phenobarbital has been researched along with Epilepsy, Complex Partial in 8 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of hyperammonemia without hepatic dysfunction as a possible cause of lethargy, stupor, and coma in a woman after valproic acid (VPA) administration, and discuss the possible different mechanisms of ammonia elevation and coma." | 4.78 | Valproate-induced coma: case report and literature review. ( Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S, 1993) |
| " The second patient complained of impotence after a rash while taking phenytoin and carbamazepine." | 3.70 | Improved sexual function in three men taking lamotrigine for epilepsy. ( Carwile, ST; Husain, AM; Miller, PP; Radtke, RA, 2000) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "Phenobarbital was the most effective anticonvulsant drug in this patient." | 1.30 | [Successful induction of tolerance in an epilepsy patient with phenobarbital allergy]. ( Fröscher, W; Kleinhans, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Luszczki, JJ | 1 |
| Patrzylas, P | 1 |
| Zagaja, M | 1 |
| Andres-Mach, M | 1 |
| Zaluska, K | 1 |
| Kondrat-Wrobel, MW | 1 |
| Szpringer, M | 1 |
| Chmielewski, J | 1 |
| Florek-Luszczki, M | 1 |
| Verrotti, A | 1 |
| Latini, G | 1 |
| Giannuzzi, R | 1 |
| Cutarella, R | 1 |
| Trotta, D | 1 |
| Morgese, G | 1 |
| Chiarelli, F | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| de Romanis, F | 1 |
| Sopranzi, N | 1 |
| Duarte, J | 1 |
| Macias, S | 1 |
| Coria, F | 1 |
| Fernandez, E | 1 |
| Clavería, LE | 1 |
| Fröscher, W | 1 |
| Kleinhans, D | 1 |
| Husain, AM | 1 |
| Carwile, ST | 1 |
| Miller, PP | 1 |
| Radtke, RA | 1 |
| Shirasaka, Y | 1 |
| Ito, M | 1 |
| Okuno, T | 1 |
| Fujii, T | 1 |
| Nozaki, K | 1 |
| Mikawa, H | 1 |
1 review available for phenobarbital and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Valproate-induced coma: case report and literature review.
Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Val | 1993 |
2 trials available for phenobarbital and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Factors associated with poor control in partial complex epilepsy.
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalograp | 2004 |
[Gamma-vinyl-GABA: first experiences in Italy. II].
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; | 1994 |
5 other studies available for phenobarbital and Epilepsy, Complex Partial
| Article | Year |
|---|---|
Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
Topics: Acetamides; Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Benzodiazepines; Clobaz | 2017 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
[Successful induction of tolerance in an epilepsy patient with phenobarbital allergy].
Topics: Adult; Anticonvulsants; Desensitization, Immunologic; Dose-Response Relationship, Drug; Drug Adminis | 1998 |
Improved sexual function in three men taking lamotrigine for epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsies, Partial; | 2000 |
Ring 14 chromosome with complex partial seizures: a case report.
Topics: Child; Chromosomes, Human, Pair 14; Electroencephalography; Epilepsy, Complex Partial; Female; Human | 1992 |