb in various forms of epilepsy].
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy; Epileps | 1984 |
Clinical value of determination of serum concentration of antiepileptics.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; In | 1984 |
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half- | 1984 |
[Plasma levels of antiepileptic agents in the treatment of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interac | 1984 |
Epilepsy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalogr | 1984 |
Effect of phenobarbital on cortical epileptogenic foci in the rat.
Topics: Animals; Cerebral Cortex; Electroencephalography; Electrophysiology; Epilepsy; Frontal Lobe; Male; O | 1981 |
[Concentration of phenobarbital in biological fluids during the treatment of epilepsy patients].
Topics: Adolescent; Adult; Chromatography, Gas; Epilepsy; Epilepsy, Temporal Lobe; Humans; Kinetics; Male; M | 1984 |
Medically resistant epilepsy: low levels of drugs in the brain or pharmacological inefficacy?
Topics: Adolescent; Adult; Brain; Drug Resistance; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin | 1984 |
Functional palatal incompetence in the fetal anticonvulsant syndrome.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy; Female; Humans; Male; Maternal-Fetal Exchan | 1984 |
Excretion of organic acids associated with biotin deficiency in chronic anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Biotin; Carbamazepine; Carboxy-Lyases; Carboxylic Acids; Epilepsy; Female; H | 1984 |
Efficacy of primidone in dogs with seizures unresponsive to phenobarbital.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Female; Male; Phenobarbital; Primidone | 1984 |
Single dose bedtime phenobarbitone therapy in epilepsy.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Phenob | 1984 |
Changes induced in human liver by long-term anticonvulsant therapy. Functional and ultrastructural data.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Endoplasm | 1984 |
[Benign neonatal familial epilepsy].
Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Phenobarbital | 1984 |
Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar | 1984 |
Chromosomal studies of peripheral blood from epileptic patients treated with phenobarbital and/or diphenylhydantoin.
Topics: Adult; Animals; Chromosome Aberrations; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; M | 1984 |
[Phenobarbital].
Topics: Adult; Child; Epilepsy; Female; Humans; Male; Phenobarbital | 1984 |
Effects of phenobarbital, diphenylhydantoin and carbamazepine on thyroid function in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; Phenytoin; Thyr | 1984 |
[Noncompliance in the treatment of epileptic children].
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Patient Complian | 1983 |
Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Gynecomastia; Humans; Male; Phenobarbital; Phenytoin; Pr | 1983 |
[Dupuytren's contracture and phenobarbital administration in epilepsy patients].
Topics: Adolescent; Adult; Bone Neoplasms; Dupuytren Contracture; Epilepsy; Female; Fibroma; Foot Diseases; | 1983 |
Oxazepam pharmacokinetics in patients with epilepsy treated long-term with phenytoin alone or in combination with phenobarbitone.
Topics: Adult; Bilirubin; Dialysis; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged | 1983 |
A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.
Topics: Absorptiometry, Photon; Adolescent; Adult; Aged; Anticonvulsants; Bone and Bones; Carbamazepine; Dru | 1983 |
Reduction of polypharmacy for epilepsy in an institution for the retarded.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Huma | 1983 |
Presenile cataracts in hydantoin-treated epileptic patients.
Topics: Adult; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rats | 1983 |
Carbamazepine--erythromycin interaction leading to carbamazepine toxicity in four epileptic children.
Topics: Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Erythromycin; Female; Humans; I | 1983 |
[Importance of timely diagnosis of benign childhood epilepsy with rolandic peaks].
Topics: Attitude to Health; Child; Child, Preschool; Combined Modality Therapy; Electroencephalography; Epil | 1983 |
[Vomiting: symptom of an epileptic seizure].
Topics: Adult; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; Female; Hu | 1983 |
[Alpha 1-acid glycoprotein and carbamazepine].
Topics: Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Orosomucoid; Phenob | 1983 |
PB:PRM ratio in patients with epilepsy treated with primidone.
Topics: Adolescent; Adult; Aging; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Primido | 1983 |
A design for the prospective evaluation of the efficacy and toxicity of antiepileptic drugs in adults.
Topics: Adult; Aged; Anticonvulsants; Behavior; Carbamazepine; Clinical Trials as Topic; Double-Blind Method | 1983 |
[Efficacy and failure of phenobarbital in the prevention of febrile convulsions. Importance of familial antecedents].
Topics: Age Factors; Epilepsy; Female; Fetal Hypoxia; Humans; Male; Phenobarbital; Pregnancy; Recurrence; Se | 1983 |
Together, phenobarbital and carbamazepine lower the alpha 1-acid glycoprotein concentration in plasma of epileptic patients.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Orosomucoid; Phenobarbital | 1984 |
Serum concentrations and efficacy of phenytoin, phenobarbital, and primidone in canine epilepsy.
Topics: Animals; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidon | 1984 |
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Anima | 1984 |
Variability of plasma phenobarbitone concentration in Asian children in Singapore.
Topics: Adolescent; Child; Child, Preschool; China; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1984 |
Antiepileptic drug utilization in pediatric patients.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Infant; Infant, Newborn; Kin | 1984 |
[Anticonvulsive combined therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Infant; Phenobarbital; Seizures; Seizur | 1980 |
[Differential treatment of epilepsy patients].
Topics: Anticonvulsants; Carbamazepine; Diagnosis, Differential; Drug Therapy, Combination; Epilepsy; Epilep | 1980 |
Consensus statement. Febrile seizures: long-term management of children with fever-associated seizures.
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Fever; Humans; Infant; Long-Term Care; National Institu | 1980 |
Pharmacokinetics of anticonvulsant drugs.
Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epil | 1980 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Mechanism of valproate-phenobarbital interaction in epileptic patients.
Topics: Adolescent; Adult; Child; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital | 1981 |
Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels.
Topics: Adolescent; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1980 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Valproic acid fails to displace phenobarbitone and carbamazepine from plasma protein binding sites in epileptic patients.
Topics: Adolescent; Adult; Binding, Competitive; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Ma | 1981 |
The effect of concurrent administration of valproate sodium on phenobarbital plasma concentration/dosage ratio in pediatric patients.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Inf | 1981 |
[Polytherapy and monotherapy in the treatment of patients with epilepsy].
Topics: Adult; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, | 1981 |
Recent advances in the treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma | 1980 |
[Spindles and spike waves in the sleep EEG of epileptic patients under administration of phenobarbital (PB) and phenytoin (DPH) (author's transl)].
Topics: Electroencephalography; Epilepsy; Evoked Potentials; Humans; Phenobarbital; Phenytoin; Sleep Stages | 1981 |
[A case of Pringle-Bourneville disease].
Topics: Adult; Carbamazepine; Epilepsy; Epilepsy, Absence; Female; Humans; Phenobarbital; Tuberous Sclerosis | 1981 |
A computer analysis of specific and aspecific interictal epileptic activity in man.
Topics: Computers; Electroencephalography; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1980 |
Increased serum phospholipids in epileptic children treated with phenobarbitone.
Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phospholipids; Valproic Acid | 1982 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem | 1982 |
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbita | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobar | 1982 |
[Studies on the mechanism of metabolic acidosis observed in the children treated with anticonvulsants].
Topics: Acidosis; Adolescent; Binding Sites; Calcium; Carbonic Anhydrases; Child; Child, Preschool; Drug The | 1982 |
[Mono- or polytherapy in the treatment of epileptic patients].
Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phen | 1983 |
Presenile cataracts in phenytoin-treated epileptic patients.
Topics: Adult; Aging; Animals; Cataract; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Rodentia | 1983 |
Plasma levels of primidone and its metabolite phenobarbital: effect of age and associated therapy.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Inte | 1983 |
Serum concentration of clonazepam and the therapeutic effect of the drug.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Clonazepam; Epilepsy; Female; Humans; Male; M | 1983 |
The influence of bilirubin, alcohol and certain drugs on the kinetics of 99mTc-Diethyl IDA (EHIDA) in humans.
Topics: Alcoholism; Bilirubin; Epilepsy; Ethanol; Humans; Imino Acids; Jaundice; Kinetics; Phenobarbital; Ph | 1983 |
Therapeutic serum concentrations of primidone and its metabolites, phenobarbital and phenylethylmalonamide in epileptic dogs.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Malonates; Phenobarbital; Phenylethylmalonamide; Primidone | 1983 |
[Epileptic seizures in chronic alcoholism].
Topics: Alcoholism; Epilepsy; Humans; Phenobarbital; Substance Withdrawal Syndrome | 1983 |
[Radioimmunologic study of the plasma concentrations of folic acid and various antiepileptic preparations during the treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Benzamidines; Drug Therapy, Combination; Epilepsy; Female; Folic | 1983 |
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals.
Topics: Acetaminophen; Animals; Anticonvulsants; Calcium; Carcinogens; Cytochrome P-450 Enzyme System; Epile | 1980 |
Nursing care study - drug overdose: dealing with an unknown quantity.
Topics: Adult; Epilepsy; Female; Flurazepam; Humans; Nursing Care; Phenobarbital | 1982 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
Dental root abnormalities and gingival overgrowth in epileptic patients receiving anticonvulsant therapy.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Gingival Hyperplasia; Humans; Intellectual Disability; M | 1980 |
Brain tumors in children exposed to barbiturates.
Topics: Adolescent; Adult; Brain Neoplasms; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenoba | 1981 |
Prescribing patterns for epilepsy.
Topics: Adult; Anticonvulsants; Child; Drug Prescriptions; Drug Therapy, Combination; Drug Utilization; Epil | 1981 |
Some immunological reactions during chronic treatment with antiepileptic drugs.
Topics: Adult; Antibody Formation; B-Lymphocytes; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; | 1981 |
Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Half-Life; Humans; | 1980 |
Valproic acid and plasma levels of phenobarbital.
Topics: Adult; Animals; Cats; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Male; Phenobar | 1980 |
[The determination of anticonvulsant drug levels in blood by enzyme immunoassay: method and clinical application (author's transl)].
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Immunoenzyme Techniques; Male; P | 1980 |
Stability of antiepileptic drug level in serum. Reliability of enzyme immunoassay method.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phe | 1980 |
Quality of care of epilepsy in Italy: multi-hospital survey of diagnosis and treatment of 1104 epileptic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Health Surveys; | 1982 |
Comparison of phenytoin and phenobarbital effects on far-field auditory and somatosensory evoked potential interpeak latencies.
Topics: Epilepsy; Evoked Potentials, Auditory; Evoked Potentials, Somatosensory; Humans; Phenobarbital; Phen | 1982 |
[Continuing treatment with phenemal in prevention of febrile convulsions. A report of children with the first febrile convulsions treated during 2 years].
Topics: Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Seizures, Febrile | 1982 |
Phenytoin: an inhibitor and inducer of primidone metabolism in an epileptic patient.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenylethylmalonamide; Phenytoin; | 1982 |
Duration of treatment for childhood epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Follow-Up Studies; Humans; Infant; Phenobarbit | 1982 |
The excretion of metabolites of the D-glucuronic acid pathway in human urine. Effect of phenobarbitone administration.
Topics: Adult; Epilepsy; Female; Glucuronates; Glucuronic Acid; Humans; Male; Middle Aged; Phenobarbital | 1982 |
Respiratory disease in patients with epilepsy on single-drug therapy with carbamazepine or phenobarbital.
Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immu | 1982 |
Differences between the concentrations of antiepileptic drugs in normal and pathological human brain.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Carbamazepine; Child; Electroencephalography; Epilepsy; F | 1982 |
Phenobarbital protein binding in neonates.
Topics: Adolescent; Aging; Blood Proteins; Child; Child, Preschool; Epilepsy; Humans; Infant; Infant, Newbor | 1982 |
[Serum beta-glucuronidase activity in patients treated with phenobarbital and diphenylhydantoin].
Topics: Adult; Drug Therapy, Combination; Enzyme Induction; Epilepsy; Female; Glucuronidase; Humans; Liver; | 1982 |
Serum phenobarbitone estimation in epilepsy.
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle A | 1982 |
Drug interactions during anticonvulsant medication.
Topics: Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phen | 1982 |
[Treatment of tinea microsporum. Metabolic interference between phenobarbital and griseofulvin].
Topics: Child; Drug Antagonism; Epilepsy; Female; Griseofulvin; Humans; Microbial Sensitivity Tests; Microsp | 1982 |
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt | 1980 |
Nonlinear kinetics of phenytoin in children.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, | 1982 |
Saliva phenobarbital and phenytoin concentrations in epileptic adolescents.
Topics: Adolescent; Child; Epilepsy; Female; Humans; Male; Patient Compliance; Phenobarbital; Phenytoin; Sal | 1981 |
Anterior spinal artery syndrome during the postpartum period.
Topics: Adult; Cerebral Hemorrhage; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange | 1981 |
A study on serum concentration of phenobarbital in epileptic children and children with febrile convulsions.
Topics: Child; Epilepsy; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1980 |
Quantitative assessment of smooth-pursuit eye movements in healthy and epileptic subjects.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electrooculography; Epilepsy; Eye Movements; Huma | 1980 |
[Phenobarbital intoxication in a patient with primidone and diphenylhydantoin (author's transl)].
Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1980 |
[Amicrobic pustulosis hypoparathyroidism epilepsy: treatment by 25-hydroxycholecalciferol].
Topics: Adolescent; Calcifediol; Diagnosis, Differential; Epilepsy; Humans; Hydroxycholecalciferols; Hypocal | 1980 |
[Influence of anti-epileptic drugs on blood lipid parameters: preliminary data].
Topics: Anticonvulsants; Carbamazepine; Cholesterol; Epilepsy; Humans; Lipids; Phenobarbital; Phenytoin; Tri | 1981 |
Ictal effects of anticonvulsant medication withdrawal in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle | 1981 |
[Polytherapy and monotherapy in the treatment of epileptic patients].
Topics: Adult; Computers; Drug Combinations; Epilepsy; Female; Humans; Male; Monitoring, Physiologic; Phenob | 1981 |
Does phenobarbital cause intracranial tumors? A follow-up through 35 years.
Topics: Adult; Brain Neoplasms; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neoplasm | 1981 |
[Epilepsy and hypocalcemia. Further considerations on a case].
Topics: Adult; Calcium; Epilepsy; Female; Goiter; Humans; Hypocalcemia; Hypoparathyroidism; Phenobarbital; P | 1981 |
Didepil for the treatment of epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Combinations; Electroencepha | 1980 |
Antiepileptic and side effects of didepil.
Topics: Adolescent; Adult; Anticonvulsants; Drug Combinations; Electroencephalography; Epilepsy; Female; Hum | 1980 |
Plasma level analysis of some antiepileptic drugs in 180 patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilep | 1980 |
The relationship between the serum levels of phenobarbital and diphenylhydantoin and clinical data in patients with drug resistant epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Resistance; Electroencephalography; Epilepsy; Femal | 1980 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal | 1981 |
Phenytoin and phenobarbitone plasma level-dose relationships in Chinese epileptic children in Singapore.
Topics: Adolescent; Child; Child, Preschool; China; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; P | 1981 |
Role of carbamazepine in reducing polypharmacy in epilepsy.
Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther | 1981 |
[Epilepsy after febrile seizures. Predisposing factors and role of phenobarbital in its prophylaxis (author's transl)].
Topics: Age Factors; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant, New | 1981 |
[Diagnosis of osteopathy caused by antiepileptic drugs].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Bone Diseases; Carbamazepine; Epilepsy; Female; Femur; Han | 1981 |
Febrile convulsions.
Topics: Child, Preschool; Epilepsy; Humans; Infant; Male; Phenobarbital; Prognosis; Seizures; Seizures, Febr | 1980 |
Improvement in antiepileptic drug levels following reduction of intervals between clinic visits.
Topics: Adolescent; Adult; Anticonvulsants; Appointments and Schedules; Carbamazepine; Epilepsy; Ethosuximid | 1980 |
Phenobarbitone and epilepsy.
Topics: Drug Prescriptions; Epilepsy; Humans; Legislation, Drug; Phenobarbital; Substance-Related Disorders; | 1980 |
Phenobarbitone and epilepsy.
Topics: Epilepsy; Humans; Legislation, Drug; Phenobarbital; Substance Withdrawal Syndrome | 1980 |
Phenobarbitone and epilepsy.
Topics: Epilepsy; Humans; Osteomalacia; Phenobarbital | 1980 |
Plasma high-density lipoprotein cholesterol in epileptics treated with various anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Cholesterol; Epilepsy; Female; Humans; Lipoproteins, HDL; Mal | 1980 |
Phenobarbitone in previously untreated epilepsy.
Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Mi | 1980 |
Antiepileptic drug distribution in cerebral cortex, ammon's horn, and amygdala in man.
Topics: Adolescent; Adult; Amygdala; Anticonvulsants; Carbamazepine; Cerebral Cortex; Child; Epilepsy; Femal | 1980 |
[Renal tubular acidification in patients treated with anticonvulsants (author's transl)].
Topics: Acidosis, Renal Tubular; Adolescent; Adult; Epilepsy; Humans; Hydantoins; Middle Aged; Phenobarbital | 1980 |
Multivariate statistical methods in toxicology: application to the analysis of outpatient clinical data for diphenylhydantoin and phenobarbital in the treatment of epilepsy.
Topics: Adolescent; Adult; Aging; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Sex | 1980 |
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
Topics: Adult; Aminopyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Half-Life; Humans; Hydroxylati | 1980 |
[Fulminating hepatitis caused by administration of isoniazid and rifampicin in a patient under chronic treatment with barbiturates].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Female; Hepatic | 1980 |
Longitudinal study of phenobarbital in serum, cerebrospinal fluid, and saliva in the dog.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Phenobarbital; Saliva | 1980 |
Stable isotope methodology and gas chromatography mass spectrometry in a pharmacokinetic study of phenobarbital.
Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Isotopes; Phenobarbital | 1980 |
Determination of dose-plasma concentration relationship of phenobarbital in epileptic patients by a new specific radioimmunoassay.
Topics: Animals; Antibodies; Antibody Specificity; Cattle; Epilepsy; Humans; Male; Phenobarbital; Rabbits; R | 1980 |
[Panmyelopathy in combined epilepsy therapy using ethosuccimide, diphenylhydantoin, and phenobarbital in childhood].
Topics: Child; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Pancytopenia; Phenobarbita | 1980 |
Febrile seizures: long-term management of children with fever-associated seizures. Summary of an NIH consensus statement.
Topics: Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Phenobarbital; Risk; Seizures; Seizures | 1980 |
Practical and theoretical aspects of phenytoin administration. I. Relationship between dose and plasma concentration.
Topics: Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; | 1980 |
Anticonvulsant-induced unclassified porphyria.
Topics: Adult; Aminolevulinic Acid; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenob | 1980 |
Rapid quantitative determination of underivatized carbamazepine, phenytoin, phenobarbital and p-hydroxyphenobarbital in biological fluids by packed column gas chromatography.
Topics: Adult; Carbamazepine; Chromatography, Gas; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; H | 1980 |
[Is primidone more efficient than phenobarbital? An attempt at a pharmacological evaluation (author's transl)].
Topics: Animals; Dogs; Epilepsy; Humans; Phenobarbital; Phenylethylmalonamide; Primidone | 1980 |
[The convulsive disease state. Apropos of 79 cases].
Topics: Adult; Aged; Anticonvulsants; Brain Diseases; Cerebrovascular Disorders; Electroencephalography; Epi | 1980 |
[Medicamentous enzyme induction and hormonal contraception. Second communication: effects of phenobarbital and phenylbutazone on hormonal contraception (author's transl)].
Topics: Adult; Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Enzyme Induction; Ep | 1980 |
Power spectral analysis of EEG characteristics during sleep in epileptics.
Topics: Adolescent; Adult; Carbamazepine; Circadian Rhythm; Electroencephalography; Epilepsy; Ethosuximide; | 1981 |
Practical considerations in anticonvulsant therapy--Part 2.
Topics: Anticonvulsants; Benzodiazepines; Cost Control; Epilepsy; Ethosuximide; Humans; Monitoring, Physiolo | 1995 |
Effects of chronic high serum levels of phenobarbital on evoked potentials in epileptic children.
Topics: Adolescent; Brain; Child; Electroencephalography; Epilepsy; Evoked Potentials, Auditory, Brain Stem; | 1994 |
Automated analysis of free and total concentrations of three antiepileptic drugs in plasma with on-line dialysis and high-performance liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Dialysis; Epilepsy; Humans; Ph | 1995 |
Effects of phenobarbital administration on results of serum biochemical analyses and adrenocortical function tests in epileptic dogs.
Topics: Adrenal Cortex; Adrenal Cortex Function Tests; Adrenocorticotropic Hormone; Alanine Transaminase; Al | 1995 |
Cytokine production in blood mononuclear cells from epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cytokines; Epilepsy; Female; Humans; Interleukin-1; Interleukin-2; | 1995 |
Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children.
Topics: Biotransformation; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dose-Response Relatio | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul | 1995 |
Is there a pathophysiological and therapeutic link between panic disorder and epilepsy?
Topics: Adult; Brain; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Magnetic Resonance Im | 1995 |
Effect of phenytoin on phenobarbital pharmacokinetics in a patient with epilepsy.
Topics: Adult; Drug Interactions; Drug Monitoring; Epilepsy; Female; Humans; Phenobarbital; Phenytoin | 1995 |
Reduced carnitine and antiepileptic drugs: cause relationship or co-existence?
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; Female; Hu | 1995 |
Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma.
Topics: Aged; Aged, 80 and over; Biliary Tract Neoplasms; Case-Control Studies; Epilepsy; Female; Humans; Li | 1995 |
Phenobarbital in hair and drug monitoring.
Topics: Adult; Drug Monitoring; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Male; | 1995 |
Childhood epilepsy in Papua New Guinea.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Meningitis; Papua New G | 1994 |
Management of canine epilepsy with phenobarbital and potassium bromide.
Topics: Algorithms; Animals; Bromides; Dog Diseases; Dogs; Drug Administration Schedule; Epilepsy; Phenobarb | 1994 |
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi | 1994 |
Childhood febrile convulsions.
Topics: Child; Epilepsy; Hippocampus; Humans; Phenobarbital; Sclerosis; Seizures, Febrile | 1994 |
Acute effects of 17 beta-estradiol on brain excitability studied in vitro and in vivo.
Topics: Animals; Brain; Cats; Decerebrate State; Electric Stimulation; Epilepsy; Estradiol; Evoked Potential | 1994 |
A survey of 100 patients in a primary health care setting in Liberia.
Topics: Epilepsy; Health Surveys; Humans; Liberia; Phenobarbital; Population Surveillance; Prevalence; Prima | 1994 |
Diagnosis and treatment.
Topics: Adolescent; Carbamazepine; Child; Developing Countries; Diagnosis, Differential; Electroencephalogra | 1994 |
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid; | 1994 |
Improvement of poor operant performance by continual intake of phenobarbital in spontaneously epileptic rats.
Topics: Administration, Oral; Animals; Conditioning, Operant; Disease Models, Animal; Epilepsy; Male; Phenob | 1994 |
[Gelastic seizures, precocious puberty and hypothalamic hamartomas. A case report and the contributions of Single Photon Emission Computed Tomography (SPECT)].
Topics: Adolescent; Epilepsy; Female; Hamartoma; Humans; Hypothalamus; Laughter; Magnetic Resonance Imaging; | 1994 |
[Repetitive serum determinations of anticonvulsants in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Female; Humans; Middle | 1993 |
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuxim | 1993 |
The effect of phenobarbital on autonomic function and epileptogenic activity induced by the hippocampal injection of penicillin in cats.
Topics: Animals; Autonomic Agents; Blood Pressure; Cats; Electrocardiography; Electroencephalography; Epilep | 1993 |
Anti-epileptic therapy and behaviour disturbances in children.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Chi | 1993 |
A case of phenobarbital behavioral toxicity presenting as a menstrually related mood disorder.
Topics: Adult; Depressive Disorder; Diagnosis, Differential; Epilepsy; Female; Humans; Intellectual Disabili | 1993 |
Effects of long barbiturate anaesthesia on eight children with severe epilepsy.
Topics: Anesthesia, General; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsies | 1993 |
The prevalence and classification of epileptic seizures in Nigerians with sickle-cell anaemia.
Topics: Adolescent; Adult; Age Factors; Anemia, Sickle Cell; Child; Child, Preschool; Electroencephalography | 1993 |
Daytime sleepiness in epileptic patients on long-term monotherapy: MSLT, clinical and psychometric assessment.
Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Electroencephalography; Epilepsy; Humans; Ma | 1993 |
Five years of anticonvulsant monitoring on site at the epilepsy clinic.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Outpatient Clinics, Hospital; Phe | 1993 |
Postmortem concentrations of phenobarbital, carbamazepine, and its metabolite carbamazepine-10,11-epoxide in different regions of the brain and in the serum: analysis of autoptic specimens from 51 epileptic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autopsy; Brain Chemistry; Carbamazepine; Child; Child, P | 1993 |
An audit of therapeutic drug monitoring of anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Monitoring; Epilepsy; Humans; Medical Audit; Nort | 1995 |
Prolonged epileptic apneas in a newborn: a case report with ictal EEG recording.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Male; Phenobarbi | 1995 |
Bromide toxicosis secondary to renal insufficiency in an epileptic dog.
Topics: Animals; Anticonvulsants; Bromides; Creatinine; Diuresis; Dog Diseases; Dogs; Drug Therapy, Combinat | 1996 |
High dietary chloride content associated with loss of therapeutic serum bromide concentrations in an epileptic dog.
Topics: Animals; Anticonvulsants; Bromides; Chlorides; Diet; Dog Diseases; Dogs; Epilepsy; Female; Liver; Ph | 1996 |
A model for estimating individualized valproate clearance values in children.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther | 1995 |
Lack of effect of histological lesions on the phenytoin and phenobarbital concentrations in the brain cortex of epileptic patients.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Cerebellum; Cerebral Cortex; Child, Preschool; Epilep | 1995 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbita | 1996 |
Learning impairment in 1-2-day-old epileptic chicks.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Chickens; Discrimination Learning; | 1996 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study.
Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship, | 1996 |
Discontinuation of phenobarbital in children: effects on neurocognitive behavior.
Topics: Adolescent; Anticonvulsants; Attention; Child; Cognition Disorders; Dose-Response Relationship, Drug | 1996 |
Seizure control after chronic pharmacotherapy in epileptic disorders beginning after 40 years of age.
Topics: Adult; Age of Onset; Aged; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital | 1995 |
[Study of the influence of anticonvulsant treatment on thyroid function].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E | 1995 |
Comparing antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1996 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate | 1996 |
[The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1996 |
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio | 1996 |
Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; | 1996 |
Steady state pharmacokinetics of carbamazepine-phenobarbital interaction in patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Interactions; Drug Therapy, Combin | 1996 |
Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Depression, Chemical; Drug Evaluation, Preclinical; Elect | 1996 |
Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Autopsy; Brain Ischemia; Case-Control Studies; Cere | 1996 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Fe | 1997 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Clinical, epidemiological and treatment results of idiopathic epilepsy in 54 labrador retrievers: a long-term study.
Topics: Administration, Oral; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Follow-Up Stud | 1997 |
[Sturge-Weber syndrome: experience with 14 cases].
Topics: Anticonvulsants; Brain; Carbamazepine; Epilepsy; Female; Humans; Infant; Magnetic Resonance Imaging; | 1997 |
Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Hyperlipidemias; Lipids | 1997 |
Extrashot-ODS, a syringe-type minicolumn sample injector for a reversed-phase high-performance liquid chromatographic column. Application to antiepileptics in human sera.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Drug Therapy, Combination; Epi | 1997 |
[Clinical and neuroradiologic aspects of pseudohypoparathyroidism. Case report].
Topics: Adolescent; Anticonvulsants; Basal Ganglia Diseases; Calcinosis; Epilepsy; Humans; Male; Phenobarbit | 1997 |
A study of pediatric brain tumors and their association with epilepsy and anticonvulsant use.
Topics: Adolescent; Adult; Anticonvulsants; Brain Neoplasms; Case-Control Studies; Child; Child, Preschool; | 1997 |
If a first antiepileptic drug fails to control a child's epilepsy, what are the chances of success with the next drug?
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cohort Studies; Drug Administ | 1997 |
[Reflex sympathetic dystrophy due to phenobarbital: a frequent and treatable condition].
Topics: Aged; Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Reflex Sympathetic Dystro | 1997 |
Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epile | 1997 |
[Optimisation of epilepsy monotherapy (clinico-pharmacological study)].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Chromatography, High Pressure Liquid; Electroencephalo | 1997 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep | 1998 |
Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool | 1998 |
Veratridine-treated brain slices: a cellular model for epileptiform activity.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Electrophysiology; Epilepsy; In Vitro Techniques | 1998 |
Does antiepileptic therapy affect immune response?
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1998 |
[Bilateral sympathetic reflex dystrophy related to phenobarbital].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Phenobarbital; Reflex Sympathetic Dystrophy | 1998 |
Comparison of anti-epileptic drug levels in different cases of sudden death.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cause of Death; Child; Child, Preschool | 1998 |
[Giant intraventricular arachnoid cyst: report of 2 cases].
Topics: Adult; Aged; Anticonvulsants; Arachnoid Cysts; Cerebral Ventricles; Cerebral Ventriculography; Elect | 1998 |
Antiepileptic drugs in developing countries.
Topics: Anticonvulsants; Child; Clinical Trials as Topic; Developing Countries; Epilepsy; Humans; India; Phe | 1998 |
Dynamic regulation of the activated, autophosphorylated state of Ca2+/calmodulin-dependent protein kinase II by acute neuronal excitation in vivo.
Topics: Animals; Antibody Specificity; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 1998 |
Antiepileptic drugs in developing countries.
Topics: Anticonvulsants; Developing Countries; Drug Utilization; Epilepsy; Humans; Phenobarbital; Phenytoin | 1998 |
[Evaluation of monitoring the efficacy of phenobarbital as an anticonvulsant agents using the fluorescence-polarization immunoassay].
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Fluorescence Polarization Immunoassay; Humans; Phenobarb | 1998 |
Changes of the EEG paroxysmal pattern during felbamate therapy in Lennox-Gastaut syndrome: a case report.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Drug Therapy, | 1998 |
Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog.
Topics: Administration, Oral; Administration, Rectal; Animals; Anticonvulsants; Benzodiazepines; Diazepam; D | 1998 |
Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants: 122 cases (1992-1996).
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Follow- | 1998 |
Serum lipids and lipoproteins in patients treated with antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Apolipoprotein A-I; Apolipoproteins B; Carbamazepine; Cholestero | 1998 |
Comparison between premortem and postmortem serum concentrations of phenobarbital, phenytoin, carbamazepine and its 10,11-epoxide metabolite in institutionalized patients with epilepsy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hospitalization; H | 1999 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi | 1999 |
Owner perception of the care of long-term phenobarbital-treated epileptic dogs.
Topics: Adult; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Humans; Life Style; Male; Pat | 1999 |
Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, phenobarbital and carbamazepine in an amygdala-kindling model of epilepsy in the rat.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Injec | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe | 1999 |
Brain-derived neurotrophic factor immunoreactivity in the limbic system of rats after acute seizures and during spontaneous convulsions: temporal evolution of changes as compared to neuropeptide Y.
Topics: Acute Disease; Animals; Anticonvulsants; Brain; Brain-Derived Neurotrophic Factor; Colchicine; Elect | 1999 |
Technical report: treatment of the child with simple febrile seizures.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 1999 |
The management of epilepsy in a hospital for people with a learning disability.
Topics: Acetates; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Uti | 1999 |
Serum total thyroxine, total triiodothyronine, free thyroxine, and thyrotropin concentrations in epileptic dogs treated with anticonvulsants.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Female; | 1999 |
Effects of phenobarbital treatment on serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Anticonvulsants; Aspartate Aminotransferases; B | 1999 |
Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cross-Cultural Comparison; Drug Approval; | 1999 |
Subtherapeutic levels of phenytoin with standard doses in infants: need to review dosage schedule.
Topics: Anticonvulsants; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Epilepsy; | 1999 |
Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyro | 1999 |
Phenobarbital still has a role in epilepsy treatment.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Retr | 1999 |
[Apparently unprovoked seizures precipitated by prefebrile condition].
Topics: Anticonvulsants; Body Temperature; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; In | 2000 |
Anticonvulsant induced osteomalacia.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant; Male; Osteomalacia; Ph | 2000 |
[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report].
Topics: Adult; Anticonvulsants; Diazepam; Dupuytren Contracture; Epilepsy; Foot Diseases; Humans; Male; Phen | 1999 |
Antiepileptic therapies in the Mifi Province in Cameroon.
Topics: Adult; Anticonvulsants; Cameroon; Delivery of Health Care; Drug Costs; Epilepsy; Female; Health Care | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; E | 2000 |
Changes in bone turnover and deoxypyridinoline levels in epileptic patients.
Topics: Adult; Alkaline Phosphatase; Amino Acids; Anticonvulsants; Bone and Bones; Calcium; Carbamazepine; C | 2000 |
[Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Epilepsy; Female; Humans; | 1999 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; | 2000 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
Drug choice and therapeutic drug monitoring in the management of canine primary epilepsy.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Monitoring; Drug Therapy, Combination; | 1999 |
A story of "Ayurvedic" tablets and misled epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epi | 1999 |
Emphasis in medicine on statistically sound and unbiased (blinded) research.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Administration Schedule; Drug Monitoring; Epilepsy; | 2000 |
[Antiepileptic drugs and carnitine].
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; M | 2000 |
Pancreatitis associated with potassium bromide/phenobarbital combination therapy in epileptic dogs.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Drug Interactions; Drug Therapy, Combination | 2000 |
[Progressive, small spotted, confluent erythema with bullae formation and general symptoms. Acute Lyell syndrome].
Topics: Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; S | 2000 |
Effect of timing of blood collection on serum phenobarbital concentrations in dogs with epilepsy.
Topics: Administration, Oral; Animals; Anticonvulsants; Blood Specimen Collection; Dog Diseases; Dogs; Epile | 2000 |
The effects on lipid and apolipoprotein serum levels of long-term carbamazepine, valproic acid and phenobarbital therapy in children with epilepsy.
Topics: Anticonvulsants; Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Carbamazepine; Child; Chole | 2000 |
Error in dosage for phenobarbital.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Medication Errors; Phenobarbital | 2000 |
Bone mineral density, vitamin D and anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Bone Density; Case-Control Studies; Epilepsy; Humans; Male; Phenobarbital; P | 2000 |
Idiopathic phenobarbital-responsive hypersialosis in the dog: an unusual form of limbic epilepsy?
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Limbic System; Male; Phenobarbital; | 2000 |
Renal tubular function in patients receiving anticonvulsant therapy: a long-term study.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; | 2000 |
Effects of antiepileptic drugs on evoked potentials in epileptic children.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
Changes in serum thyroxine and thyroid-stimulating hormone concentrations in epileptic dogs receiving phenobarbital for one year.
Topics: Analysis of Variance; Animals; Anticonvulsants; Dog Diseases; Dogs; Epilepsy; Female; Male; Phenobar | 2000 |
Comparison the cognitive effect of anti-epileptic drugs in seizure-free children with epilepsy before and after drug withdrawal.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Epilepsy; Event-Related Potentials, P300; Female; | 2001 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios.
Topics: Adolescent; Anticonvulsants; Biological Availability; Carbamazepine; Child; Dose-Response Relationsh | 2000 |
The treatment of epilepsy in developing countries: where do we go from here?
Topics: Anticonvulsants; Clinical Protocols; Cost of Illness; Developing Countries; Epilepsy; Health Policy; | 2001 |
Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholester | 2001 |
Temporal change of hippocampal enkephalin and dynorphin mRNA following trimethyltin intoxication in rats: effect of anticonvulsant.
Topics: Animals; Anticonvulsants; Dynorphins; Enkephalin, Methionine; Epilepsy; Gene Expression; Hippocampus | 2001 |
Population pharmacokinetics of carbamazepine in Singapore epileptic patients.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Bayes Theorem; Carbamazepine; Child; Child | 2001 |
[The drug hypersensitivity syndrome or DRESS syndrome to phenobarbital].
Topics: Aged; Anticonvulsants; Cholestasis, Intrahepatic; Drug Eruptions; Edema; Eosinophilia; Epilepsy; Fem | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
Antiepileptic drug utilization: a Danish prescription database analysis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Databases, Factua | 2001 |
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combinat | 2001 |
Do fits really beget fits? The effect of previous epileptic activity on the subsequent induction of the tetanus toxin model of limbic epilepsy in the rat.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Agonists | 2001 |
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venom | 2001 |
Adverse cutaneous reactions to phenobarbital in epileptic children.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Male; Phenobarbital; Retrospective Studies; Skin D | 2001 |
Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy".
Topics: Action Potentials; Animals; Anticonvulsants; Cell Size; Cell Survival; Cells, Cultured; Dose-Respons | 2001 |
Phenobarbital for mild sedation: market withdrawal.
Topics: Drug and Narcotic Control; Epilepsy; France; Humans; Hypnotics and Sedatives; Phenobarbital | 2001 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: behavior and metabolism.
Topics: Aging; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Brain; Convulsants; Epilepsy; Excita | 2002 |
[The use of normobaric hypoxia in the therapy of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Humans; Hypoxia; Middle Aged; Oxygen; Oxygen Consumpti | 2002 |
Serum lipid changes during anticonvulsive treatment serum lipids in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; | 2001 |
[Treatment of epileptic seizures resistant to phenobarbital in children during the first year of life].
Topics: Anticonvulsants; Drug Resistance; Epilepsy; Humans; Infant; Phenobarbital; Prospective Studies; Seiz | 2002 |
Phenobarbitone concentrations in the hair, saliva and plasma of eight epileptic dogs.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Epilepsy; Hair; Phen | 2002 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo | 1975 |
Activity of gamma-glutamyl transpeptidase in serum of patients receiving anticonvulsant of anticoagulant therapy.
Topics: Alkaline Phosphatase; Anticoagulants; Anticonvulsants; Aspartate Aminotransferases; Epilepsy; gamma- | 1976 |
[Determination of the phenobarbital content in the saliva of epileptic patients].
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Hydrogen-Ion Concentration; Phenobarbital; Saliva | 1976 |
Resistant transitory epilepsy in children.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Child, Preschool; Encephalomyelitis, Ac | 1976 |
[Determination of phenobarbital, mephenytoin and diphenylhydantoin in the surveillance of anticonvulsant treatment].
Topics: Barbiturates; Child; Chromatography, Gas; Epilepsy; Ether; Humans; Hydantoins; Mephenytoin; Methylat | 1976 |
[Effect of treatment with phenobarbital and/or hydantoin on the activity of serum gamma glutamyl transpeptidase].
Topics: Adult; Aged; Epilepsy; Female; gamma-Glutamyltransferase; Humans; Hydantoins; Male; Middle Aged; Phe | 1977 |
[Clinical trial with a new anti-epileptic: barbexaclone].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; M | 1977 |
[Re-evaluation of barbexaclone in 20 epileptic patients].
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Male; Phenoba | 1978 |
Use of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Phenobarbital | 1979 |
[Comparative effects of antiepileptics on the alkaline phosphatase and gamma glutamyltransferase activities in plasma and leukocytes].
Topics: Alkaline Phosphatase; Anticonvulsants; Epilepsy; gamma-Glutamyltransferase; Humans; Leukocytes; Phen | 1978 |
Letter: Phenobarbitone, liver tumours, and thorotrast.
Topics: Adenoma, Bile Duct; Aged; Carcinoma, Hepatocellular; Denmark; Epilepsy; Female; Humans; Liver Neopla | 1975 |
Amines, anticonvulsants, and epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; | 1975 |
Letter: Bioavailability of drugs after intramuscular injection.
Topics: Absorption; Administration, Oral; Adult; Biological Availability; Biotransformation; Carbamazepine; | 1975 |
Letter: Amines, anticonvulsants, and epilepsy.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; Humans; Phenobarbital; Phenytoin; Rats; Serotonin | 1975 |
Editorial: Drug levels in epilepsy.
Topics: Adult; Biological Availability; Child; Dose-Response Relationship, Drug; Drug Tolerance; Epilepsy; H | 1975 |
EEG changes after withdrawal of medication in epileptic patients.
Topics: Adult; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Humans; Phenobarbital; Phenytoin; P | 1975 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
The effect of phenytoin and ethosuximide on primidone metabolism in patients with epilepsy.
Topics: Drug Interactions; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Male; Phenobar | 1975 |
Letter: Pyridoxine and serum concentration of phenytoin and phenobarbitone.
Topics: Child; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pyridoxine; Time Factors | 1976 |
Anticonvulsants and parental epilepsy in the development of birth defects.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Epilepsy; Female; Finland; Follow-Up Studies; | 1976 |
Letter: Anticonvulsants and fetal malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pr | 1976 |
How doctors deal with epilepsy.
Topics: Adolescent; Adult; Aged; Automobile Driving; Diazepam; Drug Therapy, Combination; Electroencephalogr | 1977 |
Therapeutic and pharmacokinetic effects of increasing phenytoin in chronic epileptics on multiple drug therapy.
Topics: Adult; Biological Availability; Chronic Disease; Dose-Response Relationship, Drug; Drug Therapy, Com | 1976 |
[Treatment of Crigler-Najjar's congenital familial non-hemolytic jaundice with kernicterus].
Topics: Crigler-Najjar Syndrome; Developmental Disabilities; Epilepsy; Female; Humans; Hyperbilirubinemia; H | 1978 |
Hepatitis and anticonvulsant therapy.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Epilepsy; Humans; | 1978 |
In vivo interaction of anticonvulsant drugs. The mathematical correlation of plasma levels of anticonvulsant drugs in epileptic patients.
Topics: Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; In | 1978 |
Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy.
Topics: Adolescent; Adult; Brain Neoplasms; Child; England; Epilepsy; Female; Follow-Up Studies; Humans; Mal | 1979 |
[Clinical picture and basis for treating brain stem epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Diazepam; Epilepsies, Myoclonic; Epilepsy; Female; H | 1978 |
Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans.
Topics: Adult; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Radioimmunoassay; Thyroid Hormones | 1978 |
Bone morphology in epileptics.
Topics: Adult; Aged; Bone and Bones; Bone Diseases; Bone Resorption; Epilepsy; Female; Humans; Male; Middle | 1979 |
Bone mineral content in epileptics.
Topics: Aged; Bone and Bones; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Minerals; Muscle C | 1979 |
Letter: Exfoliative dermatitis during treatment with pheneturide.
Topics: Adult; Anticonvulsants; Dermatitis, Exfoliative; Epilepsy; Humans; Male; Phenobarbital; Phenylbutyra | 1975 |
Seizure activity and anticonvulsant drug concentration.
Topics: Anticonvulsants; Child; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administr | 1975 |
Calcium and folic acid absorption in patients taking anticonvulsant drugs.
Topics: Adult; Aged; Calcium; Cholecalciferol; Epilepsy; Folic Acid; Humans; Male; Middle Aged; Osteomalacia | 1975 |
False positive infectious mononucleosis serology in epilepsy.
Topics: Adolescent; Adult; Antibodies, Viral; Anticonvulsants; Child; Epilepsy; False Positive Reactions; Fe | 1975 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula | 1976 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Plasma albumin concentration and diphenylhydantoin binding in man.
Topics: Adolescent; Adult; Aged; Aspirin; Blood Protein Electrophoresis; Blood-Brain Barrier; Chromatography | 1975 |
Involuntary movements caused by phenytoin intoxication in epileptic patients.
Topics: Adult; Chlorpheniramine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electroencephalogra | 1975 |
[Effects of combination of anti-epileptic drugs].
Topics: Adrenergic beta-Antagonists; Anticonvulsants; Benzodiazepines; Carbamazepine; Digitoxin; Drug Intera | 1975 |
[Antiepileptic action of psychostimulating drugs. Treatment by a combination of phenobarbital and psychostimulating substances (author's transl)].
Topics: Adolescent; Adult; Child; Drug Combinations; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbi | 1975 |
Brain tumors in children exposed to barbiturates.
Topics: Adolescent; Barbiturates; Brain Neoplasms; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; | 1979 |
Brain tumors in children exposed to barbiturates.
Topics: Adolescent; Barbiturates; Brain Neoplasms; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; | 1979 |
[Immunological abnormalities in epileptic children treated with anticonvulsivant drugs (author's transl)].
Topics: Adolescent; Agammaglobulinemia; Age Factors; Antibodies, Antinuclear; Child; Child, Preschool; Epile | 1977 |
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions; | 1977 |
Management of childhood epilepsy.
Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1977 |
Implications of measuring anticonvulsant blood levels in epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Humans; Middle Aged; Patient Compliance; | 1977 |
[Study of the immunosuppressive effect of some anticonvulsants in children].
Topics: Adolescent; Anticonvulsants; B-Lymphocytes; Child; Child, Preschool; Epilepsy; Female; Humans; Immun | 1977 |
Preliminary observations on valproic acid kinetics in patients with epilepsy.
Topics: Adult; Child; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Valerates; Valproic A | 1977 |
Epilepsy and IgA deficiency--the effect of sodium valproate.
Topics: Adult; Agammaglobulinemia; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenobar | 1977 |
Choice of drug therapy in epilepsy.
Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; | 1977 |
[Plasma levels of anticonvulsants. Experiences with routine plasma level determination of 6 different anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Ethos | 1978 |
Distribution of plasma carbamazepine in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Immunoenzyme | 1977 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
Recent advances in drug therapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phen | 1979 |
The use of antiepileptic drugs.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Humans; | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T | 1977 |
[Clinical study of serum level of dipropylacetic acid sodium (Depakene) by gaschromatography (author's transl)].
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Gas; Drug Therapy, Combination; Epilepsi | 1977 |
[The effect of primidone treatment of thyroid hormones in epileptic children and adolescents (author's transl)].
Topics: Adolescent; Child; Enzyme Induction; Epilepsy; Female; Humans; Iodine; Liver; Male; Phenobarbital; P | 1977 |
Medical treatment of epilepsy: part I.
Topics: Anticonvulsants; Bromides; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combina | 1978 |
Medical treatment of epilepsy: Part II.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Calcium; Child; Drug Interactions; Epilepsy; Ep | 1978 |
Anticonvulsant therapy. Approaches to some common clinical problems.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Eth | 1979 |
Continuous phenobarbital treatment after a 'simple febrile convulsion'.
Topics: Animals; Child; Epilepsy; Humans; Phenobarbital; Recurrence; Seizures; Seizures, Febrile | 1979 |
Estimation of plasma unbound phenobarbital concentration by using mixed saliva.
Topics: Adolescent; Adult; Aged; Blood Proteins; Child; Epilepsy; Female; Humans; Kinetics; Male; Mathematic | 1979 |
Epilepsy among parents of children with facial clefts.
Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph | 1979 |
Metabolism of dimethoxymethyl phenobarbital (eterobarb) in patients with epilepsy.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Kinetics; Male; Middle Aged; Phenobarbital; Saliva; Tis | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
[Neutropenia in epilepsy patients].
Topics: Adolescent; Adult; Agranulocytosis; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epile | 1979 |
Correlation between age and plasma level/dosage ratio for phenobarbital in infants and children.
Topics: Age Factors; Body Weight; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Seizures | 1979 |
Biochemical variables related to calcium metabolism in epileptics.
Topics: Aged; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilepsy; Female; Humans; Male; | 1979 |
Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy.
Topics: Adult; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Menstruation; Phenobarbital; Phenytoin; P | 1979 |
[The frequency of adult anticonvulsant osteomalacia in relation to duration of therapy and dosage of anticonvulsants (author's transl)].
Topics: Adult; Alkaline Phosphatase; Calcium; Dose-Response Relationship, Drug; Drug Therapy, Combination; E | 1979 |
[Drug therapy of epilepsy with control of the serum level of anti-epileptic agents].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin; Primidone; | 1979 |
Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association.
Topics: Atrophy; Brain Diseases; Edema; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intesti | 1979 |
[Dupuytren's disease; current viewpoints].
Topics: Blood Circulation; Dupuytren Contracture; Epilepsy; Fascia; Female; Humans; Male; Occupational Disea | 1979 |
Epileptic-type convulsions and magnesium deficiency.
Topics: Acclimatization; Adult; Chlorides; Epilepsy; Hot Temperature; Humans; Magnesium; Magnesium Deficienc | 1979 |
Plasma renin concentration and phenobarbital levels in patients with epilepsy.
Topics: Adolescent; Adult; Angiotensinogen; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Reni | 1979 |
Clinical and genetic aspects of seizure disorders prevalent in an isolated African population.
Topics: Adolescent; Adult; Black or African American; Black People; Burns; Child; Child, Preschool; Epilepsy | 1979 |
Tears as the best practical indicator of the unbound fraction of an anticonvulsant drug.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Phenobarbital; Protein | 1979 |
[Disorders of cerebral hemodynamics and their correction in epilepsy].
Topics: Brain Ischemia; Caffeine; Cerebrovascular Circulation; Epilepsy; Humans; Papaverine; Phenobarbital | 1979 |
Interaction between plasma phenytoin and phenobarbital concentrations in epileptic patients.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Phenobarbital; Phenytoin | 1979 |
Serum levels of phenytoin and phenobarbital in epileptic patients treated with mixture antiepileptic tablets, Comital-L or Hydantol-F.
Topics: Anticonvulsants; Drug Combinations; Epilepsy; Humans; Mephobarbital; Phenobarbital; Phenytoin | 1979 |
[Quantitative analysis of EEG basic rhythms in epileptics (author's transl)].
Topics: Adult; Alpha Rhythm; Delta Rhythm; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Ag | 1979 |
Effectiveness of simplified dosage schedules on the management of ambulant epileptic patients.
Topics: Adolescent; Adult; Ambulatory Care; Drug Administration Schedule; Epilepsy; Female; Humans; Male; Mi | 1979 |
[Studies on the serum levels of the antiepileptic drugs-with particular reference to diphenylhydantoin, phenobarbital and carbamazepine-(author's transl)].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbi | 1979 |
[Anticonvulsants and osteopenia].
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Hydantoins; Male; Osteomalacia; Phenobarbital; Vitamin | 1979 |
A remedy for epilepsy.
Topics: Administration, Oral; Drug Therapy, Combination; Epilepsy; Humans; Injections; Oils; Penicillins; Ph | 1979 |
Problems with the use of conventional anticonvulsant drugs in mentally retarded individuals.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Cognition; Epilepsy; Humans; Intellec | 1979 |
Mephobarbital and phenobarbital plasma concentrations in epileptic patients treated with mephobarbital.
Topics: Chromatography, Gas; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; Mephobarbital; Phenobar | 1979 |
[Fetal hemorrhage in the newborn infant of an epileptic mother treated with phenobarbital].
Topics: Adult; Epilepsy; Female; Hemorrhage; Humans; Infant, Newborn; Male; Phenobarbital; Pregnancy | 1979 |
Plasma anticonvulsant concentrations during pregnancy.
Topics: Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1977 |
Controversies in the treatment of febrile convulsions.
Topics: Child; Epilepsy; Humans; Intelligence; Phenobarbital; Phenytoin; Prognosis; Seizures; Seizures, Febr | 1979 |
[Methsuximide in the treatment of epilepsies (author's transl)].
Topics: Adolescent; Adult; Child; Drug Evaluation; Drug Interactions; Epilepsy; Gastrointestinal Diseases; H | 1977 |
Phenytoin, phenobarbitone and serum cholesterol.
Topics: Adolescent; Adult; Cholesterol; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoi | 1977 |
[Consequeces of the elimination of a combination drug. Transition from combination antisacer: attention].
Topics: Adult; Drug Combinations; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
[Epilepsy and contraception].
Topics: Contraceptives, Oral; Contraceptives, Oral, Hormonal; Drug Interactions; Epilepsy; Female; Humans; O | 1977 |
Interaction between carbamazepine and propoxyphene in man.
Topics: Adolescent; Adult; Carbamazepine; Dextropropoxyphene; Drug Interactions; Drug Therapy, Combination; | 1977 |
[Chromosomal in study patients treated with anticonvulsant drugs].
Topics: Adolescent; Adult; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human | 1977 |
Continuous phenobarbital treatment after a 'simple febril convulsion'.
Topics: Child; Epilepsy; Humans; Phenobarbital; Seizures; Seizures, Febrile; Time Factors | 1978 |
Acute and chronic antiepileptic drug effect on the T complex interhemispheric latency difference.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Auditory Pathways; Brain; Child; Clonazepam; Electroenceph | 1978 |
Simultaneous gas liquid chromatographic dosage of phenobarbital and diphenylhydantoin in serum.
Topics: Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin | 1978 |
The effects of dose, age, and sex on the serum levels of phenobarbital and diphenylhydantoin in epileptic patients.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; M | 1978 |
[Optimizing the therapeutic process in long-term antiepileptic therapy through the determination of drug levels in patients].
Topics: Anticonvulsants; Carbamazepine; Drug Therapy; Epilepsy; Ethosuximide; Germany, East; Humans; Methods | 1978 |
[Determination of serum levels of phenobarbital and diphenylhydantoin in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobarbital; Phen | 1978 |
Compliance with anticonvulsant therapy in a hospital clinic and in the community.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Prescriptions; Epilepsy; Female; Humans; Male; | 1978 |
[Ratio of primidone to phenobarbital serum levels as a criterion in the assessment of anticonvulsive therapy with primidone (author's transl)].
Topics: Adolescent; Ambulatory Care; Child; Child, Preschool; Epilepsy; Humans; Phenobarbital; Primidone | 1978 |
Drug compliance and therapeutic considerations in 75 black epileptic children.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Ma | 1978 |
Effect of anticonvulsant therapy on serum 25-hydroxyvitamin D level.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; H | 1978 |
[Serum enzyme activity in epileptic patients].
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Epilepsy; Humans; Isoenzymes; L-Lactate De | 1978 |
[Antiepileptic emergency therapy in the adult age].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi | 1978 |
Kinetics of drug interactions in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethanol; Female; Humans; Kinet | 1978 |
[Neonatal abstinence syndrome in children whose mothers were treated for epilepsy during pregnancy].
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, D | 1978 |
Memory impairment in epileptic patients: selective effects of phenobarbital concentration.
Topics: Adult; Dose-Response Relationship, Drug; Epilepsy; Humans; Memory, Short-Term; Middle Aged; Phenobar | 1978 |
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder | 1978 |
Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.
Topics: Anticonvulsants; Denmark; Epilepsy; Female; Follow-Up Studies; Humans; Liver Neoplasms; Male; Neopla | 1978 |
[Blood levels of phenytoin and phenobarbital in epileptics treated with phenydantin and phenytoinum].
Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin | 1978 |
Effect of data transformation on t-test sensitivity.
Topics: Adult; Animals; Anticonvulsants; Epilepsy; Glucaric Acid; Guinea Pigs; Humans; Mathematics; Phenobar | 1978 |
Brain concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients.
Topics: Adolescent; Brain; Carbamazepine; Child; Epilepsy; Epoxy Compounds; Female; Humans; Male; Phenobarbi | 1978 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar | 1978 |
A comparison of the absorption of phenobarbitone given via the oral and the intramuscular route.
Topics: Absorption; Administration, Oral; Adult; Epilepsy; Female; Humans; Injections, Intramuscular; Intest | 1978 |
[Relation between epilepsy, antiepileptic therapy and Dupuytren's disease].
Topics: Dupuytren Contracture; Epilepsy; Humans; Male; Middle Aged; Phenobarbital | 1978 |
[Measurement of the blood concentration of antiepileptic drugs. II Special cases].
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbi | 1975 |
[Myoclonic cerebellar dyssynergia with epilepsy (Ramsey-Hunt syndrome). Electro-clinical study in a patient of the black race].
Topics: Adult; Black People; Cerebellar Ataxia; Electroencephalography; Epilepsy; Female; Humans; Phenobarbi | 1975 |
Pharmacokinetics of di-n-propylacetate in epileptic patients.
Topics: Administration, Oral; Aged; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; | 1975 |
Proposals on antiepileptic pharmacotherapy for use in developing countries.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam | 1976 |
Reduced cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in children with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1975 |
Criteria for selection of patients for neurosurgical treatment.
Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy; | 1975 |
Seizures in adolescents.
Topics: Adolescent; Anticonvulsants; Automobile Driving; Benzodiazepines; Carbamazepine; Diagnosis, Differen | 1975 |
Diseases of the central nervous system: Epilepsy.
Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth | 1975 |
Sensible prescribing. XI.--Juvenile and adult epilepsy.
Topics: Adolescent; Adult; Age Factors; Carbamazepine; Child; Clonazepam; Epilepsy; Epilepsy, Absence; Epile | 1975 |
Effects of different dosages of anticonvulsant drugs on mental performance in patients with chronic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Chronic Disease; Dose-Response Relationship, Drug; Epilep | 1975 |
Epilepsy: a controllable disease. Part 2. Drug therapy and nursing care.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Epilepsy; Ethosuximide; Gingival Hyperplasia; Hum | 1976 |
[Results of Fali-lepsin therapy of cerebral convulsions in childhood].
Topics: Adolescent; Age Factors; Child; Child, Preschool; Epilepsy; Epilepsy, Tonic-Clonic; Female; Fever; H | 1976 |
Phenytoin and phenobarbitone plasma clearance during pregnancy.
Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human | 1976 |
[Epileptic seizures with psychomotor symptoms and generalized spike-wave-pattern].
Topics: Adolescent; Adult; Carbamazepine; Child; Diagnosis, Differential; Drug Therapy, Combination; Electro | 1976 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Epilepsy and other seizure disorders in children: drug management.
Topics: Acetazolamide; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, T | 1976 |
Interactions of phenytoin and phenobarbital in terms of order and temporal spacing of administration in monkeys.
Topics: Animals; Drug Interactions; Epilepsy; Half-Life; Haplorhini; Macaca mulatta; Male; Phenobarbital; Ph | 1976 |
Rickets in children receiving anticonvulsant drugs. Biochemical and hormonal markers.
Topics: Adolescent; Anticonvulsants; Calcium; Child; Child, Preschool; Drug Combinations; Epilepsy; Evaluati | 1977 |
[Phenemal prophylaxis and prognosis].
Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Prognosis; Recurrence; Seizures; S | 1977 |
Experience with the EMIT method of determining anticonvulsant levels in serum.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Humans; I | 1977 |
[Liver damage after long-term administration of phenylethylbarbituric acid and diphenylhydantoin].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Leucy | 1977 |
Plasma levels of phenobarbital and phenytoin in epileptic outpatients.
Topics: Adolescent; Adult; Ambulatory Care; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Human | 1977 |
Absence of drug-induced beta-activity in the electroencephalogram. A sign of severe cerebral impairment.
Topics: Adolescent; Adult; Anticonvulsants; Beta Rhythm; Child; Child, Preschool; Electroencephalography; Ep | 1977 |
Serum levels of anticonvulsants and haematological sequelae in black epileptics.
Topics: Adolescent; Adult; Aged; Black People; Child; Child, Preschool; Drug Combinations; Epilepsy; Erythro | 1977 |
Effectiveness of daily phenobarbital in the prevention of febrile seizure recurrences in "simple" febrile convulsions and "epilepsy triggered by fever".
Topics: Child; Diagnosis, Differential; Epilepsy; Humans; Phenobarbital; Seizures; Seizures, Febrile | 1977 |
Treatment of acquired epileptic aphasia.
Topics: Aphasia; Child; Epilepsy; Ethosuximide; Female; Humans; Phenobarbital | 1977 |
[Symptomatic treatment of epilepsy].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
Evidence of osteomalacia in an outpatient group of adult epileptics.
Topics: Adult; Aged; Diet; Epilepsy; Female; Humans; Male; Middle Aged; Osteomalacia; Phenobarbital; Phenyto | 1977 |
Lack of effect of clonazepam on serum levels of diphenylhydantoin, phenobarbital and carbamazepine.
Topics: Adolescent; Adult; Benzodiazepinones; Carbamazepine; Child; Clonazepam; Drug Interactions; Drug Ther | 1977 |
The effect of anticonvulsant drugs which induce liver microsomal enzymes on derived and ingested phenobarbitone levels.
Topics: Adolescent; Adult; Biotransformation; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Fem | 1977 |
Acetazolamide-accelerated anticonvulsant osteomalacia.
Topics: Acetazolamide; Adult; Anticonvulsants; Calcium; Epilepsy; Female; Humans; Mephobarbital; Osteomalaci | 1977 |
The investigation of phenobarbitone, phenytoin and primidone in the death of epileptics.
Topics: Epilepsy; Forensic Medicine; Humans; Phenobarbital; Phenytoin; Primidone | 1977 |
[Biotransformation and its modification by barbiturates].
Topics: Binding Sites; Biotransformation; Drug Interactions; Enzyme Induction; Epilepsy; Humans; Liver; Live | 1977 |
[The anti-epileptic drugs].
Topics: Age Factors; Anticonvulsants; Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoi | 1977 |
Epilepsy.
Topics: Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
Evaluation of serum levels during prolonged combination therapy with phenytoin and phenobarbitone.
Topics: Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phenobarbital; P | 1977 |
Epileptiform seizures in domestic fowl. VI. Plasma phenobarbital concentrations and anticonvulsant activity.
Topics: Animals; Anticonvulsants; Chickens; Epilepsy; Phenobarbital; Photic Stimulation; Poultry Diseases; T | 1977 |
Seizures in childhood encephalopathy or epilepsy?
Topics: Adolescent; Child; Epilepsy; Humans; Metabolic Diseases; Neurologic Examination; Phenobarbital; Prim | 1977 |
Distribution of plasma phenobarbital, diphenylhydantoin and primidone levels in epileptic patients.
Topics: Adult; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin; Primidone | 1977 |
Factors influencing plasma phenobarbitone levels in epileptic patients.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Mephobarbital; M | 1977 |
Comparison of six procedures for the simultaneous determination of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Pri | 1977 |
Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.
Topics: Adult; Anticonvulsants; Dupuytren Contracture; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar | 1976 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Letter: status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Phenobarbital | 1976 |
Cerebrospinal fluid and plasma glutamine elevation by anticonvulsant drugs: a potential diagnostic and therapeutic trap.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Arginine; Child; Child, Preschool; Citrulli | 1976 |
Ascorbic acid concentrations in human plasma and cerebrospinal fluid [proceedings].
Topics: Ascorbic Acid; Epilepsy; Humans; Phenobarbital; Phenytoin; Primidone | 1976 |
Further observations on carbamazepine plasma levels in epileptic patients. Relationships with therapeutic and side effects.
Topics: Adult; Age Factors; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epileps | 1976 |
Anticonvulsant drugs and mental symptoms: a review.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Folic Acid | 1976 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
[Interval therapy of febrile convulsions for the management of their prognosis. I. Methods and therapeutic advice for interval therapy of febrile convulsions].
Topics: Child, Preschool; Epilepsy; Humans; Infant; Periodicity; Phenobarbital; Phenytoin; Recurrence; Seizu | 1976 |
[Interval therapy of febrile convulsions for management of the prognosis. II. Anticonvulsant longtime Fali-Lepsin therapy of complicated febrile convulsions].
Topics: Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Phenylpropanolamine; Progno | 1976 |
[Megaloblastic anemia in a patient with epilepsy treated with anticonvulsants].
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Epilepsy; Humans; Male; Phenobarb | 1976 |
The necessity of drug level monitoring in anticonvulsant drug therapy.
Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Patient Compliance; Phenobarbital; | 1976 |
The effects of phenobarbitone dose on plasma phenobarbitone levels in epileptic patients.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship | 1976 |
[Relationship between the anticonvulsive effect of phenobarbital and serum levels].
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Protein Binding | 1976 |
[An analysis of 22 years' experience with the medicinal treatment of epilepsy].
Topics: Adult; Anticonvulsants; Bromides; Caffeine; Codeine; Drug Therapy, Combination; Epilepsy; Female; Hi | 1975 |
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale | 1975 |
Method for diphenylhydantoin and phenobarbital assay by gas chromatography.
Topics: Buffers; Chloroform; Chromatography, Gas; Chromatography, Thin Layer; Colorimetry; Epilepsy; Humans; | 1975 |
The adverse effect of anticonvulsant therapy on renal allograft survival. A preliminary report.
Topics: Adolescent; Anticonvulsants; Cadaver; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Kidne | 1976 |
Letter: Epanutin and isoniazid interaction.
Topics: Adult; Carbamazepine; Drug Interactions; Electroencephalography; Epilepsy; Ethambutol; Ethosuximide; | 1975 |
Anaesthesia and the epileptic pateint. A review.
Topics: Adult; Anesthesia, General; Anticonvulsants; Barbiturates; Central Nervous System; Child, Preschool; | 1975 |
[Clinical picture and therapy of epilepsy in childhood].
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Hu | 1975 |
Red cell folate and macrocytosis during long-term anticonvulsant therapy in non-anaemic mentally. Retarded epileptics.
Topics: Dose-Response Relationship, Drug; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid | 1975 |
Letter: Withdrawal symptoms in newborn infants of epileptic mothers.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pheno | 1975 |
Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values.
Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Analysis of Variance; Aspartate Aminotra | 1975 |
Chlormethiazole in status epilepticus--three cases.
Topics: Adult; Chlormethiazole; Diazepam; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin | 1975 |
[Plasma concentration of phenytoin in epileptics--importance for the clinician].
Topics: Adult; Child; Chromatography, Gas; Dose-Response Relationship, Drug; Epilepsy; Humans; Medication Er | 1975 |
A rapid gas-liquid chromatographic determination of serum levels of phenobarbital and diphenyllhydantoin.
Topics: Chromatography, Gas; Epilepsy; Humans; Microchemistry; Phenobarbital; Phenytoin | 1975 |
Cognitive and motor-sensory performances in toxic and nontoxic epileptic subjects.
Topics: Adult; Attention; Cognition; Epilepsy; Female; Humans; Intelligence Tests; Male; Motor Skills; Pheno | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Unexpected, unexplained death in epileptic patients.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Death, Sudden; Epilepsy; Female; Humans; Male; Mid | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Anticonvulsant drug blood levels.
Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi | 1975 |
[Current viewpoints in drug treatment of epilepsy, with reference to the most common drugs in current use].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; Phenytoin | 1975 |
Relationships among dose, serum and CSF levels and urinary output in fenobarbital and fenitoin treatment of epileptics.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phe | 1975 |
Comparative study of proteins and lactic dehydrogenase isoenzymes in the blood and cerebrospinal fluid of nontreated and of phenobarbital and diphenylhydantoin treated epileptic patients.
Topics: Blood Proteins; Cerebrospinal Fluid Proteins; Epilepsy; Humans; Isoenzymes; L-Lactate Dehydrogenase; | 1975 |
Therapeutic response relationship to phenobarbital and diphenylhydantoin serum and cerebrospinal fluid levels in epileptics.
Topics: Adolescent; Adult; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Huma | 1975 |
Respiratory failure as a seizure phenomenon. A case report.
Topics: Brain Edema; Diazepam; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Respiratory Insufficiency | 1975 |
Influence of phenobarbital on bile composition in epileptic patients.
Topics: Adolescent; Adult; Aged; Bile; Bile Acids and Salts; Cholesterol; Epilepsy; Female; Humans; Male; Mi | 1975 |
Phenytoin and phenobarbital concentrations in saliva and plasma measured by radioimmunoassay.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Humans; Infant; Middle Aged; Phenobarbital; Ph | 1975 |
Folate and monoamine metabolism in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Biogenic Amines; Epilepsy; Erythrocytes; Folic Acid; Homovanilli | 1975 |
Psychosocial management of patients with complex partial seizures.
Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
[Serum phenobarbital levels in epileptics].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans | 1975 |
Proceedings: Antiepileptic effect of psychostimulant drugs (combined antiepileptic agents containing phenobarbital and a psychostimulant component).
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Psychotropic Drugs | 1975 |
[Electroencephalographic observations in a patient with epileptic photomas].
Topics: Adult; Brain; Electroencephalography; Epilepsy; Functional Laterality; Hallucinations; Humans; Male; | 1975 |
Plasma level studies on different brands of sodium diphenylhydantoin (DPH) and primidone.
Topics: Biological Availability; Capsules; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital; Phenytoi | 1975 |
[Problems in the use of anti-epileptics. 2. Resorption and the influence of resorption].
Topics: Animals; Anticonvulsants; Child; Epilepsy; Humans; Hydroxylation; Milk; Phenobarbital; Phenytoin; Po | 1975 |
Discrepancies in recommended dosage regimens of drugs.
Topics: Adult; Epilepsy; Humans; Phenobarbital; Phenytoin | 1976 |
Letter: Failure to confirm anticonvulsant hypomagnesaemia.
Topics: Epilepsy; Humans; Magnesium Deficiency; Phenobarbital; Phenytoin | 1976 |
Interaction of quinidine with anticonvulsant drugs.
Topics: Adult; Arrhythmias, Cardiac; Depression, Chemical; Drug Interactions; Enzyme Induction; Epilepsy; Fe | 1976 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1976 |
Interlaboratory variability in determination of plasma antiepileptic drug concentrations.
Topics: Anticonvulsants; Epilepsy; Ethosuximide; Humans; Laboratories; Phenobarbital; Phenytoin; Primidone; | 1976 |
Radioimmunoassay, enzyme immunoassay, spectrophotometry, and gas-liquid chromatography compared for determination of phenobarbital and diphenylhydantoin.
Topics: Chromatography, Gas; Cross Reactions; Enzymes; Epilepsy; Evaluation Studies as Topic; Humans; Immuno | 1976 |
Letter to the editor: Behavioural effects of anti-epileptic drugs.
Topics: Anticonvulsants; Child; Child Behavior; Epilepsy; Humans; Phenobarbital | 1976 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
Effects of epilepsy on daily functioning in northern Ecuador: summary of findings of a population-based research project.
Topics: Activities of Daily Living; Adaptation, Psychological; Adolescent; Adult; Carbamazepine; Cross-Secti | 1992 |
Effects of phenobarbital, carbamazepine and a combination of both on corazol-induced changes in the bioelectric activity of rat brains.
Topics: Animals; Brain; Carbamazepine; Electroencephalography; Epilepsy; Male; Pentylenetetrazole; Phenobarb | 1992 |
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy | 1992 |
"An analysis of epileptic patients nonresponsive to drugs".
Topics: Anticonvulsants; Carbamazepine; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combina | 1992 |
Cognitive effects of antiepileptic drug discontinuation.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; | 1992 |
Long-term influence of anticonvulsant agents on calcitonin, parathyroid hormone and osteocalcin.
Topics: Adult; Anticonvulsants; Calcitonin; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epi | 1992 |
Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1992 |
Glutathione adduct of hemoglobin (Hb ASSG) in hemolysates of patients on long-term antiepileptic therapy.
Topics: Carbamazepine; Epilepsy; Female; Glutathione; Glycated Hemoglobin; Humans; Isoelectric Focusing; Iso | 1992 |
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, | 1992 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
Dupuytren's and epilepsy revisited.
Topics: Adult; Aged; Anticonvulsants; Dupuytren Contracture; England; Epilepsy; Female; Fingers; Humans; Inc | 1992 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Aci | 1992 |
Influence of antiepileptic drugs on sleep patterns.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Chil | 1991 |
[Evaluation of the prevalence of side effects of phenobarbital in patients in the Champagne-Ardenne region].
Topics: Adult; Anticonvulsants; Epilepsy; Female; France; Gingivitis; Humans; Male; Middle Aged; Phenobarbit | 1991 |
[Effects of SC1001-sodium on hippocampal kindled seizures by coriaria lactone in rabbits].
Topics: Animals; Anticonvulsants; Epilepsy; Female; Hippocampus; Kindling, Neurologic; Lactones; Male; Pheno | 1991 |
[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Evaluation; Epilepsy; Humans; Middle Aged; Pheno | 1991 |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls.
Topics: Adolescent; Adult; Cognition; Cognition Disorders; Epilepsy; Humans; Middle Aged; Neuropsychological | 1991 |
Phenobarbital doses necessary to achieve 'therapeutic' concentrations in children.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug | 1991 |
Intrathecal antiepileptic drugs in experimental epilepsy.
Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, | 1991 |
Plasma uric acid in patients receiving anticonvulsant monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Prosp | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Epilepsy; Kindling | 1991 |
[Effectiveness of bromide in therapy resistant epilepsy of dogs].
Topics: Animals; Bromides; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Resistance; Epilepsy; | 1991 |
Epileptic patients refractory to drug therapy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin G; Immunoglobulins; Male; Middle Aged | 1991 |
Antiepileptic medication in pregnancy: late effects on the children's central nervous system development.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Central Nervous System; Child; Child De | 1991 |
Seizures: introduction and commentary.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valpr | 1991 |
Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital.
Topics: Adolescent; Adult; Analysis of Variance; Apolipoproteins A; Apolipoproteins B; Carbamazepine; Child; | 1991 |
Effect of phenobarbital on the pharmacokinetics of carbamazepine-10,11-epoxide, an active metabolite of carbamazepine.
Topics: Adult; Biological Availability; Carbamazepine; Drug Interactions; Epilepsy; Humans; Male; Middle Age | 1991 |
Mono- or polypharmacotherapy in institutionalized epileptic children with severe mental retardation? A team approach for optimizing antiepileptic therapy.
Topics: Adolescent; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Evaluation Studies as Topic | 1991 |
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients.
Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
Protein changes associated with cobalt-induced epileptic activity in rat cerebral cortex.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Cobalt; Electroencephalography; Epilepsy; Male; Motor Co | 1991 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug I | 1990 |
Possible roles for frequent salivary antiepileptic drug monitoring in the management of epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Female; Humans; Male; Menstrua | 1990 |
[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].
Topics: Adolescent; Adult; Brain Ischemia; Caffeine; Cerebrovascular Circulation; Drug Therapy, Combination; | 1990 |
[The use of phenobarbital and carbamazepine (finlepsin) in children with epilepsy and cerebral spastic palsy with epileptic syndrome].
Topics: Adolescent; Carbamazepine; Cerebral Palsy; Child; Dose-Response Relationship, Drug; Drug Therapy, Co | 1990 |
Direct serum injection high-performance liquid chromatographic method for the simultaneous determination of phenobarbital, carbamazepine and phenytoin.
Topics: Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Humans; Immunoenzyme Techniques; Phen | 1990 |
Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children.
Topics: Child; Epilepsy; Female; Follow-Up Studies; Humans; Intelligence; Learning Disabilities; Male; Pheno | 1990 |
Rapid anti-epileptic drug assay.
Topics: Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Hum | 1990 |
[Computerized analysis of EEG background activity in mono-therapeutic patients with epilepsy--relationships between antiepileptic drugs and types of seizures].
Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Electroencephalography; Epilepsy; Female; Huma | 1990 |
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepin | 1990 |
Five epileptic cases who manifested psychotic states under the toxic levels of antiepileptic drugs.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Humans; Phen | 1990 |
Problems of drug therapy of epilepsy in developing countries.
Topics: Anticonvulsants; Community Health Services; Developing Countries; Epilepsy; Health Services Accessib | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital | 1990 |
Comparative experimental study of antiepileptics--regional specificity of antiepileptic action of carbamazepine, phenobarbital and valproate sodium.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Male; Motor Cortex; Phenobarbital; R | 1990 |
The disposition of primidone in elderly patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Chromatography, High Pressure | 1990 |
Plasma level distribution, effect and toxicity of antiepileptic drugs among Ethiopian epileptics.
Topics: Adolescent; Adult; Child; Drug Therapy, Combination; Epilepsy; Ethiopia; Female; Humans; Male; Pheno | 1990 |
Phenobarbital treatment and major depressive disorder in children with epilepsy: a naturalistic follow-up.
Topics: Adolescent; Analysis of Variance; Carbamazepine; Child; Depressive Disorder; Epilepsy; Follow-Up Stu | 1990 |
Influence of surgery and antiepileptic drugs on seizures symptomatic of cerebral tumours.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; | 1990 |
Serum protein binding of antiepileptic drugs in Sri Lankans.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Drug Therapy, Combination; Epilep | 1990 |
Treating epilepsy in Malawi: lessons learned.
Topics: Adult; Child; Epilepsy; Follow-Up Studies; Humans; Malawi; Patient Education as Topic; Phenobarbital | 1990 |
Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding.
Topics: Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Maternal-Fetal Exch | 1990 |
Nutrition and enzyme inducers in liver tumor promotion in human and rat.
Topics: Animals; Brassica; Carcinogens; Cytochrome P-450 Enzyme System; Enzyme Induction; Epilepsy; Humans; | 1990 |
Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid.
Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Epilepsy; Esterases; Female; Humans; Male; Phenobarb | 1989 |
A model for managing epilepsy in a rural community in Africa.
Topics: Epilepsy; Health Education; Health Services Administration; Humans; Malawi; Mobile Health Units; Out | 1989 |
The prevalence of adverse reactions to anticonvulsants in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi | 1989 |
Hepatic lesions in Danish epileptics after long-term exposure to anticonvulsant drugs including phenobarbitone.
Topics: Adult; Aged; Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Denmark; Epilepsy; Hu | 1989 |
The effect of concurrent administration of sodium valproate on serum levels of primidone and its metabolite phenobarbital.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; | 1989 |
Serum free levels and evaluation anticonvulsant drug interactions.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Valproi | 1989 |
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi | 1989 |
Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention.
Topics: Anticonvulsants; Attention; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial; Ep | 1989 |
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hipp | 1985 |
Genotoxicity evaluation in patients on phenobarbital monotherapy by sister chromatid exchange.
Topics: Adult; Animals; Cricetinae; DNA; Epilepsy; Humans; Lymphocytes; Male; Phenobarbital; Sister Chromati | 1989 |
Dosing accuracy of antiepileptic drug regimens as determined by serum concentrations in outpatient epilepsy clinic patients.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Outpatients; Phenobarbital; Phenytoin | 1989 |
[Metabolism of an antiepileptic drug halonal in experimental studies].
Topics: Animals; Anticonvulsants; Barbiturates; Biological Availability; Chemical Phenomena; Chemistry; Drug | 1989 |
[Saliva phenobarbital concentration in epileptics].
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Middle Aged; Phe | 1989 |
Daily salivary anticonvulsant monitoring in patients with intractable epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Monitoring, Physiologic; Phenobarbi | 1989 |
Immunochromatographic measurement of phenobarbital in whole blood with a non-instrumented assay.
Topics: Chromatography; Epilepsy; Humans; Immunologic Techniques; Phenobarbital | 1989 |
Cancer among epileptic patients exposed to anticonvulsant drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Neoplasms; Child; Child, Preschool; Denmark; | 1989 |
Clinical and EEG response to anticonvulsants in neonatal seizures.
Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Paraldehyde; P | 1989 |
The effect of anticonvulsants on the dexamethasone suppression test.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Carbamazepine; Depressive Disorder; Dexamethasone; Epileps | 1989 |
The effect of phenobarbital on human plasma lipids.
Topics: Adult; Aged; Aging; Apolipoproteins; Body Weight; Cholesterol; Epilepsy; Female; Humans; Lipids; Mid | 1989 |
Serum 5'-nucleotidase in patients receiving anti-epileptic drugs.
Topics: 5'-Nucleotidase; Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Carbamazepine; Child; C | 1985 |
Factors that affect the induction of gamma glutamyltransferase in epileptic patients receiving anti-convulsant drugs.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Dru | 1987 |
Benign nocturnal childhood occipital epilepsy: a new syndrome with nocturnal seizures, tonic deviation of the eyes, and vomiting.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Male; Nystagmus | 1989 |
Epilepsy and mental retardation following febrile seizures in childhood.
Topics: Child; Child, Preschool; Epilepsy; Humans; Infant; Intellectual Disability; Phenobarbital; Recurrenc | 1989 |
Valproate-associated hyperammonemia and DL-carnitine supplement.
Topics: Adolescent; Adult; Ammonia; Carbamazepine; Carnitine; Child; Child, Preschool; Disabled Persons; Dru | 1987 |
Different actions of vitamin D2 and D3 on bone metabolism in patients treated with phenobarbitone/phenytoin.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Calcium; Cholecalciferol; Double-Blind Method; Epilepsy | 1985 |
Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Baclofen; Carbamazepine; Diazepam; Epilepsy; gamma-Aminobutyric Acid; Guin | 1986 |
Different metabolism of vitamin D2/D3 in epileptic patients treated with phenobarbitone/phenytoin.
Topics: 24,25-Dihydroxyvitamin D 3; 25-Hydroxyvitamin D 2; Adult; Aged; Calcifediol; Calcium; Cholecalcifero | 1986 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbill | 1988 |
Antiepileptic effects of globulin-N, an intact human immunoglobulin and its tissue-distribution in kindled cats.
Topics: Amygdala; Animals; Anticonvulsants; Autoradiography; Cats; Drug Combinations; Epilepsy; Half-Life; I | 1986 |
Use of anticonvulsants in small animals.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Dog Diseases; Dogs; Epilepsy; Epilepsy, Tonic-Clonic; | 1986 |
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbita | 1986 |
Representativity of regional to total bone mineral in healthy subjects and 'anticonvulsive treated' epileptic patients. Measurements by single and dual photon absorptiometry.
Topics: Adolescent; Adult; Age Factors; Aged; Bone and Bones; Bone Diseases, Metabolic; Epilepsy; Female; Hu | 1986 |
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
Topics: Adult; Calcium; Carbamazepine; Diet; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Ultra | 1986 |
Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy, Combination; Epil | 1986 |
Effects of coadministered antiepileptic drugs on free fractions of phenobarbital and valproic acid in epileptic children.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Serum Albumin; V | 1986 |
Monitoring of phenobarbitone in epileptic children.
Topics: Child; Child Behavior; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Protein-Energy Mal | 1987 |
[Modification of psychophysical performance of the human by anticonvulsants].
Topics: Anticonvulsants; Arousal; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mental Processes; | 1987 |
Luteinizing hormone pulsatile secretion and pituitary response to gonadotropin releasing hormone and to thyrotropin releasing hormone in male epileptic subjects on chronic phenobarbital treatment.
Topics: Adult; Epilepsy; Estradiol; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormone; Male; Middl | 1987 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; | 1987 |
Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.
Topics: Adolescent; Brain Diseases; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; | 1988 |
Delayed bone development in epileptic children assessed by microdensitometer.
Topics: Adolescent; Anticonvulsants; Bone Development; Calcifediol; Calcitriol; Child; Child, Preschool; Den | 1988 |
Withdrawal of barbiturate anticonvulsant drugs: prospective controlled study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Partial; Epi | 1988 |
[Metabolism of the anticonvulsant preparation Benzonal in the human body].
Topics: Anticonvulsants; Barbiturates; Epilepsy; Humans; Hydrolysis; Phenobarbital | 1988 |
Are phenobarbital and phenytoin obsolete in the treatment of epilepsy?
Topics: Epilepsy; Humans; Phenobarbital; Phenytoin | 1988 |
Sex steroid and gonadotropin changes during phenobarbital therapy in epilepsy.
Topics: Epilepsy; Gonadotropins, Pituitary; Humans; Luteinizing Hormone; Male; Phenobarbital | 1988 |
Free drug levels monitoring as a detector of false metabolic refractory epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged | 1988 |
Epilepsy in infancy.
Topics: Epilepsy; Humans; Infant; Infant, Newborn; Phenobarbital; Status Epilepticus | 1988 |
Epilepsy in infancy.
Topics: Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Phenobarbital | 1988 |
[Serum levels of triiodothyronine, thyroxine and thyrotropin in children with epilepsy treated with amizepine, luminal and mizodine in a monotherapy system. Preliminary report].
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbit | 1988 |
[The effects of age and concurrently administered of antiepileptic drugs on the apparent clearance of phenobarbital in epileptic children].
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Drug Therapy, | 1988 |
Seizures in the neonatal intensive care unit of the 1980s. Types, Etiologies, Timing.
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Epilepsy; Female; Gestational Age; Humans; Infant, L | 1988 |
Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.
Topics: Adult; Aged; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Phenytoin | 1988 |
Plasma and urinary taurine in epilepsy.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; T | 1988 |
Effectiveness of a therapeutic drug monitoring service as an aid to the control of canine seizures.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Female; Male; Phenobarbital; Primidone | 1988 |
Primidone and phenobarbital during lactation period in epileptic women: total and free drug serum levels in the nursed infants and their effects on neonatal behavior.
Topics: Behavior; Epilepsy; Female; Half-Life; Humans; Infant, Newborn; Milk, Human; Phenobarbital; Primidon | 1988 |
Corticosteroid-unresponsive pemphigus vulgaris following antiepileptic therapy.
Topics: Adult; Drug Interactions; Epilepsy; Humans; Male; Pemphigus; Phenobarbital; Phenytoin; Prednisolone; | 1988 |
[Reliable induction of generalized seizures in hippocampal kindling triggered with low-frequency electrical stimulations].
Topics: Animals; Cats; Electric Stimulation; Epilepsy; Haloperidol; Hippocampus; Kindling, Neurologic; Model | 1988 |
[Cytogenetic analysis of lymphocytes from epileptic dogs].
Topics: Animals; Anticonvulsants; Chromosome Aberrations; Dog Diseases; Dogs; Epilepsy; Lymphocytes; Phenoba | 1987 |
Minor additive inducing effects of phenobarbital on carbamazepine clearance in patients on combined carbamazepine-phenytoin therapy.
Topics: Aged; Carbamazepine; Drug Interactions; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Phenytoi | 1987 |
The value of investigations, the significance of perinatal and family histories and the prevalence of side effects to phenobarbitone in children with recurrent seizures.
Topics: Child Behavior; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Pregnancy; Recurrenc | 1986 |
Monitoring of drug therapy in epileptic children.
Topics: Child; Epilepsy; Humans; Monitoring, Physiologic; Phenobarbital; Phenytoin | 1987 |
Circadian patterns of vigilance and seizure susceptibility in genetically epileptic mice: heuristic aspects in neurology.
Topics: Animals; Arousal; Brain; Circadian Rhythm; Dextroamphetamine; Epilepsy; Light; Mice; Phenobarbital; | 1987 |
Phenobarbital treatment and major depressive disorder in children with epilepsy.
Topics: Adolescent; Carbamazepine; Child; Depressive Disorder; Epilepsy; Humans; Phenobarbital; Suicide, Att | 1987 |
Overrepresentation of epileptics in a consecutive series of suicide attempters seen at a children's hospital, 1978-1983.
Topics: Adolescent; Child; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Male; Phenobarbital; Risk; Sui | 1986 |
Spread and arrest of seizures: the importance of layer 4 in laminar interactions during neocortical epileptogenesis.
Topics: Action Potentials; Animals; Anticonvulsants; Bicuculline; Biomechanical Phenomena; Cats; Cerebral Co | 1986 |
Measuring anti-convulsant levels in the accident and emergency department.
Topics: Adult; Carbamazepine; Emergencies; Epilepsy; Humans; Patient Compliance; Phenobarbital; Phenytoin; P | 1986 |
[Phenomenon of "paradoxical poisoning" during antiepileptic therapy].
Topics: Adult; Anticonvulsants; Barbiturates; Carbamazepine; Child; Drug Synergism; Drug Therapy, Combinatio | 1986 |
[Concentration of benzonal in the blood of epileptic patients at different daily doses and with other anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzamidines; Epilepsy; Female; Humans; Male; Phen | 1986 |
Early prognosis of epilepsy. Effects of treatment in the first follow-up year.
Topics: Adolescent; Aged; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Female | 1986 |
Effect of influenza vaccine on serum anticonvulsant concentrations.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Influenza Vaccines; Inf | 1986 |
Correlation between the saliva and free serum concentration of phenobarbital in epileptic children.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Hydrogen-Ion Concentration; Male; Phe | 1986 |
Phenobarbital-induced pemphigus vulgaris.
Topics: Adult; Autoantibodies; Epilepsy; Extracellular Space; Female; Humans; Pemphigus; Phenobarbital | 1986 |
[Phenobarbital: an ever-current drug].
Topics: Adolescent; Adult; Aged; Child; Drug Evaluation; Epilepsy; Female; Humans; Male; Middle Aged; Phenob | 1985 |
Studies of qingyangshen (root of Cynanchum otophyllum). I. Effect of qingyangshen on copper and zinc metabolism.
Topics: Animals; Anticonvulsants; Copper; Drugs, Chinese Herbal; Epilepsy; Medicine, Chinese Traditional; Me | 1985 |
Effect of chronic anticonvulsant monotherapy on lymphocyte subpopulations in adult epileptic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Complement System Proteins; Epilepsy; Femal | 1985 |
[Determination of antiepileptic serum levels in patients with mono- and polytherapy in correlation with the clinical picture of the disease].
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Monotherapy and polytherapy for intractable epilepsies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; D | 1985 |
Interictal EEG prediction of response to antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalogr | 1985 |
Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Ethosuximi | 1985 |
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia.
Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epileps | 1985 |
The optimum use of anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phen | 1985 |
Effect of serum albumin on free fractions of phenobarbital and valproic acid in patients with convulsive seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Inf | 1985 |
Where, why, and what type of therapy.
Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum | 1985 |
Monitoring: the most important role of the pediatrician.
Topics: Activities of Daily Living; Anticonvulsants; Carbamazepine; Child, Preschool; Environmental Monitori | 1985 |
Serum concentrations of valproic acid: influence of dose and comedication.
Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps | 1985 |
Use of total and free anticonvulsant serum levels in clinical practice.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin; | 1985 |
Paroxysmal awakenings from sleep associated with excessive daytime somnolence: a form of nocturnal epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Arousal; Clonazepam; Electroencephalography; Epilepsy; Female; H | 1986 |
Compliance with anticonvulsant therapy by epileptic youth. Relationships to psychosocial aspects of adolescent development.
Topics: Adolescent; Child; Epilepsy; Female; Humans; Individuation; Male; Parent-Child Relations; Patient Co | 1986 |
Alternative single anticonvulsant drug therapy for refractory epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsy; Humans; Phenobarbital; Phenytoin; | 1986 |
The influence of seizure type on the efficacy of plasma concentrations of phenytoin, phenobarbital, and carbamazepine.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Phenytoin | 1986 |
Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy.
Topics: Adolescent; Adult; Epilepsy; Estradiol; Estriol; Estrone; Female; Gonadal Steroid Hormones; Humans; | 1986 |
Carbamazepine and carbamazepine-10,11-epoxide serum concentrations in epileptic children.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 1985 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electrocardio | 1985 |
Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan.
Topics: Adolescent; Adult; Age Factors; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Male; Mi | 1985 |
Monitoring drug noncompliance in epileptic patients: assessing phenobarbital plasma levels.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Mon | 1985 |
Epilepsy in a community--management and social impact.
Topics: Adolescent; Adult; Aged; Ambulatory Care Facilities; Carbamazepine; Craniocerebral Trauma; Epilepsy; | 1985 |
Effect of antiepileptic drugs on short-latency somatosensory evoked potentials.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephal | 1985 |
Therapeutic efficacy of phenobarbital and primidone in canine epilepsy: a comparison.
Topics: Animals; Dog Diseases; Dogs; Epilepsy; Phenobarbital; Primidone | 1985 |
Lateral gaze nystagmus in carbamazepine-treated epileptic patients: correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Nystagmus, Pathologic; Phenobarbital | 1985 |
[Anticonvulsive prophylaxis after juvenile craniocerebral injuries: a retrospective evaluation].
Topics: Anticonvulsants; Brain Concussion; Child; Drug Therapy, Combination; Electroencephalography; Epileps | 1985 |
The role of antiepileptics in sudden death in epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Death, Sudden; Epilepsy; Female; Humans; Male; Patient Compli | 1985 |
[Electroclinical characteristics of the effects of barbiturates on penicillin-induced epilepsy].
Topics: Animals; Electrocardiography; Epilepsy; Penicillins; Phenobarbital; Rabbits | 1985 |
[Convulsive crises in childhood].
Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi | 1985 |
Plasma gamma-glutamyl transpeptidase elevation in patients receiving enzyme-inducing drugs.
Topics: Acyltransferases; Depression; Drug Synergism; Enzyme Induction; Epilepsy; Ethanol; Glutamates; Human | 1971 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
4 C-sex vertex spindles.
Topics: Action Potentials; Brain; Brain Concussion; Cerebrovascular Disorders; Electroencephalography; Epile | 1973 |
Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.
Topics: Acromegaly; Adult; Anticonvulsants; Carbamazepine; Child; Diazepam; Diseases in Twins; Epilepsy; Epi | 1973 |
Are anticonvulsants oncogenic?
Topics: Anticonvulsants; Denmark; Epilepsy; Female; Humans; Male; Neoplasms; Phenobarbital; Phenytoin; Primi | 1974 |
Electron microscopical diagnosis of lipidosis with the use of rectal biopsy.
Topics: Adolescent; Aggression; Biopsy; Chlorpromazine; Epilepsy; Gait; Humans; Inclusion Bodies; Intellectu | 1974 |
[Iatrogenic algodystrophy caused by phenobarbitone].
Topics: Anxiety Disorders; Diabetes Complications; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbita | 1974 |
[Calcium metabolism during antiepileptic therapy].
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Antipsychotic Agents; Calcium; Calcium Isotopes; Creat | 1973 |
Effect of clonazepam (Ro 5-4023) on epileptic seizures.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepinones; Carbamazepine; Chlorobenzenes; Drug Evaluatio | 1973 |
Choreo-athetosis and encephalopathy induced by phenytoin.
Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile | 1974 |
Prevalence and treatment of vitamin D deficiency in children on anticonvulsant drugs.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Calcium; Cholecalciferol; Diet; Enzyme Induction; | 1974 |
Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction.
Topics: Adipates; Anticonvulsants; Child; Child, Preschool; Enzyme Induction; Epilepsy; Female; gamma-Glutam | 1974 |
Epilepsy.
Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec | 1974 |
Gastrointestinal function in anticonvulsant megaloblastic anaemia.
Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Intestinal Absorption; Phenobarbita | 1966 |
Flicker-induced cardiac arrest in a patient with epilepsy.
Topics: Adult; Electroencephalography; Epilepsy; Ergotamine; Heart Arrest; Humans; Light; Male; Phenobarbita | 1966 |
Phenobarbital and the shoulder-hand syndrome.
Topics: Adult; Aged; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital; Reflex Sympathetic Dystroph | 1966 |
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; M | 1967 |
Neuropsychiatric aspects of anticonvulsant megaloblastic anaemia.
Topics: Acetazolamide; Adult; Anemia, Macrocytic; Epilepsy; Female; Folic Acid; Humans; Male; Middle Aged; P | 1968 |
Longitudinal EEG and clinical study of children with febrile convulsions.
Topics: Acute Disease; Age Factors; Blood Chemical Analysis; Cerebral Cortex; Child, Preschool; Electroencep | 1968 |
Evoked potential studies in response to light in the baboon (Papio papio).
Topics: Animals; Cerebral Cortex; Chlorpromazine; Diazepam; Epilepsy; Evoked Potentials; Haplorhini; Light; | 1967 |
Low plasma-bilirubin in epileptics on phenobarbitone.
Topics: Bilirubin; Enzyme Induction; Epilepsy; Female; Glucuronates; Humans; Liver; Male; Phenobarbital; Sex | 1969 |
Management of convulsions.
Topics: Child; Diazepam; Epilepsy; Humans; Phenobarbital; Seizures | 1970 |
Neonatal haemorrhage following maternal anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P | 1970 |
Effect of anticonvulsant drugs on insecticide residues.
Topics: Agriculture; Epilepsy; Humans; Insecticides; Phenobarbital; Phenytoin | 1970 |
The effect of anticonvulsant therapy upon the absorption of folates.
Topics: Adult; Aged; Anticonvulsants; Biological Assay; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; | 1973 |
[Inheritance of spike-wave complexes and febrile seizures in three generations].
Topics: Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Tonic-Clonic; Ethosuximi | 1973 |
Antiepileptic therapy and rickets in children.
Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, To | 1973 |
The pattern of epilepsy in Uganda.
Topics: Adolescent; Adult; Age Factors; Black People; Child; Child, Preschool; Electroencephalography; Epile | 1973 |
Folate studies in underprivileged children with epilepsy.
Topics: Anticonvulsants; Biological Assay; Child; Child, Preschool; Epilepsy; Euglena; Folic Acid; Hematocri | 1973 |
[Worsening of epilepsies under treatment].
Topics: Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlorobenzenes; Drug Therapy, Combinati | 1973 |
Epilepsy in cerebral hydatidosis.
Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Dominance, Cerebral; Echinococcosis; Ele | 1974 |
Bioavailability of primidone in epileptic patients.
Topics: Administration, Oral; Adult; Amides; Epilepsy; Humans; Long-Term Care; Male; Malonates; Middle Aged; | 1974 |
[Anti-epileptic treatment supervision in an Medico-Pedagogic-Institute for average mental retardation].
Topics: Adolescent; Child; Child, Institutionalized; Electroencephalography; Epilepsy; Epilepsy, Absence; Ep | 1974 |
Occipital lobe epilepsy. A clinical and electroencephalographic study.
Topics: Adolescent; Adult; Blindness; Child; Diagnosis, Differential; Electroencephalography; Epilepsy; Epil | 1974 |
Therapy of seizures in children.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec | 1974 |
Megaloblastic anaemia developing during treatment of epilepsy.
Topics: Adult; Anemia, Macrocytic; Anticonvulsants; Blood; Epilepsy; Folic Acid; Hemoglobins; Humans; Huntin | 1966 |
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D | 1972 |
Paroxysmal choreoathetosis. Report of Chinese cases.
Topics: Adult; Age Factors; Athetosis; China; Electroencephalography; Epilepsy; Female; Humans; Huntington D | 1973 |
[Current criteria of medical therapy of epilepsy].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Child, Preschool; Dexamethas | 1967 |
[The treatment of epiletic seizures in childhood].
Topics: Adrenocorticotropic Hormone; Ambulatory Care; Anticonvulsants; Barbiturates; Child; Child, Preschool | 1968 |
Dilantin and metyrapone: a clinically significant example of enzyme induction.
Topics: 17-Hydroxycorticosteroids; Adrenocorticotropic Hormone; Animals; Depression, Chemical; Endoplasmic R | 1970 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Progressive myoclonus with epilepsy.
Topics: Adult; Child; Chlordiazepoxide; Epilepsy; Female; Humans; Inclusion Bodies; Lipidoses; Myoclonic Cer | 1972 |
[Vitamin D metabolism and antiepileptics].
Topics: Adolescent; Adult; Anticonvulsants; Carbon Isotopes; Child; Cholecalciferol; Chromatography; Enzyme | 1972 |
Intestinal absorption of vitamin D 3 in epileptic patients and phenobarbital-treated rats.
Topics: Adult; Aged; Animals; Anticonvulsants; Cholecalciferol; Epilepsy; Female; Humans; Hydroxylation; Int | 1972 |
Peripheral nerve function in long-term therapy with diphenylhydantoin. A clinical and electrophysiologic correlation.
Topics: Adult; Aged; Carbamazepine; Electric Stimulation; Electromyography; Epilepsy; Ethosuximide; Evoked P | 1974 |
Nerve conduction velocity in patients on long-term diphenylhydantoin therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Child; Drug Therapy, Combination; Electrodiagnosis; Epilepsy; | 1974 |
Iatrogenic disorders in epilepsy.
Topics: Adrenal Insufficiency; Anemia, Macrocytic; Animals; Anticonvulsants; Cats; Cerebellar Diseases; Drug | 1970 |
[Anticonvulsants and vitamin D metabolism (author's transl)].
Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol | 1974 |
Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Blood Coagulation Disorders; Epilepsy; Female; Human | 1971 |
Days of our years.
Topics: Anticonvulsants; Bromides; Epilepsy; Female; History, 20th Century; Humans; Male; Phenobarbital; Tri | 1967 |
Epilepsy.
Topics: Adult; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, T | 1969 |
Drug treatment of epilepsy in childhood.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil | 1969 |
Anticonvulsant drugs in idiopathic epilepsy.
Topics: Acetazolamide; Anticonvulsants; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Hydantoins; Mepho | 1970 |
A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography.
Topics: Acetazolamide; Anticonvulsants; Benzazepines; Carbamazepine; Chlordiazepoxide; Chromatography, Thin | 1971 |
[Medical treatment of epilepsy].
Topics: Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Hydantoins; | 1971 |
Serum -glytamyl transpeptidase activity in liver disease.
Topics: Acyltransferases; Adolescent; Adult; Aged; Alkaline Phosphatase; Aspartate Aminotransferases; Barbit | 1972 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Letter: Sleep epilepsy.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Delayed-Action Preparations; Dextroamphetam | 1974 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |
Letter: Anticonvulsants and vitamin D metabolism.
Topics: Child; Drug Therapy, Combination; Epilepsy; Humans; Osteomalacia; Phenobarbital; Phenytoin; Primidon | 1974 |
Argininosuccinicaciduria: clinical, metabolic and dietary study.
Topics: Affective Symptoms; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginase; Arginine; Ataxia; Child | 1974 |
Serum immunoglobulins in epilepsy.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Folic Acid; Humans; Immunoglobulin | 1974 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
A study of children with epilepsy attending ordinary schools. I: their seizure patterns, progress and behaviour in school.
Topics: Adolescent; Aggression; Attention; Child; Child Behavior Disorders; Child, Preschool; Colitis, Ulcer | 1974 |
Plasma and cerebrospinal fluid concentrations of phenobarbital in infants given single doses.
Topics: Administration, Oral; Child, Preschool; Epilepsy; Female; Fever; Humans; Infant; Injections, Intramu | 1974 |
[Plasma diphenylhydantoin concentration in epileptic patients].
Topics: Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin | 1974 |
[Considerations and research on febrile convulsions].
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha | 1974 |
[Special viewpoints in the treatment with anticonvulsants in childhood. Value of determination of serum level of anticonvulsants in the treatment of seizures].
Topics: Adolescent; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phenyt | 1974 |
Iatrogenic nutritional effects of anticonvulsants.
Topics: Adolescent; Adult; Anticonvulsants; Blood Coagulation Disorders; Bone Diseases; Child; Child, Presch | 1974 |
Letter: Effect of phenytoin on serum phenobarbitone levels.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Huma | 1974 |
Sympodia.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile | 1974 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin.
Topics: Acetazolamide; Action Potentials; Cerebellum; Electroencephalography; Epilepsy; Phenobarbital; Pheny | 1972 |
Effects of diphenylhydantoin and other antiepileptic drugs on epileptiform activity and Purkinje cell discharge rates.
Topics: Acetazolamide; Action Potentials; Animals; Anticonvulsants; Blood Pressure; Cats; Cerebellum; Electr | 1972 |
Influence of diphenylhydantoin and phenobarbital on intestinal calcium transport in the rat.
Topics: Animals; Binding, Competitive; Calcium; Calcium Isotopes; Calcium Metabolism Disorders; Epilepsy; In | 1972 |
The effects of some anticonvulsant drugs on cobalt-induced epilepsy.
Topics: Animals; Cobalt; Electroencephalography; Epilepsy; Ethosuximide; Evaluation Studies as Topic; Fronta | 1973 |
Anticonvulsant drug-serum levels in psychiatric patients with seizure disorders. Effects of certain psychotropic drugs.
Topics: Chlorpromazine; Chromatography, Gas; Diazepam; Drug Interactions; Epilepsy; Humans; Mental Disorders | 1974 |
[Acute leukemia induced by diphenylhydantoin? Apropos of 4 cases].
Topics: Adult; Bone Marrow; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukemia, Lymphoid; Lung; L | 1973 |
Diazepam as an oral long-term anticonvulsant for epileptic mental patients.
Topics: Amobarbital; Anticonvulsants; Diazepam; Epilepsy; Evaluation Studies as Topic; Female; Humans; Long- | 1972 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.
Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography; | 1972 |
[Fever convulsions].
Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care; | 1972 |
Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration.
Topics: Amides; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Primidone | 1972 |
Treatment of epilepsy by the reciprocal inhibition of anxiety.
Topics: Adult; Anxiety Disorders; Behavior Therapy; Epilepsy; Female; Humans; Learning; Phenobarbital; Phobi | 1972 |
Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients.
Topics: Adult; Chromatography, Gas; Epilepsy; Female; Folic Acid; Humans; Male; Phenobarbital; Phenytoin; Pr | 1972 |
Toxic encephalopathy with seizures secondary to ingestion of composition C-4. A clinical and electroencephalographic study.
Topics: Adult; Brain Diseases; Electroencephalography; Epilepsy; Explosions; Humans; Male; Military Medicine | 1972 |
The simultaneous determination of multiple anticonvulsant drug levels by gas-liquid chromatography. Method and clinical application.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Epilepsy; Ethosuxi | 1972 |
Follow-up of epileptic outpatients.
Topics: Adolescent; Adult; Aged; Educational Status; Employment; Epilepsy; Female; Follow-Up Studies; Humans | 1973 |
Leucine aminopeptidase isoenzyme changes after treatment with anticonvulsant drugs.
Topics: Blood Protein Electrophoresis; Blood Proteins; Epilepsy; Humans; Isoenzymes; Jaundice; Leucyl Aminop | 1973 |
Rare diseases, old drug, new knowledge.
Topics: Animals; Bilirubin; Epilepsy; Female; Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1973 |
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S | 1973 |
Diencephalic autonomic epilepsy caused by a neoplasm.
Topics: Astrocytoma; Autonomic Nervous System; Brain Neoplasms; Diencephalon; Epilepsy; Female; Humans; Infa | 1973 |
Surgical management of diastatic linear skull fractures in infants.
Topics: Age Factors; Child; Child, Preschool; Craniotomy; Epilepsy; Female; Follow-Up Studies; Humans; Infan | 1973 |
Pheneturide, a more potent liver enzyme inducer in man than phenobarbitone?
Topics: Adipates; Anticonvulsants; Enzyme Induction; Epilepsy; Female; Humans; Liver; Male; Phenobarbital; P | 1973 |
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital; | 1973 |
Rickets precipitated by anticonvulsant drugs in a child receiving prophylactic vitamin D.
Topics: Adolescent; Alkaline Phosphatase; Calcium; Epilepsy; Female; Humans; Ilium; Phenobarbital; Phenytoin | 1973 |
Preliminary observations of serum carbamazepine concentration in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Mid | 1973 |
[Genetic questionnaire. Genetic counseling for a patient with the complex association of G-6-PD deficiency, Gronblad-Strandberg syndrome (pseudo-xanthoma elasticum) and epilepsy].
Topics: Adult; Epilepsy; Favism; Genetic Counseling; Glucosephosphate Dehydrogenase Deficiency; Humans; Kidn | 1973 |
The role of antiepileptic blood levels in the treatment of patients with epilepsy.
Topics: Adult; Drug Therapy, Combination; Epilepsy; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; P | 1973 |
[Editorial: Antiepileptic agents--folic acid].
Topics: Anemia, Macrocytic; Epilepsy; Folic Acid; Folic Acid Deficiency; Humans; Phenobarbital; Phenytoin; P | 1973 |
The influence of phenobarbital and diphenylhydantoin on some blood cation transport systems in epileptics.
Topics: Adolescent; Adult; Aged; Biological Transport; Brain; Child; Child, Preschool; Electrolytes; Epileps | 1973 |
A rapid method for the estimation of anti-epileptic drugs in blood serum by gas-liquid chromatography.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Epilepsy; Ethosuximide; Evaluation Studies as T | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
The orienting reflex in epilepsy: electrographic data concerning the effect of antiepileptic treatment upon the interictal changes in the orienting reflex. Human data.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Cardiovascular System; Child; Drug Combinations; Electroc | 1973 |
Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Depression, Chemical; Drug Therapy, Combination; Epil | 1973 |
[Complications of medical therapy for epilepsy in children and adolescents].
Topics: Anticonvulsants; Child; Diplopia; Drug Hypersensitivity; Drug Therapy, Combination; Epilepsy; Headac | 1973 |
[Frequency analysis of the human EEG in relation to the blood level of phenobarbital].
Topics: Administration, Oral; Adult; Brain; Electroencephalography; Epilepsy; Humans; Phenobarbital; Statist | 1973 |
Correlation of anticonvulsant levels in human plasma and epileptogenic brain.
Topics: Animals; Brain; Cerebral Cortex; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Phenobarbit | 1973 |
[Hemostasis in epileptic patients treated with anticonvulsant drugs].
Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Blood Coagulation Factors; Child; Drug Evaluat | 1973 |
Emergency management of the patient with seizures. 1. Generalized status epilepticus.
Topics: Airway Obstruction; Anesthesia, General; Anticonvulsants; Blood Pressure Determination; Blood Specim | 1974 |
The influence of diphenylhydantoin on primidone metabolism.
Topics: Adult; Biotransformation; Chromatography, Gas; Drug Interactions; Enzyme Induction; Epilepsy; Female | 1974 |
[Letter: Teratogenic hazards in antiepileptic therapy].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg | 1974 |
Calcium metabolism in elderly epileptic patients during anticonvulsant therapy.
Topics: Aged; Alkaline Phosphatase; Calcium; Cerebrovascular Disorders; Drug Therapy, Combination; Epilepsy; | 1974 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Letter: Anticonvulsant drugs and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Fingers; Humans; Infant; Nail | 1974 |
Pharmacology for the pediatrician. Noncompliance contributing to apparent drug failure in status epilepticus.
Topics: Anticonvulsants; Benzodiazepinones; Child; Chlorobenzenes; Diazepam; Epilepsy; Ethosuximide; Female; | 1974 |
Decrease in serum diphenylhydantoin levels after withdrawal of phenobarbital in epileptics treated with both drugs.
Topics: Child; Child, Preschool; Chromatography, Gas; Epilepsy; Female; Humans; Male; Phenobarbital; Phenyto | 1974 |
Serum levels of diphenylhydantoin and phenobarbital in epileptic children receiving diphenylhydantoin, phenobarbital and-or mysoline.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenobarbital; Phenytoi | 1974 |
Serum anticonvulsant concentrations in epileptic patients with mental symptoms. A preliminary report.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Intelligence; Male; Mental Disorders; Middle Aged | 1974 |
[Rickets and osteomalacia induced by anticonvulsant drugs].
Topics: Anticonvulsants; Epilepsy; Humans; Hydantoins; Israel; Osteomalacia; Phenobarbital; Rickets; Vitamin | 1974 |
[Ethnic differences in serum phenytoin levels].
Topics: Adolescent; Adult; Child; Child, Preschool; Denmark; Epilepsy; Ethnicity; Female; Greenland; Humans; | 1974 |
Isolation of 1,4-androstadiene-3,17-dione from urine of an epileptic boy.
Topics: Adolescent; Androstenes; Chromatography, Gas; Chromatography, Paper; Chromatography, Thin Layer; Cir | 1974 |
Stress convulsions.
Topics: Adolescent; Adult; Affect; Age Factors; Child; Electroencephalography; Epilepsy; Evaluation Studies | 1974 |
Delivery of anticonvulsant drug therapy in epileptic patients assessed by plasma level analyses.
Topics: Adolescent; Adult; Child; Chromatography, Gas; Drug Therapy; Electroencephalography; Epilepsy; Human | 1974 |
[Encephalopathies in vita reducta].
Topics: Adult; Aged; Brain; Brain Death; Brain Injuries; Carbon Monoxide Poisoning; Cerebellum; Cerebral Cor | 1969 |
[Treatment of epilepsy with tegretol (5-carbamyl-5H-dibenzo (b,f) azepine)].
Topics: Adolescent; Adult; Anticonvulsants; Azepines; Child; Chlordiazepoxide; Electroencephalography; Epile | 1965 |
[New methods of seizure treatment in epilepsy].
Topics: Acetazolamide; Anticonvulsants; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tempo | 1965 |
[Treatment of epilepsy in children].
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil | 1967 |
[Experience in the clinical use of K4-1152].
Topics: Adolescent; Adult; Aged; Automatism; Child; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob | 1967 |
[On the combination treatment of epileptic attacks].
Topics: Anticonvulsants; Drug Synergism; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Ton | 1968 |
Dangers of treatment of status epilepticus with diazepam.
Topics: Adolescent; Adult; Aged; Cheyne-Stokes Respiration; Child; Diazepam; Drug Antagonism; Epilepsies, Pa | 1969 |
Low-voltage electroencephalogram in epilepsy.
Topics: Adult; Age Factors; Bemegride; Cerebral Cortex; Electric Conductivity; Electroencephalography; Epile | 1968 |
[The treatment of epilepsy with falepsin. A report of the clinical experience gained].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Tonic-Clonic; | 1968 |
Extractum belladonnae as an adjuvant to luminal in the therapy of epilepsy with a possible explanation in neurophysiological and neurochemical terms.
Topics: Acetylcholine; Adolescent; Adult; Animals; Anticonvulsants; Anura; Atropine; Cats; Cerebral Cortex; | 1968 |
[Clinical attempt to prevent post-traumatic epilepsy following severe brain injuries in adults].
Topics: Adolescent; Adult; Aged; Brain Injuries; Dibenzazepines; Electroencephalography; Epilepsy; Epilepsy, | 1969 |
[Results obtained with Depakine in epilepsy resistant to other therapies. Preliminary note].
Topics: Acetates; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epile | 1969 |
[Problems of treatment of epilepsy].
Topics: Anemia, Macrocytic; Anticonvulsants; Bromides; Diazepam; Drug Synergism; Epilepsy; Epilepsy, Tempora | 1971 |
[Effect of hydantoin together with small doses of phenobarbital in various forms of epileptic seizures].
Topics: Adolescent; Adult; Age Factors; Aged; Brain; Child; Drug Synergism; Electroencephalography; Epilepsi | 1971 |
[Results of treatment of epilepsy in children up to 14 years of age].
Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc | 1971 |
[Cerebral seizures (conclusion). 4. Therapy].
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epileps | 1971 |
Relationship between paroxysmal atrial tachycardia and paroxysmal cerebral discharges.
Topics: Anticonvulsants; Child, Preschool; Electrocardiography; Electroencephalography; Epilepsy; Humans; Hy | 1972 |
Maternal barbiturate utilization and neonatal withdrawal symptomatology.
Topics: Anticonvulsants; Apgar Score; Barbiturates; Epilepsy; Female; Gestational Age; Heroin; Humans; Infan | 1972 |
Antiepileptic drug concentrations in plasma. Clinical evaluation of 321 estimations in 237 unselected patients.
Topics: Carbamazepine; Chromatography, Gas; Chromatography, Thin Layer; Epilepsy; Humans; Methods; Phenobarb | 1972 |
Anticonvulsant hypocalcaemia.
Topics: Calcium; Epilepsy; Humans; Hypocalcemia; Phenobarbital; Phenytoin | 1972 |
Treatment of epilepsy in the light of determinations of the blood levels of anticonvulsants.
Topics: Adult; Child; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1972 |
[Preventive treatment of post-traumatic epilepsy following brain injury. Closing report summarizing results of the research done in the framework of the state research plan for the years 1965-1969; edited by Z. Servit].
Topics: Atropa belladonna; Brain Concussion; Brain Injuries; Epilepsy; Ergotamine; Humans; Hydantoins; Pheno | 1972 |
[Effect of methindione on the bioelectric activity of the brain, on cerebral circulation and on psychic disorders in epilepsy].
Topics: Adolescent; Adult; Affect; Anticonvulsants; Cerebral Cortex; Cerebrovascular Circulation; Electroenc | 1972 |
Diphenylhydantoin and epilepsy management.
Topics: Administration, Oral; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; Phenobar | 1972 |
Drug interactions. 3. Therapeutic implications of enzyme induction.
Topics: Age Factors; Child; Child, Preschool; Drug Interactions; Drug Synergism; Enzyme Induction; Epilepsy; | 1972 |
[Speech disorders in children with cerebral convulsions].
Topics: Adolescent; Barbiturates; Carbamazepine; Drug Hypersensitivity; Electroencephalography; Epilepsy; Et | 1972 |
Status epilepticus as a complication of intrathecal fluorescein. Case report.
Topics: Aged; Cerebrospinal Fluid Rhinorrhea; Contrast Media; Epilepsy; Fluoresceins; Glucocorticoids; Human | 1972 |
Febrile convulsions in early childhood.
Topics: Child, Preschool; Epilepsy; Fever; Hospitalization; Humans; Phenobarbital; Phenytoin; Seizures | 1972 |
Checking compliance of epileptic patients.
Topics: Adolescent; Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin | 1972 |
Concurrent administration of phenobarbital and diphenylhydantoin: lack of an interference effect.
Topics: Adolescent; Adult; Child; Chronic Disease; Drug Antagonism; Epilepsy; Humans; Phenobarbital; Phenoth | 1971 |
Diphenylhydantoin (Dilatin) and phenobarbital blood levels in epileptic children.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Electroencephalogr | 1971 |
[Treatment of epilepsy in the light of the determination of the anticonvulsant blood level].
Topics: Administration, Oral; Age Factors; Anticonvulsants; Drug Synergism; Epilepsy; Humans; Phenobarbital; | 1971 |
[Follow-up examinations of epileptic children who interrupted treatment of their own volition].
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Synergism; Electroencephalography; Epile | 1971 |
[Hematological control in the treatment of epilepsy].
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Epilepsy; Female; Folic Acid; Hematolo | 1971 |
Variations of serum diphenylhydantoin concentrations in epileptic out-patients.
Topics: Adolescent; Adult; Aged; Blood Proteins; Body Weight; Drug Synergism; Epilepsy; Female; Humans; Male | 1971 |
[Clinical and pharmacodynamic correlations of phenobarbital (PB) and diphenylhydantoin (DPH) in the treatment of infantile epilepsy].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Phenytoin | 1971 |
I.F. Anticonvulsants or antiepileptics. 4. Phenobarbital.
Topics: Epilepsy; Humans; Mephobarbital; Phenobarbital; Seizures | 1971 |
[Psychophysiological research on circadian rhythms in epilepsy].
Topics: Amphetamine; Animals; Circadian Rhythm; Epilepsy; Mice; Phenobarbital | 1971 |
Bone density in patients receiving long-term anticonvulsant therapy.
Topics: Absorptiometry, Photon; Adult; Alkaline Phosphatase; Anticonvulsants; Calcium; Carbamazepine; Epilep | 1971 |
Folic acid concentrations in cerebrospinal fluid in relation to anticonvulsant drugs and cerebral atrophy.
Topics: Adult; Anticonvulsants; Atrophy; Brain Diseases; Epilepsy; Female; Folic Acid; Humans; Male; Mental | 1971 |
[Our experiences with Tegretol in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Synergism; Epilepsy; Female; Headache; Humans; M | 1971 |
Folate metabolism in epileptic and psychiatric patients.
Topics: Adult; Antidepressive Agents; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hum | 1971 |
Auditory clicks in extinction of stroboscope-induced seizures.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Eyeglasses; Hearing Aids; Hum | 1965 |
Musicogenic epilepsy. A case report.
Topics: Adult; Chlordiazepoxide; Electroencephalography; Emotions; Epilepsy; Epilepsy, Temporal Lobe; Hearin | 1965 |
A clinical study of serum primidone levels.
Topics: Administration, Oral; Adolescent; Adult; Biotransformation; Child; Child, Preschool; Chromatography, | 1970 |
Interaction between phenobarbital and diphenylhydantoin in animals and in epileptic patients.
Topics: Adolescent; Adult; Animals; Brain; Brain Chemistry; Child; Child, Preschool; Chromatography, Gas; Ep | 1971 |
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Human | 1971 |
Focal spike discharges in children, a longitudinal study.
Topics: Adolescent; Aging; Central Nervous System Diseases; Cerebral Palsy; Cerebral Ventriculography; Child | 1966 |
[Experimental vestibular vertigo in healthy and in epileptic patients].
Topics: Adolescent; Adult; Calorimetry; Ear, Inner; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob | 1968 |
[Treatment of epilepsy with a combination of Gardenal and caffeine. Presentation of 84 cases].
Topics: Adolescent; Adult; Caffeine; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital | 1968 |
[Treatment of epilepsy using a combination of Gardenal and caffeine. Report of 84 cases].
Topics: Adolescent; Adult; Caffeine; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenobarbital | 1968 |
[Barbiturate poisoning via breast milk?].
Topics: Adult; Breast Feeding; Epilepsy; Female; Humans; Infant, Newborn; Milk, Human; Phenobarbital; Poison | 1969 |
Studies on the glucaric acid pathway in the metabolism of D-glucuronic acid in mammals. V. Stimulatory effect of diphenylhydantoin and phenobarbital on the D-glucaric acid synthesis in man.
Topics: Adipates; Epilepsy; Hexoses; Humans; Phenobarbital; Phenytoin; Stimulation, Chemical | 1969 |
Central effects of diphenylhydantoin (dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
[Detection and prognosis of the neonatal mal according to the electroclinical study of 150 cases].
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Congenital Abnormalities; Electroencephalography; Ep | 1969 |
Central effect of diphenylhydantoin (Dilantin) in epileptic oligophrenics during phenobarbital-primidone withdrawal, sodium bicarbonate, and ammonium chloride administration.
Topics: Adolescent; Adult; Ammonium Chloride; Bicarbonates; Epilepsy; Female; Humans; Hydrogen-Ion Concentra | 1969 |
Plasma lidocaine levels in patients treated with potential inducers of microsomal enzymes.
Topics: Adult; Anticonvulsants; Enzyme Induction; Epilepsy; Humans; Injections, Intravenous; Lidocaine; Male | 1970 |
Phenobarbital for neonatal jaundice.
Topics: Bilirubin; Eclampsia; Epilepsy; Female; Humans; Infant, Newborn; Infant, Premature; Jaundice, Neonat | 1970 |
[Case of tonic seizure].
Topics: Adult; Arm; Benzazepines; Diphenhydramine; Electroencephalography; Epilepsy; Humans; Injections, Int | 1970 |
Driving and epilepsy.
Topics: Adult; Automobile Driving; Epilepsy; Humans; Male; Middle Aged; Phenobarbital | 1970 |
Disturbance of calcium metabolism by anticonvulsant drugs.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Calcium Metabolism Disorders; Enzyme | 1970 |
The clinical significance of microsomal enzyme induction in the therapy of epileptic patients.
Topics: Adult; Chromatography; Enzyme Induction; Epilepsy; Female; Humans; Male; Microsomes, Liver; Phenobar | 1970 |
Micro-determination of serum phenobarbitone and diphenylhydantoin by gas-liquid chromatography.
Topics: Adult; Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Indicators and Reagents; Methods; Mic | 1970 |
New developments in anticonvulsant therapy.
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital; Phenytoin | 1970 |
The distribution of plasma phenytoin levels in epileptic patients.
Topics: Adult; Drug Tolerance; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Primidone | 1970 |
[Augmentation of the anticonvulsive action of phenobarbital by diacetylmono-oxime (DAM)].
Topics: Animals; Anticonvulsants; Cholinesterases; Drug Synergism; Epilepsy; Female; Male; Mice; Phenobarbit | 1970 |
Epilepsy in Uganda (urban).
Topics: Adolescent; Adult; Age Factors; Aged; Black People; Child; Child, Preschool; Epilepsy; Female; Human | 1970 |
P henobarbital-Dilantin treatment of the intrauterine patient.
Topics: Enzyme Induction; Epilepsy; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Infant, Newborn | 1970 |
[Effect of television on infant epilepsy].
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Hydantoins; L | 1970 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, | 1971 |
Urinary d-glucaric acid excretion as a measure of hepatic enzyme induction in man.
Topics: Adipates; Anticonvulsants; Barbiturates; Enzyme Induction; Epilepsy; Humans; Hyperbilirubinemia, Her | 1971 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration; | 1971 |
[Megaloblastic anemia during treatment of epilepsy with phenemal].
Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Humans; Phenobarbital | 1967 |
[Therapy of epilepsy].
Topics: Amphetamine; Anticonvulsants; Caffeine; Child; Drug Synergism; Epilepsy; Humans; Hydantoins; Phenoba | 1967 |
Epileptic seizures in non-embolic cerebral infarction.
Topics: Cerebrovascular Disorders; Epilepsy; Follow-Up Studies; Humans; Phenobarbital; Phenytoin | 1967 |
Carbamazepine: behavioral, anticonvulsant and EEG effects in chronically-hospitalized epileptics.
Topics: Adult; Anticonvulsants; Behavior; Chronic Disease; Electroencephalography; Epilepsy; Humans; Intervi | 1968 |
Serum folate deficiency in children receiving anticonvulsant therapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocyte Coun | 1968 |
Low specific gravity syndrome.
Topics: Adult; Anticonvulsants; Calcium; Chlorides; Chronic Disease; Creatinine; Epilepsy; Female; Humans; I | 1968 |
[Severe neonatal avitaminosis K in 2 infants born of a mother treated with anticonvulsants].
Topics: Adult; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Preg | 1968 |
The tuberous sclerosis complex.
Topics: Adult; Epilepsy; Female; Fluorescence; Hamartoma; Humans; Intellectual Disability; Intracranial Pres | 1968 |
Folic acid deficiency from anticonvulsant therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Defic | 1968 |
[Course of epilepsy and significance of determination of phenytoin in the serum].
Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Prognosis | 1968 |
Plasma hydroxyproline in epilepsy.
Topics: Adolescent; Adult; Collagen; Connective Tissue; Epilepsy; Female; Humans; Hydroxyproline; Male; Meth | 1968 |
[On the problem of the treatment of cerebral epilepsy during pregnancy, labor and puerperium].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Obstetric Labor Complications; Pheno | 1968 |
[Experience with the antiepileptic maliasin].
Topics: Anticonvulsants; Epilepsy; Humans; Phenobarbital | 1968 |
Mental effects of anticonvulsants, and folic acid metabolism.
Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid De | 1968 |
[Experience with Maliasin in the treatment of epileptic children (preliminary report)].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Phenob | 1968 |
[Changing of the photosensible threshold in the electroencephalogram by drugs acting in the central nervous system].
Topics: Adolescent; Adult; Aged; Barbiturates; Central Nervous System; Child; Diazepam; Electroencephalograp | 1968 |
Thin-layer chromatography of anticonvulsant drugs.
Topics: Anticonvulsants; Chromatography, Thin Layer; Epilepsy; Humans; Hydantoins; Methods; Phenobarbital; P | 1969 |
Clinico-electroencephalographic correlations in the course of epilepsy.
Topics: Adolescent; Adult; Age Factors; Brain; Electroencephalography; Epilepsy; Factor Analysis, Statistica | 1969 |
Increased metabolism of metyrapone in rats pretreated with diphenylhydantoin or phenobarbital.
Topics: Adrenal Glands; Animals; Biotransformation; Chromatography, Thin Layer; Enzyme Induction; Epilepsy; | 1969 |
Folic acid and anticonvulsive drugs.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Erythrocyte Count; Female; FIGLU Test; Folic Acid; Fol | 1969 |
Anaemia associated with phenobarbitone.
Topics: Adult; Anemia, Macrocytic; Epilepsy; Female; Humans; Phenobarbital | 1966 |
An approach to management of status epilepticus.
Topics: Epilepsy; Humans; Paraldehyde; Phenobarbital | 1966 |
Drug-induced systemic lupus erythematosus. Primidone as a possible cause.
Topics: Electroencephalography; Epilepsy; Female; Humans; Hydralazine; Hydroxychloroquine; Lupus Erythematos | 1966 |