phenobarbital has been researched along with EHS Tumor in 11 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital pretreatment reduced both the antitumor efficacy and toxicity of CCNU (factor of approximately 0." | 1.27 | Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine. ( Siemann, DW, 1983) |
| " Pharmacokinetic parameters and enzyme kinetic data both in normal and in tumor-bearing animals will be presented." | 1.26 | Importance of pharmacokinetic studies on cyclophosphamide (NSC-26271) in understanding its cytotoxic effect. ( Bartosek, I; Colombo, T; Donelli, MG; Guaitani, A; Martini, A; Modica, R; Pacciarini, MA, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (90.91) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wiebkin, P | 1 |
| Sieg, MS | 1 |
| Nelson, RE | 1 |
| Hines, RN | 1 |
| Prough, RA | 1 |
| Siemann, DW | 1 |
| Kamiya, A | 1 |
| Kojima, N | 1 |
| Kinoshita, T | 1 |
| Sakai, Y | 1 |
| Miyaijma, A | 1 |
| Wislocki, PG | 1 |
| Miller, EC | 1 |
| Miller, JA | 1 |
| McCoy, EC | 1 |
| Rosenkranz, HS | 1 |
| Grube, DD | 1 |
| Peraino, C | 1 |
| Fry, RJ | 1 |
| Donelli, MG | 1 |
| Bartosek, I | 1 |
| Guaitani, A | 1 |
| Martini, A | 1 |
| Colombo, T | 1 |
| Pacciarini, MA | 1 |
| Modica, R | 1 |
| Workman, P | 1 |
| Paolini, A | 1 |
| D'Incalci, M | 1 |
| Schuetz, EG | 1 |
| Li, D | 1 |
| Omiecinski, CJ | 1 |
| Muller-Eberhard, U | 1 |
| Kleinman, HK | 1 |
| Elswick, B | 1 |
| Guzelian, PS | 1 |
| Tonda, K | 1 |
| Kamata, S | 1 |
| Hirata, M | 1 |
| van den Brenk, HA | 1 |
| Sharpington, C | 1 |
11 other studies available for phenobarbital and EHS Tumor
| Article | Year |
|---|---|
Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma (line P815) cells.
Topics: Animals; Biotransformation; Cell Survival; Cells, Cultured; Coumarins; Cyclophosphamide; Hydrazines; | 1982 |
Effect of pretreatment with phenobarbital or SKF 525A on the toxicity and antitumor activity of lomustine.
Topics: Animals; Female; Lomustine; Mice; Mice, Inbred C3H; Nitrosourea Compounds; Phenobarbital; Proadifen; | 1983 |
Maturation of fetal hepatocytes in vitro by extracellular matrices and oncostatin M: induction of tryptophan oxygenase.
Topics: Animals; Antibodies; Cell Differentiation; Cells, Cultured; Cytochrome P-450 Enzyme System; Dimethyl | 2002 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne | 1977 |
The effect ofdietary phenobarbital on the induction of skin tumors in hairless mice with 7, 12-dimethylbenz(a)anthracene.
Topics: Administration, Oral; Animal Feed; Animals; Benz(a)Anthracenes; Diet; Dose-Response Relationship, Dr | 1975 |
Importance of pharmacokinetic studies on cyclophosphamide (NSC-26271) in understanding its cytotoxic effect.
Topics: Animals; Carcinoma 256, Walker; Chloral Hydrate; Cyclophosphamide; Disulfiram; Drug Interactions; Gl | 1976 |
Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: a possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination.
Topics: Animals; Brain; Drug Combinations; Enzyme Induction; Etanidazole; Mice; Mice, Inbred C3H; Microsomes | 1989 |
Effect of phenobarbital pretreatment on the metabolism and antitumor activity of hexamethylmelamine.
Topics: Altretamine; Animals; Cell Line; Chromatography, Gas; Drug Interactions; Female; Kinetics; Male; Mic | 1986 |
Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix.
Topics: Animals; Basement Membrane; Blood Proteins; Cell Survival; Cells, Cultured; Collagen; Culture Media; | 1988 |
Metabolism of 1-phthalidyl 5-fluorouracil in rat liver and enzyme induction by phenobarbital.
Topics: Aldehyde Oxidoreductases; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug | 1987 |
Effect of phenobarbital on growth of a metastasising, allogeneic sarcoma in the rat.
Topics: Animals; Body Weight; Cobalt Isotopes; Female; Immunosuppression Therapy; Lung Neoplasms; Lymphatic | 1972 |