phenobarbital has been researched along with Enlarged Liver in 43 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case of propofol infusion syndrome in a patient with respiratory failure and sepsis is reported." | 8.85 | Propofol infusion syndrome: case report and literature review. ( Chen, J; Cohen, N; Nadkarni, A; Orsini, J, 2009) |
| "Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes." | 5.31 | Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. ( Gallavan, RH; Goodman, JI; Jean, PA; Kolesar, GB; McKim, JM; Meeker, LS; Meeks, RG; Schoonhoven, R; Swenberg, JA; Wilga, PC, 2001) |
| "In the case of PB treatment, the hepatomegaly was found to be partly due to hypertrophy and partly to hyperplasia after 2 weeks of treatment." | 5.30 | The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. ( Carthew, P; Edwards, RE; Nolan, BM, 1998) |
| "A case of propofol infusion syndrome in a patient with respiratory failure and sepsis is reported." | 4.85 | Propofol infusion syndrome: case report and literature review. ( Chen, J; Cohen, N; Nadkarni, A; Orsini, J, 2009) |
| " We induced cirrhosis with hypertrophy in rats by simultaneous treatment with CCl4 and phenobarbital (PB) and devised a hierarchy of structure applicable to the sampling and morphometric analysis of untreated and PB-treated control livers and of cirrhotic livers." | 3.66 | A morphometric analysis of the hypertrophy of experimental liver cirrhosis. ( Buschmann, RJ; Ryoo, JW, 1983) |
| "To clarify the dose-response relationship between constitutive androstane receptor (CAR) activity and induction of cytochrome P450 2B (CYP2B) expression and hypertrophy by triazole fungicides in mouse liver, three dose levels of cyproconazole (Cypro), tebuconazole (Teb), fluconazole (Flu), and phenobarbital (PB), a typical CYP2B inducer, were administrated in diet to male wild-type (WT) and CAR-knockout (CARKO) mice for one week." | 1.39 | Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides. ( Inoue, K; Irie, K; Kodama, Y; Matsuo, S; Nishikawa, A; Ozawa, S; Takahashi, M; Tamura, K; Yoshida, M, 2013) |
| "In PB- and BS-treated livers, hepatomegaly was attributable to hepatocyte proliferation and enzyme induction." | 1.31 | Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates. ( Fujieda, Y; Furukawa, S; Goryo, M; Hayashi, K; Ikeyama, S; Miyamoto, Y; Okada, K; Tamura, T; Usuda, K, 2000) |
| "Octamethylcyclotetrasiloxane (D4) has been described as a phenobarbital-like inducer of hepatic enzymes." | 1.31 | Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. ( Gallavan, RH; Goodman, JI; Jean, PA; Kolesar, GB; McKim, JM; Meeker, LS; Meeks, RG; Schoonhoven, R; Swenberg, JA; Wilga, PC, 2001) |
| "In the case of PB treatment, the hepatomegaly was found to be partly due to hypertrophy and partly to hyperplasia after 2 weeks of treatment." | 1.30 | The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital. ( Carthew, P; Edwards, RE; Nolan, BM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (60.47) | 18.7374 |
| 1990's | 4 (9.30) | 18.2507 |
| 2000's | 6 (13.95) | 29.6817 |
| 2010's | 7 (16.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tamura, K | 1 |
| Inoue, K | 4 |
| Takahashi, M | 1 |
| Matsuo, S | 1 |
| Irie, K | 1 |
| Kodama, Y | 1 |
| Ozawa, S | 4 |
| Nishikawa, A | 4 |
| Yoshida, M | 4 |
| Asaoka, Y | 1 |
| Togashi, Y | 1 |
| Mutsuga, M | 1 |
| Imura, N | 1 |
| Miyoshi, T | 1 |
| Miyamoto, Y | 2 |
| Orsini, J | 1 |
| Nadkarni, A | 1 |
| Chen, J | 1 |
| Cohen, N | 1 |
| Donthamsetty, S | 2 |
| Bowen, W | 1 |
| Mars, W | 1 |
| Bhave, V | 1 |
| Luo, JH | 1 |
| Wu, C | 1 |
| Hurd, J | 1 |
| Orr, A | 2 |
| Bell, A | 1 |
| Michalopoulos, G | 1 |
| Makino, T | 1 |
| Kinoshita, J | 1 |
| Arakawa, S | 1 |
| Ito, K | 1 |
| Ando, Y | 1 |
| Yamoto, T | 1 |
| Teranishi, M | 1 |
| Sanbuissho, A | 1 |
| Nakayama, H | 1 |
| Lin, CW | 1 |
| Mars, WM | 1 |
| Paranjpe, S | 1 |
| Bhave, VS | 1 |
| Kang, LI | 1 |
| Bowen, WC | 1 |
| Bell, AW | 1 |
| Michalopoulos, GK | 1 |
| Nemoto, K | 3 |
| Tanaka, T | 1 |
| Ikeda, A | 1 |
| Ito, S | 1 |
| Mizukami, M | 1 |
| Hikida, T | 1 |
| Gamou, T | 3 |
| Habano, W | 2 |
| Degawa, M | 3 |
| Fujimoto, N | 1 |
| Staudinger, JL | 1 |
| Madan, A | 1 |
| Carol, KM | 1 |
| Parkinson, A | 1 |
| Bursch, W | 1 |
| Wastl, U | 1 |
| Hufnagl, K | 1 |
| Schulte-Hermann, R | 4 |
| Ryoo, JW | 1 |
| Buschmann, RJ | 1 |
| Berman, JS | 1 |
| Hiley, CR | 1 |
| Wilson, AC | 1 |
| Chatamra, K | 1 |
| Proctor, E | 1 |
| Thatcher, NJ | 1 |
| Caldwell, J | 1 |
| Carthew, P | 1 |
| Edwards, RE | 1 |
| Nolan, BM | 1 |
| Furukawa, S | 1 |
| Usuda, K | 1 |
| Fujieda, Y | 1 |
| Tamura, T | 1 |
| Hayashi, K | 1 |
| Ikeyama, S | 1 |
| Goryo, M | 1 |
| Okada, K | 1 |
| McKim, JM | 1 |
| Kolesar, GB | 1 |
| Jean, PA | 1 |
| Meeker, LS | 1 |
| Wilga, PC | 1 |
| Schoonhoven, R | 1 |
| Swenberg, JA | 1 |
| Goodman, JI | 1 |
| Gallavan, RH | 1 |
| Meeks, RG | 1 |
| Shenoy, ST | 1 |
| Peraino, C | 1 |
| Anderson, J | 3 |
| Nievel, JG | 4 |
| Robinson, N | 1 |
| Skrbic, TR | 1 |
| Bray, PJ | 1 |
| Böhm, N | 1 |
| Moser, B | 1 |
| Dagenais, M | 1 |
| Giroux, L | 1 |
| Belgiorno, J | 1 |
| Huet, PM | 1 |
| Smith, PF | 1 |
| O'Brien, KA | 1 |
| Keenan, KP | 1 |
| Paulini, D | 1 |
| Beneke, G | 4 |
| Thorpe, E | 1 |
| Walker, AI | 1 |
| Dalton, C | 1 |
| Hope, WC | 1 |
| Hope, HR | 1 |
| Sheppard, H | 1 |
| Solymoss, B | 1 |
| Zsigmond, G | 1 |
| Schlicht, I | 3 |
| Koransky, W | 3 |
| Magour, S | 2 |
| Thom, R | 1 |
| Bakshi, S | 1 |
| Bhakoo, ON | 1 |
| Platt, DS | 1 |
| Cockrill, BL | 1 |
| Paulini, K | 3 |
| Kulka, R | 3 |
| Bond, EJ | 1 |
| Butler, WH | 1 |
| De Matteis, F | 1 |
| Barnes, JM | 1 |
| Owen, NV | 1 |
| Griffing, WJ | 1 |
| Hoffman, DG | 1 |
| Gibson, WR | 1 |
| Anderson, RC | 1 |
| Burger, PC | 1 |
| Herdson, PB | 1 |
3 reviews available for phenobarbital and Enlarged Liver
| Article | Year |
|---|---|
Propofol infusion syndrome: case report and literature review.
Topics: Adult; Anesthetics, Intravenous; Drug Administration Schedule; Exanthema; Female; Hepatomegaly; Huma | 2009 |
Current trends in hepatic response tests.
Topics: Aminopyrine; Animals; Ascorbic Acid; Circadian Rhythm; Cold Temperature; Cytochromes; DDT; Dietary C | 1969 |
Join the microsomal bandwagon.
Topics: Age Factors; Animals; Anthracenes; Carbon Disulfide; Dichlorodiphenyldichloroethane; Endoplasmic Ret | 1970 |
40 other studies available for phenobarbital and Enlarged Liver
| Article | Year |
|---|---|
Dose-response involvement of constitutive androstane receptor in mouse liver hypertrophy induced by triazole fungicides.
Topics: Animals; Constitutive Androstane Receptor; Dose-Response Relationship, Drug; Enzyme Induction; Fluco | 2013 |
Histopathological image analysis of chemical-induced hepatocellular hypertrophy in mice.
Topics: Animals; Cell Nucleus; Clofibrate; Hepatocytes; Hepatomegaly; Hypertrophy; Image Processing, Compute | 2016 |
Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration.
Topics: Animals; Cell Proliferation; Hepatocytes; Hepatomegaly; Liver; Mice; Mice, Knockout; Phenobarbital; | 2010 |
Comprehensive analysis of hepatic gene and protein expression profiles on phenobarbital- or clofibrate-induced hepatic hypertrophy in dogs.
Topics: Acyl-CoA Dehydrogenase; Animals; Carnitine O-Palmitoyltransferase; Clofibrate; Dogs; Electrophoresis | 2009 |
Hepatocyte proliferation and hepatomegaly induced by phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene is suppressed in hepatocyte-targeted glypican 3 transgenic mice.
Topics: Animals; Cell Proliferation; Gene Expression Regulation; Genes, cdc; Glypicans; Hepatocytes; Hepatom | 2011 |
Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.
Topics: Animals; Clofibrate; Disease Models, Animal; Gene Expression; Hepatomegaly; Liver; Male; Oligonucleo | 2011 |
Altered expression of GADD45 genes during the development of chemical-mediated liver hypertrophy and liver tumor promotion in rats.
Topics: Animals; Cell Cycle Proteins; Clofibrate; Cytochrome P-450 Enzyme System; DNA Damage; Down-Regulatio | 2011 |
Estrogen and androgen receptor status in hepatocellular hypertrophy induced by phenobarbital, clofibrate, and piperonyl butoxide in F344 rats.
Topics: Animals; Carcinogens; CD36 Antigens; Clofibrate; Estrogen Receptor alpha; Female; Hepatomegaly; Leuk | 2012 |
Regulation of drug transporter gene expression by nuclear receptors.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biological Transport; Blotting, Northern; Constitutive Andro | 2003 |
No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction.
Topics: Animals; Apoptosis; DNA; Female; Food Deprivation; Hepatomegaly; Liver; Male; Mice; Mice, Inbred Str | 2005 |
A morphometric analysis of the hypertrophy of experimental liver cirrhosis.
Topics: Animals; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Connective Tissue; Hepatomegaly; Hypertroph | 1983 |
Comparison of the effects of the hypolipidaemic agents ICI53072 and clofibrate with those of phenobarbitone on liver size, blood flow and DNA content in the rat.
Topics: Animals; Bile; Cardiac Output; Clofibrate; DNA; Hepatomegaly; Hypolipidemic Agents; Liver; Liver Cir | 1983 |
Phenobarbitone-induced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced cirrhosis.
Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Hepatomegaly; Liver; L | 1981 |
Origins of hepatomegaly produced by dexamethasone (DEX), pregnenolone 16 alpha-carbonitrile (PCN) and phenobarbitone (PB) in female Sprague-Dawley rats.
Topics: Animals; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; F | 1994 |
The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital.
Topics: Animals; Cell Count; Cell Nucleus; Hepatomegaly; Hyperplasia; Hypertrophy; Hypnotics and Sedatives; | 1998 |
Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates.
Topics: Animals; Apoptosis; Barbital; Barbiturates; Body Weight; Bromodeoxyuridine; Cell Division; Hepatomeg | 2000 |
Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital.
Topics: Animals; Bromodeoxyuridine; DNA; Female; Hepatomegaly; Hyperplasia; Hypertrophy; Inhalation Exposure | 2001 |
Changes in liver composition in phenobarbital-induced hepatomegaly.
Topics: Animals; Cell-Free System; Hepatomegaly; Leucine; Liver; Magnesium; Male; Phenobarbital; Plants; Pol | 1977 |
Competition between the induction of hepatic protein synthesis by drugs and inhibition by actinomycin D indicating a mechanism for decreased acute toxicity in vio apparently independent of stimulated drug metabolism.
Topics: Animals; Dactinomycin; Female; Hepatomegaly; Liver; Phenobarbital; Protein Biosynthesis; Rats; Trans | 1976 |
Changes in nucleotide metabolism of the liver and fate of [14C]orotate among various pyrimidines at the outset and during induction of drug-metabolizing enzymes and hepatomegaly.
Topics: Animals; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; DNA Replication; Enzyme Indu | 1976 |
Studies on the relationship between induction of drug-metabolizing enzymes, liver enlargement and ascorbic acid excretion in rodents.
Topics: Animals; Ascorbic Acid; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; Enzyme Induct | 1976 |
Enzyme changes and turnover of various protein fractions during experimental hepatomegaly.
Topics: Animals; Butylated Hydroxytoluene; Cytosol; Female; Hepatomegaly; Methods; Microsomes, Liver; Phenob | 1975 |
[Reversible hyperplasia and hypertrophy of the mouse liver induced by a functional charge with phenobarbital].
Topics: Animals; Cell Nucleus; DNA; Dose-Response Relationship, Drug; Hepatomegaly; Liver; Male; Mice; Mitos | 1976 |
The effect of alcohol-induced hepatomegaly on portal hypertension in cirrhotic rats.
Topics: Animals; Blood Pressure; Carbon Tetrachloride; Collagen; Ethanol; Hemodynamics; Hepatomegaly; Hypert | 1992 |
Evaluation of bromodeoxyuridine labeling in hepatomegaly produced by peroxisomal proliferation or P-450 induction in rodents.
Topics: Animals; Anticholesteremic Agents; Bromodeoxyuridine; Cell Division; Cytochrome P-450 Enzyme System; | 1991 |
[Studies on liver enlargement through phenobarbital].
Topics: Animals; Body Weight; Cell Nucleus; DNA; Hepatomegaly; Injections, Intraperitoneal; Liver; Male; Nuc | 1970 |
The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, -BHC and -BHC.
Topics: Administration, Oral; Animals; DDT; Dieldrin; Female; Hepatomegaly; Hexachlorocyclohexane; Hyperplas | 1973 |
Relationship of serum triglyceride lowering to changes in hepatic composition induced by different classes of drugs.
Topics: Animals; Cholesterol; Clofibrate; Dactinomycin; DNA; Dose-Response Relationship, Drug; Glycolates; H | 1974 |
Effect of microsomal enzyme inducers on the liver changes produced by common bile-duct ligature.
Topics: Animals; Bilirubin; Common Bile Duct; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme | 1974 |
[On hepatomegaly induced by drugs].
Topics: Animals; Hepatomegaly; Hexachlorocyclohexane; Humans; Liver; Organ Size; Phenobarbital; Rats | 1967 |
[Enlargement and DNA synthesis by the liver under in influence of substances alien to the body].
Topics: Animals; DNA; Female; Hepatomegaly; Hexachlorocyclohexane; Lipid Metabolism; Liver; Liver Glycogen; | 1968 |
[Number and "ploidy" of liver cell nuclei under the influence of substances alien to the body. Analysis by means of an electronic particle counter].
Topics: Animals; Cell Nucleus; Electronics; Female; Hepatomegaly; Hexachlorocyclohexane; Hyperplasia; Hypert | 1968 |
Unusual phenobarbitone sensitivity.
Topics: Child; Drug Eruptions; Drug Hypersensitivity; Female; Hepatomegaly; Humans; Phenobarbital | 1971 |
Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities.
Topics: Alanine Transaminase; Amides; Animals; Anticholesteremic Agents; Barbiturates; Body Weight; Butyrate | 1967 |
[Age dependency of phenobarbital induced liver enlargement. Cytophotometric and autoradiographic studies].
Topics: Age Factors; Animals; Autoradiography; Cell Nucleus; Densitometry; Diploidy; DNA; Hepatomegaly; Inje | 1971 |
Effects of carbon disulphide on the liver of rats.
Topics: Animals; Carbon Disulfide; Hepatomegaly; Liver; Male; Microsomes, Liver; Necrosis; Phenobarbital; Ra | 1969 |
[Liver enlargement due to phenobarbital in dependence on age].
Topics: Age Factors; Animals; DNA; Hepatomegaly; Liver; Male; Mitosis; Organ Size; Phenobarbital; Protein Bi | 1970 |
[The mechanism of liver enlargement after treatment with different doses of phenobarbital].
Topics: Age Factors; Animals; Body Weight; DNA; Hepatomegaly; Liver; Male; Organ Size; Phenobarbital; Protei | 1971 |
Effects of dietary administration of 5-(3,4-dichloro-phenyl)-5-ethylbarbituric acid (dichlorophenobarbital) to rats: emphasis on hepatic drug-metabolizing enzymes and morphology.
Topics: Animals; Anisoles; Barbiturates; Body Weight; Chlorine; Dealkylation; Enzyme Induction; Female; Hepa | 1971 |
Phenobarbital-induced fine structural changes in rat liver.
Topics: Animals; Hepatomegaly; Liver Diseases; Phenobarbital; Proadifen; Rats | 1966 |