phenobarbital has been researched along with Dystonia in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "When phenobarbital was readministered 1 week later, the hamsters again exhibited severe dystonia." | 5.31 | Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model. ( Löscher, W; Richter, A, 2000) |
| "When phenobarbital was readministered 1 week later, the hamsters again exhibited severe dystonia." | 1.31 | Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model. ( Löscher, W; Richter, A, 2000) |
| "The underlying mechanisms of idiopathic dystonias are poorly understood." | 1.31 | Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia. ( Hamann, M; Richter, A, 2002) |
| "Attacks of sustained dystonia of the limbs and trunk can be initiated by handling or mild environmental stimuli (e." | 1.29 | Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters. ( Löscher, W; Richter, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Richter, A | 3 |
| Löscher, W | 3 |
| Hamann, M | 1 |
| Lacayo, A | 1 |
| Mitra, N | 1 |
| Fredow, G | 1 |
| Maccario, M | 1 |
| Lustman, LI | 1 |
6 other studies available for phenobarbital and Dystonia
| Article | Year |
|---|---|
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
Topics: Aging; Aminooxyacetic Acid; Animals; Cricetinae; Diazepam; Dopamine Antagonists; Dystonia; Mesocrice | 1993 |
Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.
Topics: Aging; Animals; Area Under Curve; Behavior, Animal; Cricetinae; Disease Models, Animal; Dose-Respons | 2000 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flur | 2002 |
Report of a case of phenobarbital-induced dystonia.
Topics: Dystonia; Female; Humans; Infant; Phenobarbital; Status Epilepticus | 1992 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
Paroxysmal nocturnal dystonia presenting as excessive daytime somnolence.
Topics: Adult; Carbamazepine; Diagnosis, Differential; Dystonia; Electroencephalography; Evaluation Studies | 1990 |