phenobarbital has been researched along with Dubin-Johnson Syndrome in 15 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DJS with severe cholestasis has not to our knowledge been described in the English literature." | 5.28 | Neonatal Dubin-Johnson syndrome with severe cholestasis: effective phenobarbital therapy. ( Fujisawa, T; Inokuchi, T; Kage, M; Kimura, A; Mahara, R; Ono, E; Shibao, K; Tanaka, N; Tohma, M; Ushijima, K, 1991) |
| "An oral tolerance test using a 25-mg dose of ursodeoxycholic acid was carried out in 46 patients with constitutional hyperbilirubinemias: 26 with Gilbert's syndrome, 9 with Dubin-Johnson syndrome, 7 with Rotor Syndrome, 3 with constitutional indocyanine green intolerance, and 1 with Crigler-Najjar syndrome type II; they were compared with 14 healthy control subjects." | 3.66 | Ursodeoxycholic acid oral tolerance test in patients with constitutional hyperbilirubinemias and effect of phenobarbital. ( Iida, S; Makino, I; Ohkubo, H; Okuda, K, 1981) |
| "DJS with severe cholestasis has not to our knowledge been described in the English literature." | 1.28 | Neonatal Dubin-Johnson syndrome with severe cholestasis: effective phenobarbital therapy. ( Fujisawa, T; Inokuchi, T; Kage, M; Kimura, A; Mahara, R; Ono, E; Shibao, K; Tanaka, N; Tohma, M; Ushijima, K, 1991) |
| "Phenobarbital alone has been useful, so far, in the treatment of cholesterol gallstones." | 1.25 | Barbituates and biliary function. ( Capron, JP; Erlinger, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ohkubo, H | 1 |
| Okuda, K | 1 |
| Iida, S | 1 |
| Makino, I | 1 |
| Capron, JP | 1 |
| Erlinger, S | 1 |
| Gonciarz, Z | 1 |
| Czarnecka, K | 1 |
| Wehinger, H | 1 |
| Oleĭnik, AN | 1 |
| Schenk, J | 1 |
| Stiehl, A | 1 |
| Merdler, C | 2 |
| Felner, S | 2 |
| Burke, M | 2 |
| Shani, M | 3 |
| Lurie, I | 2 |
| Olaso, V | 1 |
| Sala, T | 1 |
| Gras, D | 1 |
| Berenguer, J | 1 |
| Baguena, J | 1 |
| Kimura, A | 1 |
| Ushijima, K | 1 |
| Kage, M | 1 |
| Mahara, R | 1 |
| Tohma, M | 1 |
| Inokuchi, T | 1 |
| Shibao, K | 1 |
| Tanaka, N | 1 |
| Fujisawa, T | 1 |
| Ono, E | 1 |
| Seligsohn, U | 1 |
| Ben-Ezzer, J | 1 |
| Wennberg, RP | 1 |
| Villanueva, A | 1 |
| Llopis, J | 1 |
| García-Ciudad, P | 1 |
| Arca, A | 1 |
| Uehara, A | 1 |
| Owada, T | 1 |
| Kondo, T | 1 |
| Shimoda, S | 1 |
| Yamada, T | 1 |
4 reviews available for phenobarbital and Dubin-Johnson Syndrome
| Article | Year |
|---|---|
[Phenobarbital in the treatment of hepatic disorders of bilirubin metabolism].
Topics: Bilirubin; Cholestasis; Drug Evaluation; Humans; Hyperbilirubinemia; Jaundice, Chronic Idiopathic; L | 1979 |
[Congenital nonhemolytic hyperbilirubinemias].
Topics: Adolescent; Adult; Age Factors; Bilirubin; Child; Child, Preschool; Cholestasis; Chronic Disease; Cr | 1977 |
[Effect of phenobarbital on the intrahepatic metabolism of bilirubin].
Topics: Animals; Bile; Bilirubin; Biological Transport, Active; Cytoplasm; Drug Evaluation; Drug Interaction | 1978 |
What to do when the infant is jaundiced.
Topics: Animals; Bilirubin; Diagnosis, Differential; Erythroblastosis, Fetal; Erythropoiesis; Exchange Trans | 1971 |
11 other studies available for phenobarbital and Dubin-Johnson Syndrome
| Article | Year |
|---|---|
Ursodeoxycholic acid oral tolerance test in patients with constitutional hyperbilirubinemias and effect of phenobarbital.
Topics: Administration, Oral; Adult; Deoxycholic Acid; Female; Gilbert Disease; Humans; Hyperbilirubinemia, | 1981 |
Barbituates and biliary function.
Topics: Adenosine Triphosphatases; Animals; Bile; Bile Acids and Salts; Biliary Tract; Bilirubin; Cholelithi | 1975 |
[Hyperbilirubinemias; diagnostic and therapeutic aspects].
Topics: Adult; Bilirubin; Diagnosis, Differential; Gilbert Disease; Hemolysis; Humans; Hyperbilirubinemia; I | 1979 |
[Treatment of various forms of icterus or cholestasis with phenobarbital (author's transl)].
Topics: Adult; Anemia, Hemolytic; Cholangitis; Cholestasis; Crigler-Najjar Syndrome; Gilbert Disease; Humans | 1977 |
[Phenobarbital in Dubin-Johnson syndrome].
Topics: Humans; Jaundice, Chronic Idiopathic; Phenobarbital | 1976 |
The effect of phenobarbital on patients with Dubin-Johnson syndrome.
Topics: Adolescent; Adult; Bilirubin; Drug Evaluation; Female; Humans; Jaundice, Chronic Idiopathic; Liver; | 1976 |
[Rotor's syndrome. Effects of phenobarbital].
Topics: Child; Female; Humans; Jaundice, Chronic Idiopathic; Phenobarbital | 1976 |
Neonatal Dubin-Johnson syndrome with severe cholestasis: effective phenobarbital therapy.
Topics: Bile Acids and Salts; Bilirubin; Cholestasis; Humans; Infant, Newborn; Jaundice, Chronic Idiopathic; | 1991 |
Effect of phenobarbital on liver functions in patients with Dubin-Johnson syndrome.
Topics: Adult; Bilirubin; Biological Transport; Enzyme Induction; Factor VII; Female; Humans; Jaundice, Chro | 1974 |
[Dubin-Johnson syndrome. Action of phenobarbital].
Topics: Adult; Bilirubin; Humans; Jaundice, Chronic Idiopathic; Male; Phenobarbital | 1972 |
[2 cases of Dubin-Johnson syndrome with lowered serum bilirubin level after administration of phenobarhital].
Topics: Adult; Bilirubin; Female; Humans; Jaundice, Chronic Idiopathic; Liver; Liver Function Tests; Male; P | 1969 |