phenobarbital has been researched along with Dupuytren Contracture in 7 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Dupuytren Contracture: A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The disease occurred after one to four years of drug therapy, at dosage of 100 mg/day." | 5.37 | Dupuytren's contracture as result of prolonged administration of phenobarbital. ( Cordova, A; Moschella, F; Tripoli, M, 2011) |
| " The disease occurred after one to four years of drug therapy, at dosage of 100 mg/day." | 1.37 | Dupuytren's contracture as result of prolonged administration of phenobarbital. ( Cordova, A; Moschella, F; Tripoli, M, 2011) |
| "We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy, developed Dupuytren's and Ledderhose's diseases." | 1.30 | [Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report]. ( Coral, P; Correa Neto, Y; Nóvak, EM; Teive, HA; Werneck, LC; Zanatta, A, 1999) |
| "The incidence of Dupuytren's disease amongst the residents of two epileptic centres was found to be 12." | 1.28 | Dupuytren's and epilepsy revisited. ( Allen, J; Arafa, M; Noble, J; Royle, SG; Trail, IA, 1992) |
| " The incidence increased with the duration of epilepsy and is probably a sequel to long-term administration of phenobarbitone." | 1.26 | Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. ( Critchley, EM; Hayward, HW; Owen, VM; Vakil, SD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tripoli, M | 1 |
| Cordova, A | 1 |
| Moschella, F | 1 |
| Fröscher, W | 1 |
| Hoffmann, F | 1 |
| Coral, P | 1 |
| Zanatta, A | 1 |
| Teive, HA | 1 |
| Correa Neto, Y | 1 |
| Nóvak, EM | 1 |
| Werneck, LC | 1 |
| de Haas, WH | 1 |
| Mastrosimone, F | 1 |
| Colucci d'Amato, C | 1 |
| di Cerbo, M | 1 |
| de Angelis, G | 1 |
| Capo, G | 1 |
| Critchley, EM | 1 |
| Vakil, SD | 1 |
| Hayward, HW | 1 |
| Owen, VM | 1 |
| Arafa, M | 1 |
| Noble, J | 1 |
| Royle, SG | 1 |
| Trail, IA | 1 |
| Allen, J | 1 |
7 other studies available for phenobarbital and Dupuytren Contracture
| Article | Year |
|---|---|
Dupuytren's contracture as result of prolonged administration of phenobarbital.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Administration Schedul | 2011 |
[Dupuytren's contracture and phenobarbital administration in epilepsy patients].
Topics: Adolescent; Adult; Bone Neoplasms; Dupuytren Contracture; Epilepsy; Female; Fibroma; Foot Diseases; | 1983 |
[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report].
Topics: Adult; Anticonvulsants; Diazepam; Dupuytren Contracture; Epilepsy; Foot Diseases; Humans; Male; Phen | 1999 |
[Dupuytren's disease; current viewpoints].
Topics: Blood Circulation; Dupuytren Contracture; Epilepsy; Fascia; Female; Humans; Male; Occupational Disea | 1979 |
[Relation between epilepsy, antiepileptic therapy and Dupuytren's disease].
Topics: Dupuytren Contracture; Epilepsy; Humans; Male; Middle Aged; Phenobarbital | 1978 |
Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants.
Topics: Adult; Anticonvulsants; Dupuytren Contracture; Epilepsy; Female; Humans; Male; Middle Aged; Phenobar | 1976 |
Dupuytren's and epilepsy revisited.
Topics: Adult; Aged; Anticonvulsants; Dupuytren Contracture; England; Epilepsy; Female; Fingers; Humans; Inc | 1992 |