phenobarbital has been researched along with Drug Overdose in 37 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxepin is a tricyclic antidepressant from the group of dibenzoxepines." | 5.38 | [Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study]. ( Kołodziej, M; Krajewska, A; Majewska, M; Szponar, J, 2012) |
| " The results also revealed statistically significant greater total body clearance for phenobarbital and consequently a shorter half-life with MDAC treatment versus either urinary alkalinization alone or the combined use of both." | 5.31 | Pharmacokinetics of phenobarbital during certain enhanced elimination modalities to evaluate their clinical efficacy in management of drug overdose. ( Abdel-Rahman, HM; Mohammed Ebid, AH, 2001) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 5.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "Phenobarbital is a long-acting barbiturate often prescribed for seizure disorders." | 2.38 | Acute phenobarbital intoxication. ( Cunningham, A; Lindberg, MC; Lindberg, NH, 1992) |
| "Phenobarbital is a long-acting barbiturate, which in an overdose can cause central nervous system depression, respiratory failure and haemodynamic instability; these patients can remain obtunded for many days." | 1.39 | Successful use of haemodialysis to treat phenobarbital overdose. ( Austin, R; Hoy, M; Hoyland, K; Wildman, M, 2013) |
| "Doxepin is a tricyclic antidepressant from the group of dibenzoxepines." | 1.38 | [Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study]. ( Kołodziej, M; Krajewska, A; Majewska, M; Szponar, J, 2012) |
| "Methadone was the culprit in 3 boys and 1 girl, resulting in respiratory failure, depressed conscious state and pinpoint pupils." | 1.35 | Poisoning necessitating pediatric ICU admissions: size of pupils does matter. ( Cheung, KL; Ho, JK; Hon, KL; Hung, EC; Ng, PC, 2008) |
| "Phenobarbital has a long elimination half-life and for this reason it is advisable to use means to accelerate clearance until the clinical condition of the patient shows improvement." | 1.32 | [Accelerated elimination using hemoperfusion in a patient with phenobarbital intoxication]. ( Bouma, AW; Meynaar, IA; Peltenburg, HG; van Dam, B; Walenbergh-van Veen, MC, 2004) |
| "An erroneous diagnosis of seizure lead to phenobarbital overdose and the change of aEEG voltage and pattern assisted in a prompt diagnosis." | 1.32 | The influence of phenobarbital overdose on aEEG recording. ( Shany, E, 2004) |
| "Lamotrigine (Lamictal) is a new anticonvulsant drug recently approved for use in the United States." | 1.31 | Lamotrigine distribution in two postmortem cases. ( Jufer, RA; Levine, B; Smialek, JE, 2000) |
| "Mexiletine is a group Ib antidysrhythmic agent with electrophysiologic effects similar to lidocaine." | 1.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (10.81) | 18.7374 |
| 1990's | 6 (16.22) | 18.2507 |
| 2000's | 16 (43.24) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Tsutsumi, H | 1 |
| Yonemitsu, K | 1 |
| Sasao, A | 1 |
| Ohtsu, Y | 1 |
| Furukawa, S | 1 |
| Nishitani, Y | 1 |
| Minissale, MG | 1 |
| Giannitrapani, L | 1 |
| Capitano, A | 1 |
| Morreale, I | 1 |
| Licata, A | 1 |
| Tanikawa, A | 1 |
| Seki, S | 1 |
| Yasuda, T | 1 |
| Hasegawa, E | 1 |
| Tominaga, A | 1 |
| Iseki, K | 1 |
| Hayashida, M | 1 |
| Shinosaki, K | 1 |
| Toyokuchi, S | 1 |
| Shiroishi, T | 1 |
| Hoyland, K | 1 |
| Hoy, M | 1 |
| Austin, R | 1 |
| Wildman, M | 1 |
| Sachdeva, S | 1 |
| Bhansali, P | 1 |
| Fletcher, C | 1 |
| Jones, A | 1 |
| Miller, H | 1 |
| Mittal, V | 1 |
| Hassanian-Moghaddam, H | 1 |
| Ghadiri, F | 1 |
| Shojaei, M | 1 |
| Zamani, N | 1 |
| Hon, KL | 1 |
| Ho, JK | 1 |
| Hung, EC | 1 |
| Cheung, KL | 1 |
| Ng, PC | 1 |
| Matsusue, A | 1 |
| Hara, K | 1 |
| Kageura, M | 1 |
| Kashiwagi, M | 1 |
| Lu, W | 1 |
| Ishigami, A | 1 |
| Gotohda, T | 1 |
| Tokunaga, I | 1 |
| Nisimura, A | 1 |
| Sugimura, T | 1 |
| Kubo, S | 1 |
| Prajapati, P | 1 |
| Sheikh, MI | 1 |
| Brahmbhatt, J | 1 |
| Levine, M | 1 |
| Brooks, DE | 1 |
| Franken, A | 1 |
| Graham, R | 1 |
| George, M | 1 |
| Kitzmiller, JP | 1 |
| Ewald, MB | 1 |
| O'Donell, KA | 1 |
| Becter, ML | 1 |
| Salhanick, S | 1 |
| Kołodziej, M | 1 |
| Majewska, M | 1 |
| Krajewska, A | 1 |
| Szponar, J | 1 |
| Mégarbane, B | 1 |
| Goldgran-Tolédano, D | 1 |
| Delahaye, A | 1 |
| Gizzi, M | 1 |
| Baud, F | 1 |
| Berger, I | 1 |
| Steinberg, A | 1 |
| Schlesinger, Y | 1 |
| Seelenfreund, M | 1 |
| Schimmel, MS | 1 |
| Marx, J | 1 |
| GERSHON, S | 1 |
| SHAW, FH | 1 |
| Jacobs, F | 1 |
| Brivet, FG | 1 |
| Bouma, AW | 1 |
| van Dam, B | 1 |
| Meynaar, IA | 1 |
| Peltenburg, HG | 1 |
| Walenbergh-van Veen, MC | 1 |
| Shany, E | 1 |
| Wilding, P | 1 |
| Heath, DA | 1 |
| Lal, R | 1 |
| Faiz, S | 1 |
| Garg, RK | 1 |
| Baweja, KS | 1 |
| Guntupalli, J | 1 |
| Finkel, KW | 1 |
| Thompson, TM | 1 |
| Aks, SE | 1 |
| Ghoreishi, A | 1 |
| Bryant, SM | 1 |
| Mycyk, MB | 1 |
| Nelson, LS | 1 |
| Hoffman, RS | 2 |
| Newton, EH | 1 |
| Shih, RD | 1 |
| Martin, FL | 1 |
| McLean, AE | 1 |
| Sancak, R | 1 |
| Küçüködük, S | 1 |
| Taşdemir, HA | 1 |
| Belet, N | 1 |
| Palmer, BF | 1 |
| Levine, B | 1 |
| Jufer, RA | 1 |
| Smialek, JE | 1 |
| Mohammed Ebid, AH | 1 |
| Abdel-Rahman, HM | 1 |
| Kruse, JA | 1 |
| Carlson, RW | 1 |
| Lindberg, MC | 1 |
| Cunningham, A | 1 |
| Lindberg, NH | 1 |
| de Boer, WB | 1 |
| Kendall, PA | 1 |
| Breheny, FX | 1 |
| Lin, SL | 1 |
| Chung, MY | 1 |
2 reviews available for phenobarbital and Drug Overdose
| Article | Year |
|---|---|
Fatal rodenticide poisoning with brodifacoum.
Topics: 4-Hydroxycoumarins; Adult; Blood Coagulation Disorders; Blood Transfusion; Drug Overdose; Emergency | 1992 |
Acute phenobarbital intoxication.
Topics: Drug Overdose; Humans; Phenobarbital; Suicide | 1992 |
35 other studies available for phenobarbital and Drug Overdose
| Article | Year |
|---|---|
Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model.
Topics: Administration, Oral; Animals; Biomarkers; Carboxymethylcellulose Sodium; Chromatography, Liquid; Di | 2020 |
A questionable diagnosis in a woman with drowsiness.
Topics: Benzodiazepines; Biomarkers; Depression; Diagnosis, Differential; Drug Overdose; Female; Humans; Mid | 2021 |
Successful use of the two-tube approach for the treatment of phenobarbital poisoning without hemodialysis.
Topics: Charcoal; Drug Overdose; Enterohepatic Circulation; Female; Hemoperfusion; Humans; Hypnotics and Sed | 2019 |
[Case of phenobarbital intoxication taken to hospital three days after overdose].
Topics: Acute Disease; Anticonvulsants; Charcoal; Drug Overdose; Female; Fluid Therapy; Hospitalization; Hum | 2013 |
Successful use of haemodialysis to treat phenobarbital overdose.
Topics: Drug Overdose; Female; Humans; Hypnotics and Sedatives; Middle Aged; Phenobarbital; Renal Dialysis | 2013 |
Index of suspicion.
Topics: Adolescent; Consciousness Disorders; Coronary Vessel Anomalies; Cough; Diagnosis, Differential; Drug | 2014 |
Kaneuron: an oral solution of phenobarbital with dangerous packaging.
Topics: Administration, Oral; Anticonvulsants; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Labeli | 2015 |
Phenobarbital overdose presenting with status epilepticus: A case report.
Topics: Anticonvulsants; Drug Overdose; Humans; Male; Middle Aged; Phenobarbital; Status Epilepticus | 2016 |
Poisoning necessitating pediatric ICU admissions: size of pupils does matter.
Topics: Central Nervous System Depressants; Child; Child, Preschool; Drug Overdose; Female; Humans; Infant; | 2008 |
Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin.
Topics: Adult; Amino Acid Substitution; Antipsychotic Agents; Brain; Brain Edema; Carnitine O-Palmitoyltrans | 2009 |
Barbiturate overdose: a case report.
Topics: Adult; Drug Overdose; Fatal Outcome; Humans; Hypnotics and Sedatives; India; Male; Phenobarbital; St | 2009 |
Delayed-onset seizure and cardiac arrest after amitriptyline overdose, treated with intravenous lipid emulsion therapy.
Topics: Adolescent; Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Combined Modality Ther | 2012 |
Methadone toxicity and possible induction and enhanced elimination in a premature neonate.
Topics: Cytochrome P-450 CYP3A; Drug Overdose; Humans; Infant, Newborn; Intensive Care Units; Male; Methadon | 2012 |
[Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study].
Topics: Antidepressive Agents, Tricyclic; Coma; Complex Mixtures; Doxepin; Drug Overdose; Drug Synergism; Hu | 2012 |
[Suicide by internet].
Topics: Adult; Commerce; Drug Overdose; Drug Prescriptions; Humans; Hypnotics and Sedatives; Internet; Male; | 2002 |
Neonatal mydriasis: intravenous lidocaine adverse reaction.
Topics: Anti-Arrhythmia Agents; Anticonvulsants; Diagnosis, Differential; Drug Overdose; Drug Therapy, Combi | 2002 |
Toxicology. Protecting liver from painkiller's lethal dose.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Androstanols; Animals; Benzoquinones; Constitutive Androsta | 2002 |
Effects of bemegride on barbiturate overdosage in humans.
Topics: Barbiturates; Bemegride; Central Nervous System Stimulants; Drug Overdose; Humans; Phenobarbital | 1957 |
Conventional haemodialysis significantly lowers toxic levels of phenobarbital.
Topics: Aged; Drug Overdose; Hemoperfusion; Humans; Male; Phenobarbital; Renal Dialysis | 2004 |
[Accelerated elimination using hemoperfusion in a patient with phenobarbital intoxication].
Topics: Adult; Charcoal; Drug Overdose; Female; Hemoperfusion; Humans; Hypnotics and Sedatives; Phenobarbita | 2004 |
The influence of phenobarbital overdose on aEEG recording.
Topics: Diagnostic Errors; Drug Overdose; Electroencephalography; Humans; Hypnotics and Sedatives; Infant, N | 2004 |
Effect of paracetamol on uric acid determination.
Topics: Acetaminophen; Adult; Anticonvulsants; Autoanalysis; Bromides; Diazepam; Dose-Response Relationship, | 1975 |
Use of continuous venovenous hemodiafiltration in a case of severe phenobarbital poisoning.
Topics: Coma; Drug Overdose; Hemodiafiltration; Humans; Hypnotics and Sedatives; Hypotension; Male; Middle A | 2006 |
Case files of the toxikon medical toxicology fellowship in Chicago: the poisoned anesthesiologist.
Topics: Anesthesiology; Charcoal; Drug Overdose; Fellowships and Scholarships; Humans; Phenobarbital; Suicid | 2007 |
A somatic type delusional disorder secondary to peripheral neuropathy: a case report.
Topics: Adult; Amitriptyline; Biperiden; Brachial Plexus; Delusions; Drug Overdose; Drug Therapy, Combinatio | 2008 |
Response to self-poisoning with pet medications.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Drug Overdose; Humans; Phenobarbital; Suicide, Attempt | 2008 |
Mexiletine overdose producing status epilepticus without cardiovascular abnormalities.
Topics: Adult; Blood Pressure; Cardiovascular System; Diazepam; Drug Overdose; Drug Therapy, Combination; El | 1994 |
Cyclic antidepressant overdose: a review of current management strategies.
Topics: Animals; Antidepressive Agents, Tricyclic; Drug Overdose; Electrocardiography; Emergencies; Humans; | 1994 |
Adenosine triphosphate (ATP) levels in paracetamol-induced cell injury in the rat in vivo and in vitro.
Topics: Acetaminophen; Adenosine Triphosphate; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Dose | 1995 |
Exchange transfusion treatment in a newborn with phenobarbital intoxication.
Topics: Adult; Drug Overdose; Exchange Transfusion, Whole Blood; Female; Humans; Infant, Low Birth Weight; I | 1999 |
Effectiveness of hemodialysis in the extracorporeal therapy of phenobarbital overdose.
Topics: Adult; Anticonvulsants; Charcoal; Coma; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Phen | 2000 |
Lamotrigine distribution in two postmortem cases.
Topics: Adult; Anticonvulsants; Drug Overdose; Female; Gas Chromatography-Mass Spectrometry; Humans; Lamotri | 2000 |
Pharmacokinetics of phenobarbital during certain enhanced elimination modalities to evaluate their clinical efficacy in management of drug overdose.
Topics: Adult; Charcoal; Drug Overdose; Half-Life; Humans; Male; Phenobarbital; Respiration, Artificial | 2001 |
Alpha coma and barbiturate poisoning.
Topics: Alpha Rhythm; Barbiturates; Carbon Monoxide Poisoning; Coma; Drug Overdose; Electroencephalography; | 1989 |
Acute primidone intoxication: report of a case.
Topics: Adult; Central Nervous System; Drug Overdose; Electroencephalography; Humans; Male; Phenobarbital; P | 1989 |