phenobarbital has been researched along with Epilepsies, Myoclonic in 27 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Epilepsies, Myoclonic: A clinically diverse group of epilepsy syndromes characterized either by myoclonic seizures or by myoclonus in association with other seizure types. Myoclonic epilepsy syndromes are divided into three subtypes based on etiology: familial, cryptogenic, and symptomatic.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following its clinical development, in September 2019 the European Medicines Agency approved its indication for the adjunctive therapy of epileptic seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS), combined with clobazam (CLB), in patients of 2 years of age and older." | 9.12 | Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. ( García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V, 2021) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 9.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 7.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " Following its clinical development, in September 2019 the European Medicines Agency approved its indication for the adjunctive therapy of epileptic seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS), combined with clobazam (CLB), in patients of 2 years of age and older." | 5.12 | Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain. ( García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V, 2021) |
| "Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial." | 5.04 | Treatment of epilepsy with clonazepam and its effect on other anticonvulsants. ( Johnson, RH; Keogh, HJ; Lambie, DG; Melville, ID; Nanda, RN, 1977) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 3.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " Eight hours after 2 of 3 prophylactic antimalarial treatments with mefloquine generalized tonic-clonic seizures occurred." | 3.68 | [Suspected convulsive side-effect of mefloquine (Lariam)]. ( Besser, R; Krämer, G, 1991) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Phenobarbital is a potential therapeutic option for pharmaco-resistant EMA." | 1.62 | Low-dose phenobarbital for epilepsy with myoclonic absences: A case report. ( Ito, S; Nagata, S; Nagumo, K; Nishikawa, A; Oguni, H, 2021) |
| "Subtle seizures are the commonest type of seizures occurring in the neonatal period." | 1.36 | Management of neonatal seizures. ( Agarwal, R; Deorari, A; Paul, VK; Sankar, JM, 2010) |
| "The aggravation of habitual seizures and interictal discharges indicate ENM." | 1.35 | A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009) |
| "Melatonin was thus added to the treatment." | 1.30 | Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience. ( Acuña-Castroviejo, D; Molina-Carballo, A; Molina-Font, JA; Moreno-Madrid, F; Muñoz-Hoyos, A; Reiter, RJ; Rufo-Campos, M; Sánchez-Forte, M, 1997) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epilepsy with age-related onset of symptoms." | 1.29 | Diagnosing juvenile myoclonic epilepsy in an elderly patient. ( Grünewald, RA; Panayiotopoulos, CP, 1994) |
| "A sporadic case of myoclonus epilepsy of adult onset with a benign course is presented." | 1.27 | A sporadic case of benign myoclonus epilepsy of adult onset: its clinical aspects and electroencephalographic, polygraphic study. ( Ishigooka, J; Murasaki, M; Takahashi, A; Wakatabe, H; Yoshida, Y, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (37.04) | 18.7374 |
| 1990's | 8 (29.63) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 4 (14.81) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| García-Peñas, JJ | 1 |
| Gil Nagel-Rein, A | 1 |
| Sánchez-Carpintero, R | 1 |
| Villanueva-Haba, V | 1 |
| Ito, S | 1 |
| Nagumo, K | 1 |
| Nishikawa, A | 1 |
| Oguni, H | 1 |
| Nagata, S | 1 |
| Kosaka, T | 1 |
| Ohta, G | 1 |
| Kometani, H | 1 |
| Kawatani, M | 1 |
| Ohshima, Y | 1 |
| Cherian, A | 1 |
| Jabeen, SA | 1 |
| Kandadai, RM | 1 |
| Iype, T | 1 |
| Moturi, P | 1 |
| Reddy, M | 1 |
| Kanikannan, MA | 1 |
| Borgohain, R | 1 |
| Padmanabhan, S | 1 |
| Popławska, M | 1 |
| Wróblewska, D | 1 |
| Borowicz, KK | 2 |
| Yang, Z | 1 |
| Liu, X | 1 |
| Qin, J | 1 |
| Zhang, Y | 1 |
| Bao, X | 1 |
| Chang, X | 1 |
| Wang, S | 1 |
| Wu, Y | 1 |
| Xiong, H | 1 |
| Sankar, JM | 1 |
| Agarwal, R | 1 |
| Deorari, A | 1 |
| Paul, VK | 1 |
| Haugvicová, R | 1 |
| Bílková, E | 1 |
| Kubová, H | 2 |
| Mares, P | 2 |
| Luszczki, JJ | 1 |
| Czuczwar, SJ | 1 |
| Aujard, Y | 1 |
| Ponsot, G | 1 |
| Livet, MO | 1 |
| Pratt, JA | 1 |
| Jenner, P | 1 |
| Johnson, AL | 1 |
| Shorvon, SD | 1 |
| Reynolds, EH | 1 |
| Rothner, AD | 1 |
| Erenberg, G | 1 |
| Grünewald, RA | 1 |
| Panayiotopoulos, CP | 1 |
| Eriksson, K | 1 |
| Baer, M | 1 |
| Kilpinen, P | 1 |
| Koivikko, M | 1 |
| Ruiz-Falcó Rojas, ML | 1 |
| Gutiérrez-Solana, LG | 1 |
| Arias Alvarez, MA | 1 |
| Barrio Nicolás, A | 1 |
| López-Terradas Covisa, JM | 1 |
| Lanstiakova, M | 1 |
| Mockova, M | 1 |
| Vorlicek, J | 1 |
| Salvolini, U | 1 |
| Bonetti, MG | 1 |
| Ciritella, P | 1 |
| Molina-Carballo, A | 1 |
| Muñoz-Hoyos, A | 1 |
| Reiter, RJ | 1 |
| Sánchez-Forte, M | 1 |
| Moreno-Madrid, F | 1 |
| Rufo-Campos, M | 1 |
| Molina-Font, JA | 1 |
| Acuña-Castroviejo, D | 1 |
| Baulac, M | 1 |
| Nordmann, JP | 1 |
| Lanoé, Y | 1 |
| Gromov, SA | 1 |
| Koskiniemi, M | 1 |
| Palo, J | 1 |
| Bruni, J | 1 |
| Wilder, BJ | 1 |
| Aucamp, AK | 1 |
| Rumpl, E | 1 |
| Gerstenbrand, F | 1 |
| Hengl, W | 1 |
| Binder, H | 1 |
| Nanda, RN | 1 |
| Johnson, RH | 1 |
| Keogh, HJ | 1 |
| Lambie, DG | 1 |
| Melville, ID | 1 |
| Besser, R | 1 |
| Krämer, G | 1 |
| Ishigooka, J | 1 |
| Wakatabe, H | 1 |
| Takahashi, A | 1 |
| Yoshida, Y | 1 |
| Murasaki, M | 1 |
3 reviews available for phenobarbital and Epilepsies, Myoclonic
| Article | Year |
|---|---|
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedu | 2021 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
1 trial available for phenobarbital and Epilepsies, Myoclonic
| Article | Year |
|---|---|
Treatment of epilepsy with clonazepam and its effect on other anticonvulsants.
Topics: Adolescent; Adult; Ambulatory Care; Benzodiazepinones; Brain; Child; Clinical Trials as Topic; Clona | 1977 |
23 other studies available for phenobarbital and Epilepsies, Myoclonic
| Article | Year |
|---|---|
Low-dose phenobarbital for epilepsy with myoclonic absences: A case report.
Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsy, Absence; Humans; Male; Phenobarbital | 2021 |
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital; | 2019 |
Epilepsy with myoclonic absences in siblings.
Topics: Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Electroencephalography; Epilepsie | 2014 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Ani | 2015 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; | 2009 |
Management of neonatal seizures.
Topics: Anticonvulsants; Benzodiazepines; Electroencephalography; Epilepsies, Myoclonic; Humans; Hypocalcemi | 2010 |
Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Elec | 2002 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
[Rickets. A rare complication of anti-epileptic treatments. Report of two cases in children].
Topics: Anticonvulsants; Black People; Calcifediol; Child; Contraindications; Drug Monitoring; Electroenceph | 1976 |
Anticonvulsant drugs alter plasma tryptophan concentrations in epileptic patients: implications for antiepileptic action and mental function.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsies, Myoclon | 1984 |
Status epilepticus.
Topics: Anesthesia, General; Child; Child, Preschool; Diazepam; Epilepsies, Myoclonic; Epilepsies, Partial; | 1980 |
Diagnosing juvenile myoclonic epilepsy in an elderly patient.
Topics: Aged; Clonazepam; Drug Administration Schedule; Drug Therapy, Combination; Electroencephalography; E | 1994 |
Effects of long barbiturate anaesthesia on eight children with severe epilepsy.
Topics: Anesthesia, General; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsies | 1993 |
[Lafora disease. Report of a new case diagnosed by biopsy from the axillary skin].
Topics: Axilla; Biopsy; Carbamazepine; Child; Eccrine Glands; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; | 1993 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
Accidental intrathecal injection of ionic water-soluble contrast medium: report of a case, including treatment.
Topics: Aged; Analgesia, Epidural; Bone Neoplasms; Consciousness Disorders; Contrast Media; Critical Care; D | 1996 |
Utility of high doses of melatonin as adjunctive anticonvulsant therapy in a child with severe myoclonic epilepsy: two years' experience.
Topics: Anticonvulsants; Antioxidants; Brain; Chemotherapy, Adjuvant; Circadian Rhythm; Electroencephalograp | 1997 |
Severe visual-field constriction and side-effects of GABA-mimetic antiepileptic agents.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; Follow-Up Studies; GABA Agon | 1998 |
[Clinical picture and basis for treating brain stem epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Diazepam; Epilepsies, Myoclonic; Epilepsy; Female; H | 1978 |
Urinary excretion of indican in progressive myoclonus epilepsy without Lafora bodies. The effect of sodium valproate.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsies, Myoclonic; Humans; Indican; Phenobarbital; Valproic | 1978 |
[Electrophysiogical and neuropharmacological studies in a patient with progressive myoclonus-epilepsy (author's transl)].
Topics: Adult; Anticonvulsants; Brain; Clonazepam; Diazepam; Electroencephalography; Epilepsies, Myoclonic; | 1977 |
[Suspected convulsive side-effect of mefloquine (Lariam)].
Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Tonic-Clo | 1991 |
A sporadic case of benign myoclonus epilepsy of adult onset: its clinical aspects and electroencephalographic, polygraphic study.
Topics: Adult; Clonazepam; Drug Therapy, Combination; Electroencephalography; Epilepsies, Myoclonic; Female; | 1986 |